CN106236317A - A kind of trace injection instrument - Google Patents

Abstract

Embodiments provide a kind of trace injection instrument, wherein, described trace injection instrument includes: be relatively fixed propelling locating module and the injection module of connection, described propelling locating module is for the positioning instruction of receiving control apparatus, drive described injection module lock onto target injection position, described injection module, for the injection instruction of receiving control apparatus, carries out locating injection for described targeted injection position.Use the embodiment of the present invention, convenient and swift property and the accuracy of micro-injection can be improved.

Description

A microinjector

technical field

The invention relates to the technical field of medical instruments, in particular to a microinjection instrument.

Background technique

At present, the existing microinjection scheme for animal cerebral cortex is to perform intracerebral microinjection by manually adjusting the stereotaxic instrument and manually screwing in the Hamilton microinjector. There is a relatively large error in finding the injection position, the degree of automation is low, and the user's operation is not easy; in addition, the manual operation causes a large vibration during the advancement of the needle, which will damage the brain tissue, and the flow rate of the bolus injection is also unstable. Lead to large differences in individual injections. Therefore, an intelligent microinjection protocol is needed.

Contents of the invention

The technical problem to be solved by the embodiments of the present invention is to provide a micro-injection instrument, which can improve the convenience, quickness and accuracy of micro-injection.

On the one hand, an embodiment of the present invention discloses a microinjection apparatus, which includes: a propulsion and positioning module and an injection module that are relatively fixedly connected, and the propulsion and positioning module is used to receive a positioning instruction from a control device, and drive the The injection module locks the target injection position, and the injection module is used to receive an injection command from the control device, and perform positioning injection for the target injection position.

Wherein optionally, the propulsion positioning module includes: a first sliding table and a first motor, the fixed end of the first sliding table is fixedly connected to the first motor;

When receiving a positioning command from the control device, the first motor drives the first sliding table, and the injection module searches for and locks the target injection position indicated by the positioning command.

Wherein optionally, the injection module includes a second sliding table, a second motor and an injector, and the fixed end of the second sliding table is fixedly connected to the sliding end of the first sliding table and the second motor respectively, The sliding end of the second slide is fixedly connected to the syringe;

When receiving an injection command from the control device, the second motor drives the injector through the second sliding table to perform positioning injection at the target injection position.

Optionally, the microinjection instrument further includes: a fixed module, the fixed module includes a fixed rod clamp, one end of the fixed rod clamp is connected with the sliding end of the first sliding table, and the fixed rod clamp The other end is provided with a fixing clip for holding and fixing the syringe.

Wherein optionally, the syringe includes a capillary needle, and the sliding end of the second sliding platform is fixedly connected to an end of the needle far away from the capillary needle.

Wherein optionally, the syringe includes a piston, a liquid suction cylinder, and a capillary needle, the sliding end of the second sliding table is fixedly connected to the piston, the piston is connected to the inner wall of the liquid suction cylinder, and the capillary needle Installed on the liquid suction cylinder in a screw or buckle manner, so that when receiving an injection instruction from the control device, the second motor drives the piston of the syringe to move through the second sliding table, and The target injection site is used for positioning injection.

Wherein optionally, the capillary needle is formed by hot drawing of a capillary, and the inner diameter of the capillary is not more than 1mm.

Wherein optionally, the capillary refers to a non-metal conduit or a glass conduit.

Optionally, the syringe is filled with silicone oil for micro-aspiration or injection at the needle end close to the capillary needle.

Optionally, the second slide table includes any one of a slide rod, a rotating screw, and a push rod, and the first motor and the second motor include a stepping motor or a driver.

It can be seen that a micro-injection instrument disclosed in the embodiment of the present invention includes a push positioning module and an injection module that are relatively fixedly connected. location, the injection module is used to receive the injection instruction from the control device, and perform positioning injection for the target injection position; in this way, it can automatically and intelligently perform positioning injection according to the actual needs of the animal, which improves the convenience and speed of micro-injection precision and precision.

Description of drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description are only These are some embodiments of the present invention. Those skilled in the art can also obtain other drawings based on these drawings without creative work.

Fig. 1 is the structural representation of a kind of microinjection apparatus of the embodiment of the present invention;

Fig. 2 is a schematic structural view of a microinjection apparatus according to another embodiment of the present invention.

detailed description

In order to enable those skilled in the art to better understand the solutions of the present invention, the following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only It is an embodiment of a part of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.

The terms "first", "second" and "third" (if any) and the like in the description and claims of the present invention and the above drawings are used to distinguish different objects, rather than to describe a specific order. Furthermore, the term "comprise", as well as any variations thereof, is intended to cover a non-exclusive inclusion. For example, a process, method, system, product or device comprising a series of steps or units is not limited to the listed steps or units, but optionally also includes unlisted steps or units, or optionally further includes For other steps or units inherent in these processes, methods, products or apparatuses.

Please refer to FIG. 1 , which is a schematic structural diagram of a microinjection apparatus according to an embodiment of the present invention. The microinjection apparatus according to this embodiment of the present invention may include a push positioning module 10 and an injection module 11, and the push positioning module 10 and the described The injection modules 11 are fixedly connected to each other, and the push positioning module 10 can be used to drive the push positioning module 10 and the push positioning module 10 when receiving a positioning instruction sent by a control device (such as a controller). The injection module 11 moves/advances according to the preset trajectory indicated by the positioning instruction, so that the injection module 11 finds and locks the target injection position corresponding to the positioning instruction; further, when the injection module 11 When receiving the injection instruction sent from the control device, the injection module 11 can perform corresponding drug injection or drug inhalation for the above-mentioned locked target injection position.

It can be seen that a micro-injection instrument disclosed in the embodiment of the present invention includes a push positioning module and an injection module that are relatively fixedly connected. location, the injection module is used to receive the injection instruction from the control device, and perform positioning injection for the target injection position; in this way, it can automatically and intelligently perform positioning injection according to the actual needs of the animal, which improves the convenience and speed of micro-injection precision and precision.

Please also refer to FIG. 2 , which is a schematic structural diagram of a microinjection apparatus according to another embodiment of the present invention. The microinjection apparatus in this embodiment of the present invention may include the above-mentioned propulsion positioning module 10 and injection module 11 , wherein the The propulsion and positioning module 10 includes: a first slide 1 and a first motor 2, the fixed end 100 of the first slide is fixedly connected to the first motor 2;

When receiving a positioning command from the control device, the first motor 2 drives the first slide 1 and the injection module 11 to find and lock the target injection position indicated by the positioning command.

In specific implementation, referring to Fig. 2, the fixed end 100 of the first sliding table 1 can be fixedly connected with the first motor 2 and the stereotaxic instrument 3 respectively, and the sliding end 101 of the first sliding table 1 can be It is fixedly connected with the injection module 11, wherein, when the animal needs to be injected with medicine, the brain stereotaxic instrument 3 can stereotaxically locate the position of the animal in three-dimensional space, and further fix the above-mentioned sliding table 1 on the The end of the Z-axis handle of the stereotaxic instrument 3. The first motor 2 can be controlled and driven by an external driver or controller. Optionally, the user/system can customize and store the input/stored control/positioning instructions in the microcontroller of the controller, wherein the positioning instructions can be The embodiment of the present invention does not limit the information including user/system custom settings such as preset motion track, motion distance, preset target positioning position and the like. When the first motor 2 receives the control/positioning instruction sent by the controller (that is, the control device), the first motor 2 can drive the first slide table 1 according to the instruction of the positioning instruction to perform preset The sliding of the trajectory will also drive the injection module 11 fixedly connected to the sliding end 101 of the first sliding table 1 to run on the same trajectory, so that the injection module can search and determine the corresponding desired object. The target injection site for the animal to be injected (such as a certain location in the cerebral cortex).

Optionally, the injection module 11 includes a second sliding table 4, a second motor 5 and an injector 6, and the fixed end 400 of the second sliding table 4 is connected to the sliding end 101 of the first sliding table and the The second motor 5 is fixedly connected, and the sliding end 401 of the second sliding table is fixedly connected with the syringe 6;

When receiving an injection command from the control device, the second motor 5 drives the injector 6 through the second sliding table 4 to perform positioning injection for the target injection position.

In specific implementation, the sliding end 101 of the first sliding table 1 can also be fixedly connected with the fixed end 401 of the second sliding table 4, and the fixed end 401 of the second sliding table 4 can also be connected with the second motor 5 Electrically connected, the sliding end of the second sliding table 4 is fixedly connected with the syringe 6, so that when the above-mentioned first motor 2 receives the positioning command, it can simultaneously drive the second sliding table 4 and the second motor 5 behind , and the syringe 6 move together, so that the syringe 6 finds/locks to the corresponding target injection position. Further, after the syringe is found/locked to the target injection position, if the second motor 5 receives an injection command from a control device (such as an external controller), the second motor 5 can drive the The second sliding platform 4 slides up and down correspondingly, allowing it to touch the syringe 6, or give the syringe 6 a force to make the syringe 6 aim at the current position (ie the above-mentioned locked target injection position) Carry out the corresponding drug positioning injection. Or, the sliding end 401 of the second sliding table 4 can also be fixedly connected with a push rod 7 (such as a thin stainless steel rod), and the push rod 7 is fixedly connected with the syringe 6, so that when the second motor After receiving the injection instruction, the target injection position is positioned for injection by sliding the second slide table 4 and pushing the push rod 7 against the syringe 6 at the same time. Optionally, the user/system can customize and store the input/stored control/injection instructions in the single-chip microcomputer of the controller device (such as the controller), wherein the injection instructions can include the dose of the injected drug, the injection start time, and The information such as the injection end time is not limited in this embodiment of the present invention.

Optionally, the microinjection instrument further includes: a fixed module 12, the fixed module 12 includes a fixed rod clamp 8, and one end 80 of the fixed rod clamp is connected to the sliding end 101 of the first sliding table, so The other end 81 of the fixing rod clamp is provided with a fixing clip 9 for clamping and fixing the syringe 6 .

Referring to Fig. 2, it can be seen that the microinjection instrument also includes a fixed rod clamp 8, and one end 80 of the fixed rod clamp is connected to the sliding end 101 of the first sliding table 1 and the fixed end of the second sliding table 4. 400 is fixedly connected, and the other end 81 of the fixing rod clamp is/is provided with a fixing clip 82, and the fixing clip 82 is used for clamping and fixing the syringe 6, so that the syringe 6 is positioned during injection. Phenomena such as position shift or shaking.

Wherein optionally, the syringe 6 includes a capillary needle 60, and the sliding end 40 of the second sliding table 4 is fixedly connected to an end of the needle far away from the capillary needle.

When the syringe 6 is only a microinjection needle, such as a capillary needle, the fixing clip 82 of the fixed rod clamp 8 can be clamped on the microinjection needle, and the second slide table 4 The sliding end 401 can be fixedly connected with the tail end of the microinjection needle, or referring to FIG. inside the tube.

Optionally, the syringe 6 includes a piston 61, a liquid suction cylinder 62, and a capillary needle 60, the sliding end 401 of the second sliding table 4 is fixedly connected to the piston 61, and the piston 61 is connected to the liquid suction tube. The inner wall of the cylinder 62 is connected, and the capillary needle 60 is installed on the liquid suction cylinder 62 in a screw or buckle manner, so that when receiving an injection instruction from the control device, the second motor passes through the second slide The stage drives the piston of the syringe to move, and performs positioning injection to the target injection position.

When the syringe 6 is a syringe including a piston 61, a liquid suction cylinder 62, and a capillary needle 60, the connection relationship between the syringe 6 and the second slide 4 can be: the second slide 4 The sliding end 401 of the sliding end 401 or the push rod 7 connected with the lower end of the sliding end 401 of the second sliding table 4 can be directly connected with the piston 61, and the piston 61 can be installed in the liquid suction cylinder 62, and the The inner wall of the liquid suction cylinder 62 is in contact, and the capillary needle 60 is mounted on the liquid suction cylinder 62 in a screw or buckle manner, so that when the second motor 5 receives an injection command, the The second sliding table 4 directly pushes or indirectly pushes the piston through the push rod 7, and then pushes the liquid suction cylinder 62 through the capillary needle 60 to absorb or inject the corresponding medicine due to the relationship of air pressure.

Optionally, the directions of the axes of the above-mentioned first slide table 1, second slide table 4 and push rod 7 relative to each other may be parallel to each other, that is, the above-mentioned first slide table 1, second slide table 4 and push rod 7 It may be consistent with the sliding direction (such as the up and down sliding direction) of the preset trajectory indicated in the control instruction (such as the positioning instruction and the injection instruction).

Wherein optionally, the capillary needle 60 is formed by thermal drawing of a capillary, and the inner diameter of the capillary is not more than 1mm.

Wherein optionally, the capillary refers to a non-metal conduit or a glass conduit.

Preferably, the syringe 6 in the microinjector provided by the embodiment of the present invention can adopt a capillary needle, and the capillary needle can refer to a capillary needle made by heat-drawing a capillary tube, and can be pierced by a capillary needle The push rod 7 at the tail end is driven to carry out corresponding drug inhalation and injection. Wherein, the capillary needle can be made of non-metallic materials (such as glass, plastic, etc.), and the inner diameter of the capillary needle can be less than or equal to 1 mm (millimeter).

Optionally, the syringe 6 is filled with silicone oil for micro-aspiration or injection at the needle end close to the capillary needle.

Optionally, the second slide table 4 includes any one of a slide rod, a rotating screw, and a push rod, and the first motor 2 and the second motor 5 include a stepping motor or a driver.

Optionally, a certain amount of silicone oil can be pre-injected into the syringe 6 in the embodiment of the present invention, or filled with silicone oil, so that the syringe 6 can be used for inhalation or injection of a small amount of medicine. Preferably, the second sliding table 4 provided by the embodiment of the present invention may include any one of a slide rod, a rotating screw, and a push rod, and the first motor 2 and the second motor 5 provided by the embodiment of the present invention may include The embodiment of the present invention does not limit the stepping motor, the driver, or the components or devices used to drive the components in the microinjector to move.

It can be seen that the embodiment of the present invention integrates the propulsion positioning module and the injection module to form a microinjector, and both modules can receive the control of a control device (such as a single-chip microcomputer) to realize fully automatic programmable automatic injection, avoiding Manual error; on the other hand, the embodiments of the present invention can also use disposable or disposable heat-drawn capillary needles instead of traditional Hamilton needles, which can realize rapid replacement of needles, improve operating efficiency, and reduce costs.

As mentioned above, the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: it can still understand the foregoing The technical solutions recorded in each embodiment are modified, or some of the technical features are replaced equivalently; and these modifications or replacements do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims (10)

1. a trace injection instrument, it is characterised in that described trace injection instrument includes: be relatively fixed the propelling locating module of connection And injection module, described propelling locating module, for the positioning instruction of receiving control apparatus, drives described injection module to lock mesh Mark injection position, described injection module is for the injection instruction of receiving control apparatus, and it is fixed to carry out for described targeted injection position Position injection.

2. trace injection instrument as claimed in claim 1, it is characterised in that described propelling locating module includes: the first slide unit and First motor, the fixing end of described first slide unit is fixing with described first motor to be connected；

When receiving the positioning instruction of control equipment, described first motor drives described first slide unit and described injection mould The targeted injection position indicated by described positioning instruction is searched and locked to block.

3. trace injection instrument as claimed in claim 1, it is characterised in that described injection module includes the second slide unit, the second electricity Machine and syringe, the fixing end of described second slide unit is fixed with the sliding end of described first slide unit and described second motor respectively Connecting, the sliding end of described second slide unit is fixing with described syringe to be connected；

When the injection receiving control equipment instructs, described second motor drives described syringe needle by described second slide unit Described targeted injection position is carried out locating injection.

4. the trace injection instrument as described in any one in claim 1-3, it is characterised in that described trace injection instrument also wraps Including: stuck-module, described stuck-module includes fixing bar cramp, one end of described fixing bar cramp and the sliding end of described first slide unit Connecting, the other end of described fixing bar cramp is provided with fixation clamp, is used for clamping and fix described syringe.

5. trace injection instrument as claimed in claim 3, it is characterised in that described syringe includes capillary tube pin, described second The sliding end of slide unit is fixed with the syringe needle one end away from described capillary tube pin and is connected.

6. trace injection instrument as claimed in claim 3, it is characterised in that described syringe includes piston, imbibition cylinder, capillary tube Pin, the sliding end of described second slide unit is fixing with described piston to be connected, and described piston is connected with described imbibition cylinder inwall, described hair Tubule pin is arranged on described imbibition cylinder in the way of screw socket or buckle, during to instruct in the injection receiving control equipment, and institute State the second motor and driven the piston movement of described syringe by described second slide unit, and carry out described targeted injection position determining Position injection.

7. the trace injection instrument as described in claim 5 or 6, it is characterised in that described capillary tube pin is that capillary tube hot-drawn forms, The internal diameter of described capillary tube is less than 1mm.

8. trace injection instrument as claimed in claim 7, it is characterised in that described capillary tube refers to that non-metallic conduit or glass are led Pipe.

9. the trace injection instrument as described in claim 5 or 6, it is characterised in that be marked with silicone oil in described syringe, with close Syringe needle one end of described capillary tube pin carries out trace suction or injection.

10. the trace injection instrument as described in any one in claim 1-3, it is characterised in that the second slide unit includes slide bar, turns Any one in dynamic screw rod, pushing ram, described first motor and described second motor include stepper motor or driver.