CN106170301A - 一种模拟细胞体内环境的微流体器件及其应用 - Google Patents
一种模拟细胞体内环境的微流体器件及其应用 Download PDFInfo
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- CN106170301A CN106170301A CN201480001474.6A CN201480001474A CN106170301A CN 106170301 A CN106170301 A CN 106170301A CN 201480001474 A CN201480001474 A CN 201480001474A CN 106170301 A CN106170301 A CN 106170301A
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Abstract
本发明公开了一种模拟细胞体内环境的微流体器件及其应用，包括进液口、出液口、以及至少一微流体腔；微流体腔具有入口通道与出口通道，入口通道连通进液口，出口通道连通出液口；微流体腔内设置众多微结构元素，其中具有微斜坡结构。该微流体器件能够模拟细胞体内环境，高效、柔和，利于细胞保护、识别和释放，增强并促进细胞和抗体的亲和作用，增加细胞和抗体的接触时间和面积，可用于癌症研究，各种癌症的临床诊断的研究，以及个人诊断肿瘤靶向治疗的研究。因其切变应力小，使细胞能够承受较高的流速，可以缩短样品处理时间，提高分离效率；从而实现了快速样品处理，减少生物标记的损伤，保护了生物标记的原始性和完整性。
Description
PCT国内申请，说明书已公开。
Claims (10)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2014/092950 WO2016086374A1 (zh) | 2014-12-03 | 2014-12-03 | 一种模拟细胞体内环境的微流体器件及其应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106170301A true CN106170301A (zh) | 2016-11-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480001474.6A Pending CN106170301A (zh) | 2014-12-03 | 2014-12-03 | 一种模拟细胞体内环境的微流体器件及其应用 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN106170301A (zh) |
| WO (1) | WO2016086374A1 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106955384A (zh) * | 2017-05-04 | 2017-07-18 | 中国药科大学 | 一种循环肿瘤细胞捕获装置 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019142650A1 (ja) * | 2018-01-16 | 2019-07-25 | 株式会社アペレ | 血液凝固時間測定用カートリッジ及び血液凝固時間測定装置 |
| CN113804658B (zh) * | 2020-06-11 | 2023-06-06 | 京东方科技集团股份有限公司 | 微流控流道结构、检测系统及其使用方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020086436A1 (en) * | 1992-05-21 | 2002-07-04 | Biosite Incorporated | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
| US20070080976A1 (en) * | 2005-10-11 | 2007-04-12 | Shaw-Hwa Parng | Biochip with microchannels |
| US20130071611A1 (en) * | 2011-09-21 | 2013-03-21 | Stmicroelectronics S.R.L. | Three-dimensional integrated structure having a high shape factor, and related forming method |
| CN103630470A (zh) * | 2007-04-16 | 2014-03-12 | 通用医疗公司以马萨诸塞州通用医疗公司名义经营 | 使粒子在微通道中聚集的系统和方法 |
| CN103998932A (zh) * | 2011-06-29 | 2014-08-20 | 中央研究院 | 使用表面涂层对生物物质的捕获、纯化和释放 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9180453B2 (en) * | 2008-08-15 | 2015-11-10 | University Of Washington | Method and apparatus for the discretization and manipulation of sample volumes |
| US9957472B2 (en) * | 2011-09-22 | 2018-05-01 | Georgia Tech Research Corporation | Deterministic high-density single-cell trap array |
| CN103865752B (zh) * | 2014-03-07 | 2015-10-28 | 复旦大学附属中山医院 | 循环肿瘤细胞捕获和分类磁性微流控芯片及其制造和使用 |
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2014
- 2014-12-03 CN CN201480001474.6A patent/CN106170301A/zh active Pending
- 2014-12-03 WO PCT/CN2014/092950 patent/WO2016086374A1/zh not_active Ceased
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020086436A1 (en) * | 1992-05-21 | 2002-07-04 | Biosite Incorporated | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
| US20070080976A1 (en) * | 2005-10-11 | 2007-04-12 | Shaw-Hwa Parng | Biochip with microchannels |
| CN103630470A (zh) * | 2007-04-16 | 2014-03-12 | 通用医疗公司以马萨诸塞州通用医疗公司名义经营 | 使粒子在微通道中聚集的系统和方法 |
| CN103998932A (zh) * | 2011-06-29 | 2014-08-20 | 中央研究院 | 使用表面涂层对生物物质的捕获、纯化和释放 |
| US20130071611A1 (en) * | 2011-09-21 | 2013-03-21 | Stmicroelectronics S.R.L. | Three-dimensional integrated structure having a high shape factor, and related forming method |
Non-Patent Citations (1)
| Title |
|---|
| SHANNON L. STOTT，ET AL: "Isolation of circulating tumor cells using a microvortex-generating herringbone-chip", 《PNAS》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106955384A (zh) * | 2017-05-04 | 2017-07-18 | 中国药科大学 | 一种循环肿瘤细胞捕获装置 |
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| Publication number | Publication date |
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| WO2016086374A1 (zh) | 2016-06-09 |
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Effective date of abandoning: 20200602 |