CN106008367A - 嘧菌酯合成方法 - Google Patents
嘧菌酯合成方法 Download PDFInfo
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- CN106008367A CN106008367A CN201510803481.4A CN201510803481A CN106008367A CN 106008367 A CN106008367 A CN 106008367A CN 201510803481 A CN201510803481 A CN 201510803481A CN 106008367 A CN106008367 A CN 106008367A
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- azoxystrobin
- synthesis method
- present
- fluoxastrobin
- synthetic method
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- 239000005730 Azoxystrobin Substances 0.000 title abstract 2
- WFDXOXNFNRHQEC-GHRIWEEISA-N azoxystrobin Chemical compound CO\C=C(\C(=O)OC)C1=CC=CC=C1OC1=CC(OC=2C(=CC=CC=2)C#N)=NC=N1 WFDXOXNFNRHQEC-GHRIWEEISA-N 0.000 title abstract 2
- 238000001308 synthesis method Methods 0.000 title abstract 2
- 239000005784 Fluoxastrobin Substances 0.000 claims description 6
- UFEODZBUAFNAEU-NLRVBDNBSA-N fluoxastrobin Chemical compound C=1C=CC=C(OC=2C(=C(OC=3C(=CC=CC=3)Cl)N=CN=2)F)C=1C(=N/OC)\C1=NOCCO1 UFEODZBUAFNAEU-NLRVBDNBSA-N 0.000 claims description 6
- 238000010189 synthetic method Methods 0.000 claims description 6
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 2
- IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 abstract description 2
- VAYGXNSJCAHWJZ-UHFFFAOYSA-N dimethyl sulfate Chemical compound COS(=O)(=O)OC VAYGXNSJCAHWJZ-UHFFFAOYSA-N 0.000 abstract description 2
- 238000000034 method Methods 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000011987 methylation Effects 0.000 abstract 1
- 238000007069 methylation reaction Methods 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 241000221785 Erysiphales Species 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 206010039509 Scab Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 241000193738 Bacillus anthracis Species 0.000 description 1
- 241000233652 Chytridiomycota Species 0.000 description 1
- 241000219112 Cucumis Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- IUOKJNROJISWRO-UHFFFAOYSA-N N-(2-cyano-3-methylbutan-2-yl)-2-(2,4-dichlorophenoxy)propanamide Chemical compound CC(C)C(C)(C#N)NC(=O)C(C)OC1=CC=C(Cl)C=C1Cl IUOKJNROJISWRO-UHFFFAOYSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 241000233679 Peronosporaceae Species 0.000 description 1
- 235000014443 Pyrus communis Nutrition 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 230000001035 methylating effect Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
本发明涉及一种嘧菌酯合成方法。本发明创新采用清洁碳酸二甲酯代替传统的高毒硫酸二甲酯作甲基化试剂，不但提高单步收率从80%提高到90%，而且实现了清洁生产。
Description
技术领域
本发明涉及一种嘧菌酯合成方法，属于农药技术领域。
背景技术
嘧菌酯是一种高效、广谱、新型杀菌剂，具有内吸传导、预防、保护、治疗等多重作用，可抑制几乎所有的真菌界（子囊菌亚门、担子菌亚门、鞭毛菌亚门和半知菌亚门）病菌孢子的萌发及产生，也可控制菌丝体的生长。并且还可抑制病原孢子侵入，具有良好的保护活性，全面有效控制蔬菜、果树、花卉等植物的各种真菌病害，如白粉病、霜霉病、黑星病、炭疽病、锈病、疫病、颖枯病、网斑病、稻瘟病等。特别对草莓白粉病、甜瓜白粉病、黄瓜白粉病、梨黑星病有特效。
因此提供一种清洁生产、并且提高收率的嘧菌酯合成方法就显得极为需要。
发明内容
本发明针对上述缺陷，目的在于提供一种能提高收率，实现清洁生产的嘧菌酯合成方法。
为此本发明采用的技术方案是：
本发明的优点是：本发明创新采用清洁碳酸二甲酯代替传统的高毒硫酸二甲酯作甲基化试剂，不但提高单步收率从80%提高到90%，而且实现了清洁生产。
具体实施方式
本发明采用的技术方案是：
。
本发明的目的是提供一种新的合成路线，至于原料中各组分的含量及相关反应条件（比如说温度、反应时间等）均可以通过常规的手段获得，其并不是本发明的创新点，因此就不加以叙述。
经过实际检测，依据本发明合成路线的方法稻瘟酰胺缩合收率普遍能达到92%以上，个别的能达到95%以上，因此本发明的合成路线提供了一种全新的合成方法，具有极大的应用价值。
Claims (1)
1.嘧菌酯合成方法，其特征在于，按照以下步骤进行：
。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510803481.4A CN106008367A (zh) | 2015-11-20 | 2015-11-20 | 嘧菌酯合成方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510803481.4A CN106008367A (zh) | 2015-11-20 | 2015-11-20 | 嘧菌酯合成方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106008367A true CN106008367A (zh) | 2016-10-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510803481.4A Pending CN106008367A (zh) | 2015-11-20 | 2015-11-20 | 嘧菌酯合成方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106008367A (zh) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1206401A (zh) * | 1996-02-17 | 1999-01-27 | 巴斯福股份公司 | 2－(2－甲基苯基)－3－甲氧基丙烯酸甲酯的制备方法 |
| CN101157657A (zh) * | 2007-10-24 | 2008-04-09 | 北京颖新泰康科技有限公司 | 嘧菌酯及其类似物的制备方法 |
| CN103030598A (zh) * | 2012-12-17 | 2013-04-10 | 上海禾本药业有限公司 | 甲氧基丙烯酸酯类杀菌剂的制备方法 |
| WO2014190997A1 (en) * | 2013-05-28 | 2014-12-04 | Cheminova A/S | Process for preparing 4,6-bis(aryloxy)pyrimidine derivatives |
-
2015
- 2015-11-20 CN CN201510803481.4A patent/CN106008367A/zh active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1206401A (zh) * | 1996-02-17 | 1999-01-27 | 巴斯福股份公司 | 2－(2－甲基苯基)－3－甲氧基丙烯酸甲酯的制备方法 |
| CN101157657A (zh) * | 2007-10-24 | 2008-04-09 | 北京颖新泰康科技有限公司 | 嘧菌酯及其类似物的制备方法 |
| CN103030598A (zh) * | 2012-12-17 | 2013-04-10 | 上海禾本药业有限公司 | 甲氧基丙烯酸酯类杀菌剂的制备方法 |
| WO2014190997A1 (en) * | 2013-05-28 | 2014-12-04 | Cheminova A/S | Process for preparing 4,6-bis(aryloxy)pyrimidine derivatives |
Non-Patent Citations (1)
| Title |
|---|
| 贾新明，等: "DMC在有机合成中的应用研究进展", 《广东化工》 * |
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Application publication date: 20161012 |
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