CN106039035A - 一种全面提升人体免疫力的中药组合物 - Google Patents
一种全面提升人体免疫力的中药组合物 Download PDFInfo
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- CN106039035A CN106039035A CN201610641377.4A CN201610641377A CN106039035A CN 106039035 A CN106039035 A CN 106039035A CN 201610641377 A CN201610641377 A CN 201610641377A CN 106039035 A CN106039035 A CN 106039035A
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Abstract
本发明公开了一种全面提升人体免疫力的中药组合物，该中药组合物是以韭菜子、金锁阳、覆盆子、肉苁蓉、黑枸杞、玛卡、铁皮石斛、灵芝、淫羊藿、黄芪、菟丝子为原料药制备而成。本发明的中药组合物采用中药作为原料药，无毒无副作用，原料来源丰富、配伍合理、制备工艺简单、成本低廉、疗效好，见效快，可制备成多种剂型，满足不同患者的需求，易于在临床上推广。
Description
技术领域
本发明属于中药领域，涉及一种全面提升人体免疫力的中药组合物。
背景技术
免疫力是人体自身的防御机制，是人体识别和消灭外来入侵的任何异物(病毒、细菌、真菌等)，处理衰老、损伤、死亡、变性的自身细胞以及识别和处理体内突变细胞和病毒感染细胞的能力。免疫力是人体识别和排除“异己”的生理反应。人体内执行这一功能的是免疫系统。“免疫”一词最早见于中国明代医书《免疫类方》，指的是“免除疫疠”，也就是防治传染病之意。
随着社会的发展，人们的生活和工作压力变的也越来越大，随之导致身体机能下降，造成身体免疫力低下。免疫力低下的身体极易招致细菌、病毒、真菌等感染，因此免疫力低下最直接的表现就是容易生病。因经常患病，加重了机体的消耗，所以一般有体质虚弱、营养不良、精神萎靡、疲乏无力、食欲降低、睡眠障碍等表现，生病、打针吃药便成了家常便饭。每次生病都要很长时间才能恢复，而且常常反复发作。长此以往会导致身体和智力发育不良，还易诱发重大疾病。
目前人们调节免疫力的方法：1、喝酸奶、饮开水、吃海鲜、吃大蒜和洋葱、多吃含锌食物、吃食用菌类、经常喝绿茶、饮用红酒、喝鸡汤、吃动物肝脏，户外锻炼。2、吃冬虫夏草、补充谷氨酰胺、补充精氨酸、服用鲨鱼肝油、吃牛初乳、饮人参茶和木瓜汁、吃维生素及富含维生素的食品、补充胶原蛋白、补充超氧化物歧化酶及海苔、食用蜂产品、注射羊胎素、食用乳免疫蛋白、多吃含硒钙铁锌镁锰量丰富的食品。3、目前用于调节人体免疫力的还有许多西药制剂、中药制剂、保健品等。上述方法各有优势又各有不足，所以研究开发以我国中药材资源优势和祖国医学理论优势为背景的、无毒无副作用的、质优价廉的产品有其巨大社会价值和经济价值。
发明内容
为了克服现有技术的不足，本发明的目的在于提供一种利用天然原料药制备而成的全面提升人体免疫力的中药组合物。本发明的中药组合物无毒无副作用、见效快、疗效好、配伍合理、制备工艺简单、成本低廉，适于在临床上推广使用。
为了实现上述目的，本发明采用了如下技术方案：
本发明提供了一种全面提升人体免疫力的中药组合物，其特征在于，所述中药组合物是以韭菜子、金锁阳、覆盆子、肉苁蓉、黑枸杞、玛卡、铁皮石斛、灵芝、淫羊藿、黄芪、菟丝子为原料药制备而成。
进一步，所述中药组合物是由以下重量份配比的原料药制备而成：韭菜子1-5份，金锁阳1-5份，覆盆子1-5份，肉苁蓉1-5份，黑枸杞1-5份，玛卡1-5份，铁皮石斛1-5份，灵芝1-5份，淫羊藿1-5份，黄芪1-5份，菟丝子1/(10～15)份。
优选地，所述中药组合物是由以下重量份配比的原料药制备而成：韭菜子2份，金锁阳2份，覆盆子3份，肉苁蓉3份，黑枸杞3份，玛卡2份，铁皮石斛2份，灵芝2.5份，淫羊藿2.5份，黄芪3份，菟丝子1/12份。
本发明提供了一种药物制剂，所述药物制剂的有效成分是由前面所述的中药组合物制备而成。
进一步，所述药物制剂包括但不限于，片剂、丸剂、胶囊剂、颗粒剂、口服液。
进一步，所述丸剂包括水丸、蜜丸、糖衣丸、胶丸、肠溶丸，或滴丸。
本发明还提供了前面所述的中药组合物的制备方法，所述制备方法包括如下步骤：
将上述各原料药洗净、烘干后，研磨成细粉混合均匀；
或
将上述各原料药洗净、烘干、粉碎后加水、乙醇等常用提取溶剂提取数次，合并提取液，过滤，滤液即为本发明的中药组合物。
本发明还提供了前面所述的药物制剂的制备方法，所述制备方法包括如下步骤：
(1)制备前面所述的中药组合物；
(2)将步骤(1)制备所述的中药组合物按照药剂学的常规工艺和常用药用辅料制备成所述药物制剂。
药剂学上的常规工艺是本领域技术人员熟知的。
进一步，本发明还提供了前面所述的药物制剂的制备方法，所述制备方法包括如下步骤：
(1)制备前面所述的中药组合物；
(2)将步骤(1)的中药组合物浓缩成膏；而后将膏干燥、粉碎然后加入适当的药用辅料备成所述的药物制剂。
这些药用辅料的应用是制剂领域所公知的。根据实际制剂的需要，本领域技术人员可以从现有制剂辅料中进行筛选。
药用辅料包括但不限于，
稀释剂：淀粉、糖粉、乳糖、糊精、微晶纤维素、无机盐、糖醇类等。
润湿剂与粘合剂：纯化水、乙醇、明胶、聚乙二醇、纤维素衍生物等。
崩解剂：淀粉、羧甲基淀粉钠、纤维素衍生物、交联聚维酮等。
润滑剂：硬脂酸镁、微粉硅胶、滑石粉、聚乙二醇等。
助溶剂：水、乙醇、甘油、丙二醇、液状石蜡、植物油等。
矫味剂：蔗糖、单糖、芳香剂等。
防腐剂：苯甲酸、山梨酸、甲酯、乙酯、丙酯等。
本发明还提供了前面所述的中药组合物在制备提升人体免疫力的药物或保健品中的应用。
本发明还提供了前面所述的药物制剂在制备提升人体免疫力的药物或保健品中的应用。
本发明的优点和有益效果：
本发明的中药组合物采用中药作为原料药，无毒无副作用，原料来源丰富、配伍合理、制备工艺简单、成本低廉、疗效好，见效快，可制备成多种剂型，满足不同患者的需求，易于在临床上推广。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白，以下结合实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。
本说明书中公开的所有特征，或公开的所有方法或过程中的步骤，除了相互排斥的特质和/或步骤以外，均可以以任何方式组合，除非特别叙述，均可被其他等效或具有类似目的的替代特征加以替换，即，除非特别叙述，每个特征之一系列等效或类似特征中的一个实施例而已。
实施例1全面提升免疫力的中药组合物的制备
步骤如下：
1、称取以下重量份配比的原料药：韭菜子1份，金锁阳1份，覆盆子1份，肉苁蓉1份，黑枸杞1份，玛卡1份，铁皮石斛1份，灵芝1份，淫羊藿1份，黄芪1份，菟丝子1/10份。
2、将上述中药原料粉碎混合均匀。
实施例2全面提升免疫力的中药组合物的制备
步骤如下：
1、称取以下重量份配比的原料药：韭菜子5份，金锁阳5份，覆盆子5份，肉苁蓉5份，黑枸杞5份，玛卡5份，铁皮石斛5份，灵芝5份，淫羊藿5份，黄芪5份，菟丝子1/15份。
2、将上述各原料药用五倍量的水煎煮两次，每次两小时。滤过合并滤液，静置48小时后取其上清液减压浓缩成清膏后粉碎成细粉，或减压浓缩成稠膏。
实施例3全面提升免疫力的中药组合物的制备
步骤如下：
1、称取以下重量份配比的原料药：韭菜子2份，金锁阳2份，覆盆子3份，肉苁蓉3份，黑枸杞3份，玛卡2份，铁皮石斛2份，灵芝2.5份，淫羊藿2.5份，黄芪3份，菟丝子1/12份。
2、将上述原料药用三倍量的85％的乙醇回流三次，每次一小时。合并滤液，减压浓缩成清膏后粉碎成细粉，或减压浓缩成稠膏。
实施例4药物制剂的制备
1、口服液的制备
(1)按照实施例1-实施例3中的方法制备中药组合物清膏；
(2)加入20％苯甲酸乙醇溶液5ml和24％山梨酸钾溶液5ml，搅匀，冷藏48h以上，滤过，加水调整至每毫升含有生药5.5g，搅匀，灌封，即得口服液。
2、片剂的制备
(1)按照实施例1-实施例3中的方法制备中药组合物清膏；
(2)加入辅料淀粉、乙醇、滑石粉，制得片剂。
3、胶囊剂的制备
(1)按照实施例1-实施例3中的方法制备中药组合物清膏；
(2)加入辅料淀粉、乙醇、糊精、硬脂酸镁，装入胶囊壳、制得胶囊剂。
4、颗粒剂的制备
(1)按照实施例1-实施例3中的方法制备中药组合物清膏；
(2)加入辅料糖粉、淀粉、糊精、乙醇，制得颗粒剂。
5、所述丸剂的制备方法包括以下步骤：
(1)按照实施例2-实施例3中的方法制备中药组合物稠膏；
(2)将膏状物团成丸状，即得。
实施例5中药组合物及其制备的药物制剂的疗效
1.临床资料：2015年3月至2016年5月，共选取100例免疫力低下患者为治疗对象，其中男50人，女50人，年龄为10-60岁，平均38.5岁。
2.疗效评定标准
(1)显效：体质明显增强，四肢有力，精力充沛，脸色改善，睡眠和消化等方面的亚健康状态明显改善；
(2)有效：体质有所增强，四肢较有力，精力和脸色均有所好转，睡眠和消化等方面的亚健康状态也有所改善；
(3)无效：症状及各项检查未见改善。
3.治疗方法：饭后口服实施例4制备的口服液，每日早晚两次，每次150ml，共服用1个月。
4.治疗结果：临床观察结果显示，其中85例免疫力低下者服用本药物1个月后，体质明显增强，精力充沛，为显效；11例免疫力低下者服用本药物1个月后，体质有所增强，四肢较有力，为有效；6例免疫力低下者服用本药物1个月后，症状无所改善，为无效。总有效率为94％。
以上内容是结合具体的优选实施方式对本发明所作的进一步详细说明，不能认定本发明的具体实施只局限于这些说明。对于本发明所属技术领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干简单推演或替换，都应当视为属于本发明的保护范围。
Claims (10)
1.一种全面提升人体免疫力的中药组合物，其特征在于，所述中药组合物是以韭菜子、金锁阳、覆盆子、肉苁蓉、黑枸杞、玛卡、铁皮石斛、灵芝、淫羊藿、黄芪、菟丝子为原料药，按药剂学的常规工艺制备而成。
2.根据权利要求1所述的中药组合物，其特征在于，所述中药组合物是由以下重量份的原料药制备而成：韭菜子1-5份，金锁阳1-5份，覆盆子1-5份，肉苁蓉1-5份，黑枸杞1-5份，玛卡1-5份，铁皮石斛1-5份，灵芝1-5份，淫羊藿1-5份，黄芪1-5份，菟丝子1/(10～15)份。
3.根据权利要求2所述的中药组合物，其特征在于，所述中药组合物是由以下重量份的原料药制备而成：韭菜子2份，金锁阳2份，覆盆子3份，肉苁蓉3份，黑枸杞3份，玛卡2份，铁皮石斛2份，灵芝2.5份，淫羊藿2.5份，黄芪3份，菟丝子1/12份。
4.一种药物制剂，其特征在于，所述药物制剂的有效成分是由权利要求1-3中任一项所述的中药组合物制备而成。
5.根据权利要求4所述的药物制剂，其特征在于，所述药物制剂是片剂、丸剂、胶囊剂、颗粒剂、口服液中的任意一种。
6.根据权利要求5所述的药物制剂，其特征在于，所述丸剂包括水丸、蜜丸、糖衣丸、胶丸、肠溶丸，或滴丸。
7.权利要求1-3中任一项所述的中药组合物的制备方法，其特征在于，所述制备方法包括如下步骤：
按照权利要求1-3中任一项中记载的原料药的配比称取各原料药，洗净、烘干后，研磨成细粉混合均匀；
或
将上述各原料药洗净、烘干、粉碎后加水、乙醇等常用提取溶剂提取数次，合并提取液，过滤，滤液即为本发明的中药组合物。
8.权利要求4-6中任一项所述的药物制剂的制备方法，其特征在于，所述制备方法包括如下步骤：
(1)制备权利要求1-3中任一项所述的中药组合物；
(2)将步骤(1)制备所述的中药组合物按照药剂学的常规工艺和常用药用辅料制备成所述药物制剂。
9.权利要求1-3中任一项所述的中药组合物在制备提升人体免疫力的药物或保健品中的应用。
10.权利要求4-6中任一项所述的药物制剂在制备提升人体免疫力的药物或保健品中的应用。
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