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CN106232616A - 两亲性合成抗菌肽、其药物组合物及其用途 - Google Patents

两亲性合成抗菌肽、其药物组合物及其用途 Download PDF

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Publication number
CN106232616A
CN106232616A CN201580020639.9A CN201580020639A CN106232616A CN 106232616 A CN106232616 A CN 106232616A CN 201580020639 A CN201580020639 A CN 201580020639A CN 106232616 A CN106232616 A CN 106232616A
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CN
China
Prior art keywords
derivative
pharmaceutically acceptable
acceptable salt
peptide
amino acids
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CN201580020639.9A
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English (en)
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CN106232616B (zh
Inventor
刘克良
邹存彬
孟庆斌
刘兴东
王晨宏
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Academy of Military Medical Sciences AMMS of PLA
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Institute of Pharmacology and Toxicology of AMMS
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

本发明属于生物医药领域，提供了一类具有自由巯基或其二聚体的抗菌肽、其药物组合物及用途。

Description

PCT国内申请，说明书已公开。

Claims (19)

  1. PCT国内申请，权利要求书已公开。
CN201580020639.9A 2014-04-24 2015-04-24 两亲性合成抗菌肽、其药物组合物及其用途 Expired - Fee Related CN106232616B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201410166654 2014-04-24
CN2014101666541 2014-04-24
PCT/CN2015/077337 WO2015161820A1 (zh) 2014-04-24 2015-04-24 两亲性合成抗菌肽、其药物组合物及其用途

Publications (2)

Publication Number Publication Date
CN106232616A true CN106232616A (zh) 2016-12-14
CN106232616B CN106232616B (zh) 2019-10-25

Family

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Family Applications (1)

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CN201580020639.9A Expired - Fee Related CN106232616B (zh) 2014-04-24 2015-04-24 两亲性合成抗菌肽、其药物组合物及其用途

Country Status (2)

Country Link
CN (1) CN106232616B (zh)
WO (1) WO2015161820A1 (zh)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110128544A (zh) * 2019-04-03 2019-08-16 中国农业大学 一种具有免疫调节和抗炎功能的杂合肽及其制备方法与应用
WO2021129779A1 (zh) * 2019-12-26 2021-07-01 李瑛� 一种新型两亲性蛋白、其制备方法及用途
CN114805821A (zh) * 2022-04-28 2022-07-29 上海摩漾生物科技有限公司 一种基于纤维素的可降解抗菌肽及其制备方法
CN116332777A (zh) * 2023-02-20 2023-06-27 华中科技大学 二芳基苯甲胺类化合物、制备及作为载体合成多肽的应用
CN118307634A (zh) * 2023-03-31 2024-07-09 中国人民解放军军事科学院军事医学研究院 一种抗菌肽衍生物及其合成方法和在抗耐药菌方面中的应用
CN120118198A (zh) * 2025-01-27 2025-06-10 中国人民解放军军事科学院军事医学研究院 一种两亲性双环肽及其应用

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3018561A1 (en) 2016-03-21 2017-09-28 Rhode Island Council On Postsecondary Education Ph-sensitive peptides
US11130781B2 (en) 2017-04-25 2021-09-28 Universiteit Utrecht Holding B.V. Antimicrobial peptides and their use
US20220411472A1 (en) * 2019-07-02 2022-12-29 Fred Hutchinson Cancer Center Self-assembling circular tandem repeat proteins with increased stability
CN114989254B (zh) * 2022-06-17 2023-11-03 中山大学 一种多肽及其设计方法和在制备抑制具核梭杆菌产品或预防结直肠癌药物中的应用
CN116874562A (zh) * 2023-07-28 2023-10-13 兰州大学 以Rn为转角的具有KW重复序列的中心对称β-发卡型抗菌肽及其应用
CN118480089B (zh) * 2024-05-07 2025-04-22 东北农业大学 抗酶解的双子型表面活性剂样抗菌肽及制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101040848A (zh) * 2007-04-19 2007-09-26 上海交通大学 两亲性聚合物载药纳米粒子的制备方法
CN101570569A (zh) * 2008-04-29 2009-11-04 昆山博青生物科技有限公司 合成抗菌肽、其制备方法及应用
CN102079821A (zh) * 2009-10-07 2011-06-01 强生消费者公司 含有超亲水两亲性共聚物的组合物及其应用方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2468033C2 (ru) * 2006-07-10 2012-11-27 Пба3 БиоМед ГмбХ Антибактериальные пептиды
DE102007036128A1 (de) * 2007-07-23 2009-02-12 Universität Leipzig Antibiotische Peptide

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101040848A (zh) * 2007-04-19 2007-09-26 上海交通大学 两亲性聚合物载药纳米粒子的制备方法
CN101570569A (zh) * 2008-04-29 2009-11-04 昆山博青生物科技有限公司 合成抗菌肽、其制备方法及应用
CN102079821A (zh) * 2009-10-07 2011-06-01 强生消费者公司 含有超亲水两亲性共聚物的组合物及其应用方法

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110128544A (zh) * 2019-04-03 2019-08-16 中国农业大学 一种具有免疫调节和抗炎功能的杂合肽及其制备方法与应用
CN110128544B (zh) * 2019-04-03 2020-12-01 中国农业大学 一种具有免疫调节和抗炎功能的杂合肽及其制备方法与应用
WO2021129779A1 (zh) * 2019-12-26 2021-07-01 李瑛� 一种新型两亲性蛋白、其制备方法及用途
CN114805821A (zh) * 2022-04-28 2022-07-29 上海摩漾生物科技有限公司 一种基于纤维素的可降解抗菌肽及其制备方法
CN114805821B (zh) * 2022-04-28 2023-02-03 上海摩漾生物科技有限公司 一种基于纤维素的可降解抗菌肽及其制备方法
CN116332777A (zh) * 2023-02-20 2023-06-27 华中科技大学 二芳基苯甲胺类化合物、制备及作为载体合成多肽的应用
CN118307634A (zh) * 2023-03-31 2024-07-09 中国人民解放军军事科学院军事医学研究院 一种抗菌肽衍生物及其合成方法和在抗耐药菌方面中的应用
CN120118198A (zh) * 2025-01-27 2025-06-10 中国人民解放军军事科学院军事医学研究院 一种两亲性双环肽及其应用

Also Published As

Publication number Publication date
CN106232616B (zh) 2019-10-25
WO2015161820A1 (zh) 2015-10-29

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Inventor after: Meng Qingbin

Inventor after: Zou Cunbin

Inventor after: Liu Xingdong

Inventor after: Wang Chenhong

Inventor after: Liu Keliang

Inventor before: Liu Keliang

Inventor before: Zou Cunbin

Inventor before: Meng Qingbin

Inventor before: Liu Xingdong

Inventor before: Wang Chenhong

TA01 Transfer of patent application right
TA01 Transfer of patent application right

Effective date of registration: 20190813

Address after: 100850 Taiping Road, Beijing, Haidian District, No. 27

Applicant after: ACADEMY OF MILITARY MEDICAL SCIENCES

Address before: 100850 Taiping Road, Beijing, Haidian District, No. 27

Applicant before: INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES PLA CHINA

GR01 Patent grant
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CF01 Termination of patent right due to non-payment of annual fee
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Granted publication date: 20191025