CN106174814B - A kind of antibacterial gloves and preparation method thereof - Google Patents

Abstract

The invention discloses an antibacterial glove and a preparation method thereof. During the preparation, the glove is put into a pretreatment solution for pretreatment, then the pretreatment glove is immersed in the activation solution for activation, washed with pure water, then immersed in the antibacterial solution, and then Wash with pure water, then immerse in cross-linking solution, graft under ultraviolet light, wash with pure water, and finally immerse in the antibacterial solution after the above treatment, wash with pure water, and dry in a ventilated place at room temperature to obtain antibacterial gloves. The antibacterial medical gloves prepared by the invention have good biocompatibility, are non-toxic, non-irritating, and non-sensitizing to the skin, and have long-lasting and stable antibacterial properties. The preparation method has simple process, good antibacterial effect of the glove, and is safe and stable. The source of the raw material is extensive, the composition and the preparation method are simple, and the enlarged production can be realized.

Description

A kind of antibacterial glove and preparation method thereof

technical field

The invention relates to the technical field of medical materials, in particular to an antibacterial glove and a preparation method thereof.

Background technique

Commonly used medical gloves contain a large amount of bacterial nutrients, which can easily cause the growth of bacteria or microorganisms, thereby causing infection. Nano-silver antibacterial gloves and its manufacturing method (200610039471) invented nano-silver antibacterial gloves, which have a good antibacterial effect, but silver ions are easy to be reduced and change color, and the antibacterial effect is significantly reduced after reduction, and the price is relatively expensive, and it is easy to accumulate in the human body Harm to human body. Inorganic nano-composite antibacterial rubber latex glove liquid masterbatch and its preparation method (CN105532655) Invented inorganic nano-antibacterial liquid masterbatch, the nano-particles are small in size, easy to agglomerate, and have uneven antibacterial effect.

The invention relates to an antibacterial glove and a preparation method thereof. The antibacterial layer is grafted on the medical glove. The manufacturing method is as follows: a. first pretreating the gloves, b. secondly immersing the gloves in the activation solution, activating the surface, and washing with pure water for later use, c. then immersing the gloves in the antibacterial solution, washing with pure water for later use, d. Immerse in the cross-linking solution, graft the antibacterial layer under ultraviolet light, wash with pure water and set aside, e. Immerse the gloves in the remaining antibacterial solution, wash with pure water and set aside, f. Dry in a ventilated place at room temperature to obtain. This method is simple and easy to implement, has long-term and stable antibacterial effect, and is suitable for enlarged production.

Contents of the invention

The object of the present invention is to provide a non-toxic, non-irritating, non-sensitizing antibacterial glove with safe and stable antibacterial performance to the skin and a preparation method thereof, so as to solve the problems raised in the above-mentioned background technology.

To achieve the above object, the present invention provides the following technical solutions:

A preparation method for antibacterial gloves, comprising the following steps:

1) Put the gloves into the pretreatment solution for pretreatment to prepare pretreated gloves for use;

2) Dip the pretreatment gloves into the activation solution for activation, wash with pure water, and set aside;

3) Then immerse in the antibacterial solution, wash with pure water, and set aside;

4) Then immerse in the cross-linking solution, graft under ultraviolet light, wash with pure water, and set aside;

5) Then immerse in the antibacterial solution treated in step 3), wash with pure water, and set aside;

6) Dry in a ventilated place at room temperature to obtain antibacterial gloves.

As a further solution of the present invention: the pretreatment solution in step 1) adopts one or any combination of ethanol, isopropanol and acetone, and the treatment time is 1-30min;

As a further solution of the present invention: in step 2), the activation solution is composed of a swelling agent and a coupling agent; the mass ratio of the swelling agent to the coupling agent is 1:19-1:99, and the activation time is 1-10 minutes.

As a further scheme of the present invention: swelling agent adopts toluene, xylene, ethylbenzene, naphtha, normal hexane, normal heptane, cyclohexane, turpentine, dipentene, diethyl ketone, methyl isobutyl ketone , n-butyl acetate, isobutyl acetate or any combination. As the coupling agent, one or a mixture of titanate coupling agent and silane coupling agent is used.

As a further solution of the present invention: in step 3), the bacteriostatic liquid component adopts one or any combination of natural bacteriostatic agent chitosan or its derivatives, the concentration is 1%-10%, and the soaking time is 5- 60min. Chitosan is a high-molecular alkaline polysaccharide polymer with free amino groups in the shell molecule. It is easy to form salts in acidic solutions and is cationic. Its complex spatial structure contains highly active functional groups, showing the characteristics of antibiotics, and can inhibit the growth and activity of various bacteria.

As a further solution of the present invention: in step 4), the crosslinking solution uses one or any combination of glutaraldehyde, formaldehyde, glyoxal, and epichlorohydrin, and its concentration is 1%-5%, and the grafting time 0.5-10h.

As a further solution of the present invention: in step 5), the time for immersing in the bacteriostatic solution treated in step 3) is 3-10 minutes.

As a further solution of the present invention: the pure water cleaning time is 5-40s.

As a further solution of the present invention: in step 6), the glove drying time is not less than 2 hours.

Another object of the present invention is to provide antibacterial gloves made by the above preparation method.

Compared with prior art, the beneficial effect of the present invention is:

The antibacterial medical gloves prepared by the invention have good biocompatibility, are non-toxic, non-irritating, and non-sensitizing to the skin, and have long-lasting and stable antibacterial properties. The preparation method has simple process, good antibacterial effect of the glove, and is safe and stable. The source of the raw material is extensive, the composition and the preparation method are simple, and the enlarged production can be realized.

detailed description

The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Apparently, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

Example 1

In the embodiment of the present invention, a kind of preparation method of antibacterial gloves comprises the following steps:

1) Solution preparation:

Activation solution: the coupling agent and the swelling agent are mixed evenly at a mass ratio of 1:39;

Bacteriostatic solution: prepare a chitosan solution with a concentration of 5%;

Cross-linking solution: Prepare a 2.5% glutaraldehyde aqueous solution.

2) Glove pretreatment: immerse ordinary gloves in ethanol for 10 minutes before use;

3) Glove activation: immerse the gloves treated in step 2) into the activation solution in step 1) for activation for 5 minutes, rinse with purified water for 20 seconds, and set aside;

4) Soak the gloves in step 3) in the antibacterial solution in step 1) for 30 minutes, rinse with purified water for 20 seconds, and set aside;

5) Grafting: Immerse the treatment gloves in step 4) into the crosslinking solution in step 1), and carry out grafting under ultraviolet light for 2 hours; rinse with purified water for 20 seconds, and set aside;

6) Immerse the gloves treated in step 5) in the remaining antibacterial solution for 5 minutes, rinse with purified water for 20 seconds, and set aside;

7) Place the gloves treated in step 6) in a ventilated place for drying, and the drying time is 10 hours.

Glove antibacterial performance test

The antibacterial effect of the product was tested according to the standard method of "Technical Specifications for Disinfection" (2002), and the results are shown in Table 1.

Table 1

Staphylococcus aureus Escherichia coli Inhibition zone/mm 10.5mm 10.0mm Antibacterial rate 100% 100%

Example 2

In the embodiment of the present invention, a kind of preparation method of antibacterial gloves comprises the following steps:

1) Solution preparation:

Activation solution: the coupling agent and the swelling agent are mixed evenly at a mass ratio of 1:39;

Antibacterial solution: prepare a chitosan solution with a concentration of 3%;

Cross-linking solution: prepare a glutaraldehyde aqueous solution with a concentration of 2.5%;

2) Glove pretreatment: immerse ordinary gloves in ethanol for 10 minutes before use;

3) Glove activation: immerse the gloves treated in step 2) into the activation solution in step 1) for activation for 5 minutes, rinse with purified water for 20 seconds, and set aside;

4) Soak the gloves in step 3) in the antibacterial solution in step 1) for 30 minutes, rinse with purified water for 20 seconds, and set aside;

5) Grafting: Immerse the treatment gloves in step 4) into the cross-linking solution in step 1), and carry out grafting under ultraviolet light for 3 hours; rinse with purified water for 20 seconds, and set aside;

6) Immerse the gloves treated in step 5) in the remaining antibacterial solution for 5 minutes, rinse with purified water for 20 seconds, and set aside;

7) Place the gloves treated in step 6) in a ventilated place for drying, and the drying time is 10 hours.

Glove antibacterial performance test

The antibacterial effect of the product was tested according to the standard method of "Technical Specifications for Disinfection" (2002), and the results are shown in Table 2.

Table 2

Staphylococcus aureus Escherichia coli Inhibition zone/mm 9.7mm 9.5mm Antibacterial rate 100% 100%

Example 3

In the embodiment of the present invention, a kind of preparation method of antibacterial gloves comprises the following steps:

1) Solution preparation:

Activation solution: the coupling agent and the swelling agent are mixed evenly at a mass ratio of 1:19;

Antibacterial solution: prepare a chitosan solution with a concentration of 1%;

Cross-linking solution: prepare a glutaraldehyde aqueous solution with a concentration of 1%;

2) Glove pretreatment: immerse ordinary gloves in ethanol for 30 minutes before use;

3) Glove activation: immerse the gloves treated in step 2) into the activation solution in step 1) for activation for 1 minute, rinse with purified water for 5 seconds, and set aside;

4) Soak the gloves in step 3) in the antibacterial solution in step 1) for 5 minutes, rinse with purified water for 5 seconds, and set aside;

5) Grafting: Immerse the treatment gloves in step 4) into the crosslinking solution in step 1), and carry out grafting under ultraviolet light for 0.5h; rinse with purified water for 5s, and set aside;

6) Immerse the gloves treated in step 5) in the remaining antibacterial solution for 5 minutes, rinse with purified water for 5 seconds, and set aside;

7) Place the gloves treated in step 6) in a ventilated place for drying, and the drying time is 2 hours.

Glove antibacterial performance test

The antibacterial effect of the product was tested according to the standard method of "Technical Specifications for Disinfection" (2002), and the results are shown in Table 3.

table 3

Staphylococcus aureus Escherichia coli Inhibition zone/mm 8.2mm 8.1mm Antibacterial rate 90% 92%

Example 4

In the embodiment of the present invention, a kind of preparation method of antibacterial gloves comprises the following steps:

1) Solution preparation:

Activation solution: the coupling agent and the swelling agent are mixed evenly at a mass ratio of 1:99;

Bacteriostatic solution: prepare a chitosan solution with a concentration of 10%;

Cross-linking solution: prepare a glutaraldehyde aqueous solution with a concentration of 5%;

2) Glove pretreatment: immerse ordinary gloves in ethanol for 1 min, and set aside;

3) Glove activation: immerse the gloves treated in step 2) into the activation solution in step 1) for activation for 10 minutes, rinse with purified water for 40 seconds, and set aside;

4) Soak the gloves in step 3) in the antibacterial solution in step 1) for 60 minutes, rinse with purified water for 40 seconds, and set aside;

5) Grafting: Immerse the treatment gloves in step 4) into the crosslinking solution in step 1), and carry out grafting under ultraviolet light for 12 hours; rinse with purified water for 40 seconds, and set aside;

6) Immerse the gloves treated in step 5) in the remaining antibacterial solution for 5 minutes, rinse with purified water for 40 seconds, and set aside;

7) Place the gloves treated in step 6) in a ventilated place for drying, and the drying time is 8 hours.

Glove antibacterial performance test

The antibacterial effect of the product was tested according to the standard method of "Technical Specifications for Disinfection" (2002), and the results are shown in Table 4.

Table 4

Staphylococcus aureus Escherichia coli Inhibition zone/mm 9.0mm 8.8mm Antibacterial rate 94% 93%

It will be apparent to those skilled in the art that the invention is not limited to the details of the above-described exemplary embodiments, but that the invention can be embodied in other specific forms without departing from the spirit or essential characteristics of the invention. Accordingly, the embodiments should be regarded in all points of view as exemplary and not restrictive, the scope of the invention being defined by the appended claims rather than the foregoing description, and it is therefore intended that the scope of the invention be defined by the appended claims rather than by the foregoing description. All changes within the meaning and range of equivalents of the elements are embraced in the present invention.

In addition, it should be understood that although this specification is described according to implementation modes, not each implementation mode only contains an independent technical solution, and this description in the specification is only for clarity, and those skilled in the art should take the specification as a whole , the technical solutions in the various embodiments can also be properly combined to form other implementations that can be understood by those skilled in the art.

Claims (7)

1. a preparation method for antibacterial gloves, is characterized in that, comprises the following steps: 1) Put the gloves into the pretreatment solution for pretreatment to prepare pretreatment gloves for use. The pretreatment solution is composed of one or more of ethanol, isopropanol, and acetone, and the treatment time is 1- 30min; 2) Dip the pretreated gloves into the activation solution for activation, wash with pure water, and set aside. The activation solution is composed of a swelling agent and a coupling agent; the mass ratio of the swelling agent to the coupling agent is 1:19-1:99, and the activation time is 1-10min; 3) Immerse in the antibacterial solution, wash with pure water, and set aside. The antibacterial solution is made of natural antibacterial agent chitosan or one of its derivatives or any combination, and its concentration is 1%-10%. The soaking time 5-60min; 4) Then immerse in the cross-linking solution, graft under ultraviolet light, wash with pure water, and set aside; 5) Then immerse in the antibacterial solution treated in step 3), wash with pure water, and set aside; 6) Dry in a ventilated place at room temperature to obtain antibacterial gloves. 2. the preparation method of antibacterial gloves according to claim 1 is characterized in that, swelling agent adopts toluene, dimethylbenzene, ethylbenzene, naphtha, normal hexane, normal heptane, cyclohexane, turpentine, dipentene , diethyl ketone, methyl isobutyl ketone, n-butyl acetate, isobutyl acetate or any combination; the coupling agent is one of titanate coupling agent and silane coupling agent or Mix the two. 3. The preparation method of antibacterial gloves according to claim 1, characterized in that, in step 4), the crosslinking solution uses one or any combination of glutaraldehyde, formaldehyde, glyoxal, and epichlorohydrin, The concentration is 1%-5%, and the grafting time is 0.5-10h. 4. The preparation method of antibacterial gloves according to claim 1, characterized in that, in step 5), the time for immersing in the bacteriostatic solution treated in step 3) is 3-10 minutes. 5. the preparation method of antibacterial gloves according to claim 1, is characterized in that, pure water cleaning time is 5-40s. 6. The preparation method of antibacterial gloves according to claim 1, characterized in that, in step 6), the drying time of the gloves is not less than 2 hours. 7. an antibacterial glove that the arbitrary described preparation method of claim 1-6 makes.