CN105816909A - Method for preparing high-elasticity high-absorbency hemostatic and bacteriostatic expansive sponge - Google Patents

Abstract

The invention discloses a highly elastic and highly liquid-absorbing hemostatic and antibacterial expansion sponge and a preparation method thereof, which belong to the field of medical materials. In the present invention, polyvinyl alcohol is stirred in deionized water to form a solution, and surfactants and sodium alginate are added to the solution, and the sodium alginate is mixed evenly by stirring, then catalyst, crosslinking agent and bacteriostatic agent are added, and the mixture is stirred at high speed Then pour into the mold for cross-linking reaction. Put the mold into an oven to shape, and then soak the sample in the antibacterial agent solution or sol to make a sodium alginate composite polyvinyl acetalized expansion sponge; or add silver to the polyvinyl alcohol sodium alginate mixed solution Ammonia solution, and then generate silver through silver mirror reaction, and synthesize sodium alginate-nano-silver composite polyvinyl acetalization expansion sponge. The invention is light in weight, small in thermal conductivity, good in biocompatibility, fast in dry state wetting rate, high in strength, high in liquid absorption rate and expansion rate, and can be used as medical hemostasis, antibacterial dressing and orthopedic or nasal surgery filling material.

Description

A kind of preparation method of high elasticity and high liquid absorption hemostatic antibacterial expansion sponge

technical field

The present invention relates to a polyvinyl acetalized expansion sponge used in many fields such as medical hemostasis, biological antibacterial, rapid wound healing, bone filling, nasal cavity, gum and other surgical fillings, especially relates to a kind of good biocompatibility, A polyvinyl acetalized swelling sponge with fast liquid absorption rate and fast liquid absorption expansion rate, a medical carrier, antibacterial, and reduced wound infection rate, and a preparation method thereof.

Background technique

Polyvinyl acetal sponges, especially polyvinyl acetalized sponges with a foaming structure within a certain range of acetalization, have super strong liquid absorption capacity, and their liquid absorption times can reach several times their own weight. Dozens of times. In addition, it has a high liquid absorption rate, good wet elasticity after absorbing liquid, and fast drying speed, so it is widely used in the medical field. Compared with traditional gelatin, cotton, and gauze hemostatic materials, its hemostatic, swelling , stretching and shrinkage properties have obvious advantages, and the development prospect is good.

Sodium alginate (SA) is a natural polysaccharide extracted from brown algae or bacteria, which can be used as a scaffold material for medical purposes and has good biocompatibility. Calcium alginate fibers formed by ionic cross-linking can absorb 15-20 times its own weight of blood to form alginate oil gel to play a hemostatic effect on bleeding wounds, and it has been widely used in surgical hemostasis.

In terms of medical use, traditional medical materials such as gauze and cotton balls will stick to the wound during use and cause mechanical damage when replaced. In addition, there will be shortcomings such as shedding of fine fibers and poor permeability. On the one hand, due to the integrated molding of the sponge material, there will be no sponge debris falling off during use; Wound means hemostasis.

Most medical sponges are polyurethane sponges, and the production procedures are relatively complicated. Polyurethane sponge has poor elasticity and hard texture, so it is not suitable for absorbing liquid to stop bleeding in surgical wounds, and can only be used for preoperative disinfection. In addition, the burning of waste polyurethane sponge will generate a large amount of toxic gas containing cyano groups, which is difficult to deal with. Modified PVA sponge has improved the disadvantages of poor elasticity and hard texture of polyurethane sponge to a certain extent, but because it only has a single liquid absorption performance, it does not have the function of timely and rapid hemostasis, and cannot meet the treatment of surgery or open wounds. need.

Commonly used absorbable hemostatic sponges include chitosan, gelatin sponge, etc. Their mechanisms of action and methods of use are different, and their hemostatic effects are also different. Chitosan (chitosans) is a natural polymer material with good biocompatibility, but the hemostatic sponge prepared only from chitosan is not ideal for large bleeding wounds. Gelatin sponge is prepared from gelatin extracted and purified from animal skin, and is used in surgery and first aid, but gelatin sponge has poor adhesion, is easy to fall off, and increases the possibility of wound infection.

The following problems exist in the currently disclosed patents: starch and the like are used as foaming agents to prepare medical modified PVA fast liquid-absorbing sponges, but the residual foaming agent contacts the wound, which is likely to cause rejection of the matrix, foaming agent cleaning and pollution Problems also restrict its production and application; using sodium bicarbonate as a foaming agent, a highly water-absorbing foamed polyvinyl alcohol sponge is prepared, the product cells are not uniform, the size is different, the process is difficult to control, and the product yield is low; Alcohol and chitosan are used as raw materials, formaldehyde is used as a crosslinking agent, sulfuric acid is used as a catalyst, and a surfactant is used to prepare a polyvinyl formal sponge with antibacterial properties. Chitosan is introduced to reduce the water absorption and softness of the material , so that the composite material does not have the characteristics of rapid expansion when absorbing water. In addition, medical dressings with high elasticity, high liquid absorption, flexibility, good biocompatibility, bacteriostasis and anti-infection are urgently needed.

The present invention is based on the above needs, in order to overcome the defects of the above preparation methods, solve the low yield, qualitative change, and uneven bubbles caused by traditional production methods, and solve the problem that current medical sponges cannot meet actual needs, it is necessary to develop a sponge with high absorption capacity. Liquid, rapid swelling performance, good biocompatibility and soft texture swelling sponge, and make it have hemostatic and antibacterial ability.

Contents of the invention

The invention provides a polyvinyl acetalized expansion sponge with few types of raw materials, simple preparation process and low production cost, which is liquid-absorbing, hemostatic, antibacterial, and has good biocompatibility. It has high porosity and open-pore structure. Material high liquid absorption and fast swelling capacity. The alginate used is a natural polysaccharide carbohydrate, which can accelerate the blood coagulation process, so that the sponge can be used in surgical operations to clean up exudate and coagulate to stop bleeding. The polysaccharide-modified polyvinyl alcohol acetalized expansion sponge prepared by the invention is soft in texture and has a resilience close to 100%. It is suitable as a filling sponge for nasal surgery, plays a role of hemostatic support, and can also be used as a medical dressing to play antibacterial and hemostatic effects. The present invention can also adjust physical performance indicators such as the pore size, elasticity, strength, water absorption rate and water absorption ratio of the expanded sponge within a wide range, so as to meet the different requirements of different application fields for product performance.

A highly elastic and highly liquid-absorbent hemostatic and antibacterial expansion sponge, characterized in that the material includes polyvinyl alcohol, sodium alginate, bacteriostatic agent or silver ammonia solution, crosslinking agent, catalyst, and surfactant; wherein, The degree of alcoholysis of polyvinyl alcohol is between 80% and 90%, and the average degree of polymerization is between 1000 and 2000; the amount of each material is calculated by weight: polyvinyl alcohol 5% to 10%, sodium alginate 1% to 5 %, bacteriostatic agent 6%~8%, crosslinking agent 7%~9%, catalyst 1~3%, surfactant 0.25%~0.45%, balance water, balance water 50%~60%, silver ammonia solution 5% to 10%. The hemostatic and antibacterial expansion sponge has a water absorption ratio of 9 to 25 times and a volume expansion ratio of 10 to 15 times.

As mentioned above, the bacteriostatic agent is one or more of inorganic bacteriostatic agents, organic bacteriostatic agents and photocatalytic bacteriostatic agents; the crosslinking agent is an aldehyde solution, which is one of formaldehyde, glutaraldehyde, and fatty aldehyde or more; the catalyst is one or more of hydrochloric acid, sulfuric acid; the surfactant is sodium dodecylsulfonate, ammonium lauryl sulfate, sodium dodecylbenzenesulfonate one or more.

The preparation of the hemostatic and antibacterial expansion sponge is divided into two methods, the compound antibacterial agent method and the silver ammonia solution reaction synthesis method.

1. The specific preparation process of compound antibacterial agent method is:

Step 1, the dissolution of polyvinyl alcohol and sodium alginate,

Weigh polyvinyl alcohol and distilled water at a mass ratio of 1:5 to 1:9, mix it with distilled water, stir and dissolve it in a constant temperature water bath at 85°C to 95°C until the solution is clear and transparent;

Adjust the temperature of the constant temperature water bath to 50-70°C, weigh the sodium alginate according to the mass ratio of polyvinyl alcohol to sodium alginate at 1:0.1-1:1, add it to the above polyvinyl alcohol solution, and continue stirring until the alginic acid Sodium dissolves evenly;

Step 2, the addition scheme of surfactant and catalyst,

Add the mixed solution of surfactant and catalyst to the mixed solution of polyvinyl alcohol sodium alginate, and stir at a low speed for 2 to 5 minutes, so that the surfactant and catalyst can be uniformly dispersed in the solution;

Step 3, the addition of cross-linking agent

Weigh a certain amount of aldehyde solution according to the molar ratio of polyvinyl alcohol and aldehyde in the acetal reaction, add it to the mixed solution obtained in step 2, quickly increase the stirring speed, and stir for 6-15 minutes.;

Step 4: Polyvinyl acetalization expansion sponge molding,

Inject the mixed liquid obtained in step 3 into the mold, put the mold into an oven, adjust the temperature to 50-75°C to continue the cross-linking, take out the mold after 6-8 hours, take the expanded sponge out of the mold, and use deionized Rinse with water for 2 to 5 times, cut into a suitable shape, soak the cut product in a solution containing hydrogen peroxide, or soak in an ultrasonic cleaning tank for ultrasonic cleaning;

Step five, antibacterial compound

Soak the deeply cleaned sample in the solution or sol of bacteriostatic agent accounting for 6% to 8% of the total mass of the system, so that the sample is completely submerged, and take out the sample after 10 to 15 hours to obtain a highly elastic, highly liquid-absorbent hemostatic and antibacterial agent Polyvinyl acetalized expanded sponge finished product.

Wherein, the antibacterial agent can also be added together with the crosslinking agent in step three.

The polyvinyl acetalized expansion sponge has a three-dimensional network open-pore structure, and the average pore size is between

Between 10μm and 1500μm, the porosity is between 30% and 60%, and the porosity is between 60% and 90%.

Between, the degree of acetalization is between 50% and 85%.

2. The specific preparation process of silver ammonia solution reaction synthesis method is:

Step 1, the dissolution of polyvinyl alcohol and sodium alginate;

Weigh polyvinyl alcohol and distilled water at a mass ratio of 1:5 to 1:9, mix it with distilled water, stir and dissolve it in a constant temperature water bath at 85°C to 95°C until the solution is clear and transparent;

Adjust the temperature of the constant temperature water bath to 50-70°C, weigh the sodium alginate according to the mass ratio of polyvinyl alcohol to sodium alginate at 1:0.1-1:1, add it to the above polyvinyl alcohol solution, and continue stirring until the alginic acid Sodium dissolves evenly;

Step 2, the addition scheme of surfactant and catalyst,

Add the mixed solution of surfactant and catalyst into the mixed solution of polyvinyl alcohol sodium alginate, stir at low speed for 2-5 minutes, so that the surfactant and catalyst can be evenly dispersed in the solution;

Step 3, the addition of silver ammonia solution,

Slowly drop the prepared silver ammonia solution into the polyvinyl alcohol sodium alginate mixed solution with a dropping funnel, and let it stand for 2 to 3 minutes after dropping to make the silver ammonia solution evenly dispersed;

Step 4, the addition of cross-linking agent and silver mirror reaction,

Weigh a certain amount of aldehyde solution according to the molar ratio of polyvinyl alcohol and aldehyde in the acetal reaction, add the aldehyde solution to the mixed solution obtained in step 2, quickly increase the stirring speed, and a silver mirror reaction occurs: take formaldehyde as an example (NH ₄ ) ₂ CO ₃ : HCHO+4[Ag(NH ₃ ) ₂ ]OH=(NH ₄ ) ₂ CO ₃ +4Ag↓+6NH ₃ +2H ₂ O,

Black-brown Ag is formed, stir for 6-15 minutes;

Step 5. High elasticity, high fluid absorption, hemostatic and antibacterial polyvinyl acetalization expansion sponge molding,

Inject the mixed liquid obtained in step 4 into the mold, put the mold into an oven, adjust the temperature to 50-75°C, and continue the cross-linking, take out the mold after 6-8 hours, take the expanded sponge out of the mold, and use deionized Fully wash with water, cut into a suitable shape, soak the cut product in an ultrasonic cleaning tank for ultrasonic cleaning, and finally obtain a finished product of high elasticity, high liquid absorption, hemostatic and antibacterial polyvinyl acetalized expansion sponge.

Step 5. High elasticity, high liquid absorption, hemostatic and antibacterial polyvinyl acetalization expansion sponge molding

Inject the mixed liquid obtained in step 4 into the mold, put the mold into an oven, adjust the temperature to 50-75°C, and continue the cross-linking, take out the mold after 6-8 hours, take the expanded sponge out of the mold, and use deionized Fully wash with water, cut into a suitable shape, soak the cut product in an ultrasonic cleaning tank for ultrasonic cleaning, and finally obtain a finished product of high elasticity, high liquid absorption, hemostatic and antibacterial polyvinyl acetalized expansion sponge.

Compared with the prior art, the present invention has the following advantages and beneficial effects

1. The polyvinyl acetalized expansion sponge with high elasticity, high liquid absorption, hemostatic antibacterial and antibacterial properties obtained by the present invention has a resilience close to 100%, and has good tensile strength, and no debris will fall off, which overcomes the existing medical gauze During the operation, there will be problems such as shedding of fine fibers, poor absorption of tissue fluid or blood, and low efficiency. It has excellent biocompatibility and cell affinity, and can quickly absorb a large amount of tissue fluid and blood from the wound during the operation. , can effectively reduce the interference of the outflow fluid to the operation and will not leave debris.

2. The polyvinyl acetalized expansion sponge with high elasticity and high liquid absorption, hemostasis and antibacterial properties obtained in the present invention has relatively excellent liquid absorption performance, can absorb 10 to 20 times its own weight of normal saline, and expands in volume after absorbing liquid It can reach 10-15 times, which is a big improvement compared with ordinary sponges.

3. The polyvinyl acetalized expansion sponge with high elasticity, high liquid absorption, hemostasis and antibacterial properties obtained in the present invention has good antibacterial ability, and has good antibacterial effect on various bacteria, and can be used for different antibacterial Bacterial environment, compound the appropriate antibacterial agent on the expansion sponge.

4. The preparation process of the present invention is simple, the process is mature, the production efficiency is high, and the product production cycle is short; the raw materials used are low in cost, easy to obtain, and easy to synthesize; production water is saved, production energy consumption is reduced, and production discharge is reduced. Using surfactants and adopting the method of mechanical stirring to make air bubbles, the pore size and porosity are controllable, and the product cells are uniform.

Description of drawings

Figure 1 is a schematic diagram of the chemical structure of the acetal reaction

Figure 2(a)(b) is the optical microscope and scanning electron microscope images of sodium alginate composite polyvinyl acetalized expanded sponge

Fig. 3 is a scanning electron micrograph of nano-silver/sodium alginate composite polyvinyl acetalized swelling sponge.

detailed description

The present invention will be further described below in conjunction with specific examples of implementation. It should be understood that these embodiments are only used to illustrate the present invention rather than limit the scope of the present invention. In addition, it should be understood that after reading the content taught by the present invention, those skilled in the art can make various equivalent changes to the present invention, which also fall within the scope required by the claims of the present application.

Example 1

Step 1: remove a certain amount of PVA, and add a certain amount of deionized water according to the requirement that the mass ratio of PVA to deionized water is 1:5. Heat and stir in a water bath at 95°C for 1 hour to fully dissolve the PVA particles. Adjust the temperature of the constant temperature water bath to 60°C, weigh the sodium alginate according to the mass ratio of polyvinyl alcohol to sodium alginate as 1:0.2, add it to the above polyvinyl alcohol solution, continue to stir until the sodium alginate dissolves evenly, and let stand 0.5h, remove air bubbles and keep warm.

Step 2: Add the mixed solution of surfactant and catalyst to the mixed solution of polyvinyl alcohol sodium alginate, and stir at a low speed for 2 to 5 minutes, so that the surfactant and catalyst can be uniformly dispersed in the solution, so that the surfactant and catalyst can be uniformly dispersed. dispersed into the solution.

Step 3: Weigh the formaldehyde solution according to the mass ratio of polyvinyl alcohol and formaldehyde solution at 1:1, add the formaldehyde solution into the mixed solution, quickly increase the stirring speed, and stir for about 6-8 minutes.

Step 4: Inject the mixed liquid into the mold, put the mold into an oven, adjust the temperature to 60°C to continue the crosslinking, take out the mold after 6-8 hours, take the expansion sponge out of the mold, and rinse with deionized water for 2 ~5 times, cut into a suitable shape, soak the cut product in an ultrasonic cleaning tank for ultrasonic cleaning.

Step 5. Soak the deep-cleaned sample in 8% quaternary ammonium salt solution accounting for the total mass of the system, so that the sample is completely submerged, and take out the sample after 12 hours to obtain a quaternary ammonium salt-sodium alginate composite polyvinyl acetalized expansion sponge finished product.

Example 2

Step 1. Remove a certain amount of PVA, and add a certain amount of deionized water according to the requirement that the mass ratio of PVA to deionized water is 1:7. Heat and stir in a water bath at 95°C for 1 hour to fully dissolve the PVA particles. Adjust the temperature of the constant temperature water bath to 60°C, weigh the sodium alginate according to the mass ratio of polyvinyl alcohol to sodium alginate as 1:0.6, add it to the above polyvinyl alcohol solution, continue to stir until the sodium alginate dissolves evenly, and let stand 0.5h, remove air bubbles and keep warm.

Step 2: Add the mixed solution of surfactant and catalyst into the mixed solution of polyvinyl alcohol sodium alginate, and stir at a low speed for 2-5 minutes, so that the surfactant and catalyst can be uniformly dispersed in the solution.

Step 3, take the glutaraldehyde solution by weighing the glutaraldehyde solution as 1:1.5 according to the mass ratio of polyvinyl alcohol to the glutaraldehyde solution, add it to the mixed solution, add _TiO particles accounting for 6% of the total mass of the system at the same time, and quickly increase the stirring speed, Stir for about 6-8 minutes.

Step 4: Inject the mixed liquid into the mold, put the mold into an oven, adjust the temperature to 60°C to continue the crosslinking, take out the mold after 6-8 hours, take the expansion sponge out of the mold, and rinse with deionized water for 2 ~5 times, cut into a suitable shape, soak the cut product in an ultrasonic cleaning tank for ultrasonic cleaning, and obtain a finished composite polyvinyl acetalized expansion sponge.

Example 3

Step 1: remove a certain amount of PVA, and add a certain amount of deionized water according to the requirement that the mass ratio of PVA to deionized water is 1:8. Heat and stir in a water bath at 95°C for 1 hour to fully dissolve the PVA particles. Adjust the temperature of the constant temperature water bath to 60°C, weigh the sodium alginate according to the mass ratio of polyvinyl alcohol to sodium alginate as 1:1, add it to the above polyvinyl alcohol solution, continue to stir until the sodium alginate dissolves evenly, and let stand 0.5h, remove air bubbles and keep warm.

Step 2: Add the mixed solution of surfactant and catalyst into the mixed solution of polyvinyl alcohol sodium alginate, and stir at a low speed for 2-5 minutes, so that the surfactant and catalyst can be uniformly dispersed in the solution.

Step 3: Weigh the fatty aldehyde solution according to the mass ratio of polyvinyl alcohol and fatty aldehyde to 1:1, add it into the mixed solution, quickly increase the stirring speed, and stir for about 6-8 minutes.

Step 4: Inject the mixed liquid into the mold, put the mold into an oven, adjust the temperature to 60°C to continue the crosslinking, take out the mold after 6-8 hours, take the expansion sponge out of the mold, and rinse with deionized water for 2 ~5 times, cut into a suitable shape, soak the cut product in an ultrasonic cleaning tank for ultrasonic cleaning.

Step 5. Soak the deep-cleaned sample in 150ml of nano-silver solution with a mass fraction of 0.15mol/L, immerse the sample completely in the solution for 12 hours, and then take out the sample to obtain a finished composite polyvinyl acetalized expanded sponge.

Example 4

Step 1. Remove a certain amount of PVA, and add a certain amount of deionized water according to the requirement that the mass ratio of PVA to deionized water is 1:6. Heat and stir in a water bath at 95°C for 1 hour to fully dissolve the PVA particles. Adjust the temperature of the constant temperature water bath to 60°C, weigh the sodium alginate according to the mass ratio of polyvinyl alcohol to sodium alginate as 1:0.6, add it to the above polyvinyl alcohol solution, continue to stir until the sodium alginate dissolves evenly, and let stand 0.5h, remove air bubbles and keep warm.

Step 2. Drop the prepared 0.1mol/L silver ammonia solution into the polyvinyl alcohol sodium alginate mixed solution with a dropping funnel, and let it stand for 2-3 minutes after dropping to make the silver ammonia solution evenly dispersed.

Step 3: Add the mixed solution of surfactant and catalyst into the mixed solution of polyvinyl alcohol sodium alginate, and stir at a low speed for 2-5 minutes, so that the surfactant and catalyst can be uniformly dispersed in the solution.

Step 4: According to the ratio of polyvinyl alcohol and glycolaldehyde to 1:1 glycolaldehyde solution, add it to the mixed solution, quickly increase the stirring speed, and stir for 6-15 minutes when black-brown Ag is formed.

Step 5. Inject the mixed liquid into the mold, put the mold into an oven, adjust the temperature to 60°C, and continue the cross-linking. After 6-8 hours, take out the mold, take out the expansion sponge from the mold, and rinse with deionized water for 2 ~5 times, cut into a suitable shape, soak the cut product in an ultrasonic cleaning tank for ultrasonic cleaning, and finally obtain a composite polyvinyl acetalized expansion sponge product.

Claims (7)

1. a high resiliency high liquid-absorbing hemostatic bacteriostatic expandable sponges, it is characterised in that described material includes gathering Vinyl alcohol, sodium alginate, antibacterial or silver ammino solution, cross-linking agent, catalyst, surfactant；Wherein, The alcoholysis degree of polyvinyl alcohol is between 80%～90%, and average degree of polymerization is between 1000～2000；Each material Consumption is by weight: polyvinyl alcohol 5%～10%, sodium alginate 1%～5%, antibacterial 6%～8%, Cross-linking agent 7%～9%, catalyst 1～3%, surfactant 0.25%～0.45%, excess water 50%～60%, Silver ammino solution 5%～10%.

A kind of high resiliency high liquid-absorbing hemostatic bacteriostatic expandable sponges the most according to claim 1, its feature Being, described antibacterial is one or more in inorganic antibacterial, organic antibacterial and photocatalysis antibacterial； Cross-linking agent is aldehyde solution, is formaldehyde, glutaraldehyde, one or more in fatty aldehyde；Described catalyst be hydrochloric acid, One or more in sulphuric acid；Described surfactant be dodecyl sodium sulfate, ammonium lauryl sulfate, ten One or more in dialkyl benzene sulfonic acids sodium.

A kind of high resiliency high liquid-absorbing hemostatic bacteriostatic expandable sponges the most according to claim 1, its feature Being, sponge sucks in water, and multiple is 9～25 times, and volume expansion ratio is 10～15 times.

4. the preparation of an a kind of high resiliency high liquid-absorbing hemostatic bacteriostatic expandable sponges according to claim 1 Method, it is characterised in that the preparation of hemostatic bacteriostatic expandable sponges uses compound preservative legal system, and it specifically prepares work Skill is:

Step one, polyvinyl alcohol and the dissolving of sodium alginate,

It is that 1:5～1:9 weighing polyvinyl alcohol mixes with distilled water in mass ratio, by it at 85 DEG C～95 DEG C of constant temperature In water-bath, stirring at low speed is dissolved to solution clear；

Water bath with thermostatic control pot temperature is adjusted to 50～70 DEG C, is 1:0.1～1:1 by polyvinyl alcohol and sodium alginate mass ratio Weigh sodium alginate, join in above-mentioned poly-vinyl alcohol solution, continue stirring to sodium alginate and be uniformly dissolved；

Step 2, surfactant and the interpolation scheme of catalyst,

Adding surfactant and catalyst mixed solution in polyvinyl alcohol mixed solution of sodium alginate, low speed stirs Mix 2～5min, enable surfactant and catalyst to evenly spread in solution；

Step 3, the addition of cross-linking agent

Weigh certain mass aldehyde solution by the molar ratio of aldolisation polyvinyl alcohol Yu aldehyde, join in step 2 In the mixed solution of gained, heighten rapidly speed of agitator, stir 6～15min.；

Step 4, Polyvinyl acetal expandable sponges molding,

Inject in mould step 3 obtains mixing liquid, mould put into baking oven, adjust the temperature to 50～ 75 DEG C, make crosslinking proceed, behind 6～8h, take out mould, expandable sponges is removed from the molds, spends Ionized water rinses 2～5 times, is cut into suitable shape, is immersed in the product after cutting containing hydrogen peroxide Solution in, or be immersed in ultrasonic cleaning tank and carry out ultrasonic cleaning；

Step 5, antibacterial are compound

The sample cleaned through the degree of depth is immersed in the solution or molten of the antibacterial that the system gross mass of accounting for is 6%～8% In glue, make the whole submergence of sample, after 10～15h, take out sample, obtain high resiliency high liquid-absorbing hemostatic bacteriostatic and gather Vinyl acetal expandable sponges finished product.

The preparation side of a kind of high resiliency high liquid-absorbing hemostatic bacteriostatic expandable sponges the most according to claim 4 Method, it is characterised in that antibacterial is together to add with cross-linking agent in step 3.

The preparation side of a kind of high resiliency high liquid-absorbing hemostatic bacteriostatic expandable sponges the most according to claim 4 Method, it is characterised in that described Polyvinyl acetal expandable sponges, has three-dimensional netted open-celled structure, Mean pore size between 10 μm～1500 μm, percent opening between 30%～60%, porosity Between 60%～90%, acetalizing degree is between 50%～85%.

The preparation side of a kind of high resiliency high liquid-absorbing hemostatic bacteriostatic expandable sponges the most according to claim 1 Method, it is characterised in that the preparation of hemostatic bacteriostatic expandable sponges uses silver ammino solution reaction synthesis method,

Concrete preparation technology is:

Step one, polyvinyl alcohol and the dissolving of sodium alginate；

It is that 1:5～1:9 weighing polyvinyl alcohol mixes with distilled water in mass ratio, by it at 85 DEG C～95 DEG C of constant temperature In water-bath, stirring at low speed is dissolved to solution clear；

Water bath with thermostatic control pot temperature is adjusted to 50～70 DEG C, is 1:0.1～1:1 by polyvinyl alcohol and sodium alginate mass ratio Weigh sodium alginate, join in above-mentioned poly-vinyl alcohol solution, continue stirring to sodium alginate and be uniformly dissolved；

Step 2, surfactant and the interpolation scheme of catalyst,

Surfactant and catalyst mixed solution, the slow-speed of revolution is added in polyvinyl alcohol mixed solution of sodium alginate Stirring 2～5min, enables surfactant and catalyst to evenly spread in solution；

Step 3, the addition of silver ammino solution,

The silver ammino solution that will have configured, is slowly dropped in polyvinyl alcohol mixed solution of sodium alginate with Dropping funnel, Stand 2～3min after dripping off, make silver ammino solution be uniformly dispersed；

Step 4, the addition of cross-linking agent and silver mirror reaction,

Weigh certain mass aldehyde solution by the molar ratio of aldolisation polyvinyl alcohol Yu aldehyde, aldehyde solution is joined In step 2 in the mixed solution of gained, heighten rapidly speed of agitator, silver mirror reaction occurs: have dark brown Ag Generate, stir 6～15min；

Step 5, high resiliency high liquid-absorbing hemostatic bacteriostatic Polyvinyl acetal expandable sponges molding,

Inject in mould step 4 obtains mixing liquid, mould put into baking oven, adjust the temperature to 50～ 75 DEG C, make crosslinking proceed, behind 6～8h, take out mould, expandable sponges is removed from the molds, spends Ionized water fully cleans, and is cut into suitable shape, is immersed in ultrasonic cleaning tank by the product after cutting and carries out Ultrasonic cleaning, finally gives high resiliency high liquid-absorbing hemostatic bacteriostatic Polyvinyl acetal expandable sponges finished product.