CN1060050C - Jiawei double coptis medicament and preparing method thereof - Google Patents
Jiawei double coptis medicament and preparing method thereof Download PDFInfo
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a modified double coptis medicament and a preparation method thereof. The modified double coptis medicament mainly contains bear gall powder, cornu gorais, scutellaria, honeysuckle and forsythia fruit. When the modified double coptis medicament is prepared, the methods of saponification, hydrolysis, decoction and the like are mainly adopted, and the medicinal materials are deeply processed so as to fully utilize the effective components of the medicinal materials. The prepared medicines can be made into liquid dosage forms and solid dosage forms. The modified double coptis medicament can be used for curing severe wind-warm pyretic pulmonary diseases; the modified double coptis medicament has the functions for clearing away heat and toxic materials, resolving phlegm, relieving convulsion, etc., and is a first-aid Chinese patent medicine with high efficiency and quick efficiency.
Description
The present invention is a kind of Jiawei double coptis medicament and preparation method thereof.
Chinese traditional treatment febrile illness with a long history, mainly contain typhoid fever school and epidemic febrile diease schools for a long time, they have all accumulated rich experience separately, common theoretical basis is also arranged, for the acute calenture rapid onset, the characteristics that change of illness state is also fast, they have set up and have closed typhoid fever and epidemic febrile disease is the dialectical Therapeutic Method of one, disease controlling as early as possible, and then reach the purpose of treatment is though it is various in style to treat the Chinese patent medicine of primary disease now, but truly have efficient quick-acting kinds also very in great shortage, existing 'Shuang Hualian ' injection agent contains Flos Lonicerae, Radix Scutellariae and Fructus Forsythiae are applicable to the wind-warm lung-heat exterior syndrome phase, though acute calenture is had certain curative effect, but to the serious symptom acute calenture, be his-and-hers watches interior syndrome phase and interior syndrome's phase, then due to illness heavy medicine is light, so the curative effect difficulty is played.
An object of the present invention is to provide all medicable Jiawei double coptis medicament of interior syndrome's phase of holding concurrently of a kind of the exterior and the interior card phase to acute calenture.
Another object of the present invention provides a kind of preparation method of above-mentioned Jiawei double coptis medicament,
Contain total urso cholic acid, Cornu Naemorhedi hydrolysate, baicalin, Flos Lonicerae extract and Fructus Forsythiae extract in the composition of this Jiawei double coptis medicament, wherein the shared parts by weight of each composition are as follows:
Total urso cholic acid 20-60 part
Cornu Naemorhedi hydrolysate 100-300 part
Baicalin 200-300 part
Flos Lonicerae extract 200-300 part
Fructus Forsythiae extract 450-550 part
Described total urso cholic acid hardship, cold, element, have spasmolytic, function of gallbladder promoting, heat clearing away, detoxifcation, antibacterial, eliminate the phlegm, effect such as blood pressure lowering, can also replace with the synthetic Fel Ursi powder.
Described Cornu Naemorhedi hydrolysate have heat clearing away, relieving convulsion, make eye bright, function such as detoxifcation, cure mainly diseases such as headache due to pathogenic wind-heat, unhappiness, haematemesis, optic atrohic blindness, toxic swelling and pediatric epilepsy scared.Contain a large amount of keratin in the Cornu Naemorhedi, can generate 18 seed amino acids and lipoid, phospholipid, cholesterol etc. after the hydrolysis, also can separate out free sugar, in conjunction with sugar and glucosamine and 12 kinds of trace element.
Can also contain water in the described Jiawei double coptis medicament, make the medicament of liquid dosage form.
Effects such as Jiawei double coptis medicament of the present invention is used for the treatment of the serious symptom wind-warm lung-heat disease, has heat-clearing and toxic substances removing, and it is relieving convulsion to reduce phlegm are a kind of efficient and quick-acting first aid Chinese patent medicines.
This medicament is preparation like this: Fel Ursi powder is obtained total urso cholic acid through saponification, purification; Through decocting, hydrolysis and purification obtain the Cornu Naemorhedi hydrolysate with Cornu Naemorhedi; With the Radix Scutellariae decocting in water after acid precipitation, precipitate with ethanol, purification obtain baicalin; Obtain the Fructus Forsythiae extracting solution with obtaining Forsythia volatile oil behind the Fructus Forsythiae decocting in water and boiling liquid by purification; With the Flos Lonicerae decocting in water, boil the liquid purification, drying obtains Flos Lonicerae extract.
With the extract drying of the above-mentioned medicine of respectively distinguishing the flavor of, mix after, can obtain electuary, hard capsule or the powder of the solid type of Jiawei double coptis.
Above-mentioned extract of respectively distinguishing the flavor of medicine is dissolved in water, prepares oral liquid, the injection (as aqueous injection, injectable powder, intravenous drip agent) that can obtain liquid dosage form.
Water described in the preparation process can be deionized water or water for injection,
Below in conjunction with embodiment the present invention is described in more detail.
Embodiment
A kind of Jiawei double coptis oral liquid, its composition contain total urso cholic acid, Cornu Naemorhedi hydrolysate, baicalin, Flos Lonicerae extract and Fructus Forsythiae extract, and wherein the shared parts by weight of each composition are as follows:
40 parts of total urso cholic acids
200 parts of Cornu Naemorhedi hydrolysates
250 parts of baicalins
250 parts of Flos Lonicerae extracts
500 parts of Fructus Forsythiae extracts
Its preparation process is: Fel Ursi powder is added the doubly deionized water of (as 10 times) amount of 8-12, add the doubly solid sodium hydroxide of (as 10 times) amount of Fel Ursi powder 8-12 again, the dissolving post-heating boils and carries out saponification, constantly replenishes the moisture content that boils off simultaneously, keeps the original volume amount, stop heating after about 16-20 hour (as 18 hours), put cold back and stir adding hydrochloric acid down, arrive below the pH value to 2.0, the precipitation of separating out is taken out be washed till neutrality, room temperature or cold drying obtain thick total urso cholic acid.This thick total urso cholic acid is added the doubly ethyl acetate of (as 5 times) amount of 4-5, the quiet charcoal of work that adds the 8-12% (as 10%) of thick total urso cholic acid amount again, being back to thick total urso cholic acid together on return channel dissolves fully, filtered while hot, the anhydrous sodium sulfate that in filtrate, adds thick total urso cholic acid amount 15-25% (20%), the placement filtration of spending the night, filtrate is reclaimed ethyl acetate, when being 2 times of amounts of thick total urso cholic acid left and right sides to concentrated liquid measure, taking-up is put cold, put refrigerator and cooled and hid 3-5 days, sucking filtration obtains crystallization, obtains total urso cholic acid in drying below 75 ℃.
Cornu Naemorhedi is added the doubly water for injection of (as 10 times) amount of 8-12, decoct more than 3 hours, filter; Medicinal residues add the doubly water for injection of (as 8 times) amount of 8-10 again, decoct 2 hours again, filter merging filtrate; With the 6-10 8M sulphuric acid of (as 8 times) amount doubly, heating hydrolysis 8-10 hour puts warm after-filtration, the filtrate harvesting till do not have a brown granule with medicinal residues; Precipitation adds doubly (as 5 times) amount water for injection of about 4-5, stirs heated and boiled 20-30 minute, take off filtered while hot, collect washing liquid, precipitation adds about 4-5 again and doubly measures water for injection, stir, reheat boiled 20-30 minute, took off filtered while hot, collected washing liquid for the second time, the precipitation of getting after washing is put into test tube on a small quantity, add certain water gaging, heated and boiled 5 minutes, liquid 5ml is boiled in leaching, add 1 triketone test solution, heating a moment should be negative or extremely weak positive reaction, merges hydrolyzed solution and washing liquid several times, transfers PH to 3.5-5.0 (as 4.2) filtration with 16% lime cream, the leaching hydrolyzed solution, precipitate as above method washing 2-3 time, each washing liquid and last hydrolyzed solution merge, and discard precipitation; Decocting liquid and hydrolyzed solution are merged, and heating evaporation treats that the 2-3 that medicinal liquid is concentrated into raw material (Cornu Naemorhedi) amount doubly measures, emit dense medicinal liquid cold to room temperature, stir and to add dense ethanol down, make to contain the alcohol amount and reach 60-75% (70%), put into refrigerator, cold preservation (about 5 ℃) filtered to get filtrate more than 24 hours; Filtrate is added fresh water for injection, and rare extremely quite material quantity 4-5 doubly measures, and adds the needle-use activated carbon of this solution amount 0.3-1% (as 0.5%), and agitating heating is boiled 15 minutes filtered while hot and got filtrate.
Radix Scutellariae is pulverized the back add doubly (as 8 times) amount boiling water of 8-10, heating keeps little boiling 1 hour, filter, medicinal residues add 5-6 times of water gaging again, reheat is little to boil 30-40 minute, filter, merge filtrate twice, transfer below the pH value to 3 with hydrochloric acid, 30 ℃ are incubated half an hour, placement is spent the night, the bottom precipitation is stirred evenly with 6-8 times of water gaging, regulate pH value to 6-8 (as 7.2) with 10% caustic lye of soda, constantly be stirred to precipitation and dissolve fully, filter, filtrate reuse dilute hydrochloric acid is regulated pH value to 6-8 (as 6.5), under agitation add equivalent 95% ethanol, filter, it is 1-3 (as pH value 2) that filtrate is transferred pH value with concentrated hydrochloric acid, place after 30 minutes 60 ℃ of insulations and to spend the night, the precipitation separated out with air-dry, is obtained thick baicalin, reuse 4-6 times of water suspendible, regulate pH value to 6-8 (as 7.2), be stirred to dissolving, and add thick Radix Scutellariae glycoside amount 2-5% (as 3.5%) active carbon, stir, at heat tracing 30-40 more than 80 ℃ minute, filter, filtrate adds dilute hydrochloric acid, and pH value transfers to 6-8 (as 7), under agitation add equivalent 95% ethanol, sucking filtration transfers to 2-4 (as 2.8) with hydrochloric acid, and 60 ℃ are incubated 30-40 minute, placement is spent the night, separate out fully at refining baicalin, through drain crystallization, and obtain baicalin in drying below 70 ℃.
To add deionized water in the Fructus Forsythiae, heated and boiled is extracted volatile oil in volatile oil extractor, obtain Forsythia volatile oil; Liquid is boiled in filtration, obtains filtrate; Medicinal residues add 6-7 times of water gaging again, heated and boiled 0.5-1.0 hour, filter, merge decoction liquor, this decoction liquor heating evaporation, when solution to be concentrated remains material quantity 2-3 times, cool, under agitation add dense ethanol, make the alcohol amount of containing reach 60-70% (68%), put into cold room, cold preservation separates out precipitation more than 24 hours fully, filters, and gets filtrate, heating recovery ethanol, to there not being the alcohol flavor, obtain Fructus Forsythiae water extract, the reheat evaporation and concentration is to the thick paste shape, move and in vacuum desiccator, be dried to below the water content 10% (weight), obtain exsiccant Fructus Forsythiae extract.
With adding the doubly deionized water of (as 12 times) of spice amount 10-14 in the Flos Lonicerae, be heated to boiling, in insulation hot dipping more than 90 ℃ 1.5 hours, filter to get filtrate, medicinal residues add 6-8 times of deionized water again, and hot dipping is 10 hours again, gets filtrate, discards medicinal residues; Merge filtrate twice, carry out the 2 times volumes of evaporation and concentration, cool, under agitation add dense ethanol to inventory, make the alcohol amount of containing reach 65-75% (as 70%), put in the cold room and placed 24 hours, filter, get pure filtrate, distilling under reduced pressure is reclaimed ethanol to runny plaste (d=1.05) and is emitted, divide 3-4 extraction, filtering extract, reclaim under reduced pressure n-butyl alcohol with a certain amount of n-butyl alcohol; Extract is carried out obtaining Flos Lonicerae extract behind the vacuum drying.
Press formula ratio with total urso cholic acid, baicalin, Fructus Forsythiae extract and Flos Lonicerae extract, add certain fresh water for injection respectively, be stirred to suspendible, drip 10% sodium hydroxide solution respectively, constantly stir and make each medicine dissolving; Get the total urso cholic acid sodium solution, add Forsythia volatile oil, make the volatile oil solubilising with grinding molten method, be dissolved in the total urso cholic acid sodium solution, under agitation add Flos Lonicerae, Fructus Forsythiae extract solution and Radix Scutellariae glycoside solution afterwards, stir evenly, place a period of time, the mensuration pH value is 7-8 (as 7.6); Getting the Cornu Naemorhedi hydrolyzed solution under agitation is added in the above-mentioned mixed liquid gradually, with 10% sodium hydroxide its pH value is remained on 7-8 (as 7.6), finish until mixing, measurement volumes is added fresh water for injection to full dose 1000ml, adds amount of liquid medicine 0.3% pin with applying flexibly charcoal, heated and boiled 15 minutes, filter, must clarify medicinal liquid, after G
4Filter bulb and microporous membrane, sterilization gets finished product.
Claims (5)
1, a kind of Jiawei double coptis medicament is characterized in that being made up of the composition of following portions by weight:
Total urso cholic acid 20-60 part
Cornu Naemorhedi hydrolysate 100-300 part
Baicalin 200-300 part
Flos Lonicerae extract 200-300 part
Fructus Forsythiae extract 450-550 part
Wherein total urso cholic acid is to be obtained through saponification, purification by Fel Ursi powder; The Cornu Naemorhedi hydrolysate is obtained through decocting, hydrolysis and purification by Cornu Naemorhedi; Fructus Forsythiae extract obtains Forsythia volatile oil after by the Fructus Forsythiae decocting in water and boils liquid by purification again and obtain; Flos Lonicerae extract by Flos Lonicerae through decocting in water, boil the liquid purification, drying obtains.
2, medicament as claimed in claim 1 is characterized in that substituting total urso cholic acid with the synthetic Fel Ursi powder.
3, claim 1 or 2 described medicaments preparation methods, it is characterized in that Fel Ursi powder is added the deionized water that 8-12 doubly measures, add the solid sodium hydroxide that Fel Ursi powder 8-12 doubly measures again, the dissolving post-heating boils and carries out saponification, constantly replenish the moisture content that boils off simultaneously, keep the original volume amount, after 16-20 hour, stop heating, put the stirring of cold back and add hydrochloric acid down, to below the pH value to 2.0, the precipitation taking-up of separating out is washed till neutrality, and room temperature or cold drying obtain thick total urso cholic acid; This thick total urso cholic acid is added the ethyl acetate that 4-5 doubly measures, the quiet charcoal of work that adds the 8-12% of thick total urso cholic acid amount again is back to thick total urso cholic acid together and dissolves filtered while hot fully on return channel, the anhydrous sodium sulfate that in filtrate, adds thick total urso cholic acid amount 15-25%, the placement filtration of spending the night, filtrate is reclaimed ethyl acetate, when concentrating liquid measure and be 2 times of amounts of thick total urso cholic acid left and right sides, taking-up is put cold, put refrigerator and cooled and hid 3-5 days, sucking filtration obtains crystallization, obtains total urso cholic acid in drying below 75 ℃;
Cornu Naemorhedi is added the water for injection that 8-12 doubly measures, decoct more than 3 hours, filter; Medicinal residues add the water for injection that 8-10 doubly measures again, decoct 2 hours again, filter merging filtrate; With the 8M sulphuric acid that medicinal residues are doubly measured with 6-10, heating hydrolysis 8-10 hour puts warm after-filtration, the filtrate harvesting till do not have a brown granule; Precipitation adds 4-5 and doubly measures water for injection, stirs heated and boiled 20-30 minute, take off filtered while hot, collect washing liquid, precipitation adds 4-5 again and doubly measures water for injection, stir, reheat boiled 20-30 minute, took off filtered while hot, collected washing liquid for the second time, the precipitation of getting after washing is put into test tube on a small quantity, add certain water gaging, heated and boiled 5 minutes, liquid 5ml is boiled in leaching, add 1 triketone test solution, heating a moment should be negative or extremely weak positive reaction, merges hydrolyzed solution and washing liquid several times, and PH to 3.5-5.0 filters with 16% lime cream accent, the leaching hydrolyzed solution, precipitate as above method washing 2-3 time, each washing liquid and last hydrolyzed solution merge, and discard precipitation; Decocting liquid and hydrolyzed solution are merged, and heating evaporation treats that the 2-3 that medicinal liquid is concentrated into raw material Cornu Naemorhedi amount doubly measures, and emits dense medicinal liquid cold to room temperature, stirs to add dense ethanol down, makes to contain the alcohol amount and reach 60-75%, puts into refrigerator, and cold preservation filtered to get filtrate more than 24 hours; Filtrate is added fresh water for injection, and rare extremely quite material quantity 4-5 doubly measures, and adds the needle-use activated carbon of this solution amount 0.3-1%, and agitating heating is boiled 15 minutes filtered while hot and got filtrate;
Radix Scutellariae is pulverized back adding 8-10 doubly measure boiling water, heating keeps little boiling 1 hour, filter, medicinal residues add 5-6 times of water gaging again, and reheat is little to boil 30-40 minute, filter, merge filtrate twice, transfer below the pH value to 3 with hydrochloric acid, 30 ℃ are incubated half an hour, and placement is spent the night, the bottom precipitation is stirred evenly with 6-8 times of water gaging, regulate pH value to 6-8 with 10% caustic lye of soda, constantly be stirred to precipitation and dissolve fully, filter, filtrate reuse dilute hydrochloric acid is regulated pH value to 6-8, under agitation add equivalent 95% ethanol, filter, it is 1-3 that filtrate is transferred pH value with concentrated hydrochloric acid, place after 30 minutes 60 ℃ of insulations and to spend the night, the precipitation separated out with air-dry, is obtained thick baicalin, reuse 4-6 times of water suspendible, regulate pH value to 6-8, be stirred to dissolving, and add thick Radix Scutellariae glycoside amount 2-5% active carbon, stir, at heat tracing 30-40 more than 80 ℃ minute, filter, filtrate adds dilute hydrochloric acid, and pH value transfers to 6-8, under agitation add equivalent 95% ethanol, sucking filtration transfers to 2-4 with hydrochloric acid, and 60 ℃ are incubated 30-40 minute, placement is spent the night, separate out fully at refining baicalin, through drain crystallization, and obtain baicalin in drying below 70 ℃;
To add deionized water in the Fructus Forsythiae, heated and boiled is extracted volatile oil in volatile oil extractor, obtain Forsythia volatile oil; Liquid is boiled in filtration, obtains filtrate; Medicinal residues add 6-7 times of water gaging again, heated and boiled 0.5-1.0 hour, filter, merge decoction liquor, this decoction liquor heating evaporation, when solution to be concentrated remains material quantity 2-3 times, cool, under agitation add dense ethanol, make the alcohol amount of containing reach 60-70%, put into cold room, cold preservation separates out precipitation more than 24 hours fully, filters, and gets filtrate, heating recovery ethanol, to there not being the alcohol flavor, obtain Fructus Forsythiae water extract, the reheat evaporation and concentration is to the thick paste shape, move and in vacuum desiccator, be dried to below the water content 10% (weight), obtain exsiccant Fructus Forsythiae extract;
With adding spice amount 10-14 deionized water doubly in the Flos Lonicerae, be heated to boiling, in insulation hot dipping more than 90 ℃ 1.5 hours, filter to get filtrate, medicinal residues add 6-8 times of deionized water again, and hot dipping is 1.0 hours again, gets filtrate, discards medicinal residues; Merge filtrate twice, carry out the 2 times volumes of evaporation and concentration, cool, under agitation add dense ethanol to inventory, make the alcohol amount of containing reach 65-75%, put in the cold room and placed 24 hours, filter, get pure filtrate, when reclaiming ethanol to runny plaste d=1.05, distilling under reduced pressure emits, divide 3-4 extraction, filtering extract, reclaim under reduced pressure n-butyl alcohol with a certain amount of n-butyl alcohol; Extract is carried out obtaining Flos Lonicerae extract behind the vacuum drying;
Press formula ratio with total urso cholic acid, baicalin, Fructus Forsythiae extract and Flos Lonicerae extract, add certain fresh water for injection respectively, be stirred to suspendible, drip 10% sodium hydroxide solution respectively, constantly stir and make each medicine dissolving; Get the total urso cholic acid sodium solution, add Forsythia volatile oil, make the volatile oil solubilising with grinding molten method, be dissolved in the total urso cholic acid sodium solution, under agitation add Flos Lonicerae, Fructus Forsythiae extract solution and Radix Scutellariae glycoside solution afterwards, stir evenly, place a period of time, the mensuration pH value is 7-8; Getting the Cornu Naemorhedi hydrolyzed solution under agitation is added in the above-mentioned mixed liquid gradually, with 10% sodium hydroxide its pH value is remained on 7-8, finish, measurement volumes until mixing, add fresh water for injection to full dose 1000ml, add amount of liquid medicine 0.3% pin with applying flexibly charcoal, heated and boiled 15 minutes is filtered, must clarify medicinal liquid, after G4 filter bulb and microporous membrane, sterilization gets finished product.
4, preparation method as claimed in claim 3 is characterized in that being made as solid dosage forms electuary, hard capsule or powder.
5, preparation method as claimed in claim 3 is characterized in that described injection comprises aqueous injection, injectable powder, intravenous drip agent with oral liquid, the injection that extract is dissolved in water, mixed preparing is liquid dosage form of each flavor medicine.
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| CN102784203A (en) * | 2011-05-20 | 2012-11-21 | 上海凯宝药业股份有限公司 | Tanreqing tablet and preparation method thereof |
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| CN101890048B (en) * | 2009-05-21 | 2013-12-04 | 上海凯宝药业股份有限公司 | Total bile acid extract of bear bile powder and preparation method and application of injection thereof |
| CN105395616A (en) * | 2013-12-02 | 2016-03-16 | 李兴惠 | Injection for clearing heat, eliminating phlegm and removing toxicity |
| CN105687327A (en) * | 2014-11-25 | 2016-06-22 | 哈药集团中药二厂 | Traditional Chinese medicinal composition for treating adenoidal hypertrophy and nasal polyp, and preparation method and application thereof |
| CN104814925A (en) * | 2015-05-20 | 2015-08-05 | 上海凯宝药业股份有限公司 | Heat-clearing and phlegm-eliminating oral liquid and preparation method thereof |
| CN114432365A (en) * | 2021-12-30 | 2022-05-06 | 上海凯宝药业股份有限公司 | Phlegm-heat clearing aerosol inhalation preparation and application thereof |
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| CN1044760A (en) * | 1989-11-11 | 1990-08-22 | 黑龙江中医学院 | Preparation of injection of Chinese medicines |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1044760A (en) * | 1989-11-11 | 1990-08-22 | 黑龙江中医学院 | Preparation of injection of Chinese medicines |
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| CN102784203A (en) * | 2011-05-20 | 2012-11-21 | 上海凯宝药业股份有限公司 | Tanreqing tablet and preparation method thereof |
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