CN106187850A - 一种可用作麻醉剂的化合物 - Google Patents
一种可用作麻醉剂的化合物 Download PDFInfo
- Publication number
- CN106187850A CN106187850A CN201610539603.8A CN201610539603A CN106187850A CN 106187850 A CN106187850 A CN 106187850A CN 201610539603 A CN201610539603 A CN 201610539603A CN 106187850 A CN106187850 A CN 106187850A
- Authority
- CN
- China
- Prior art keywords
- compound
- narcotic
- formula
- anesthetics
- narcotic compound
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 13
- 230000003533 narcotic effect Effects 0.000 title claims abstract description 8
- 125000000304 alkynyl group Chemical group 0.000 claims abstract description 4
- 239000003193 general anesthetic agent Substances 0.000 claims description 9
- 229940035674 anesthetics Drugs 0.000 claims description 7
- 206010002091 Anaesthesia Diseases 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 238000006303 photolysis reaction Methods 0.000 description 1
- 238000000197 pyrolysis Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明涉及一种可用作麻醉剂的化合物，其通式为:
Description
技术领域
本发明涉及一种可用作麻醉剂的化合物。
背景技术
麻醉药是医学手术中必不可少的药物，通常分为全身麻醉药和局部麻醉药，而全身麻醉药深入抑制大脑皮层，使人神志消失。传统使用的全身麻醉药由乙醚和含氟化合物，但该类药物储存要求较高，易发生光解、热解，稳定性差，存放不当即存在杂质，影响麻醉效果，甚至导致麻醉安全事故。因此迫切需要开发一种高效、无毒副作用、无杂质、存放稳定的麻醉药化合物。
发明内容
本发明的目的是提供一种存放稳定，无杂质产生，使用安全、高效、无毒副作用的可用作麻醉剂的化合物。
本发明的技术方案是：一种可用作麻醉剂的化合物，其通式为:
;
式中：R1为氮杂环烷基，R2为直链C3-C5炔基。
该化合物在制备麻醉药中的用途。
采用该化合物制备麻醉药，可避免在生产、储存、运输中分解产生杂质，影响麻醉安全，提高使用安全性。
具体实施方式
一种可用作麻醉剂的化合物，其通式为:
;
式中：R1为氮杂环烷基，R2为直链C3-C5炔基。
该化合物在制备麻醉药中的用途。
Claims (2)
1.一种可用作麻醉剂的化合物，其通式为:
;
式中：R1为氮杂环烷基，R2为直链C3-C5炔基。
2.权利要求1的化合物在制备麻醉药中的用途。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610539603.8A CN106187850A (zh) | 2016-07-11 | 2016-07-11 | 一种可用作麻醉剂的化合物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610539603.8A CN106187850A (zh) | 2016-07-11 | 2016-07-11 | 一种可用作麻醉剂的化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106187850A true CN106187850A (zh) | 2016-12-07 |
Family
ID=57473383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610539603.8A Pending CN106187850A (zh) | 2016-07-11 | 2016-07-11 | 一种可用作麻醉剂的化合物 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106187850A (zh) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101516844A (zh) * | 2006-07-18 | 2009-08-26 | 格吕伦塔尔有限公司 | 具有对阿片样受体体系的活性的4-杂芳基取代的1-氨基环己烷-1-和环己烯-1-衍生物 |
-
2016
- 2016-07-11 CN CN201610539603.8A patent/CN106187850A/zh active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101516844A (zh) * | 2006-07-18 | 2009-08-26 | 格吕伦塔尔有限公司 | 具有对阿片样受体体系的活性的4-杂芳基取代的1-氨基环己烷-1-和环己烯-1-衍生物 |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20161207 |
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| WD01 | Invention patent application deemed withdrawn after publication |