CN105738432B - Blood sugar test paper hydrophilic film stable and reliable for performance - Google Patents
Blood sugar test paper hydrophilic film stable and reliable for performance Download PDFInfo
- Publication number
- CN105738432B CN105738432B CN201610058104.7A CN201610058104A CN105738432B CN 105738432 B CN105738432 B CN 105738432B CN 201610058104 A CN201610058104 A CN 201610058104A CN 105738432 B CN105738432 B CN 105738432B
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- hydrophilic film
- test paper
- blood sugar
- sugar test
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- 238000012360 testing method Methods 0.000 title claims abstract description 40
- 239000008280 blood Substances 0.000 title claims abstract description 39
- 210000004369 blood Anatomy 0.000 title claims abstract description 39
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 18
- 238000001035 drying Methods 0.000 claims abstract description 14
- 229920006267 polyester film Polymers 0.000 claims abstract description 13
- 229940051841 polyoxyethylene ether Drugs 0.000 claims abstract description 12
- 229920000056 polyoxyethylene ether Polymers 0.000 claims abstract description 12
- 150000002191 fatty alcohols Chemical class 0.000 claims abstract description 10
- 239000000463 material Substances 0.000 claims abstract description 9
- 239000007787 solid Substances 0.000 abstract description 6
- 230000032683 aging Effects 0.000 abstract description 5
- 239000003292 glue Substances 0.000 abstract description 5
- 239000002245 particle Substances 0.000 abstract description 5
- 239000000843 powder Substances 0.000 abstract description 4
- 230000000903 blocking effect Effects 0.000 abstract description 2
- 238000005096 rolling process Methods 0.000 abstract description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 10
- 239000008103 glucose Substances 0.000 description 10
- 108090000790 Enzymes Proteins 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 229940088598 enzyme Drugs 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000004366 Glucose oxidase Substances 0.000 description 3
- 108010015776 Glucose oxidase Proteins 0.000 description 3
- 238000003483 aging Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 229940116332 glucose oxidase Drugs 0.000 description 3
- 235000019420 glucose oxidase Nutrition 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000006258 conductive agent Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- KTWOOEGAPBSYNW-UHFFFAOYSA-N ferrocene Chemical compound [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- -1 potassium ferricyanide Chemical compound 0.000 description 2
- 229920001169 thermoplastic Polymers 0.000 description 2
- 239000004416 thermosoftening plastic Substances 0.000 description 2
- 229940005561 1,4-benzoquinone Drugs 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000030595 Glucokinase Human genes 0.000 description 1
- 108010021582 Glucokinase Proteins 0.000 description 1
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000004054 benzoquinones Chemical class 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 125000001153 fluoro group Chemical class F* 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 150000002908 osmium compounds Chemical class 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 150000003304 ruthenium compounds Chemical class 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000010148 water-pollination Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/401—Salt-bridge leaks; Liquid junctions
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Laminated Bodies (AREA)
Abstract
The invention discloses a kind of blood sugar test paper hydrophilic film stable and reliable for performance, the blood sugar test paper includes test paper body, forms the polyester film of the test paper body base material and be coated on the hydrophilic film of the polyester film surface, it is characterised in that：The hydrophilic film ethanol solution is dissolved in by fatty alcohol polyoxyethylene ether after, by being attached to the polyester film surface after being coated with drying tunnel drying and forming.The hydrophilic film of the present invention, does not have glue solid fraction powder or particle when cutting or rolling cut, will not produce the hidden danger for blocking hydrophilic film sample holes on blood sugar test paper；Moreover, the hydrophilic film of the present invention, ageing resistance and homogeneity are greatly enhanced.
Description
Technical field
The present invention relates to blood sugar test paper, especially a kind of hydrophilic film stable and reliable for performance on blood sugar test paper.
Background technology
According to the sound of China《National news are broadcasted》Report, cut-off on November 15th, 2013 " world's diabetes day ", China's sugar
Urine patient's number is up to 1.14 hundred million, is also being increased every year with 1.5% speed.Therefore, as one kind have concurrently medical instrument and
The blood glucose high speed tester of consumer electronic product, is widely used in the detection and analysis to blood glucose.The test of blood glucose high speed tester
Principle is：Apply certain constant voltage at the blood sugar test paper electrode both ends of insertion blood glucose high speed tester（Such as 300mV）, work as quilt
After survey blood sample sucks electrode working zone by the hydrophilic film on blood sugar test paper, the glucose oxidase in test paper electrode surface workspace
Redox reaction occurs with the glucose in blood sample, after quick biochemical reaction, the response that enzyme electrode test paper produces is electric
Stream（About between 0.1~10 μ A）It is in a linear relationship with concentration of glucose in tested blood sample, it is single in blood glucose high speed tester
The size of blood sample response current is detected under the control of piece machine, so that accurate blood glucose concentration value be calculated and quickly surveyed in blood glucose
Try instrument liquid crystal screen display final result.
Any type blood sugar test paper all can't do without following main component：Oxidoreducing enzyme（Such as glucose oxidase, Portugal
Grape sugar-NAD-dehydrogenase, glucose-PQQ-dehydrogenase and glucose-FAD-dehydrogenase etc.）, various conducting mediums（As benzoquinones,
The potassium ferricyanide, ferrocene, ruthenium compound, osmium compound etc.）, and binder（As hydroxyethyl cellulose, carboxymethyl cellulose,
Stabilizer of surfactant and enzyme and conductive agent etc.）.Table 1 lists domestic and international more commonly used blood sugar test paper at present and makes
Base stock.
Table 1
| Test paper base material | Binder | Conductive agent | Reagent enzyme | Surfactant |
| PET | Hydroxyethyl cellulose | 1,4-benzoquinone | Glucose oxidase | Qula is led to |
| PP | Carboxymethyl cellulose | The potassium ferricyanide | Glucose dehydrogenase | Soil temperature |
| PC | Collagen | Ferrocene | Glucokinase | DOW CORNING defoamer |
| PVC | Seaweed acid gel | Metallic conduction compound | Fluorine class surfactant |
In blood sugar test paper, influence accuracy of detection in addition to mentioned component, also have one layer of crucial material, here it is parent
Moisture film.When tested blood sample is dropped on blood sugar test paper, drop of blood can quickly be spread and suck electrode working zone by hydrophilic film, with true
Protect the progress of blood sugar test.Its essence of hydrophilic film is exactly polyester film（PET) surface is coated with hydrophilic substance, in the prior art,
Hydrophilic film is coated with using thermoplastic hydrophilic material（Hydrophilic substance is dissolved in solvent-based thermal plastic material, by being coated with drying tunnel drying parent
Water substance adheres to pet sheet face in the case where thermoplastic matchmaker connects）, so as to reach hydrophilic effect.This hydrophilic film, hydrophilic substance with
Colloidal solid form is present in pet sheet face, and bulk hydrophilic film is being cut into the parent that can be positioned in blood glucose high speed tester
During moisture film bar, inevitably have glue solid fraction powder or particle produces, these glue solid fraction powder or particle can be in cut-off knives（Or rolling
Knife）Blade at accumulate, if cleaning not in time, these cementation sprills or particle fall on hydrophilic film bar, will direct shadow
Detection result and precision are rung, causes unqualified generation.
The content of the invention
The object of the present invention is to provide the preferable and stable and reliable for performance blood sugar test paper use of a kind of anti-aging property, homogeneity
Hydrophilic film.
To achieve the above object, the present invention adopts the following technical scheme that：
A kind of blood sugar test paper hydrophilic film stable and reliable for performance, the blood sugar test paper include test paper body, form the examination
The polyester film of hard copy body base material and the hydrophilic film for being coated on the polyester film surface, it is characterised in that：The hydrophilic film is by fat
Alcohol polyoxyethylene ether be dissolved in ethanol solution after, by being coated be attached to the polyester film surface after drying tunnel drying and form.
In the ethanol solution of the fatty alcohol polyoxyethylene ether, the weight percent content of fatty alcohol polyoxyethylene ether is 1-
3%。
PE films are compounded with the hydrophilic film.
Compared with prior art the beneficial effects of the invention are as follows：Due to the adoption of the above technical scheme, the hydrophilic film is by fat
Fat alcohol polyoxyethylene ether be dissolved in ethanol solution after, by being coated be attached to the polyester film surface after drying tunnel drying and form, should
Oily matter does not have the generation of glue solid fraction material, when making hydrophilic film bar is cut or roller is cut, does not just have glue solid fraction powder or particle
Produce, without clearing up blade, the hidden danger for blocking hydrophilic film sample holes on blood sugar test paper will not be produced；Moreover, the present invention's is hydrophilic
Film, ageing resistance and homogeneity are greatly enhanced.
Brief description of the drawings
Fig. 1 is the structure diagram of the present invention.
Embodiment
As shown in Figure 1, the present invention is a kind of blood sugar test paper hydrophilic film stable and reliable for performance, the blood sugar test paper includes
Test paper body 1, the polyester film 101 for forming 1 base material of test paper body and the hydrophilic film 2 for being coated on 101 surface of polyester film,
The hydrophilic film 2 ethanol solution is dissolved in by fatty alcohol polyoxyethylene ether after, by be coated with after drying tunnel drying be attached to it is described poly-
101 surface of ester film is formed.Preferably, in the ethanol solution of the fatty alcohol polyoxyethylene ether, fatty alcohol polyoxyethylene ether
Weight percent content is 1-3%, and the optimal weight percent content 3% of fatty alcohol polyoxyethylene ether, this ratio can be true
Protecting hydrophilic film 2 has optimal effect.In order to be protected in blood sugar test paper using preceding to hydrophilic film 2, in the hydrophilic film 2 also
Can be with compound PE film 3.
It is the hydrophily and ageing resistance experimental result to hydrophilic film of the present invention below；
Sample message：132mm wide * 100m long, no PE films.Volume 1, single side is hydrophilic.
Experimental method：
Received sample hydrophilic film is opened in clean area packing workshop and cuts into the current specification of production, then aritificial cut-off
Into 6mm wide * 5cm long, dispensed with drying bottle.Before test, with drying bottle take a part of hydrophilic film be placed on test between constant temperature 30
More than minute, contact angle test is pressed《Hydrophilic film examination criteria》The test method test of middle contact angle, remaining hydrophilic film are placed on
Aging in 60 DEG C of baking ovens, extracts weekly the test of part hydrophilic film once later, and (adhesivesresearch, is shown in existing AR
Www.adhesivesresearch.com) hydrophilic film contrasts.
As can be seen from the above table：The contact angle of the present invention and the deviation of maxima and minima are slightly larger than AR when unaged
Hydrophilic film, but contact angle after AR hydrophilic film agings and when unaged differ larger and maxima and minima deviation also compared with
Greatly, the anti-aging property and homogeneity for illustrating the present invention are better than AR hydrophilic films.
Compared with the AR hydrophilic films of import, the price of every square metre of the present invention is less than its half, and current market accounts for
There is rate steadily improving.
Claims (3)
1. a kind of blood sugar test paper hydrophilic film stable and reliable for performance, the blood sugar test paper includes test paper body（1）, form the examination
Hard copy body（1）The polyester film of base material（101) and it is coated on the polyester film（101）The hydrophilic film on surface（2）, it is characterised in that：
The hydrophilic film（2）After being dissolved in ethanol solution by fatty alcohol polyoxyethylene ether, by be coated with after drying tunnel drying be attached to it is described
Polyester film（101）Surface is formed.
2. blood sugar test paper hydrophilic film stable and reliable for performance according to claim 1, it is characterised in that：The fatty alcohol
In the ethanol solution of polyoxyethylene ether, the weight percent content of fatty alcohol polyoxyethylene ether is 1-3%.
3. blood sugar test paper hydrophilic film stable and reliable for performance according to claim 1 or 2, it is characterised in that：Described
Hydrophilic film（2）On be compounded with PE films（3）.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610058104.7A CN105738432B (en) | 2016-01-27 | 2016-01-27 | Blood sugar test paper hydrophilic film stable and reliable for performance |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610058104.7A CN105738432B (en) | 2016-01-27 | 2016-01-27 | Blood sugar test paper hydrophilic film stable and reliable for performance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105738432A CN105738432A (en) | 2016-07-06 |
| CN105738432B true CN105738432B (en) | 2018-05-11 |
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ID=56246891
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610058104.7A Active CN105738432B (en) | 2016-01-27 | 2016-01-27 | Blood sugar test paper hydrophilic film stable and reliable for performance |
Country Status (1)
| Country | Link |
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| CN (1) | CN105738432B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109453677A (en) * | 2018-12-19 | 2019-03-12 | 杭州快诊新材料科技有限公司 | The manufacturing method of two-sided hydrophilic film |
| CN109453675A (en) * | 2018-12-19 | 2019-03-12 | 杭州快诊新材料科技有限公司 | Two-sided hydrophilic film coating system |
| CN112162095A (en) * | 2020-09-24 | 2021-01-01 | 上海印标包装有限公司 | Hydrophilic film and manufacturing method thereof |
| CN114414560A (en) * | 2021-12-30 | 2022-04-29 | 广东环凯生物技术有限公司 | Test paper for measuring total chlorine, preparation method thereof and method for rapidly measuring total chlorine |
| CN116087286B (en) * | 2023-03-10 | 2024-08-23 | 上海微创生命科技有限公司 | Biosensor and preparation method and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1867407A (en) * | 2003-10-17 | 2006-11-22 | 3M创新有限公司 | Surfactant composition having stable hydrophilic character |
| CN101246175A (en) * | 2007-02-14 | 2008-08-20 | 胡军 | Silk screen printing method for producing blood sugar test paper |
| CN101303358A (en) * | 2007-05-10 | 2008-11-12 | 胡军 | Siphoning type blood sugar test paper |
| CN104007255A (en) * | 2014-05-16 | 2014-08-27 | 中南林业科技大学 | Aflatoxin B1 rapid detection test paper strip and preparation method and application thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2402759B1 (en) * | 2010-06-29 | 2014-02-26 | Actherm Inc. | Testing strip for detecting a fluidic sample |
-
2016
- 2016-01-27 CN CN201610058104.7A patent/CN105738432B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1867407A (en) * | 2003-10-17 | 2006-11-22 | 3M创新有限公司 | Surfactant composition having stable hydrophilic character |
| CN101246175A (en) * | 2007-02-14 | 2008-08-20 | 胡军 | Silk screen printing method for producing blood sugar test paper |
| CN101303358A (en) * | 2007-05-10 | 2008-11-12 | 胡军 | Siphoning type blood sugar test paper |
| CN104007255A (en) * | 2014-05-16 | 2014-08-27 | 中南林业科技大学 | Aflatoxin B1 rapid detection test paper strip and preparation method and application thereof |
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| Publication number | Publication date |
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| CN105738432A (en) | 2016-07-06 |
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