CN105793682A - Temperature change indicator and method of manufacture - Google Patents
Temperature change indicator and method of manufacture Download PDFInfo
- Publication number
- CN105793682A CN105793682A CN201380080170.9A CN201380080170A CN105793682A CN 105793682 A CN105793682 A CN 105793682A CN 201380080170 A CN201380080170 A CN 201380080170A CN 105793682 A CN105793682 A CN 105793682A
- Authority
- CN
- China
- Prior art keywords
- organic
- sensor
- instruction
- solid polymer
- instruction material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
- G01K11/00—Measuring temperature based upon physical or chemical changes not covered by groups G01K3/00, G01K5/00, G01K7/00 or G01K9/00
- G01K11/12—Measuring temperature based upon physical or chemical changes not covered by groups G01K3/00, G01K5/00, G01K7/00 or G01K9/00 using changes in colour, translucency or reflectance
- G01K11/16—Measuring temperature based upon physical or chemical changes not covered by groups G01K3/00, G01K5/00, G01K7/00 or G01K9/00 using changes in colour, translucency or reflectance of organic materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
- G01K11/00—Measuring temperature based upon physical or chemical changes not covered by groups G01K3/00, G01K5/00, G01K7/00 or G01K9/00
- G01K11/12—Measuring temperature based upon physical or chemical changes not covered by groups G01K3/00, G01K5/00, G01K7/00 or G01K9/00 using changes in colour, translucency or reflectance
- G01K11/18—Measuring temperature based upon physical or chemical changes not covered by groups G01K3/00, G01K5/00, G01K7/00 or G01K9/00 using changes in colour, translucency or reflectance of materials which change translucency
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Investigating Or Analyzing Materials Using Thermal Means (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Temperature Or Quantity Of Heat (AREA)
Abstract
Description
背景技术 Background technique
将各种物品从例如仓库、加工厂或制药公司的它们的原始地点运输到例如超市或药房的它们的预期目的地会将这些物品暴露于各种热负荷。达短或长的持续时间的诸如极高温或适当高温的热负荷会导致物品的损坏或效力丧失。需要保护诸如冷冻食品、饮料、医药和疫苗的物品免于暴露于高温。因此，对于正确监视物品以确保运输期间的正确的温度控制存在需求。 Transporting various items from their original location such as a warehouse, processing plant or pharmaceutical company to their intended destination such as a supermarket or pharmacy exposes these items to various thermal loads. Thermal loads, such as very high or moderately high temperatures, of short or long duration can result in damage or loss of effectiveness of the article. Items such as frozen foods, beverages, medicines and vaccines need to be protected from exposure to high temperatures. Therefore, there is a need to properly monitor items to ensure proper temperature control during transport.
可以使用记录随时间推移的温度的电子系统，但是这种系统昂贵且要求活动监视、数据存储、校准和针对预期用户的训练。测量且报告包括暴露温度和暴露持续时间的热历史的简单的、成本效益好的系统将是有益的。 Electronic systems that record temperature over time are available, but such systems are expensive and require activity monitoring, data storage, calibration, and training for the intended user. A simple, cost-effective system that measures and reports thermal history including exposure temperature and exposure duration would be beneficial.
发明概述 Summary of the invention
在一实施例中，一种制造热负荷传感器的方法可以包括：将至少一种有机指示材料封装在固体聚合物基质内，其中有机指示材料可以在有机指示材料的相变温度下扩散到固体聚合物基质中，并且其中扩散程度可以指示传感器上的热负荷。在一些实施例中，封装可以包括：将第一可固化聚合物材料添加到容器中，固化第一可固化聚合物材料以形成第一固化聚合物材料；将有机指示材料形成为比第一固化聚合物材料小的形状；将有机指示材料置于第一固化聚合物材料上；将第二可固化聚合物材料施加到有机指示材料和第一固化聚合物材料上从而封装有机指示材料；以及固化第二可固化聚合物材料以形成第二固化聚合物材料。 In one embodiment, a method of fabricating a thermal load sensor may include encapsulating at least one organic indicating material within a solid polymer matrix, wherein the organic indicating material can diffuse into the solid polymer at the phase transition temperature of the organic indicating material. matrix, and the degree of diffusion therein can be indicative of the thermal load on the sensor. In some embodiments, encapsulating may include: adding a first curable polymer material to the container, curing the first curable polymer material to form a first cured polymer material; polymeric material small shape; organic indicator material placed on the first cured polymeric material; second curable polymeric material applied to the organic indicator material and the first cured polymeric material thereby encapsulating the organic indicator material; and curing The second curable polymer material to form a second cured polymer material.
在一实施例中，制作化学或生物负荷传感器的方法可以包括：将至少一种有机指示材料封装在固体聚合物基质内，其中有机指示材料在与目标材料接触时可以扩散到固体聚合物基质中，所述目标材料触发放热反应以将有机指示材料加热到相变温度，并且其中扩散程度可以指示传感器上的化学或生物负荷。在一些实施例中，封装可以包括：将第一可固化聚合物材料添加到容器中；固化第一可固化聚合物材料以形成第一固化聚合物材料；将有机指示材料形成为比第一固化聚合物材料小的形状；将有机指示材料放置到第一固化聚合物材料上；将第二可固化聚合物材料施加到有机指示材料和第一固化聚合物材料上从而封装有机指示材料；以及固化第二可固化聚合物材料以形成第二固化聚合物材料。 In one embodiment, a method of fabricating a chemical or bioburden sensor may include encapsulating at least one organic indicator material within a solid polymer matrix, wherein the organic indicator material diffuses into the solid polymer matrix upon contact with a target material , the target material triggers an exothermic reaction to heat the organic indicator material to a phase transition temperature, and wherein the degree of diffusion can indicate chemical or biological burden on the sensor. In some embodiments, encapsulating may include: adding a first curable polymer material to the container; curing the first curable polymer material to form a first cured polymer material; polymeric material small shape; organic indicator material is placed on the first cured polymeric material; second curable polymeric material is applied to the organic indicator material and the first cured polymeric material thereby encapsulating the organic indicator material; and curing The second curable polymer material to form a second cured polymer material.
在一实施例中，热负荷传感器可以包括固体聚合物基质，以及封装在所述固体聚合物基质内的至少一种有机指示材料，其中有机指示材料在有机指示材料的相变温度下会扩散到固体聚合物基质中，并且其中扩散程度可以指示传感器上的热负荷。 In one embodiment, the thermal load sensor may comprise a solid polymer matrix, and at least one organic indicator material encapsulated within the solid polymer matrix, wherein the organic indicator material diffuses to In the solid polymer matrix, and the degree of diffusion therein can indicate the thermal load on the sensor.
在一实施例中，化学或生物负荷传感器可以包括固体聚合物基质以及封装在固体聚合物基质内的至少一种有机指示材料，其中有机指示材料在与目标材料接触时会扩散到固体聚合物基质中，所述目标材料触发放热反应以将有机指示材料加热到相变温度，并且其中扩散程度可以指示传感器上的化学或生物负荷。 In one embodiment, a chemical or bioburden sensor may comprise a solid polymer matrix and at least one organic indicator material encapsulated within the solid polymer matrix, wherein the organic indicator material diffuses into the solid polymer matrix upon contact with a target material In , the target material triggers an exothermic reaction to heat the organic indicator material to a phase transition temperature, and where the degree of diffusion can indicate chemical or biological burden on the sensor.
在另外的实施例中，制造品可以包括传感器，该传感器具有固体聚合物基质以及封装在固体聚合物基质内的至少一种有机指示材料，其中有机指示材料在有机指示材料的相变温度下会扩散到固体聚合物基质中，并且其中扩散程度可指示传感器上的目标负荷。 In further embodiments, an article of manufacture may include a sensor having a solid polymer matrix and at least one organic indicator material encapsulated within the solid polymer matrix, wherein the organic indicator material will degrade at the phase transition temperature of the organic indicator material. Diffuses into the solid polymer matrix, and the degree of diffusion therein can be indicative of the target loading on the sensor.
在一实施例中，检测热负荷的方法可以包括：提供至少一个热负荷传感器，所述至少一个热负荷传感器具有固体聚合物基质以及封装在固体聚合物基质内的至少一种有机指示材料；以及基于有机指示材料在固体聚合物基质内的扩散量来确定来自所述至少一个热负荷传感器的热负荷。 In an embodiment, a method of detecting a thermal load may comprise: providing at least one thermal load sensor having a solid polymer matrix and at least one organic indicating material encapsulated within the solid polymer matrix; and The thermal load from the at least one thermal load sensor is determined based on the amount of diffusion of the organic indicator material within the solid polymer matrix.
在一实施例中，检测化学或生物负荷的方法可以包括：提供至少一个化学或生物负荷传感器，所述至少一个化学或生物负荷传感器具有固体聚合物基质以及封装在固体聚合物基质内的至少一种有机指示材料；以及基于有机指示材料在固体聚合物基质内的扩散量来检测来自所述至少一个化学或生物负荷传感器的化学或生物负荷。 In an embodiment, a method of detecting a chemical or bioburden may include providing at least one chemical or bioburden sensor having a solid polymer matrix and at least one sensor encapsulated within the solid polymer matrix. an organic indicator material; and detecting a chemical or bioburden from the at least one chemical or bioburden sensor based on the amount of organic indicator material diffused within the solid polymer matrix.
附图说明 Description of drawings
图1描绘了根据一实施例的制造负荷传感器的示例性的方法的流程图。 FIG. 1 depicts a flowchart of an exemplary method of fabricating a load sensor according to an embodiment.
图2描绘了根据一实施例的热负荷传感器的截面图示。 2 depicts a cross-sectional illustration of a thermal load sensor according to an embodiment.
图3描绘了根据一实施例的化学或生物负荷传感器的截面图示。 3 depicts a cross-sectional illustration of a chemical or bioburden sensor according to an embodiment.
发明详述 Detailed description of the invention
本公开不限于所描述的特定的系统、设备和方法，因为这些会变化。本说明书中使用的术语仅为了描述特定变型例或实施例的目的，而不意在限制范围。 This disclosure is not limited to the particular systems, devices and methods described, as these may vary. Terms used in this specification are for the purpose of describing specific modifications or embodiments only, and are not intended to limit the scope.
如该文档中使用的，除非上下文明确规定，否则单数形式“一”、“一个”和“该”包括复数指代物。除非做出相反的限定，否则本文所使用的全部的技术和科学术语具有与本领域普通技术人员所惯常理解的相同的含义。本公开的任何内容均不应解释为承认在该公开中描述的实施例由于在先发明而不被赋予先于这些公开内容的权利。如该文档中使用的，术语“包括”意指“包含，但不限于”。 As used in this document, the singular forms "a," "an," and "the" include plural referents unless the context clearly dictates otherwise. Unless defined to the contrary, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. Nothing in this disclosure should be construed as an admission that the embodiments described in this disclosure are not entitled to antedate such disclosure by virtue of prior invention. As used in this document, the term "including" means "including, but not limited to".
为了本申请的目的，下面的术语应当具有下面阐述的相应意义。 For the purposes of this application, the following terms shall have the corresponding meanings set forth below.
本文所使用的“负荷”是指对象或材料经受的、对对象或材料产生影响的任何状况。“热负荷”是指对对象或材料产生影响的任何温度。“化学负荷”是指对对象或材料产生影响的任何化学物质。“生物负荷”是指对对象或材料产生影响的任何生物物质。 As used herein, "load" refers to any condition to which an object or material is subjected that affects the object or material. "Thermal load" means any temperature that affects an object or material. "Chemical load" means any chemical substance that affects an object or material. "Bioburden" means any biological matter that affects an object or material.
“传感器”是指任何检测或测量物理、生物或化学性质并且记录、指示或以其它方式对物理、生物或化学性质进行响应的设备或装置。例如，热负荷传感器是检测温度变化并且通过诸如传感器上的颜色变化的任何报告方法来指示该温度变化的传感器。 "Sensor" means any device or device that detects or measures a physical, biological or chemical property and records, indicates or otherwise responds to the physical, biological or chemical property. For example, a thermal load sensor is a sensor that detects a change in temperature and indicates that temperature change by any means of reporting, such as a color change on the sensor.
“有机指示材料”是对热、化学或生物负荷进行响应的任何有机材料。“可固化聚合物材料”是基于聚合物的且在开始材料内的聚合物链的交联之后导致材料的不同密度的任何材料。 An "organic indicator material" is any organic material that responds to thermal, chemical or biological loads. A "curable polymer material" is any material that is polymer based and that results in a different density of the material after initiating crosslinking of the polymer chains within the material.
“固体聚合物基质”是基于聚合物的、其中嵌入了其它材料或对象的处于固态的材料。 A "solid polymer matrix" is a polymer-based material in a solid state into which other materials or objects are embedded.
图1描绘了根据实施例的制作负荷传感器的示例性的方法的流程图。在一实施例中，负荷传感器可以是热负荷传感器。在一实施例中，负荷传感器可以是化学负荷传感器。在一实施例中，负荷传感器可以是化学负荷传感器。在一实施例中，负荷传感器可以是生物负荷传感器。在一实施例中，传感器可以是热负荷传感器、化学负荷传感器和生物负荷传感器中的一种或多种。 FIG. 1 depicts a flowchart of an exemplary method of fabricating a load sensor according to an embodiment. In an embodiment, the load sensor may be a thermal load sensor. In an embodiment, the load sensor may be a chemical load sensor. In an embodiment, the load sensor may be a chemical load sensor. In an embodiment, the load sensor may be a bioburden sensor. In an embodiment, the sensor may be one or more of a thermal load sensor, a chemical load sensor, and a biological load sensor.
在一些实施例中，可通过将至少一种有机指示材料封装在固体聚合物基质中来制作负荷传感器。在一些实施例中，在传感器是热负荷传感器的情况下，有机指示材料可以在有机指示材料的相变温度下或该温度之上的温度下扩散到固体聚合物基质中。在其它实施例中，在传感器是化学或生物负荷传感器的情况下，有机指示材料可以在与目标材料接触时扩散到固体聚合物基质中，所述目标材料触发放热反应以将有机指示材料加热到相变温度。扩散程度可以指示传感器上的热、化学或生物负荷。在一些实施例中，热、生物或化学负荷可被指示为固体聚合物基质从透明到至少大体不透明的变化。在其它实施例中，热、化学或生物负荷可被指示为固体聚合物基质的任何颜色变化。颜色变化可以是可见光谱内的任何颜色并且可以根据有机指示材料的扩散而变换成较亮或较暗的阴影。在一些实施例中，热负荷可以包括暴露时间。在其它实施例中，热负荷可以包括暴露温度。在另外的实施例中，热负荷可以包括暴露时间和暴露温度。在一些实施例中，化学或生物负荷可以包括暴露时间、目标材料的浓度、目标材料的类型或它们的任意组合。 In some embodiments, a load sensor can be fabricated by encapsulating at least one organic indicating material in a solid polymer matrix. In some embodiments, where the sensor is a thermal load sensor, the organic indicating material may diffuse into the solid polymer matrix at a temperature at or above the phase transition temperature of the organic indicating material. In other embodiments, where the sensor is a chemical or bioburden sensor, the organic indicator material can diffuse into the solid polymer matrix upon contact with the target material, which triggers an exothermic reaction to heat the organic indicator material to the phase transition temperature. The degree of diffusion can indicate thermal, chemical or biological load on the sensor. In some embodiments, thermal, biological, or chemical loading may be indicated as a change in the solid polymer matrix from transparent to at least substantially opaque. In other embodiments, thermal, chemical or biological burden may be indicated as any color change of the solid polymer matrix. The color change may be any color within the visible spectrum and may shift to a lighter or darker shade depending on the diffusion of the organic indicating material. In some embodiments, thermal load may include exposure time. In other embodiments, the thermal load may include exposure temperature. In additional embodiments, the thermal load may include exposure time and exposure temperature. In some embodiments, chemical or bioburden may include exposure time, concentration of target material, type of target material, or any combination thereof.
在一些实施例中，相变温度可以是约15℃至约350℃。例如，相变温度可以是约15℃、约30℃、约40℃、约50℃、约60℃、约70℃、约80℃、约90℃、约100℃、约125℃、约150℃、约175℃、约200℃、约225℃、约250℃、约275℃、约300℃、约325℃、约350℃或这些值中的任意值之间的范围(包含端点)。在一些实施例中，相变温度可以为约30℃至约300℃。 In some embodiments, the phase transition temperature may be from about 15°C to about 350°C. For example, the phase transition temperature can be about 15°C, about 30°C, about 40°C, about 50°C, about 60°C, about 70°C, about 80°C, about 90°C, about 100°C, about 125°C, about 150°C , about 175°C, about 200°C, about 225°C, about 250°C, about 275°C, about 300°C, about 325°C, about 350°C, or a range between any of these values, inclusive. In some embodiments, the phase transition temperature may be from about 30°C to about 300°C.
在一些实施例中，有机指示材料可以是在相变温度下经历从固体到液体的相变的疏水材料。在一些实施例中，有机指示材料可以具有带至少2个碳原子的碳链。在其它实施例中，有机指示材料可以具有带至少2个碳原子到至少100个碳原子的碳链。例如，有机指示材料可以具有带至少2个碳原子、至少3个碳原子、至少4个碳原子、至少5个碳原子、至少6个碳原子、至少7个碳原子、至少8个碳原子、至少9个碳原子、至少10个碳原子、至少15个碳原子、至少20个碳原子、至少50个碳原子、至少100个碳原子或这些值中的任意两个值之间的任意范围的碳链。在另外的实施例中，有机指示材料可以是具有至少2个碳原子到至少100个碳原子的烷烃(paraffin)。在一些实施例中，有机指示材料可以是具有至少9个碳原子的烷烃。有机指示材料可以是石蜡(paraffinwax)。 In some embodiments, the organic indicating material may be a hydrophobic material that undergoes a phase transition from solid to liquid at a phase transition temperature. In some embodiments, the organic indicating material can have a carbon chain with at least 2 carbon atoms. In other embodiments, the organic indicating material can have a carbon chain with at least 2 carbon atoms to at least 100 carbon atoms. For example, the organic indicator material can have at least 2 carbon atoms, at least 3 carbon atoms, at least 4 carbon atoms, at least 5 carbon atoms, at least 6 carbon atoms, at least 7 carbon atoms, at least 8 carbon atoms, at least 9 carbon atoms, at least 10 carbon atoms, at least 15 carbon atoms, at least 20 carbon atoms, at least 50 carbon atoms, at least 100 carbon atoms, or any range between any two of these values carbon chain. In further embodiments, the organic indicating material may be a paraffin having at least 2 carbon atoms to at least 100 carbon atoms. In some embodiments, the organic indicating material can be an alkane having at least 9 carbon atoms. The organic indicator material may be paraffin wax.
在一些实施例中，固体聚合物基质可以包括第一可固化聚合物材料。在一些实施例中，固体聚合物基质可以进一步包括第二可固化聚合物材料。在一些实施例中，第一可固化聚合物材料和第二可固化聚合物中的至少之一可以是疏水弹性体材料。在其它实施例中，第一可固化聚合物材料和第二可固化聚合物中的至少之一可以是聚碳酸酯、丙烯酸酯聚合物、聚氨酯、硅氧烷型聚合物，和/或上述物质中的任何物质的共聚物。在另外的实施例中，第一可固化聚合物材料和第二可固化聚合物中的至少之一可以是聚二甲基硅氧烷。 In some embodiments, the solid polymer matrix can include a first curable polymer material. In some embodiments, the solid polymer matrix can further include a second curable polymer material. In some embodiments, at least one of the first curable polymer material and the second curable polymer can be a hydrophobic elastomeric material. In other embodiments, at least one of the first curable polymer material and the second curable polymer may be polycarbonate, acrylate polymer, polyurethane, silicone-type polymer, and/or the foregoing Copolymers of any substance. In further embodiments, at least one of the first curable polymer material and the second curable polymer may be polydimethylsiloxane.
在其中传感器是化学或生物负荷传感器的实施例中，目标材料可以是农药、激素、微生物、染料成份、聚合物、氢气、酸、碱、挥发性有机化合物或它们的任意组合。酸可以包括例如乙酸、苯甲酸、碳酸、甲酸、盐酸、硫化氢、硝酸、磷酸、硫酸或它们的任意组合。碱例如可以包括氢氧化铵、氢氧化钙、氢氧化钾、氢氧化钠或它们的任意组合。 In embodiments where the sensor is a chemical or bioburden sensor, the target material may be a pesticide, hormone, microbe, dye component, polymer, hydrogen, acid, base, volatile organic compound, or any combination thereof. Acids may include, for example, acetic acid, benzoic acid, carbonic acid, formic acid, hydrochloric acid, hydrogen sulfide, nitric acid, phosphoric acid, sulfuric acid, or any combination thereof. The base may include, for example, ammonium hydroxide, calcium hydroxide, potassium hydroxide, sodium hydroxide, or any combination thereof.
在图1中示出了根据实施例的制作负荷传感器的方法。参考图1，第一可固化聚合物材料可以被添加105到容器中。容器可具有特定的形状或容积，诸如立方体、长方体、方锥体、三角锥体、三棱柱、六棱柱、圆锥体、球体、圆柱体或它们的任意组合。通过倾倒材料、逐滴添加材料、分配材料等可将第一可固化聚合物材料添加105到容器中。 A method of fabricating a load sensor according to an embodiment is shown in FIG. 1 . Referring to FIG. 1 , a first curable polymer material may be added 105 to the container. The container may have a specific shape or volume, such as a cube, cuboid, square pyramid, triangular pyramid, triangular prism, hexagonal prism, cone, sphere, cylinder, or any combination thereof. The first curable polymer material may be added 105 to the container by pouring the material, adding the material drop by drop, dispensing the material, or the like.
第一可固化聚合物材料可以被固化110。在一些实施例中，第一可固化聚合物材料的固化110可通过化学添加剂、紫外线辐射、电子束、热或它们的任意组合来执行。在其他实施例中，第一可固化聚合物材料的固化110可经由用以实现第一可固化聚合物材料的不同程度的固化的多个步骤来执行。在另外的实施例中，第一可固化聚合物材料的固化110可以是台阶式固化、斜坡式固化、单一强度固化或任何其它固化方法。在一些实施例中，第一可固化聚合物材料的固化110可在存在氧气的情况下进行。在其它实施例中，第一可固化聚合物材料可在不存在氧气的情况下被固化110。在一些实施例中，第一可固化聚合物材料可在约20℃至约350℃的温度下被固化110。例如，该材料可以在约20℃、约40℃、约60℃、约80℃、约100℃、约120℃、约140℃、约160℃、约180℃、约200℃、约250℃、约300℃、约350℃或者这些值中的任意值之间的范围内(包含端点)的温度下被固化110。在一些实施例中，第一可固化聚合物材料可固化110成柔性状态。 The first curable polymer material may be cured 110 . In some embodiments, curing 110 of the first curable polymer material may be performed by chemical additives, ultraviolet radiation, electron beam, heat, or any combination thereof. In other embodiments, curing 110 of the first curable polymer material may be performed via multiple steps to achieve different degrees of curing of the first curable polymer material. In further embodiments, the curing 110 of the first curable polymer material may be step curing, ramp curing, single intensity curing, or any other curing method. In some embodiments, curing 110 of the first curable polymer material may be performed in the presence of oxygen. In other embodiments, the first curable polymer material can be cured 110 in the absence of oxygen. In some embodiments, the first curable polymer material can be cured 110 at a temperature of about 20°C to about 350°C. For example, the material can be heated at about 20°C, about 40°C, about 60°C, about 80°C, about 100°C, about 120°C, about 140°C, about 160°C, about 180°C, about 200°C, about 250°C, Cured 110 at a temperature in a range between about 300° C., about 350° C., or any of these values, inclusive. In some embodiments, the first curable polymer material is curable 110 into a flexible state.
可以形成115有机指示材料。在一些实施例中，可以形成115多种有机指示材料。在一些实施例中，可以通过将有机指示材料构造成立方体、长方体、方锥体、三角锥体、三棱柱、六棱柱、圆锥体、球体、圆柱体或它们的组合，来形成115有机指示材料。在其它实施例中，将有机指示材料形成115为一形状可以包括使有机指示材料在腔室内热成形。在其它实施例中，将有机指示材料形成115成一形状可以包括机械地切割固相有机指示材料。 An organic indicating material can be formed 115 . In some embodiments, more than 115 organic indicating materials can be formed. In some embodiments, the organic indicator material can be formed 115 by structuring the organic indicator material into cubes, cuboids, square pyramids, triangular pyramids, triangular prisms, hexagonal prisms, cones, spheres, cylinders or combinations thereof . In other embodiments, forming 115 the organic indicating material into a shape may include thermoforming the organic indicating material within the chamber. In other embodiments, forming 115 the organic indicating material into a shape may include mechanically cutting the solid phase organic indicating material.
在其它实施例中，形成115有机指示材料可以包括将有机指示材料构造成圆柱体。在其它实施例中，该圆柱体可以具有约1毫米至约30毫米的截面直径。例如，圆柱体可以具有约1毫米、约2毫米、约3毫米、约4毫米、约5毫米、约6毫米、约7毫米、约8毫米、约9毫米、约10毫米、约20毫米、约30毫米或者在这些值中的任意值之间的范围(包含端点)的截面直径。在其它实施例中，圆柱体可以具有约0.5毫米至约20毫米的高度。例如，圆柱体可以具有约0.5毫米、约1毫米、约2毫米、约3毫米、约4毫米、约5毫米、约10毫米、约20毫米或者在这些值中的任意值之间的范围(包含端点)的高度。在一个实施例中，圆柱体可以具有约1毫米至约10毫米的直径以及具有约0.5毫米至约5毫米的高度。在特定的实施例中，圆柱体可以具有约4毫米的直径，以及约2毫米的高度。 In other embodiments, forming 115 the organic indicating material may include configuring the organic indicating material as a cylinder. In other embodiments, the cylinder may have a cross-sectional diameter of about 1 millimeter to about 30 millimeters. For example, the cylinder may have dimensions of about 1 mm, about 2 mm, about 3 mm, about 4 mm, about 5 mm, about 6 mm, about 7 mm, about 8 mm, about 9 mm, about 10 mm, about 20 mm, A cross-sectional diameter of about 30 millimeters or a range between any of these values, inclusive. In other embodiments, the cylinder may have a height of about 0.5 millimeters to about 20 millimeters. For example, the cylinder may have a diameter of about 0.5 mm, about 1 mm, about 2 mm, about 3 mm, about 4 mm, about 5 mm, about 10 mm, about 20 mm, or a range between any of these values ( height inclusive). In one embodiment, the cylinder may have a diameter of about 1 millimeter to about 10 millimeters and a height of about 0.5 millimeters to about 5 millimeters. In a particular embodiment, the cylinder may have a diameter of about 4 millimeters, and a height of about 2 millimeters.
有机指示材料可放置120在第一固化聚合物材料上。在一些实施例中，有机指示材料可以放置120在第一固化聚合物材料的中心处。在其它实施例中，有机指示材料可以放置120成偏离第一固化聚合物材料的中心。 An organic indicator material may be placed 120 on the first cured polymer material. In some embodiments, an organic indicator material may be placed 120 at the center of the first cured polymer material. In other embodiments, the organic indicator material may be placed 120 off-center of the first cured polymer material.
化学反应剂可任选地放置125成邻近有机指示材料的表面。在一些实施例中，化学反应剂可以催化放热反应，放热反应加热有机指示材料。在其它实施例中，化学反应剂可以与目标材料反应且经历随后对有机指示材料进行加热的放热反应。在一些实施例中，化学反应剂可以是乙酸、氢氧化铵、氢氧化钙、碳酸、盐酸、过氧化氢、镁、硝酸、氧气、钯、铂、氢氧化钾、盐、氢氧化钠、硫酸、二氧化钛或它们的任意组合。在一些实施例中，化学反应剂可以具有荧光标签。 A chemical reactant may optionally be placed 125 adjacent to the surface of the organic indicating material. In some embodiments, the chemical reactant can catalyze an exothermic reaction that heats the organic indicating material. In other embodiments, the chemical reactant may react with the target material and undergo an exothermic reaction that subsequently heats the organic indicating material. In some embodiments, the chemical reactant may be acetic acid, ammonium hydroxide, calcium hydroxide, carbonic acid, hydrochloric acid, hydrogen peroxide, magnesium, nitric acid, oxygen, palladium, platinum, potassium hydroxide, salt, sodium hydroxide, sulfuric acid , titanium dioxide, or any combination thereof. In some embodiments, chemical reagents can have fluorescent labels.
第二可固化聚合物材料可被施加130。在一些实施例中，通过倾倒材料、逐滴添加材料、分配材料等等，可以施加130第二可固化聚合物材料。 A second curable polymer material may be applied 130 . In some embodiments, the second curable polymer material may be applied 130 by pouring the material, adding the material dropwise, dispensing the material, and the like.
第二可固化聚合物材料可被固化135。在一些实施例中，第二可固化聚合物材料可通过化学添加剂、紫外线辐射、电子束、热或它们的任意组合来固化135。在其它实施例中，第二可固化聚合物材料的固化135可以经由用以实现第二可固化聚合物材料的不同程度的固化的多个步骤来执行。在另外的实施例中，第二可固化聚合物材料的固化135可以是台阶式固化、斜坡式固化、单一强度固化或任何其它固化方法。在一些实施例中，第二可固化聚合物材料可在存在氧气的情况下固化135。在其它实施例中，第二可固化聚合物材料可在不存在氧气的情况下固化135。在其它实施例中，第二可固化聚合物材料可在约20℃至约350℃的温度下被固化135。例如，材料可在约20℃、约40℃、约60℃、约80℃、约100℃、约120℃、约140℃、约160℃、约180℃、约200℃、约250℃、约300℃、约350℃或者在这些值中的任意值之间的范围内(包含端点)的温度下被固化135。在一些实施例中，第二可固化聚合物材料可固化135成柔性状态。 The second curable polymer material may be cured 135 . In some embodiments, the second curable polymer material can be cured 135 by chemical additives, ultraviolet radiation, electron beam, heat, or any combination thereof. In other embodiments, curing 135 of the second curable polymer material may be performed via multiple steps to achieve different degrees of curing of the second curable polymer material. In further embodiments, curing 135 of the second curable polymer material may be step curing, ramp curing, single intensity curing, or any other curing method. In some embodiments, the second curable polymer material can be cured 135 in the presence of oxygen. In other embodiments, the second curable polymer material can be cured 135 in the absence of oxygen. In other embodiments, the second curable polymer material may be cured 135 at a temperature of about 20°C to about 350°C. For example, the material can be heated at about 20°C, about 40°C, about 60°C, about 80°C, about 100°C, about 120°C, about 140°C, about 160°C, about 180°C, about 200°C, about 250°C, about Cured 135 at a temperature of 300°C, about 350°C, or a range between any of these values, inclusive. In some embodiments, the second curable polymer material can be cured 135 into a flexible state.
在一些实施例中，有机指示材料可以在扩散到固体聚合物基质中时形成固体聚合物基质中的可视指示器。可视指示器可以指示扩散程度以及因此指示传感器上的热、化学或生物负荷。在一些实施例中，可视指示器可以提供对热、化学或生物负荷的度量。在一些实施例中，可将标志(index)放置140在固体聚合物基质上邻近有机指示材料的地方，以便度量可视指示器。标志可以包含词语和/或线标记。在一些实施例中，线标记可以指示用来度量有机指示材料的扩散程度的距离。在其它实施例中，词语“安全”和“不安全”可用在线标记之上。在另外的实施例中，标志可以是围绕有机指示材料的一个或多个同心环。同心环可以用来度量有机指示材料扩散进入固体聚合物基质中的距离。在有机指示材料扩散超过标志时标志可以是充当热负荷的二元指示器的不透明覆盖物。标志可以是位于传感器底部的不透明且着色的形状，在有机指示材料扩散进入固体聚合物基质中后，其会被有机指示材料遮住。在一些实施例中，可将多个标志放置140在固体聚合物材料上，以便度量可视指示器。 In some embodiments, the organic indicator material can form a visual indicator in the solid polymer matrix when diffused into the solid polymer matrix. Visual indicators can indicate the degree of diffusion and thus thermal, chemical or biological load on the sensor. In some embodiments, a visual indicator can provide a measure of thermal, chemical or biological burden. In some embodiments, an index can be placed 140 on the solid polymer matrix adjacent to the organic indicator material to measure the visual indicator. Logos can contain words and/or line marks. In some embodiments, the line markers may indicate a distance used to measure the degree of diffusion of the organic indicating material. In other embodiments, the words "safe" and "unsafe" may be placed on top of the inline markings. In further embodiments, the markers may be one or more concentric rings surrounding the organic indicating material. Concentric rings can be used to measure the distance that the organic indicator material diffuses into the solid polymer matrix. The marker may be an opaque covering that acts as a binary indicator of thermal load when the organic indicating material diffuses beyond the marker. The marker can be an opaque, colored shape at the bottom of the sensor that is obscured by the organic indicator material after it diffuses into the solid polymer matrix. In some embodiments, a plurality of markers may be placed 140 on the solid polymer material to measure visual indicators.
在图2中示出了用于检测热负荷的热负荷传感器205。在一些实施例中，热负荷传感器205可以具有固体聚合物基质210以及至少一种有机指示材料215。在一些实施例中，热负荷传感器205可以是立方体、长方体、方锥体、三角锥体、三棱柱、六棱柱、圆锥体、球体、圆柱体或它们的组合的形状。 A thermal load sensor 205 for detecting thermal loads is shown in FIG. 2 . In some embodiments, thermal load sensor 205 may have a solid polymer matrix 210 and at least one organic indicating material 215 . In some embodiments, the thermal load sensor 205 may be in the shape of a cube, a cuboid, a square pyramid, a triangular pyramid, a triangular prism, a hexagonal prism, a cone, a sphere, a cylinder, or a combination thereof.
在一些实施例中，固体聚合物基质210可以是疏水弹性体材料。在其它实施例中，固体聚合物基质210可以是聚碳酸酯、丙烯酸酯聚合物、聚氨酯、硅氧烷型聚合物以及上述物质中的任意物质的共聚物。在另外的实施例中，固体聚合物基质210可以是聚二甲基硅氧烷。在一实施例中，固体聚合物基质210可以是处于柔性状态的聚二甲基硅氧烷。 In some embodiments, solid polymer matrix 210 may be a hydrophobic elastomeric material. In other embodiments, the solid polymer matrix 210 may be polycarbonate, acrylate polymers, polyurethane, silicone-type polymers, and copolymers of any of the foregoing. In other embodiments, the solid polymer matrix 210 may be polydimethylsiloxane. In one embodiment, the solid polymer matrix 210 may be polydimethylsiloxane in a flexible state.
在一些实施例中，有机指示材料215可以封装在固体聚合物基质210内。在一些实施例中，有机指示材料215可以是在相变温度下经历从固态到液态的相变的疏水材料。在一些实施例中，有机指示材料215可具有带至少2个碳原子的碳链。在其它实施例中，有机指示材料215可以具有带至少2个碳原子到至少100个碳原子的碳链。例如，有机指示材料215可具有至少2个碳原子、至少3个碳原子、至少4个碳原子、至少5个碳原子、至少6个碳原子、至少7个碳原子、至少8个碳原子、至少9个碳原子、至少10个碳原子、至少15个碳原子、至少20个碳原子、至少50个碳原子、至少100个碳原子或者这些值之间的任意范围。在另外的实施例中，有机指示材料215可以是具有至少2个碳原子到至少100个碳原子的烷烃。在一些实施例中，有机指示材料可以是具有至少9个碳原子的烷烃。在其它实施例中，有机指示材料215可以是石蜡。在一些实施例中，热负荷传感器205可以包括多种有机指示材料215。 In some embodiments, organic indicating material 215 may be encapsulated within solid polymer matrix 210 . In some embodiments, the organic indicator material 215 may be a hydrophobic material that undergoes a phase transition from solid to liquid at a phase transition temperature. In some embodiments, the organic indicating material 215 may have a carbon chain with at least 2 carbon atoms. In other embodiments, the organic indicating material 215 may have a carbon chain with at least 2 carbon atoms to at least 100 carbon atoms. For example, the organic indicator material 215 can have at least 2 carbon atoms, at least 3 carbon atoms, at least 4 carbon atoms, at least 5 carbon atoms, at least 6 carbon atoms, at least 7 carbon atoms, at least 8 carbon atoms, At least 9 carbon atoms, at least 10 carbon atoms, at least 15 carbon atoms, at least 20 carbon atoms, at least 50 carbon atoms, at least 100 carbon atoms, or any range between these values. In further embodiments, the organic indicating material 215 may be an alkane having at least 2 carbon atoms to at least 100 carbon atoms. In some embodiments, the organic indicating material can be an alkane having at least 9 carbon atoms. In other embodiments, the organic indicating material 215 may be paraffin. In some embodiments, thermal load sensor 205 may include various organic indicating materials 215 .
在一些实施例中，有机指示材料215可以为如下形状：立方体、长方体、方锥体、三角锥体、三棱柱、六棱柱、圆锥体、球体、圆柱体以及它们的组合。在其它实施例中，有机指示材料215可以是圆柱体。在其它实施例中，圆柱体可以具有约1毫米至约30毫米的截面直径。例如，圆柱体可以具有约1毫米、约2毫米、约3毫米、约4毫米、约5毫米、约6毫米、约7毫米、约8毫米、约9毫米、约10毫米、约20毫米、约30毫米或者在这些值中的任意值之间的范围(包含端点)的截面直径。在其它实施例中，圆柱体可以具有约0.5毫米到约20毫米的高度。例如，圆柱体可以具有约0.5毫米、约1毫米、约2毫米、约3毫米、约4毫米、约5毫米、约10毫米、约20毫米或在这些值中的任意值之间的范围(包含端点)的高度。在一个实施例中，圆柱体可以具有约1毫米到约10毫米的直径以及约0.5毫米到约5毫米的高度。在特定的实施例中，圆柱体可以具有约4mm的直径，以及约2mm的高度。 In some embodiments, the organic indicator material 215 may be in the following shapes: cube, cuboid, square pyramid, triangular pyramid, triangular prism, hexagonal prism, cone, sphere, cylinder, and combinations thereof. In other embodiments, organic indicating material 215 may be a cylinder. In other embodiments, the cylinder may have a cross-sectional diameter of about 1 millimeter to about 30 millimeters. For example, the cylinder may have dimensions of about 1 mm, about 2 mm, about 3 mm, about 4 mm, about 5 mm, about 6 mm, about 7 mm, about 8 mm, about 9 mm, about 10 mm, about 20 mm, A cross-sectional diameter of about 30 millimeters or a range between any of these values, inclusive. In other embodiments, the cylinder may have a height of about 0.5 millimeters to about 20 millimeters. For example, the cylinder may have a diameter of about 0.5 mm, about 1 mm, about 2 mm, about 3 mm, about 4 mm, about 5 mm, about 10 mm, about 20 mm, or a range between any of these values ( height inclusive). In one embodiment, the cylinder may have a diameter of about 1 millimeter to about 10 millimeters and a height of about 0.5 millimeters to about 5 millimeters. In a particular embodiment, the cylinder may have a diameter of about 4mm, and a height of about 2mm.
在一些实施例中，有机指示材料215可位于固体聚合物基质210的中心。在其它实施例中，有机指示材料215相对于固体聚合物基质210不居中。 In some embodiments, organic indicator material 215 may be located at the center of solid polymer matrix 210 . In other embodiments, the organic indicating material 215 is not centered relative to the solid polymer matrix 210 .
在一些实施例中，有机指示材料215可以在有机指示材料215的相变温度下扩散到固体聚合物基质210中。扩散程度可以指示传感器205上的热负荷。在一些实施例中，热负荷可以被指示为固体聚合物基质210从透明到不透明的变化。可选地，热负荷可被指示为固体聚合物基质210的颜色的任何变化。颜色的变化可以是可见光谱内的任意颜色并且可以基于有机指示材料215的扩散而变成较亮或较暗的阴影。 In some embodiments, the organic indicating material 215 can diffuse into the solid polymer matrix 210 at the phase transition temperature of the organic indicating material 215 . The degree of diffusion may indicate the thermal load on the sensor 205 . In some embodiments, thermal load may be indicated as a change in solid polymer matrix 210 from transparent to opaque. Alternatively, thermal load may be indicated as any change in the color of the solid polymer matrix 210 . The color change can be any color within the visible spectrum and can be a lighter or darker shade based on the diffusion of the organic indicating material 215 .
在一些实施例中，热负荷可以包括暴露时间。在其它实施例中，热负荷可以包括暴露温度。在另外的实施例中，热负荷可以包括暴露时间和暴露温度这两者。 In some embodiments, thermal load may include exposure time. In other embodiments, the thermal load may include exposure temperature. In further embodiments, the thermal load may include both exposure time and exposure temperature.
在一些实施例中，热负荷传感器205可以包括标志220，其位于固体聚合物基质210上邻近有机指示材料215的地方，以便度量由有机指示材料215形成的可视指示器。标志220还可以包括词语和/或标记。标记可以例如是线标记。在一些实施例中，标志可以包括至少第一标记和第二标记。在一些实施例中，标记可以指示度量有机指示材料的扩散程度的距离。在其它实施例中，词语“安全”和“不安全”可以用在线标记上方。其它词语或符号也可用来指示热负荷，或者指示检测化学或生物负荷的传感器的化学或生物负荷，如下文要描述的，并且可以例如是“长时间暴露于负荷”、“适度暴露于负荷”以及“未暴露于负荷”，或者是表示在变化的环境温度、变化的污染物浓度、暴露于负荷的变化的暴露时间段或者它们的组合下相对于负荷的暴露的沿着标志的符号。在另外的实施例中，标志可以是围绕有机指示材料的一个或多个同心环。同心环可以用来度量有机指示材料扩散进入固体聚合物基质的距离。当有机指示材料扩散超过标志时，标志可以是充当热负荷的二元指示器的不透明覆盖物。标志可以是位于传感器底部的不透明且着色的形状，在有机指示材料扩散进入固体聚合物基质后，其会被有机指示材料遮住。在一些实施例中，热负荷传感器205可以包括位于固体聚合物基质210上的多个标志，以便度量可视指示器。 In some embodiments, thermal load sensor 205 may include marker 220 positioned on solid polymer matrix 210 adjacent to organic indicating material 215 to measure the visual indicator formed by organic indicating material 215 . Logo 220 may also include words and/or indicia. The markings may for example be line markings. In some embodiments, the logo can include at least a first indicia and a second indicium. In some embodiments, the marker may indicate a distance measuring the degree of diffusion of the organic indicating material. In other embodiments, the words "safe" and "unsafe" may be marked above the lines. Other words or symbols may also be used to indicate thermal load, or to indicate chemical or biological burden of a sensor that detects chemical or biological burden, as will be described below, and may be, for example, "prolonged exposure to load", "moderate exposure to load" and "Not exposed to load," or a symbol along the sign indicating exposure relative to load at varying ambient temperatures, varying pollutant concentrations, varying exposure periods of exposure to load, or a combination thereof. In further embodiments, the markers may be one or more concentric rings surrounding the organic indicating material. Concentric rings can be used to measure the distance an organic indicator material diffuses into a solid polymer matrix. When the organic indicating material diffuses beyond the marker, the marker may be an opaque covering that acts as a binary indicator of thermal load. The marker can be an opaque, colored shape at the bottom of the sensor that is obscured by the organic indicator material after it diffuses into the solid polymer matrix. In some embodiments, thermal load sensor 205 may include a plurality of markings on solid polymer substrate 210 for scaled visual indicators.
通过将传感器设在物品的表面上或者其中留存有物品的容器的表面上、以及基于有机指示材料215扩散到固体聚合物基质210中的扩散量来确定来自传感器的热负荷，热负荷传感器可用于检测物品上的热负荷。物品可以是任何对热负荷敏感的品类并且可以例如是食品、药品或电子设备。 By placing the sensor on the surface of the item or the surface of the container in which the item is retained, and determining the thermal load from the sensor based on the amount of diffusion of the organic indicator material 215 into the solid polymer matrix 210, a thermal load sensor can be used to Detects thermal load on items. Items can be of any category that is sensitive to thermal loads and can be, for example, food, pharmaceuticals or electronic equipment.
图3中示出了化学或生物负荷传感器205。图3包含了图2的全部特征，增加了化学反应剂和用于化学反应剂的储存器325。 A chemical or bioburden sensor 205 is shown in FIG. 3 . Figure 3 incorporates all the features of Figure 2 with the addition of a chemical reagent and a reservoir 325 for the chemical reagent.
在一些实施例中，化学或生物负荷传感器205可以包括被布置为邻近有机指示材料215的表面的化学反应剂。在一些实施例中，化学或生物负荷传感器205可以包括用于在固体聚合物基质210内且邻近有机指示材料215的化学反应剂的储存器325。在一些实施例中，化学或生物负荷传感器205可以包括用于在固体聚合物基质310内且邻近多个有机指示材料215的化学反应剂的多个储存器325。在一些实施例中，化学反应剂可催化放热反应，放热反应加热有机指示材料215。在其它实施例中，化学反应剂可以与目标材料反应且经历随后将对有机指示材料进行加热的放热反应。 In some embodiments, chemical or bioburden sensor 205 may include a chemical reagent disposed adjacent to a surface of organic indicator material 215 . In some embodiments, the chemical or bioburden sensor 205 may include a reservoir 325 for a chemical reagent within the solid polymer matrix 210 and adjacent to the organic indicator material 215 . In some embodiments, chemical or bioburden sensor 205 may include a plurality of reservoirs 325 for chemical reagents within solid polymer matrix 310 and adjacent to plurality of organic indicator materials 215 . In some embodiments, the chemical reactant may catalyze an exothermic reaction that heats the organic indicating material 215 . In other embodiments, the chemical reactant may react with the target material and undergo an exothermic reaction that will subsequently heat the organic indicating material.
在一些实施例中，目标材料可以是农药、激素、微生物、染料成份、聚合物、氢气、酸、碱、挥发性有机化合物或它们的任意组合。酸可以包括例如乙酸、苯甲酸、碳酸、甲酸、盐酸、硫化氢、硝酸、磷酸、硫酸或它们的任意组合。碱例如可以包括氢氧化铵、氢氧化钙、氢氧化钾、氢氧化钠或它们的任意组合。 In some embodiments, the target material may be pesticides, hormones, microorganisms, dye components, polymers, hydrogen, acids, bases, volatile organic compounds, or any combination thereof. Acids may include, for example, acetic acid, benzoic acid, carbonic acid, formic acid, hydrochloric acid, hydrogen sulfide, nitric acid, phosphoric acid, sulfuric acid, or any combination thereof. The base may include, for example, ammonium hydroxide, calcium hydroxide, potassium hydroxide, sodium hydroxide, or any combination thereof.
在一些实施例中，化学反应剂可以是乙酸、氢氧化铵、氢氧化钙、碳酸、盐酸、过氧化氢、镁、硝酸、氧气、钯、铂、氢氧化钾、盐、氢氧化钠、硫酸、二氧化钛或它们的任意组合。 In some embodiments, the chemical reactant may be acetic acid, ammonium hydroxide, calcium hydroxide, carbonic acid, hydrochloric acid, hydrogen peroxide, magnesium, nitric acid, oxygen, palladium, platinum, potassium hydroxide, salt, sodium hydroxide, sulfuric acid , titanium dioxide, or any combination thereof.
在一些实施例中，化学或生物负荷可以包括针对目标材料的暴露时间、目标材料浓度、目标材料的类型或它们的任意组合。 In some embodiments, the chemical or biological burden may include exposure time to the target material, target material concentration, type of target material, or any combination thereof.
通过将传感器设在被怀疑具有化学或生物目标材料的环境中以及基于有机指示材料215扩散到固体聚合物基质210内的扩散量来确定来自传感器的化学或生物负荷，化学或生物负荷传感器205可以用于检测化学或生物目标材料。 By placing the sensor in an environment suspected of having a chemical or biological target material and determining the chemical or bioburden from the sensor based on the amount of diffusion of the organic indicator material 215 into the solid polymer matrix 210, the chemical or bioburden sensor 205 can For detection of chemical or biological target materials.
上述的传感器可被并入制造品中。在一些实施例中，制造品可以包括传感器205，诸如图2和图3所示的那些。 The sensors described above may be incorporated into articles of manufacture. In some embodiments, an article of manufacture may include sensors 205 , such as those shown in FIGS. 2 and 3 .
在一些实施例中，传感器205可以是热负荷传感器205。在一些实施例中，热负荷可以包括暴露时间。在其它实施例中，热负荷可以包括暴露温度。在另外的实施例中，热负荷可以包括暴露时间和暴露温度。 In some embodiments, sensor 205 may be thermal load sensor 205 . In some embodiments, thermal load may include exposure time. In other embodiments, the thermal load may include exposure temperature. In additional embodiments, the thermal load may include exposure time and exposure temperature.
在一些实施例中，传感器205可以是化学或生物负荷传感器205。在一些实施例中，化学或生物负荷可以包括针对目标材料的暴露时间、目标材料的浓度、目标材料的类型或它们的任意组合。在一些实施例中，传感器205可以暴露于目标材料。在一些实施例中，有机指示材料215可以与目标材料反应且促成放热反应，放热反应将有机指示材料215加热到相变温度。 In some embodiments, sensor 205 may be a chemical or bioburden sensor 205 . In some embodiments, the chemical or bioburden may include exposure time to the target material, concentration of the target material, type of target material, or any combination thereof. In some embodiments, sensor 205 may be exposed to a target material. In some embodiments, the organic indicating material 215 can react with the target material and cause an exothermic reaction that heats the organic indicating material 215 to a phase transition temperature.
在一些实施例中，目标材料可以是农药、激素、微生物、染料成份、聚合物、氢气、酸、碱、挥发性有机化合物或它们的任意组合。酸可以包括例如乙酸、苯甲酸、碳酸、甲酸、盐酸、硫化氢、硝酸、磷酸、硫酸或它们的任意组合。碱例如可以包括氢氧化铵、氢氧化钙、氢氧化钾、氢氧化钠或它们的任意组合。 In some embodiments, the target material may be pesticides, hormones, microorganisms, dye components, polymers, hydrogen, acids, bases, volatile organic compounds, or any combination thereof. Acids may include, for example, acetic acid, benzoic acid, carbonic acid, formic acid, hydrochloric acid, hydrogen sulfide, nitric acid, phosphoric acid, sulfuric acid, or any combination thereof. The base may include, for example, ammonium hydroxide, calcium hydroxide, potassium hydroxide, sodium hydroxide, or any combination thereof.
在一些实施例中，制造品可以可选地包括化学反应剂。在一些实施例中，化学反应剂可以邻近形成的有机指示材料215。在一些实施例中，化学反应剂可以催化放热反应，放热反应加热有机指示材料。在其它实施例中，化学反应剂可以在传感器暴露于目标材料后经历与目标材料的放热反应并导致将有机指示材料215加热到相变温度。在另外的实施例中，制造品可以包括由有机指示材料215形成的、固体聚合物基质210中的可视指示器。可视指示器可以指示扩散程度且因此指示传感器205上的目标负荷。 In some embodiments, an article of manufacture may optionally include chemical reactants. In some embodiments, a chemical reactant may be adjacent to the formed organic indicator material 215 . In some embodiments, the chemical reactant can catalyze an exothermic reaction that heats the organic indicating material. In other embodiments, the chemical reactant may undergo an exothermic reaction with the target material and cause heating of the organic indicating material 215 to a phase transition temperature upon exposure of the sensor to the target material. In further embodiments, an article of manufacture may include a visual indicator in a solid polymer matrix 210 formed from an organic indicating material 215 . The visual indicator may indicate the degree of diffusion and thus the target load on the sensor 205 .
示例 example
示例1：制造热负荷传感器的方法Example 1: Method of manufacturing a thermal load sensor
在筒状的空的容器中制作热负荷传感器。将具有单体和交联剂的5毫米厚的一层未固化的聚二甲基硅氧烷(PDMS)预聚物倾倒到容器中。未固化的PDMS在凝胶点温度(90℃)下被固化成凝胶。石蜡被用作有机指示材料。石蜡被热成形为具有4毫米的直径和2毫米的高度的四个圆柱体。四个石蜡圆柱体被放置到固化的PDMS的中心处并且均等地间隔开。额外的5毫米的一层未固化的PDMS被倾倒到石蜡圆柱体上以完全覆盖石蜡圆柱体。未固化的PDMS在与先前的一层PDMS类似的条件下被固化。热负荷传感器的表面压印有用于热负荷度量的可视标记物。具有被PDMS封装剂包围的石蜡盘的热负荷传感器被从容器切割去除。热负荷传感器放置在80℃的热板上30分钟。石蜡扩散到PDMS基质中并且产生在包围石蜡的PDMS中被均匀间隔开的云状环。云状环绕着石蜡的位置形成同心环。观察到，随着传感器暴露于热的时间增加，石蜡的扩散程度增大并且因此同心环的数量也增加。可视标记物是从石蜡的位置向外延伸的线标记，线标记被校准以基于石蜡的扩散程度来指示暴露时间。因此，热负荷传感器可以检测热负荷，诸如如该示例中描述的暴露于高温的暴露时间。 Fabricate a thermal load sensor in a cylindrical empty container. A 5 mm thick layer of uncured polydimethylsiloxane (PDMS) prepolymer with monomer and crosslinker was poured into the container. Uncured PDMS is cured into a gel at the gel point temperature (90 °C). Paraffin was used as an organic indicator material. Paraffin was thermoformed into four cylinders with a diameter of 4 mm and a height of 2 mm. Four paraffin cylinders were placed into the center of the cured PDMS and equally spaced. An additional 5 mm layer of uncured PDMS was poured onto the paraffin cylinder to completely cover the paraffin cylinder. Uncured PDMS was cured under similar conditions to the previous layer of PDMS. The surface of the thermal load sensor is embossed with visual markers for thermal load measurement. A thermal load sensor with a paraffin disk surrounded by PDMS encapsulant was cut from the container. The heat load sensor was placed on a hot plate at 80°C for 30 minutes. The paraffin diffuses into the PDMS matrix and creates cloud-like rings that are evenly spaced in the PDMS surrounding the paraffin. Clouds form concentric rings around the location of the paraffin. It was observed that as the time the sensor was exposed to heat increased, the degree of paraffin diffusion and thus the number of concentric rings also increased. Visual markers are line markers extending outward from the location of the paraffin that are calibrated to indicate exposure time based on the degree of paraffin spread. Thus, a thermal load sensor can detect thermal loads, such as exposure time to high temperatures as described in this example.
示例2：用于检测生物目标材料的传感器Example 2: Sensors for detecting biological target materials
传感器将被用于检测生物负荷。传感器将具有封装烷烃圆柱体的丙烯酸酯聚合物基质以及被布置为邻近烷烃圆柱体的过氧化氢的储存器。将在丙烯酸酯聚合物基质上邻近烷烃圆柱体的地方包括标志。标志将具有指示酵母污染物的风险的两个线标记，一条线将具有在其上方的词语‘低风险’，并且另一条线将距烷烃圆柱体更远且将具有在其上方的词语‘高风险’。传感器将被设计成检测周围环境中的酵母。传感器将被附接到一盒苹果。当环境中存在酵母时，过氧化氢将与酵母反应且释放热量。该热量将熔化石蜡，导致石蜡扩散到丙烯酸酯聚合物基质中。标志将被用于确定石蜡的扩散程度以判定在周围环境中检测到的酵母量是否已达到会污染苹果的水平。 Sensors will be used to detect bioburden. The sensor will have an acrylate polymer matrix encapsulating the alkane cylinder and a reservoir of hydrogen peroxide disposed adjacent to the alkane cylinder. A logo will be included adjacent to the alkane cylinder on the acrylate polymer matrix. The sign will have two line markings indicating the risk of yeast contamination, one line will have the word 'low risk' above it and the other line will be further from the alkane cylinder and will have the word 'high' above it risk'. The sensors will be designed to detect yeast in the surrounding environment. The sensor will be attached to a box of apples. When yeast is present in the environment, the hydrogen peroxide will react with the yeast and release heat. This heat will melt the paraffin, causing the paraffin to diffuse into the acrylate polymer matrix. Flags will be used to determine the extent of paraffin spread to determine whether yeast levels detected in the surrounding environment have reached levels that would contaminate the apples.
在上面的详细说明中，参考了附图，附图构成了详细说明的一部分。在附图中，除非上下文指出，否则相似的符号通常表示相似的部件。在详细说明、附图和权利要求中所描述的示例性实施例不意在限制。可以使用其它实施例，并且可以做出其它改变，而不偏离本文呈现的主题的精神或范围。将易于理解的是，如本文大致描述且如图中所图示的，本公开的方案可以以各种不同配置来布置、替代、组合、分离和设计，所有这些都在本文中明确地构思出。 In the above detailed description, reference was made to the accompanying drawings, which form a part hereof. In the drawings, similar symbols typically identify similar components, unless context dictates otherwise. The exemplary embodiments described in the detailed description, drawings, and claims are not meant to be limiting. Other embodiments may be utilized, and other changes may be made, without departing from the spirit or scope of the subject matter presented herein. It will be readily understood that, as generally described herein and illustrated in the drawings, aspects of the present disclosure may be arranged, substituted, combined, separated and designed in various configurations, all of which are expressly contemplated herein .
本公开不限于本文所描述的特定实施例，这些实施例意图作为各方案的示例。可以在不偏离其精神和范围的情况下做出多种改进和变型，这对于本领域技术人员而言是显而易见的。通过前面的说明，除了本文所列举的那些之外，在本公开的范围内的功能上等同的方法和装置对于本领域技术人员而言将是显而易见的。旨在使这些改进和变型落在所附权利要求书的范围内。本公开仅受所附权利要求书以及这些权利要是所给予权利的等同方案的整个范围所限制。应当理解的是，本公开不限于特定的方法、试剂、化合物组成或生物系统，当然这些会变化。还应理解的是，本文所使用的术语是仅仅是为了描述特定实施例的目的，而不意在限制。 This disclosure is not to be limited by the particular embodiments described herein, which are intended as illustrations of various aspects. Various modifications and variations will be apparent to those skilled in the art that can be made without departing from its spirit and scope. Functionally equivalent methods and apparatuses within the scope of the present disclosure, in addition to those enumerated herein, will be apparent to those skilled in the art from the foregoing description. It is intended that such improvements and modifications come within the scope of the appended claims. The present disclosure is to be limited only by the appended claims, along with the full scope of equivalents to which such rights are entitled. It is to be understood that this disclosure is not limited to particular methods, reagents, compositions of compounds or biological systems, which can, of course, vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting.
关于本文中基本上任何复数和/或单数术语的使用，本领域技术人员可以根据上下文和/或应用适当地从复数变换成单数和/或从单数变换成复数。为了清晰的目的，本文中明确地阐明了各单数/复数的置换。 With respect to the use of substantially any plural and/or singular term herein, those skilled in the art can switch from the plural to the singular and/or from the singular to the plural as appropriate depending on the context and/or application. For purposes of clarity, each singular/plural permutation is explicitly set forth herein.
本领域技术人员将理解，一般地，本文所使用的术语，尤其是随附权利要求(例如，随附权利要求的主体)中所使用的术语，通常意在为“开放式”术语(例如，术语“包括”应当解释为“包括但不限于”，术语“具有”应解释为“至少具有”，术语“包括”应解释为“包括但不限于”，等等)。本领域技术人员还理解，如果意图表达引导性权利要求记述项的具体数量，该意图将明确地记述在权利要求中，并且在不存在这种记述的情况下，不存在这样的意图。例如，为辅助理解，下面的随附权利要求可能包含了引导性短语“至少一个”和“一个或多个”的使用以引导权利要求记述项。然而，这种短语的使用不应解释为暗指不定冠词“一”或“一个”引导权利要求记述项将包含该所引导的权利要求记述项的任何特定权利要求局限于仅包含一个该记述项的实施例，即使当同一权利要求包括了引导性短语“一个或多个”或“至少一个”以及诸如“一”或“一个”的不定冠词(例如，“一”和/或“一个”应当解释为表示“至少一个”或“一个或多个”)；这同样适用于对于用于引导权利要求记述项的定冠词的使用。另外，即使明确地记述了被引导的权利要求记述项的具体数量，本领域技术人员将理解到这些记述项应当解释为至少表示所记述的数量(例如，没有其它修饰语的裸记述“两个记述项”表示至少两个记述项或两个以上的记述项)。此外，在使用类似于“A、B和C等中的至少一个”的惯用法的那些实例中，通常这样的构造旨在表达本领域技术人员理解该惯用法的含义(例如，“具有A、B和C中的至少一个的系统”将包括但不限于仅具有A、仅具有B、仅具有C、具有A和B、具有A和C、具有B和C、和/或具有A、B和C等等的系统)。在使用类似于“A、B或C等中的至少一个”的惯用法的那些实例中，通常这样的构造旨在表达本领域技术人员理解该惯用法的含义(例如，“具有A、B或C中的至少一个的系统”将包括但不限于仅具有A、仅具有B、仅具有C、具有A和B、具有A和C、具有B和C、和/或具有A、B和C等等的系统)。本领域技术人员将进一步理解，呈现两个以上可选项的几乎任何分离词和/或短语，无论是在说明书、权利要求或附图中，都应理解为设想包括一项、任一项或两项的可能性。例如，术语“A或B”将理解为包括“A”或“B”或“A和B”的可能性。 Those skilled in the art will appreciate that terms used herein in general, and especially in the appended claims (e.g., the body of the appended claims), are generally intended to be "open-ended" terms (e.g., The term "comprising" shall be interpreted as "including but not limited to", the term "having" shall be interpreted as "having at least", the term "including" shall be interpreted as "including but not limited to", etc.). It will also be understood by those within the art that if a specific number of an introductory claim recitation is intended, that intent will be explicitly recited in the claim, and in the absence of such recitation no such intent is present. For example, as an aid to understanding, the following appended claims may contain usage of the introductory phrases "at least one" and "one or more" to introduce claim recitations. However, use of this phrase should not be construed to imply that the indefinite article "a" or "an" introduces a claim recitation to limiting any particular claim containing the introduced claim recitation to containing only one of that recitation. even when the same claim includes the introductory phrase "one or more" or "at least one" and an indefinite article such as "a" or "an" (e.g., "a" and/or "a " should be construed to mean "at least one" or "one or more"); the same applies to the use of definite articles used to introduce claim recitations. In addition, even if the specific number of the introduced claim recitation items is explicitly recited, those skilled in the art will understand that these recitation items should be interpreted as at least indicating the recited number (for example, the bare recitation "two" without other modifiers A description item" means at least two description items or more than two description items). Furthermore, in those instances where a idiom similar to "at least one of A, B, and C, etc." is used, generally such constructions are intended to convey what those skilled in the art understand the idiom to mean (e.g., "has A, A system of at least one of B and C" will include, but is not limited to, having only A, only B, only C, having A and B, having A and C, having B and C, and/or having A, B, and C and other systems). In those instances where a idiom similar to "at least one of A, B, or C, etc." is used, generally such constructions are intended to convey the meaning that those skilled in the art understand the idiom (e.g., "having A, B, or A system of at least one of C" would include, but is not limited to, having only A, only B, only C, having A and B, having A and C, having B and C, and/or having A, B and C, etc. etc. system). Those skilled in the art will further appreciate that virtually any discrete word and/or phrase presenting two or more alternatives, whether in the specification, claims, or drawings, is to be understood as contemplated to include either, either, or both. item possibility. For example, the term "A or B" will be understood to include the possibilities of "A" or "B" or "A and B."
另外，在根据马库什组(Markushgroup)描述本公开的特征或方案的情况下，本领域技术人员将理解的是本公开也因此以马库什组的任何独立成员或成员的子组来描述。 Additionally, where features or aspects of the disclosure are described in terms of a Markush group, those skilled in the art will understand that the disclosure is also thereby described in terms of any individual member or subgroup of members of the Markush group .
本领域技术人员将理解的是，为了任何以及全部的目的，诸如在提供所撰写的说明书方面，本文所公开的全部范围也涵盖了任何和全部的可能的子范围及其子范围的组合。可以容易地认识到任何所列范围都充分地描述了同一范围并且使同一范围分解成至少均等的两半、三份、四份、五份、十份等等。作为非限制示例，本文所论述的每个范围可以容易地分解成下三分之一、中三分之一和上三分之一，等等。本领域技术人员还将理解的是，诸如“多达”、“至少”等所有的语言包括所记述的数量并且是指如上文所论述的随后可以分解成子范围的范围。最后，本领域技术人员将理解的是，范围包括每个独立的成员。因此，例如，具有1-3个单元的组是指具有1个、2个或3个单元的组。类似地，具有1-5个单元的组是指具有1个、2个、3个、4个、或5个单元的组，等等。 It will be understood by those skilled in the art that for any and all purposes, such as in terms of providing a written description, all ranges disclosed herein also encompass any and all possible subranges and combinations of subranges thereof. It can be readily appreciated that any listed range fully describes and divides the same range into at least equal halves, three parts, four parts, five parts, ten parts, etc. As a non-limiting example, each range discussed herein can be easily broken down into a lower third, a middle third, and an upper third, and so on. Those skilled in the art will also understand that all language such as "up to," "at least," etc. includes the recited quantity and refers to ranges that can then be broken down into sub-ranges as discussed above. Finally, as will be understood by those skilled in the art, a range includes each individual member. Thus, for example, a group having 1-3 units refers to groups having 1, 2 or 3 units. Similarly, a group having 1-5 units refers to groups having 1, 2, 3, 4, or 5 units, and so on.
上文公开的各种以及其它特征和功能或其替选方案可以组合成多个其它不同的系统或应用。本领域技术人员可随后做出对其的各种当前不可预见的或不可预期的替选方案、修改方案、变型例或改进，其中每个同样旨在由公开的实施例所涵盖。 Various of the above-disclosed and other features and functions, or alternatives thereof, may be combined into many other different systems or applications. Various presently unforeseen or unanticipated alternatives, modifications, variations or improvements thereto may subsequently be made by those skilled in the art, each of which is also intended to be encompassed by the disclosed embodiments.
Claims (100)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CA2013/050764 WO2015051437A1 (en) | 2013-10-10 | 2013-10-10 | A temperature change indicator and methods of making the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105793682A true CN105793682A (en) | 2016-07-20 |
| CN105793682B CN105793682B (en) | 2018-12-28 |
Family
ID=52812385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380080170.9A Expired - Fee Related CN105793682B (en) | 2013-10-10 | 2013-10-10 | Temperature changes indicator and its manufacturing method |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US9841381B2 (en) |
| CN (1) | CN105793682B (en) |
| WO (1) | WO2015051437A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110470412A (en) * | 2019-09-19 | 2019-11-19 | 清华大学 | A kind of diffused temperature-time label and its Activiation method |
| CN111065901A (en) * | 2017-07-11 | 2020-04-24 | 因特瑞有限公司 | Time temperature indicating label |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112649424A (en) * | 2020-12-14 | 2021-04-13 | 安徽中青检验检测有限公司 | Pesticide detection device and method for food detection |
| US20240035902A1 (en) * | 2022-07-29 | 2024-02-01 | Temptime Corporation | Dual heat-freeze indicator |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1174987A (en) * | 1996-08-22 | 1998-03-04 | 旭电机株式会社 | Indicator for overheat test |
| CN201159676Y (en) * | 2007-10-10 | 2008-12-03 | 万宸霞 | Temperature-time indication label |
| CN101365933A (en) * | 2005-11-08 | 2009-02-11 | 坦普泰姆公司 | Combined freezing indicator |
| CN101646744A (en) * | 2007-01-22 | 2010-02-10 | 弗雷什波因特控股有限公司 | Time temperature indicator based on oligomeric spiroaromatic compounds |
| CN101718597A (en) * | 2009-12-04 | 2010-06-02 | 河南农业大学 | Diffusible time-temperature indicator, indicator card and preparation method of the indicator card |
| US20100192833A1 (en) * | 2009-02-02 | 2010-08-05 | Brady Worldwide, Inc. | Temperature Sensitive Films |
| CN102132336A (en) * | 2008-07-21 | 2011-07-20 | 纳诺福卡斯有限公司 | Labels used to show high temperature exposure |
| US20120079981A1 (en) * | 2010-09-29 | 2012-04-05 | Temptime Corporation | Temperature-activated time-temperature indicator |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5053339A (en) * | 1988-11-03 | 1991-10-01 | J P Labs Inc. | Color changing device for monitoring shelf-life of perishable products |
| US5667303A (en) * | 1995-03-10 | 1997-09-16 | Minnesota Mining And Manufacturing Company | Time-temperature integrating indicator device |
| US6244208B1 (en) * | 1998-04-29 | 2001-06-12 | 3M Innovative Properties Company | Time-temperature integrating indicator device with barrier material |
| JP4789083B2 (en) * | 2004-07-15 | 2011-10-05 | 株式会社ジークエスト | Temperature sensitive seal |
| CN104428644B (en) * | 2012-05-11 | 2017-11-03 | 泰坦公司 | Dual-function heat indicator and preparation method |
-
2013
- 2013-10-10 CN CN201380080170.9A patent/CN105793682B/en not_active Expired - Fee Related
- 2013-10-10 WO PCT/CA2013/050764 patent/WO2015051437A1/en not_active Ceased
- 2013-10-10 US US15/027,644 patent/US9841381B2/en not_active Expired - Fee Related
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1174987A (en) * | 1996-08-22 | 1998-03-04 | 旭电机株式会社 | Indicator for overheat test |
| CN101365933A (en) * | 2005-11-08 | 2009-02-11 | 坦普泰姆公司 | Combined freezing indicator |
| CN101646744A (en) * | 2007-01-22 | 2010-02-10 | 弗雷什波因特控股有限公司 | Time temperature indicator based on oligomeric spiroaromatic compounds |
| CN201159676Y (en) * | 2007-10-10 | 2008-12-03 | 万宸霞 | Temperature-time indication label |
| CN102132336A (en) * | 2008-07-21 | 2011-07-20 | 纳诺福卡斯有限公司 | Labels used to show high temperature exposure |
| US20100192833A1 (en) * | 2009-02-02 | 2010-08-05 | Brady Worldwide, Inc. | Temperature Sensitive Films |
| CN101718597A (en) * | 2009-12-04 | 2010-06-02 | 河南农业大学 | Diffusible time-temperature indicator, indicator card and preparation method of the indicator card |
| US20120079981A1 (en) * | 2010-09-29 | 2012-04-05 | Temptime Corporation | Temperature-activated time-temperature indicator |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111065901A (en) * | 2017-07-11 | 2020-04-24 | 因特瑞有限公司 | Time temperature indicating label |
| CN110470412A (en) * | 2019-09-19 | 2019-11-19 | 清华大学 | A kind of diffused temperature-time label and its Activiation method |
| CN110470412B (en) * | 2019-09-19 | 2020-09-25 | 清华大学 | Diffusion type temperature time label and activation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| US9841381B2 (en) | 2017-12-12 |
| WO2015051437A1 (en) | 2015-04-16 |
| CN105793682B (en) | 2018-12-28 |
| US20160258873A1 (en) | 2016-09-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7571695B2 (en) | Freeze indicators, flexible freeze indicators and manufacturing methods | |
| DK1952110T3 (en) | Combined frost indicators | |
| CN105793682A (en) | Temperature change indicator and method of manufacture | |
| Kuswandi et al. | Smart packaging: sensors for monitoring of food quality and safety | |
| US7624698B2 (en) | Freeze indicators suitable for mass production | |
| US10737270B2 (en) | Assay wells with hydrogel as a well-contents separator | |
| WO2007106463A2 (en) | Changed condition indicator | |
| NO328633B1 (en) | Full-historical time-temperature indicator system, its production and use, and combination product comprising the indicator system | |
| CN112469979B (en) | Flexible sensor label system | |
| CN102132336A (en) | Labels used to show high temperature exposure | |
| CN115363578A (en) | Biological sample containment system and label | |
| Dalmoro et al. | Encapsulation of sensors for intelligent packaging | |
| US10677660B2 (en) | Temperature traceable indicator and method for manufacturing same | |
| KR102113112B1 (en) | Variable display apparatus | |
| US20120083043A1 (en) | Temperature-time indicator system based on irreversible color changes, and corresponding method | |
| US20120307865A1 (en) | Internal temperature indicator | |
| KR20240020142A (en) | Temperature-Responsive Hydrogel Microcapsule with Phase-Change Oil Layer and Temperature History Indicator Using the Same | |
| Kumar et al. | Communicative Packaging Systems for Safety of Food Products | |
| Jazukevičiūtė et al. | Nanoparticles and Smart Materials Application in Packaging and Printing Technologies. | |
| CN211717660U (en) | Combined temperature indicator | |
| CN102252771B (en) | Combination freeze indicators | |
| Khan et al. | Food‐Activated Microneedle Sensor for Real‐Time, Colorimetric Spoilage Monitoring of Pre‐Packaged Food |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20181228 Termination date: 20191010 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |