CN1060365C - New medicine for curing burn, traumatism and preparation method thereof - Google Patents
New medicine for curing burn, traumatism and preparation method thereof Download PDFInfo
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- CN1060365C CN1060365C CN96118155A CN96118155A CN1060365C CN 1060365 C CN1060365 C CN 1060365C CN 96118155 A CN96118155 A CN 96118155A CN 96118155 A CN96118155 A CN 96118155A CN 1060365 C CN1060365 C CN 1060365C
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- 239000003814 drug Substances 0.000 title claims abstract description 51
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 239000007788 liquid Substances 0.000 claims abstract description 5
- 238000011282 treatment Methods 0.000 claims description 11
- 239000007765 cera alba Substances 0.000 claims description 8
- 239000009286 sanguis draxonis Substances 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 6
- 206010048038 Wound infection Diseases 0.000 claims description 5
- 230000008030 elimination Effects 0.000 claims description 3
- 238000003379 elimination reaction Methods 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 241000202807 Glycyrrhiza Species 0.000 claims description 2
- 241000545442 Radix Species 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 206010052428 Wound Diseases 0.000 abstract description 20
- 208000027418 Wounds and injury Diseases 0.000 abstract description 20
- 230000001225 therapeutic effect Effects 0.000 abstract description 2
- 238000002560 therapeutic procedure Methods 0.000 abstract description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 241000118825 Alkanna tinctoria Species 0.000 abstract 1
- 244000061520 Angelica archangelica Species 0.000 abstract 1
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000001287 Guettarda speciosa Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 208000004210 Pressure Ulcer Diseases 0.000 abstract 1
- 206010042674 Swelling Diseases 0.000 abstract 1
- 206010044546 Traumatic ulcer Diseases 0.000 abstract 1
- 230000002421 anti-septic effect Effects 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 239000009136 dragon's blood Substances 0.000 abstract 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 abstract 1
- 239000008159 sesame oil Substances 0.000 abstract 1
- 235000011803 sesame oil Nutrition 0.000 abstract 1
- 230000008961 swelling Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 229940045860 white wax Drugs 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 9
- 230000000844 anti-bacterial effect Effects 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 206010053615 Thermal burn Diseases 0.000 description 7
- 239000002674 ointment Substances 0.000 description 7
- 241000699670 Mus sp. Species 0.000 description 6
- 208000015181 infectious disease Diseases 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 239000002547 new drug Substances 0.000 description 3
- 230000000472 traumatic effect Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 208000009043 Chemical Burns Diseases 0.000 description 2
- 208000018380 Chemical injury Diseases 0.000 description 2
- 206010039509 Scab Diseases 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 210000001217 buttock Anatomy 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000001524 infective effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000003357 wound healing promoting agent Substances 0.000 description 2
- 208000003656 Electric Burns Diseases 0.000 description 1
- 206010063560 Excessive granulation tissue Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 206010033892 Paraplegia Diseases 0.000 description 1
- 244000179560 Prunella vulgaris Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010042682 Swelling face Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 230000000680 avirulence Effects 0.000 description 1
- 229960004755 ceftriaxone Drugs 0.000 description 1
- VAAUVRVFOQPIGI-SPQHTLEESA-N ceftriaxone Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C(=O)NN1C VAAUVRVFOQPIGI-SPQHTLEESA-N 0.000 description 1
- 229940121657 clinical drug Drugs 0.000 description 1
- 238000011443 conventional therapy Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
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- 210000001126 granulation tissue Anatomy 0.000 description 1
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- 238000002347 injection Methods 0.000 description 1
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- 210000003141 lower extremity Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a novel medicine for curing burns and traumatic ulcers and a preparation method thereof. The medicine is a liquid medicine prepared from the raw materials of dahurian angelica, alkanna tinctoria, licorice root, angelica, white wax, dragon blood, borneol and sesame oil. The medicine of the present invention has strong antiseptic function, quickly alleviates pain. The present invention adopts exposure therapy, so the medicine is convenient in use. The medicine is widely suitable for various burns, wounds, infected wound surfaces, innominate toxic swellings, bed sores, etc., and has significant therapeutic effect.
Description
The present invention relates to a kind of new drug for the treatment of burn, wound infections, specifically compound Chinese medicinal preparation.The invention still further relates to the manufacture method of this medicine.
Burn, scald, chemical burn, wound, be a kind of common, come accidental wound suddenly, the patient suffering, heavy then threat to life brings serious economic problems and social problem to family social.In existing many burn medicines,, also has unsatisfactory part owing to many reasons such as prescription and making.Some analgesic effect is poor, and a little less than some antibacterial action, some skin moistening skin-protecting function is poor, some blood activating and promoting tissue regeneration function is poor, some patient misery of changing dressings, and doctor's labor intensity is big, some therapeutic domain is little, and overemphasized gnotobasis is not suitable for vast rural area and different medical unit and uses.War or earthquake particularly taking place, large quantities of wounded occur, then feels simply helpless especially.The Chinese patent communique discloses some burn medicines, as publication number CN1065014, CN1068495, CN107538, CN1079163 etc.Treatment at present burns preferably that medicine is the moist expose burn ointment of Beijing bright Academy of Traditional Chinese Medicine development, and this medicine is found a good sale in more than 20 countries and regions in the world, is national major scientific and technological achievement and national new drug.This medicine reaches not infective wound surface to 1 degree, 2 degree burn patients, and curative effect is fine.But to the infection suppurates wound surface, antibacterial and anti-inflammation functions is undesirable.Because three big difficulties of treatment burn, the one, pain, the 2nd, dehydration, the 3rd, infect.And infect is modal difficulty, can't resolve if infect to close, and that this medicine is just not very desirable.
The object of the present invention is to provide a kind of pain relieving fast, antibacterial action is strong, eutherapeutic burn and wound healing agent.Another object of the present invention provides the preparation method of this burn, wound healing agent.
The objective of the invention is to realize that by following technical proposals a kind of medicine for the treatment of burn, wound is the medicament of being made by the following weight proportion raw material:
Oleum Sesami 600--1000 part Radix Angelicae Sinensis 25--50 part Radix Angelicae Dahuricae 25--51 part
Radix Arnebiae (Radix Lithospermi) 25--55 part Radix Glycyrrhizae 25--60 part white beeswax 1--5 part
Sanguis Draxonis 1-20 part Borneolum Syntheticum 20--40 part
Medicine preferred weight proportioning of the present invention is:
25 parts of 25 parts of Radixs Angelicae Dahuricae of 600 parts of Radix Angelicae Sinensis of Oleum Sesami
2 parts of 25 parts of white beeswax of 24 portions of Radix Glycyrrhizaes of Radix Arnebiae (Radix Lithospermi)
20 parts of 10 parts of Borneolum Syntheticums of Sanguis Draxonis
The preparation method of medicine of the present invention is:
A, take by weighing each raw material by formula proportion;
B, Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, Radix Arnebiae (Radix Lithospermi), Radix Glycyrrhizae are put into Oleum Sesami soaked 1-3 days;
C, will soak medicine heating one hour, treat that temperature stops heating when reaching 200 ℃;
D, elimination medicinal residues add Sanguis Draxonis, white beeswax, Borneolum Syntheticum again, medicament.
This medicine is a red liquid, thickness slightly, and the tool aromatic odor, nontoxic, nonirritant is pure Chinese medicine compound liquid preparation, temporarily called after " wound oil is scalded in China ".
Medicine of the present invention is through animal experiment and clinical trial, and the result shows: this medical instrument has anti-inflammation, detumescence, pain relieving, invigorates blood circulation, the function of granulation promoting.Evident in efficacy to treatment water, burning hot wound, chemical burn, electric burn, dark 2 degree and 3 degree wound surface.Be characterized in that 1. pain relieving is fast, but pain relieving in 1-3 minute; 2. antibacterial action is strong, the infective wound surface coating once, can form a scab next day, generally do not need injection of antibiotics; 3. adopt exposure method, easy to use, need not wrap up; 4. medical expense is low, but than conventional therapy cost saving 50-90%; 5. cure soon, alleviate patient's misery; 6. generally do not require under the gnotobasis and operate.
Nineteen ninety-five, the inventor is scalded wound oil with China and is carried out every contrast test with Pekinese's moist expose burn ointment, successively does local toxicity test, skin irritation test, scalds contrast test, invigorates blood circulation and antibacterial tests with 60 Kunming kind white mice and 4 TWOs.Result of the test: preceding 2 tests, two kinds of equal avirulences of medicament, non-stimulated, zero difference.Scald contrast test, every group with 10 of white mice, all cuts off left side buttocks hair, causes 2 * 1cm to scald face with 90 ℃ boiled water, and coating respectively all heals with wound surface in 8 days of medicine of the present invention, with 10 days of moist expose burn ointment healing substantially.Invigorate blood circulation and antibacterial tests, the white mice tail is cut off 1/2 or 1/3, the first group is coated with medicine of the present invention, and the second group is coated with moist expose burn ointment, obvious difference after 3 days, and the dry incrustation of the wound surface of first group, the white mice activity is freely.The dull state of the appearance of second group, the wound has secretions to overflow.After 8 days, the white mice tail of first group survives, and the white mice tail of second group is withered to diminish.In addition, artificially antibacterial is put into the white mouse wound face, causes infection, the antibacterial and anti-inflammation functions of medicine of the present invention obviously is better than moist expose burn ointment as a result.Henceforth, do contrast test with the burn cream of Hong Kong, the U.S. again, the analgesic antiphlogistic effect of medicine of the present invention is all excellent as a result.
Example surplus clinical drug of the present invention uses 600, effective percentage 100%, and obviously be better than various burn medicines.Now enumerating several cases is described below:
1, Li Tingting, woman, 3 years old, the woman of the Shaoyang City suburb Li Le of public security bureau honor, boiled water is scalded two lower limb, is diagnosed as shallow 2 degree and scalds area 20%, once be in hospital 27 days in Shaoyang City hospital, wound surface is coated with moist expose burn ointment, and cooperates supporting treatments such as antibiotic therapy and blood transfusion, shared go surplus the medical fee 5000 yuan, traumatic infection becomes 3 degree by shallow 2 degree, and body temperature continues at 39 ℃.After the inventor uses medicine of the present invention instead, i.e. incrustation after 24 hours, all antibiotic of stopping using after coating 2 times, body temperature is reduced to 37 ℃ two days later, the band medicine goes home to treat after three days, once a day, and wound surface recovery from illness in 15 days, do not make skin graft, do not influence function yet, only spend surplus the medical fee 100 yuan.
2, Zhou Lanying, the woman, 32 years old, Shaoyang City Shuan Po mountain range four company's families of workers and staff were scalded face because of pressure cooker cooks congee, and treat 4 days with moist expose burn ointment in city's fire-fighting detachment earlier, spend more than 600 yuan of medical fee, and facial swelling is more very.After being coated with China, the inventor scalds wound oil once, whole detumescences of a face in evening and incrustation, and form a scab was coated with once in back two days, recovery from illness after 3 days, preventing from scar, even also show young, beautiful before the ratio scald.
3, Yang Lan, woman, 20 years old, three workers of place of Hu'nan Prov. No.4 Engineering Co., because of traumatic injury causes the paraplegia long-term bed, cause the large stretch of skin ischemic necrosis in buttocks back to suppurate, produce Ceftriaxone treatment with the U.S. every day, medical fee was more than 400 yuan in one day, and traumatic infection suppurates, and all there is one foul smell in whole corridor.Wound oil is scalded with China in the back, is coated with every day once, and just control traumatic infection in 3 days, and fresh granulation tissue occurs, and inactive antibiotics.Wound healing after March.For company saves nearly 100,000 yuan of medical fee.
In August nineteen ninety-five, this medicine is openly on probation in worker's hospital of Hu'nan Prov. No.4 Engineering Co., because of evident in efficacy, has been subjected to medical circle and patient's popular welcome and praise." Shaoyang daily paper ", Shaoyang TV close, how tame news unit such as " Shenzhen Special Zone Daily " has given report.Former leader Mr. Pan Junqi of the United Front Work Department of the Central Committee very appreciated after using this medicine, and inventor and this medicine was introduced to Hunan Province vice-governor Wang Keying.On March 22nd, 1996, professor expert that Hunan Province Department of Public Health convenes units such as Hunan College of Traditional Chinese Medicine, Research Inst. of Traditional Chinese Medicine, Hunan Medical University adopts unanimously the review of setting up the project of this medicine.This medicine has now caused the concern and the attention of international medical community.
Embodiment: select for use quality to meet the raw material of Chinese medicine of Chinese Pharmacopoeia regulation, take by weighing Oleum Sesami 600Kg by prescription, Radix Angelicae Sinensis 25kg, Radix Angelicae Dahuricae 25kg, Radix Arnebiae (Radix Lithospermi) 24kg, Radix Glycyrrhizae 25kg, white beeswax 22kg, Sanguis Draxonis 10kg, Borneolum Syntheticum 20kg.Earlier Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, Radix Arnebiae (Radix Lithospermi), Radix Glycyrrhizae being put into Oleum Sesami soaked 3 days; To soak medicine heating 1 hour then, and continue to heat up and treat that temperature stops heating when reaching 200 ℃; The elimination medicinal residues add Sanguis Draxonis, white beeswax, Borneolum Syntheticum again, medicament.Pack with bottle, mark medicine name, function cure mainly, usage and dosage etc. gets final product.
Claims (4)
1, a kind of medicine for the treatment of burn, wound infections is characterized in that it is the medicament of being made by the following weight proportion raw material:
Oleum Sesami 600--1000 part Radix Angelicae Sinensis 25--50 part Radix Angelicae Dahuricae 25--51 part
Radix Arnebiae (Radix Lithospermi) 25--55 part Radix Glycyrrhizae 25--60 part white beeswax 1--5 part
Sanguis Draxonis 1--20 part Borneolum Syntheticum 20--40 part
2, the medicine of treatment burn according to claim 1, wound infections, wherein the weight proportion of each raw material is:
25 parts of 25 parts of Radixs Angelicae Dahuricae of 600 parts of Radix Angelicae Sinensis of Oleum Sesami
2 parts of 25 parts of white beeswax of 24 portions of Radix Glycyrrhizaes of Radix Arnebiae (Radix Lithospermi)
20 parts of 10 parts of Borneolum Syntheticums of Sanguis Draxonis
3, the medicine of treatment burn according to claim 1 and 2, wound infections is characterized in that said medicament is a liquid, and medicinal liquid is red, and thickness has aromatic odor slightly.
4, the preparation method of the described medicine of claim 1 is characterized in that:
A, take by weighing each raw material by formula proportion;
B, Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, Radix Arnebiae (Radix Lithospermi), Radix Glycyrrhizae are put into Oleum Sesami soaked 1-3 days;
C, will soak medicine heating one hour, treat that temperature stops heating when reaching 200 ℃;
D, elimination medicinal residues add Sanguis Draxonis, white beeswax, Borneolum Syntheticum again, medicament.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96118155A CN1060365C (en) | 1996-05-08 | 1996-05-08 | New medicine for curing burn, traumatism and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96118155A CN1060365C (en) | 1996-05-08 | 1996-05-08 | New medicine for curing burn, traumatism and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1164407A CN1164407A (en) | 1997-11-12 |
| CN1060365C true CN1060365C (en) | 2001-01-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96118155A Expired - Fee Related CN1060365C (en) | 1996-05-08 | 1996-05-08 | New medicine for curing burn, traumatism and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1060365C (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1053836C (en) * | 1997-09-03 | 2000-06-28 | 田明行 | Ointment for wounds and sores and preparation thereof |
| CN100372562C (en) * | 2003-05-19 | 2008-03-05 | 魏茂武 | Bedsore ointment and its prepn process |
| CN101406583B (en) * | 2008-11-28 | 2011-05-25 | 邹连琦 | Externally applied Chinese medicine ointment for treating pyogenic skin infection caused by skin traumatism |
| CN102512573B (en) * | 2012-01-14 | 2013-05-08 | 崔合芳 | Nursing liquid for promoting wound healing |
| CN103007000A (en) * | 2013-01-11 | 2013-04-03 | 湖南邵阳华仁堂药业发展有限公司 | New medicine for treating burns and wounds and preparation method thereof |
| CN104474187A (en) * | 2014-11-18 | 2015-04-01 | 张大群 | Traditional Chinese medicine plaster for treating scald and abscess |
| CN108186729A (en) * | 2018-03-08 | 2018-06-22 | 上海市第七人民医院 | A kind of Chinese medicine composition and its application |
| CN108310160A (en) * | 2018-04-27 | 2018-07-24 | 李永建 | A kind of Chinese medicine composition for treating bedsore |
| CN109758530A (en) * | 2019-01-31 | 2019-05-17 | 凤庆县中医医院 | A kind of External used shengji paste |
| CN110279785A (en) * | 2019-07-08 | 2019-09-27 | 亳州职业技术学院 | A kind of skin repairing dahurian angelica pain-relieving powder and preparation method thereof |
| CN116440216A (en) * | 2023-04-14 | 2023-07-18 | 江苏涛梅健康产业管理服务有限公司 | Composition for treating pressure sores, preparation method and application |
| CN117338868A (en) * | 2023-11-02 | 2024-01-05 | 成都中医药大学附属医院(四川省中医医院) | A kind of Shengui skin healing oil and its preparation method and application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1052789A (en) * | 1989-07-31 | 1991-07-10 | 周学林 | A kind of preparation method of ointment for treating burn |
-
1996
- 1996-05-08 CN CN96118155A patent/CN1060365C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1052789A (en) * | 1989-07-31 | 1991-07-10 | 周学林 | A kind of preparation method of ointment for treating burn |
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| CN1164407A (en) | 1997-11-12 |
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Applicant after: Shaoyang Hunan Shan Xiu Pharmaceutical Chemical Co., Ltd. Applicant before: Song Weiguo |
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Address after: Hunan nine Shaoyang County Public Bridge Industrial Development Zone Patentee after: Hunan Shaoyang Huarentang Pharmaceutical Development Co., Ltd. Address before: Hunan nine Shaoyang County Public Bridge Industrial Development Zone Patentee before: Shaoyang Hunan Shan Xiu Pharmaceutical Chemical Co., Ltd. |
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