CN106176276A - A kind of have defying age and the skin matrix of antiallergic effect and preparation and application thereof - Google Patents
A kind of have defying age and the skin matrix of antiallergic effect and preparation and application thereof Download PDFInfo
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- CN106176276A CN106176276A CN201610860954.9A CN201610860954A CN106176276A CN 106176276 A CN106176276 A CN 106176276A CN 201610860954 A CN201610860954 A CN 201610860954A CN 106176276 A CN106176276 A CN 106176276A
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- 239000011159 matrix material Substances 0.000 title claims abstract description 116
- 230000003266 anti-allergic effect Effects 0.000 title claims abstract description 54
- 238000002360 preparation method Methods 0.000 title claims abstract description 54
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 53
- XXRYFVCIMARHRS-UHFFFAOYSA-N propan-2-yl n-dimethoxyphosphorylcarbamate Chemical compound COP(=O)(OC)NC(=O)OC(C)C XXRYFVCIMARHRS-UHFFFAOYSA-N 0.000 claims abstract description 33
- 239000002537 cosmetic Substances 0.000 claims abstract description 27
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 26
- 238000003756 stirring Methods 0.000 claims description 50
- 239000000203 mixture Substances 0.000 claims description 28
- 239000008367 deionised water Substances 0.000 claims description 27
- 229910021641 deionized water Inorganic materials 0.000 claims description 27
- 238000002156 mixing Methods 0.000 claims description 20
- 230000000550 effect on aging Effects 0.000 claims description 18
- 229920001503 Glucan Polymers 0.000 claims description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 15
- 238000007599 discharging Methods 0.000 claims description 13
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 11
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 11
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 10
- TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 claims description 9
- 229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 claims description 8
- 210000000582 semen Anatomy 0.000 claims description 7
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 5
- JVTIXNMXDLQEJE-UHFFFAOYSA-N 2-decanoyloxypropyl decanoate 2-octanoyloxypropyl octanoate Chemical compound C(CCCCCCC)(=O)OCC(C)OC(CCCCCCC)=O.C(=O)(CCCCCCCCC)OCC(C)OC(=O)CCCCCCCCC JVTIXNMXDLQEJE-UHFFFAOYSA-N 0.000 claims description 5
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 5
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 108090000526 Papain Proteins 0.000 claims description 5
- 239000004365 Protease Substances 0.000 claims description 5
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 5
- 229940069521 aloe extract Drugs 0.000 claims description 5
- 102000004139 alpha-Amylases Human genes 0.000 claims description 5
- 108090000637 alpha-Amylases Proteins 0.000 claims description 5
- 229940024171 alpha-amylase Drugs 0.000 claims description 5
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 5
- 230000008859 change Effects 0.000 claims description 5
- 229920001577 copolymer Polymers 0.000 claims description 5
- 229940119170 jojoba wax Drugs 0.000 claims description 5
- 239000000787 lecithin Substances 0.000 claims description 5
- 229940067606 lecithin Drugs 0.000 claims description 5
- 235000010445 lecithin Nutrition 0.000 claims description 5
- 229940055729 papain Drugs 0.000 claims description 5
- 235000019834 papain Nutrition 0.000 claims description 5
- 229960005323 phenoxyethanol Drugs 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 5
- 238000000605 extraction Methods 0.000 claims description 3
- 229940038580 oat bran Drugs 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 230000001681 protective effect Effects 0.000 claims description 2
- 239000002884 skin cream Substances 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 32
- 101100381997 Danio rerio tbc1d32 gene Proteins 0.000 abstract description 6
- 101100381999 Mus musculus Tbc1d32 gene Proteins 0.000 abstract description 6
- 230000003020 moisturizing effect Effects 0.000 abstract description 5
- 239000000758 substrate Substances 0.000 abstract description 5
- 235000016709 nutrition Nutrition 0.000 abstract description 4
- 230000035764 nutrition Effects 0.000 abstract description 4
- 238000010521 absorption reaction Methods 0.000 abstract description 3
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 abstract 1
- 229920002498 Beta-glucan Polymers 0.000 abstract 1
- 108060006613 prolamin Proteins 0.000 description 37
- 239000000047 product Substances 0.000 description 21
- 230000000052 comparative effect Effects 0.000 description 14
- 235000015424 sodium Nutrition 0.000 description 11
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 description 10
- 229940014041 hyaluronate Drugs 0.000 description 10
- 239000008346 aqueous phase Substances 0.000 description 9
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- 150000004676 glycans Chemical class 0.000 description 5
- 235000013336 milk Nutrition 0.000 description 5
- 239000008267 milk Substances 0.000 description 5
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- 229920001282 polysaccharide Polymers 0.000 description 5
- 239000005017 polysaccharide Substances 0.000 description 5
- 230000037394 skin elasticity Effects 0.000 description 5
- 239000003995 emulsifying agent Substances 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 241001506047 Tremella Species 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
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- 230000002829 reductive effect Effects 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 240000008620 Fagopyrum esculentum Species 0.000 description 2
- 235000009419 Fagopyrum esculentum Nutrition 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000011038 discontinuous diafiltration by volume reduction Methods 0.000 description 2
- 150000002333 glycines Chemical class 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000009759 skin aging Effects 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003255 anti-acne Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 239000011248 coating agent Substances 0.000 description 1
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- 239000000287 crude extract Substances 0.000 description 1
- 235000021438 curry Nutrition 0.000 description 1
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- 230000002951 depilatory effect Effects 0.000 description 1
- 238000010612 desalination reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- SOROIESOUPGGFO-UHFFFAOYSA-N diazolidinylurea Chemical compound OCNC(=O)N(CO)C1N(CO)C(=O)N(CO)C1=O SOROIESOUPGGFO-UHFFFAOYSA-N 0.000 description 1
- 229960001083 diazolidinylurea Drugs 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- -1 elite Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 238000012634 optical imaging Methods 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
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- 230000007480 spreading Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
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- 230000002195 synergetic effect Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the technical field of cosmetics, disclose and a kind of there are defying age and the skin matrix of antiallergic effect and preparation and application thereof.Described skin matrix is composed of the following components: the avenin of 35～40 weight portions, the Herba bromi japonici beta glucan of 30～35 weight portions, the hyaluronate sodium of 1～2 weight portions and the water of 23～34 weight portions.The skin matrix antiallergic of present invention effect of releiving is notable；In substrate, active component can be degraded by skin, Transdermal absorption, provides nutrition for skin, has long-acting moisturizing, crease-resistant effect；Be used for described skin matrix in cosmetics to bring to product releive, antiallergic, moisturizing and increase elastic effect.
Description
Technical field
The invention belongs to the technical field of cosmetics, be specifically related to a kind of skin matrix with defying age and antiallergic effect
And preparation method thereof with the application in cosmetics.
Background technology
Cosmetic industry have passed through the development of many decades, and the aspect such as its dosage system, efficacy effect, security and stability has
Great increase and lifting.
From the point of view of developing according to dosage form, develop into from initial soft petroleum ointment and the moisturizing cream with soap base as emulsion stabilizer
Table live body system cleansing milk, soap base system cleansing milk, amino acid system cleansing milk and emulsification system cleansing milk of today；Water preparation, W/O
Type emulsion, O/W type emulsion；W/o type cream, O/W type cream；Tens of kinds of vanishing cream, BB frost, skin lotion, elite, gel curry etc.
System.
From the point of view of efficacy effect, develop into whitening and freckle-removing product of today, antiallergic from the initial moisture-keeping efficacy that only has
Product, defying age wrinkle removing product, foundation cream class modified product, sunscreen product, cleaning series products, educate send out product, hair dyeing product, a hair-waving
Product, depilatory, U.S. milk product, vigorous and graceful product, deodorising product etc..
In terms of security and stability, produce fine chemicals by now from initial extensive style, from heavy metal originally
Exceed standard, abuse the specification spreading unchecked the strictest law & policy by now of unauthorized substances, no matter in terms of regulation or from
From the point of view of the development angle of brand names self, safety and stability will be all a main trend that cannot reverse.
Along with the increase of people's life stress, and the impact of environmental factors, the toleration of skin is deteriorated, by extraneous each
Kind stimulating and easily to produce allergy, some chemical compositions also Diazolidinyl Urea in cosmetics, such as preservative, in order to ensure shelf life
Product quality, most of cosmetics are all added with chemical preservative.Meanwhile, consumer increasingly focuses on multi-efficiency product
Product, the product containing only single effect cannot meet the most far away consumer demand.
Summary of the invention
In order to overcome the shortcoming and defect of prior art, the primary and foremost purpose of the present invention is to provide a kind of containing avenin
There is senile-resistant efficacy and the skin matrix of antiallergic effect.
Another object of the present invention is to provide the preparation method of above-mentioned skin matrix.
It is still another object of the present invention to provide the application of above-mentioned skin matrix.
The purpose of the present invention is achieved through the following technical solutions:
A kind of skin matrix with defying age and antiallergic effect, is made up of the following component counted by weight:
In described skin matrix, avenin, avenabeta glucosan, hyaluronate sodium and water each composition weight sum is
100；Described water is deionized water.
Described avenin uses repeatedly zymohydrolysis extracting method to obtain.
Described avenin is that to select De-fatted oat bran skin be raw material, uses α-amylase and papain to carry out successively
Enzymolysis and extraction obtains.
Described employing α-amylase carries out the condition of enzymolysis: the temperature of enzymolysis is 50～60 DEG C, preferably 55 DEG C；Enzymolysis
Time be 25～35min, preferably 30min.
Described α-amylase addition is the 0.5% of bran of Fagopyrum esculentum Moench weight.
Described papain carries out the temperature that condition is enzymolysis of enzymolysis and is 70～85 DEG C, preferably 80 DEG C；Enzymolysis
Time is 100～130min, preferably 120min.
Described papain dosage is the 0.75% of bran of Fagopyrum esculentum Moench weight.
Described avenin is that to select De-fatted oat bran skin be raw material, uses α-amylase to carry out enzymolysis, separates crude extract,
Use papain to carry out enzymolysis again, take supernatant, obtain containing avenin solution.
The preparation method of a kind of antiallergic skin matrix with defying age and antiallergic effect, specifically includes following steps:
(1) being slowly added to by the hyaluronate sodium of 1～2 weight portions in the water of 23～34 weight portions, constant temperature stirs, and obtains
Bright matter acid sodium solution；
(2) by the avenin of 35～40 weight portions, 30～35 weight portion avenabeta glucosan add hyaluronate sodium
In solution, stir 5～15min, low speed homogenizing, cooling, discharging, obtain, containing avenin, there is defying age and antiallergic effect
Skin matrix.
Described in step (1), mixing speed is 1000～1500rpm；Described constant temperature mixing time is 30min～60min；
The temperature of described constant temperature stirring is 40～50 DEG C.
Described in step (2), mixing speed is 800～1000rpm；The homogenizing speed of described low speed homogenizing be 1000～
(homogenizing speed can not be too high, otherwise will destroy the space structure of this macromolecule polysaccharide, thus affects product effect for 1500rpm
Really)；The time of described low speed homogenizing is 0.5～5min.
Described in step (2), chilling temperature is 25～30 DEG C.
The cosmetics that the described skin matrix with defying age and antiallergic effect comprises substrate for preparation.
Described in the described cosmetics comprising substrate, skin matrix percentage by weight in these cosmetics is 10～20%.
Described cosmetics are skin-care cosmetics, including emulsion, eye essence, astringent and essence.
Described cosmetics are functional type cosmetics, protect including Moisturizer, crease-resistant skin care item, Skin whitening care cosmetics, anti-acne
Skin product and antiallergic are releived skin care item.
A kind of astringent comprising skin matrix, is made up of following components:
Component A: glycerol 5.0%～10.0%, biological propylene glycol 5.0%～8.0%, Carbopol 941 0.05%～
0.15%；
B component: methyl hydroxybenzoate 0.1%～0.2%, pantothenylol 0.2%～0.5%, deionized water 60.88%～
79.56%；
Component C: essence 0.01%～0.03%, Cremophor RH40 0.05%～0.15%, described in have anti-ageing
Old and the skin matrix 10%～20% of antiallergic effect；
D component: triethanolamine 0.03%～0.09%.
A kind of protective skin cream comprising skin matrix, is made up of following component by mass percentage:
Component A: lecithin (emulsifying agent) 1.0%～2.5%, Jojoba oil 2%～5%, Semen Tritici aestivi germ oil 1%～3%,
16/18 alcohol 0.5%～1.5%；
B component: acrylate copolymer 0.5%～1.0%, methyl hydroxybenzoate 0.1%～0.2%, butanediol 5%～
10%, deionized water 54.3%～78.6%；
Component C: phenoxyethanol 0.3%～0.5%, Aloe extract 1%～2%；
D component: described in there is the skin matrix 10%～20% of defying age and antiallergic effect.
Avenin is with natural high-quality Herba bromi japonici as raw material, uses the work that the skin protection of biological enzyme technology research and development, clean skin are special
Property albumen.It has the performance of keeping humidity of excellence, slows down skin water loss.Containing abundant aminoacid group, supplement skin nutrition, create
Healthy skin quality, delay skin aging, reduces skin coarseness.The Herba bromi japonici antipruritic composition of distinctive antiallergic contained, it is possible to the most pre-
Prevent and extenuate phenomena of cutaneous irritation, relax preservative and other products zest to skin.
Avenabeta glucosan is the short chain glucosan of a kind of molecular weight, and its basic structure is a kind of linear polysaccharide, makees
For the effective ingredient of cosmetics, resisting skin allergy ability can be improved, activate immunologic function, delay skin aging, it is possible to smooth
Fine wrinkles, improves skin elasticity, improves skin texture degree；There is the straight-chain molecular structure of uniqueness, impart good transdermal
Absorbent properties；Simultaneously facilitate fibroblast synthesis collagen protein, promote wound healing, repair impaired skin, give skin such as
Smooth sense of touch is moistened as silk.
The present invention, through two kinds of antiallergic of experiment sieving, the composition of the effect such as crease-resistant, is made by the Synergistic between each composition
With, play the multiple efficacies such as antiallergic to greatest extent.The mechanism producing this potentiation is tentatively inferred as the extraction of these materials
From the covalent bond between same raw material, these materials, hydrogen bond and the coefficient result of hydrophobic bond effect.It addition, the present invention
Not only there is antiallergic releive effect, also there is replenishing water and preserving moisture, crease-resistant effect.Owing to the active component of the present invention can be by skin
Transdermal degraded Transdermal absorption, can be that skin provides nutrition, have long-acting moisturizing, releive, effect of antiallergic, wrinkle removal.
Compared with prior art, the present invention has the following advantages and beneficial effect:
1, in substrate prepared in the present invention, each active component (avenin, avenabeta glucosan) can be dropped by skin
Solve, Transdermal absorption, provide nutrition for skin, there is long-acting antiallergic, effect of releiving；
2, the effect of releiving of the skin matrix antiallergic prepared by the present invention is obvious, and moistening effect is obvious, greasy skin；
3, make an addition to skin matrix prepared by the present invention, in the cosmetics such as eye cream, facial cream, astringent, these products to be given
Bring good moisturizing, releive, crease-resistant effect.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited to this.
Embodiment 1
The preparation method of a kind of skin matrix with defying age and antiallergic effect containing avenin, concretely comprises the following steps:
(1) opening stirring (rotating speed is 1000rpm), under the conditions of 45 DEG C, by 1 weight portion hyaluronate sodium, (China's good fortune is auspicious
Reach company, trade name HA) it is slowly added in 29 parts by weight of deionized water, constant temperature stirring 30min, obtain hyaluronate sodium molten
Liquid；
(2) 30 weight portion avenins, 40 parts of avenabeta glucosans are sequentially added into sodium hyaluronate solution, stir 5min
After (rotating speed of stirring is 800rpm), then low speed homogenizing (homogenizing speed is 1500rpm) 3min, it is cooled to 25 DEG C, discharging, obtain
Containing avenin, there is defying age and the skin matrix of antiallergic effect.
The application of described skin matrix:
A kind of eye essence comprising skin matrix, is made up of following component by mass percentage:
Component A: lecithin (emulsifying agent) 1.0%, Jojoba oil 2%, Semen Tritici aestivi germ oil 1%, 16/18 alcohol 0.5%；
B component: acrylate copolymer 0.5%, methyl hydroxybenzoate 0.1%, butanediol 5%, deionized water 78.6%
Component C: phenoxyethanol 0.3%, Aloe extract 1%；
D component: described skin matrix 10%.
The preparation method of the above-mentioned eye essence comprising skin matrix:
(1) component A is added oil cauldron, open stirring (rotating speed is 1000rpm) and be warming up to 80 DEG C, be incubated 10min, obtain
Oil phase mixed liquor；
(2) B component is added aqueous phase pot, open stirring (rotating speed is 600rpm) and be warming up to 85 DEG C, be incubated 15min,
To aqueous phase mixed liquor；
(3) after aqueous phase mixed liquor being sucked emulsifying pot, emulsifying pot stirring (rotating speed is 60rpm) is opened, by controlling vacuum
Oil phase mixed liquor is slowly sucked (mixed liquor of 1500g about 15min sucks) emulsifying pot by valve, then keeps vacuum (vacuum
Degree is for-0.05MPa) and mixing speed constant, unlatching homogenizer carries out homogenizing, homogenizing time 5min immediately, and the rotating speed of homogenizing is
3000rpm；
(4) open temperature lowering water after homogenizing completes and be cooled to 40 DEG C, add component C stirring 5min (rotating speed is 60rpm), open
Homogenizer carries out homogenizing, and the time of homogenizing is 1min, and the rotating speed of homogenizing is 1500rpm；It is subsequently adding D component, stirs 15min
(rotating speed is 40rpm), discharging, obtain comprising the eye essence of skin matrix.
Embodiment 2
The preparation method of a kind of skin matrix with defying age and antiallergic effect containing avenin, concretely comprises the following steps:
(1) opening stirring (rotating speed is 800rpm), under the conditions of 45 DEG C, by 1.5 weight portion hyaluronate sodiums, (China's good fortune is auspicious
Reach company, trade name HA) it is slowly added in 28.5 parts by weight of deionized water, constant temperature stirring 30min, obtain hyaluronate sodium molten
Liquid；
(2) 35 weight portion avenin extracts, 35 parts of avenabeta glucosans are sequentially added into sodium hyaluronate solution, stir
After mixing 5min (rotating speed of stirring is 800rpm), then low speed homogenizing (homogenizing speed is 1500rpm) 3min, it is cooled to 25 DEG C, goes out
Material, obtains having and has defying age and the skin matrix of antiallergic effect containing avenin.
The application of described skin matrix:
A kind of eye essence comprising skin matrix, is made up of following component by mass percentage:
Component A: lecithin (emulsifying agent) 2%, Jojoba oil 3%, Semen Tritici aestivi germ oil 2%, 16/18 alcohol 1%；
B component: acrylate copolymer 0.8%, methyl hydroxybenzoate 0.15%, butanediol 8%, deionized water 71.15%
Component C: phenoxyethanol 0.4%, Aloe extract 1.5%；
D component: described skin matrix 10%.
The preparation method of the above-mentioned eye essence comprising skin matrix:
(1) component A is added oil cauldron, open stirring (rotating speed is 1000rpm) and be warming up to 80 DEG C, be incubated 10min, obtain
Oil phase mixed liquor；
(2) B component is added aqueous phase pot, open stirring (rotating speed is 600rpm) and be warming up to 85 DEG C, be incubated 15min,
To aqueous phase mixed liquor；
(3) after aqueous phase mixed liquor being sucked emulsifying pot, emulsifying pot stirring (rotating speed is 60rpm) is opened, by controlling vacuum
Oil phase mixed liquor is slowly sucked (mixed liquor of 1500g about 15min sucks) emulsifying pot by valve, then keeps vacuum (vacuum
Degree is for-0.05MPa) and mixing speed constant, unlatching homogenizer carries out homogenizing, homogenizing time 5min immediately, and the rotating speed of homogenizing is
3000rpm；
(4) open temperature lowering water after homogenizing completes and be cooled to 40 DEG C, add component C stirring 5min (rotating speed is 60rpm), open
Homogenizer carries out homogenizing, and the time of homogenizing is 1min, and the rotating speed of homogenizing is 1500rpm；It is subsequently adding D component, stirs 15min
(rotating speed is 40rpm), discharging, obtain comprising the eye essence of skin matrix.
Embodiment 3
The preparation method of a kind of skin matrix with defying age and antiallergic effect containing avenin, concretely comprises the following steps:
(1) stirring (rotating speed is 800rpm) is opened, under the conditions of 45 DEG C, by 2 weight portion hyaluronate sodiums (China Fu Ruida
Company, trade name HA) it is slowly added in 28 parts by weight of deionized water, constant temperature stirring 30min, obtain sodium hyaluronate solution；
(2) 40 weight portion avenins, 30 parts of avenabeta glucosans are sequentially added into sodium hyaluronate solution, stir 5min
Afterwards (rotating speed is 800rpm), then low speed homogenizing (homogenizing speed is 1500rpm) 3min, it is cooled to 25 DEG C, discharging, obtain containing Herba bromi japonici
Albumen there is defying age and the skin matrix of antiallergic effect.
The application of described skin matrix:
A kind of eye essence comprising skin matrix, is made up of following component by mass percentage:
Component A: lecithin (emulsifying agent) 2.5%, Jojoba oil 5%, Semen Tritici aestivi germ oil 3%, 16/18 alcohol 1.5%；
B component: acrylate copolymer 1%, methyl hydroxybenzoate 0.2%, butanediol 8%, deionized water 56.3%
Component C: phenoxyethanol 0.5%, Aloe extract 2%；
D component: described skin matrix 20%.
The preparation method of the above-mentioned eye essence comprising skin matrix:
(1) component A is added oil cauldron, open stirring (rotating speed is 1000rpm) and be warming up to 80 DEG C, be incubated 10min, obtain
Oil phase mixed liquor；
(2) B component is added aqueous phase pot, open stirring (rotating speed is 600rpm) and be warming up to 85 DEG C, be incubated 15min,
To aqueous phase mixed liquor；
(3) after aqueous phase mixed liquor being sucked emulsifying pot, emulsifying pot stirring (rotating speed is 60rpm) is opened, by controlling vacuum
Oil phase mixed liquor is slowly sucked (mixed liquor of 1500g about 15min sucks) emulsifying pot by valve, then keeps vacuum (vacuum
Degree is for-0.05MPa) and mixing speed constant, unlatching homogenizer carries out homogenizing, homogenizing time 5min immediately, and the rotating speed of homogenizing is
3000rpm；
(4) open temperature lowering water after homogenizing completes and be cooled to 40 DEG C, add component C stirring 5min (rotating speed is 60rpm), open
Homogenizer carries out homogenizing, and the time of homogenizing is 1min, and the rotating speed of homogenizing is 1500rpm；It is subsequently adding D component, stirs 15min
(rotating speed is 40rpm), discharging, obtain comprising the eye essence of skin matrix.
Comparative example a:
A kind of antiallergic skin matrix with senile-resistant efficacy containing avenin, by the following component counted by weight
Composition: 2 weight portion hyaluronate sodiums, 58 parts by weight of deionized water, 40 weight portion avenins；Its preparation method is with embodiment 3
The preparation method of middle skin matrix.
A kind of eye essence (i.e. comprising the cosmetics of skin matrix) comprising skin matrix, by following by percent mass
Component composition than meter；Each component and content are with the eye essence comprising skin matrix in embodiment 3；Its preparation method is same
The preparation method of eye essence in embodiment 3；
Comparative example b:
A kind of antiallergic skin matrix with senile-resistant efficacy containing avenin, by the following component counted by weight
Composition: 2 weight portion hyaluronate sodiums, 58 parts by weight of deionized water, 40 weight portion avenabeta glucosans；Its preparation method is with implementing
The preparation method of skin matrix in example 3.
A kind of eye essence (i.e. comprising the cosmetics of skin matrix) comprising skin matrix, by following by percent mass
Component composition than meter；Each component and content are with the eye essence comprising skin matrix in embodiment 3；Its preparation method is same
The preparation method of eye essence in embodiment 3.
Comparative example c:
A kind of antiallergic skin matrix with senile-resistant efficacy containing avenin, by the following component counted by weight
Composition: 2 weight portion hyaluronate sodiums, 28 parts by weight of deionized water, 35 weight portion avenins；35 weight portion tremella polysaccharides, its
Preparation method is with the preparation method of skin matrix in embodiment 3.
A kind of eye essence (i.e. comprising the cosmetics of skin matrix) trial effect test comprising skin matrix:
Tested crowd: 60 adult female volunteers, the age is between 45～55 one full year of life；
Test method: in the eye essence using embodiment 1-3 to prepare near the eyes, embodiment 1～3 and comparative example a～c system
Eye essence (consumption is about 1/4 Semen Glycines size) prepared by standby skin matrix and comparative example a-b；Persistently use 1 week and 4
Zhou Houyong FOITS method (skin fast optical imaging method), measures skin pattern change, and this technology evaluation skin around the eyes microgroove is deep
Degree and length reduce degree, and its test result is as shown in table 1.
Can be seen that from test result, the effect of the eye essence prepared by embodiment 3 is best；Skin matrix is added
The embodiment 1-3 effect comparison ratio of whole compositions (avenin, avenabeta glucosan, hyaluronate sodium and deionized waters)
The effect of embodiment a-c to be got well；And the effect of the eye essence of embodiment 3 preparation is better than eye prepared by comparative example
Essence effect sum；Comparative example's average wrinkle volume reduction sum is less than the average wrinkle volume reduction of embodiment 3.
The effect of the effect of the skin matrix of adding ingredient tremella polysaccharide not (avenin+avenabeta glucosan+hyaluronate sodium)
The best.Therefore, in described skin matrix, each composition has the most collaborative effect at crease-resistant aspect and obtains preferable effect.
Embodiment 4
The preparation method of a kind of antiallergic skin matrix with senile-resistant efficacy containing avenin, concretely comprises the following steps:
(1) stirring (rotating speed is 800rpm) is opened, under the conditions of 45 DEG C, by 1 weight portion hyaluronate sodium (China Fu Ruida
Company, trade name HA) slowly add 24 weight portions (every the hyaluronate sodium of one minute addition 0.1～0.2 weight portion)
In ionized water, constant temperature stirring 30min, obtain sodium hyaluronate solution；
(2) 30 weight portion avenins, 40 parts of avenabeta glucosans are sequentially added into sodium hyaluronate solution, stir 5min
Afterwards (rotating speed is 800rpm), then low speed homogenizing (homogenizing speed is 1200rpm) 3min, it is cooled to 25 DEG C, discharging, obtain containing Herba bromi japonici
The antiallergic skin matrix with multi-efficiency of albumen.
The application of described skin matrix:
A kind of essence (i.e. comprising the cosmetics of skin matrix) comprising skin matrix, by following by mass percentage
Component composition:
Component A: glycerol 5.0%, biological propylene glycol 8.0%, Carbopol 941 0.05%；
B component: methyl hydroxybenzoate 0.1%, pantothenylol 0.2%, deionized water 76.56%；
Component C: essence 0.01%, Cremophor RH40 0.05%, above-mentioned skin matrix 10%；
D component: triethanolamine 0.03%.
The preparation method of the above-mentioned essence comprising skin matrix: component A is loaded in container, with mobile agitator with
The rotating speed of 2500rpm is uniformly dispersed (mixing time is 10min), obtains component A mixture；Deionized water is added water preparation pot,
It is heated to 70 DEG C, opens stirring (mixing speed is 1000rpm), add in component A mixture and B component surplus in deionized water
Remaining component, is continuously heating to 85 DEG C, is incubated 30min；Mixing speed is reduced to 500rpm, opens temperature lowering water and be cooled to 40 DEG C
Time, in water preparation pot, add component C (essence and Cremophor RH40 being pre-mixed uniformly), stir 10min；The most again
Add D component, stir 5min, discharging, obtain comprising the essence of skin matrix.
Embodiment 5
The preparation method of a kind of antiallergic skin matrix with senile-resistant efficacy containing avenin, concretely comprises the following steps:
(1) opening stirring (rotating speed is 800rpm), under the conditions of 45 DEG C, by 1.5 weight portion hyaluronate sodiums, (China's good fortune is auspicious
Reach company, trade name HA) slowly add 23.5 weight (every the hyaluronate sodium of one minute addition 0.1～0.2 weight portion)
In part deionized water, constant temperature stirring 30min, obtain sodium hyaluronate solution；
(2) 35 weight portion avenins, 35 parts of avenabeta glucosans are sequentially added into sodium hyaluronate solution, stir 5min
Afterwards (rotating speed is 800rpm), then low speed homogenizing (homogenizing speed is 1500rpm) 3min, it is cooled to 25 DEG C, discharging, obtain having and contain
The antiallergic skin matrix with multi-efficiency of avenin.
The application of described skin matrix:
A kind of essence (i.e. comprising the cosmetics of skin matrix) comprising skin matrix, by following by mass percentage
Component composition:
Component A: glycerol 7.5%, biological propylene glycol 6.5%, Carbopol 941 0.1%；
B component: methyl hydroxybenzoate 0.15%, pantothenylol 0.35%, deionized water 70.17%；
Component C: essence 0.02%, Cremophor RH40 0.1%, above-mentioned skin matrix 15%；
D component: triethanolamine 0.06%.
The preparation method of the above-mentioned essence comprising skin matrix: component A is loaded in container, with mobile agitator with
The rotating speed of 2500rpm is uniformly dispersed (mixing time is 10min), obtains component A mixture；Deionized water is added water preparation pot,
It is heated to 70 DEG C, opens stirring (mixing speed is 1000rpm), add in component A mixture and B component surplus in deionized water
Remaining component, is continuously heating to 85 DEG C, is incubated 30min；Mixing speed is reduced to 500rpm, opens temperature lowering water and be cooled to 40 DEG C
Time, in water preparation pot, add component C (essence and Cremophor RH40 being pre-mixed uniformly), stir 10min；The most again
Add D component, stir 5min, discharging, obtain comprising the essence of skin matrix.
Embodiment 6
The preparation method of a kind of antiallergic skin matrix with senile-resistant efficacy containing avenin, concretely comprises the following steps:
(1) stirring (rotating speed is 800rpm) is opened, under the conditions of 45 DEG C, by 2 weight portion hyaluronate sodiums (China Fu Ruida
Company, trade name HA) slowly add 23 weight portions (every the hyaluronate sodium of one minute addition 0.1～0.2 weight portion)
In ionized water, constant temperature stirring 30min, obtain sodium hyaluronate solution；
(2) 40 weight portion avenins, 30 parts of avenabeta glucosans are sequentially added into sodium hyaluronate solution, stir 5min
Afterwards (rotating speed is 800rpm), then low speed homogenizing (homogenizing speed is 1500rpm) 3min, it is cooled to 25 DEG C, discharging, obtain containing Herba bromi japonici
The antiallergic skin matrix with multi-efficiency of albumen.
The application of described skin matrix:
A kind of essence (i.e. comprising the cosmetics of skin matrix) comprising skin matrix, by following by mass percentage
Component composition:
Component A: glycerol 10%, biological propylene glycol 5%, Carbopol 941 0.15%；
B component: methyl hydroxybenzoate 0.2%, pantothenylol 0.5%, deionized water 63.88%；
Component C: essence 0.03%, Cremophor RH40 0.15%, above-mentioned skin matrix 20%；
D component: triethanolamine 0.09%.
The preparation method of the above-mentioned essence comprising skin matrix: component A is loaded in container, with mobile agitator with
The rotating speed of 2500rpm is uniformly dispersed (mixing time is 10min), obtains component A mixture；Deionized water is added water preparation pot,
It is heated to 70 DEG C, opens stirring (mixing speed is 1000rpm), add in component A mixture and B component surplus in deionized water
Remaining component, is continuously heating to 85 DEG C, is incubated 30min；Mixing speed is reduced to 500rpm, opens temperature lowering water and be cooled to 40 DEG C
Time, in water preparation pot, add component C (essence and Cremophor RH40 being pre-mixed uniformly), stir 10min；The most again
Add D component, stir 5min, discharging, obtain comprising the essence of skin matrix.
Comparative example d:
A kind of antiallergic skin matrix with senile-resistant efficacy containing avenin, by the following component counted by weight
Composition: 2 weight portion hyaluronate sodiums, 58 parts by weight of deionized water, 40 weight portion avenins；Its preparation method is with embodiment 6
The preparation method of middle skin matrix；
A kind of essence (i.e. comprising the cosmetics of skin matrix) comprising skin matrix, by following by mass percentage
Component composition；Each component and content are with the essence comprising skin matrix in embodiment 6；Its preparation method is with embodiment 6
The preparation method of middle essence；
Comparative example e:
A kind of antiallergic skin matrix with senile-resistant efficacy containing avenin, by the following component counted by weight
Composition: 2 weight portion hyaluronate sodiums, 58 parts by weight of deionized water, 40 weight portion avenabeta glucosans；Its preparation method is with implementing
The preparation method of skin matrix in example 6；
A kind of essence (i.e. comprising the cosmetics of skin matrix) comprising skin matrix, by following by mass percentage
Component composition；Each component and content are with the essence comprising skin matrix in embodiment 6；Its preparation method is with embodiment 6
The preparation method of middle essence.
Comparative example f:
A kind of antiallergic skin matrix with senile-resistant efficacy containing avenin, by the following component counted by weight
Composition: 2 weight portion hyaluronate sodiums, 28 parts by weight of deionized water, 35 weight portion avenins；35 weight portion tremella polysaccharides；Its
Preparation method is with the preparation method of skin matrix in embodiment 6.
A kind of essence trial effect test comprising skin matrix:
Method of testing: select 80 sensitive flesh volunteers (40～50 years old) to participate in free trial activity, be divided into 6 groups.Respectively
Investigate comprising prepared by essence, the skin matrix of embodiment 4～6 preparation and comparative example d-e prepared by embodiment 4-6 to protect
Face skin is recovered natural elasticity by the essence of skin substrate, prevents several aspects such as wrinkle of skin and coarse, desalination microgroove
Improvement situation is also periodically fed back.
Require that each group is all that (smear general consumption is a Semen Glycines size every time, mainly with face in conventionally use
Portion's coating thin layer is as the criterion), the most once.
Sensory testing results:
After essence prepared by the firm skin matrix having tried out embodiment 6 preparation and embodiment 4-6, trier's skin is quick
Sensitivity reduces, and face skin is general red has weakening in various degree.Skin beauty water profit is substantially.The essence of embodiment 6 is releived and is felt brighter
Aobvious, trier feels that product is comfortable, general red minimizing of generating heat.
Comparative example d: after fresh out of essence, trier's skin is general red slightly to be weakened；After persistently using 1 month, trier
Skin sensitivity and general red phenomenon improve increase.
Comparative example e: after fresh out of essence, trier's skin is general red slightly to be weakened；After persistently using 1 month, trier
Skin sensitivity and general red phenomenon improve increase.
According to trier's subjective assessment, the using effect of comparative example relatively embodiment has certain gap.
Thus illustrate, the skin matrix of the present invention skin can be played antiallergic, releive, anti-ageing, moisture-keeping function, and will
It adds the effect being favorably improved skin care item in skin care item to, and effect is satisfactory.
Skin elasticity is tested:
Use skinanalysis apparatus (Derma-Expert MC760) that volunteer both sides cheek is carried out skin elasticity detection, its
Test result is as shown in table 2:
From Table 2, it can be seen that the essence prepared by embodiment 4-6 can preferably increase skin elasticity, and real
The effect executing example 6 is best.
Table 2: the situation of change of skin elasticity value
Above-described embodiment is the preferably embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Restriction, the change made under other any spirit without departing from the present invention and principle, modify, substitute, combine, letter
Change, all should be the substitute mode of equivalence, be included in protection scope of the present invention.
Claims (10)
1. a skin matrix with defying age and antiallergic effect, it is characterised in that: by the following component counted by weight
Composition:
The most according to claim 1, there is defying age and the skin matrix of antiallergic effect, it is characterised in that: described skin matrix
Middle avenin, avenabeta glucosan, hyaluronate sodium and water each composition weight sum is 100；Described water is deionized water；
Described avenin is that to select De-fatted oat bran skin be raw material, uses α-amylase and papain to carry out enzymolysis successively
Extraction obtains.
The preparation method of the skin matrix with defying age and antiallergic effect the most according to claim 1 or claim 2, its feature exists
In: specifically include following steps:
(1) being slowly added to by the hyaluronate sodium of 1～2 weight portions in the water of 23～34 weight portions, constant temperature stirs, and obtains hyalomitome
Acid sodium solution；
(2) by the avenin of 35～40 weight portions, 30～35 weight portion avenabeta glucosan add sodium hyaluronate solution
In, stirring, low speed homogenizing, cooling, discharging, obtain, containing avenin, there is defying age and the skin matrix of antiallergic effect.
The most according to claim 3, there is the preparation method of the skin matrix of defying age and antiallergic effect, it is characterised in that: step
Suddenly the homogenizing speed of low speed homogenizing described in (2) is 1000～1500rpm.
The most according to claim 3, there is the preparation method of the skin matrix of defying age and antiallergic effect, it is characterised in that: step
Suddenly constant temperature mixing time described in (1) is 30min～60min；The temperature of described constant temperature stirring is 40～50 DEG C；
Described in step (2), mixing time is 5～15min, and the time of described low speed homogenizing is 0.5～5min.
The most according to claim 3, there is the preparation method of the skin matrix of defying age and antiallergic effect, it is characterised in that: step
Suddenly mixing speed described in (1) is 1000～1500rpm；Described in step (2), mixing speed is 800～1000rpm.
The most according to claim 1, there is the change that the skin matrix of defying age and antiallergic effect comprises skin matrix for preparation
Cosmetic.
Application the most according to claim 7, it is characterised in that comprise skin protection base described in the cosmetics of skin matrix described in:
The weight content of matter is 10～20%.
9. the astringent comprising the skin matrix described in claim 1 with defying age and antiallergic effect, it is characterised in that:
It is made up of following components:
Component A: glycerol 5.0%～10.0%, biological propylene glycol 5.0%～8.0%, Carbopol 941 0.05%～0.15%；
B component: methyl hydroxybenzoate 0.1%～0.2%, pantothenylol 0.2%～0.5%, deionized water 60.88%～79.56%；
Component C: essence 0.01%～0.03%, Cremophor RH40 0.05%～0.15%, described in have defying age and
The skin matrix 10%～20% of antiallergic effect；
D component: triethanolamine 0.03%～0.09%.
10. comprising a protective skin cream for the skin matrix described in claim 1 with defying age and antiallergic effect, its feature exists
In: it is made up of following component by mass percentage:
Component A: lecithin 1.0%～2.5%, Jojoba oil 2%～5%, Semen Tritici aestivi germ oil 1%～3%, 16/18 alcohol 0.5%
～1.5%；
B component: acrylate copolymer 0.5%～1.0%, methyl hydroxybenzoate 0.1%～0.2%, butanediol 5%～10%, go
Ionized water 54.3%～78.6%；
Component C: phenoxyethanol 0.3%～0.5%, Aloe extract 1%～2%；
D component: described in there is the skin matrix 10%～20% of defying age and antiallergic effect.
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| CN108619001A (en) * | 2018-06-25 | 2018-10-09 | 上海交通大学医学院 | A kind of red ginseng facial mask and preparation method thereof of preservative free addition |
| CN108904384A (en) * | 2018-08-15 | 2018-11-30 | 广东丸美生物技术股份有限公司 | Skin matrix, preparation method and application and cosmetics |
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| CN109330965A (en) * | 2018-12-14 | 2019-02-15 | 诺斯贝尔化妆品股份有限公司 | A cosmetic composition containing plant extract |
| CN112274453A (en) * | 2020-11-06 | 2021-01-29 | 广东丸美生物技术股份有限公司 | Skin-care matrix with whitening, anti-allergy and anti-aging functions and preparation method and application thereof |
| CN112274453B (en) * | 2020-11-06 | 2022-05-17 | 广东丸美生物技术股份有限公司 | Skin-care matrix with whitening, anti-allergy and anti-aging functions and preparation method and application thereof |
| CN113069394A (en) * | 2021-02-26 | 2021-07-06 | 广东袋鼠妈妈生物科技有限公司 | Antiallergic composite extract, extraction method and application formula |
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