CN105560911A - Traditional Chinese medicine for treating hypertension and preparation method thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicine for treating hypertension and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 to 15 parts of prunella vulgaris, 10 to 20 parts of root of kudzu vine, 3 to 5 parts of rhizoma gastrodiae, 3 to 4 parts of eucommia, 5 to 8 parts of ligusticum wallichii, 6 to 8 parts of oriental waterplantain rhizome, 5 to 6 parts of haw, 10 to 12 parts of earthworm, 10 to 12 parts of red sage root, and 10 to 12 parts of cassia seed. The invention aims to provide a traditional Chinese medicine that has a quick effect and is capable of shortening the time of treatment, and a preparation method thereof.

Description

A kind of traditional Chinese medicine for treating hypertension and preparation method thereof

technical field

The invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine for treating hypertension and a preparation method thereof.

Background technique

Hypertension is a common middle-aged and elderly disease. It is a chronic disease mainly manifested by continuous increase in arterial blood pressure. It may be accompanied by functional lesions of the heart, blood vessels, brain and organs. The two main causes of hypertension are Usually genetic and environmental factors, heredity is a kind of force majeure, but environmental factors require patients to pay attention to life and eating habits. Compound apocynum tablets are generally used for lowering blood pressure in the existing clinics, and there are simple and rough phenomena in the production of traditional Chinese medicines. There are many kinds of antihypertensive drugs on the market, but they are all accompanied by different degrees of side effects, and most hypertensive patients are elderly people, and too many side effects are not beneficial to the health of the elderly.

Contents of the invention

The purpose of the present invention is to overcome the deficiencies in the above-mentioned prior art and provide a kind of Chinese medicine for treating high blood pressure with fast drug effect and shortened patient's medication time and its preparation method.

The technical solution of the present invention is achieved in the following way: a Chinese medicine for treating hypertension, which is prepared from the following raw materials: Prunella vulgaris, Pueraria lobata, Gastrodia elata, Eucommia ulmoides, Rhizoma Chuanxiong, Alisma, hawthorn, earthworm, salvia miltiorrhiza, cassia seed, The parts by weight of these raw materials are as follows: 10~15 parts, 10~20 parts, 3~5 parts, 3~4 parts, 5~8 parts, 6~8 powders, 5~6 parts, 10~12 parts, 10 parts ~12 servings, 10~12 servings.

A method for preparing enteric-coated capsules of traditional Chinese medicine for treating hypertension. The preparation method is as follows: after immersing earthworm in water for 30 minutes, ultrasonically extract twice at 25°C, one time with 12 times the amount for 40 minutes, and the other time with 10 times the amount for 40 minutes. Minutes, filter the combined filtrate, concentrate under reduced pressure at 55-60°C to a relative density, make 1.3 extracts at 60°C, set aside, and set aside; Pueraria elata, Gastrodia elata, Salvia miltiorrhiza, Prunella vulgaris, Eucommia, Cassia, Alisma Hawthorn was soaked in water for 30 minutes at 55°C, ultrasonically extracted twice, one time 10 times of water for 40 minutes, the other time 8 times of water for 40 minutes, filtered and combined filtrate, concentrated under reduced pressure at 55-60°C to a density of 1.15 at 60°C For the extract, add ethanol with a concentration of 95% to make the alcohol content reach 70%, let it stand overnight, the supernatant is 55-60°C, recover the ethanol under reduced pressure and concentrate it to a relative density of 1.3, which is the extract at 60°C, and store it separately. For standby, Rhizoma Chuanxiong was soaked in 60% ethanol for 30 minutes, then ultrasonically extracted twice at 55°C, both times were 8 times the amount for 60 minutes, filtered, combined and concentrated under reduced pressure at 55-60°C to a relative density of 1.3, which was 60°C. Paste, combine the above three parts of the extract, add an appropriate amount of microcrystalline cellulose, stir well, mix evenly, vacuum dry at 55-60°C, take it out, crush it, and pass it through a 20-mesh sieve to get powder; select enteric-coated capsule shells for powder filling It can be made into enteric-coated capsules.

The pharmacology and drug properties of above-mentioned raw materials are as follows:

Prunella vulgaris: Compendium of Materia Medica, pure yang qi, cures eye pain, has the function of nourishing Jueyin blood function, relieves internal heat, relieves liver fire, improves eyesight and nourishes liver.

Pueraria lobata root: property and flavor tropism, pungent, sweet, flat, return to the spleen, stomach meridian, lightly disperse muscles, promote yang, pungent and sweet, lightly raise hair, enter Yangming meridian, treat typhoid fever, stroke, Yangming headache, Zhang element day , Headache like a broken. Efficacy: 1. Detoxifying muscles, reducing fever and promoting body fluid; 2. Elevating Qi, treating vertigo, tinnitus, deafness, heartache, cataract and eye diseases, etc.

Gastrodia elata: property and flavor, meridian distribution, sweet, flat, liver meridian return. Efficacy and application: extinguishing wind, calming the liver, can suppress liver yin, calming wind wood, is an important medicine for nourishing yin, nourishing liquid and quenching wind, used for dizziness and headache caused by liver yang, such as Tianma Gouding drink, medical heart Wu, Banxia Baizhu Tianma Decoction, in short Gastrodia elata has the effect of calming the liver and calming the wind, so it can be used for wind diseases of deficiency and excess, cold and heat. All winds and dizziness belong to the liver, so Gastrodia elata enters the meridian of Jueyin to cure various diseases.

Eucommia ulmoides, the liver meridian qi is divided into medicines, moistens dryness, nourishes liver deficiency, enters the liver and nourishes the kidney to make the mother fruit.

Rhizoma Chuanxiong: promoting blood circulation and dispelling blood stasis; promoting qi to relieve depression; dispelling wind and relieving pain.

Alisma: Sweet, light, and cold return to the kidney and bladder meridians, have the function of diuresis and warming, and expel heat. Insufficiency of kidney yin, dizziness and spermatorrhea caused by hyperactivity of deficiency fire, etc., because of its cold property, the heat of the kidney and bladder can be released, and the lower Especially suitable for transferring heat and humidity. Alisma treats deficiency of kidney yin, dizziness caused by excess of asthenic fire, and hawthorn can dissolve blood clots, gas clots, activate blood and reduce sebum, and its effect on blood pressure can make blood pressure drop slowly and persistently. curative effect is taken seriously.

Hawthorn: Rosaceae plant, the fruit of hawthorn or wild hawthorn (meridian distribution) enters the spleen, stomach, liver meridian (Materia Medica Meridian), enters Foot Yangming, Taiyin meridian, (Ningyuan Shijian Materia Medica) dissolves blood clots and air clots , promoting blood circulation, and the effect on blood pressure, anesthetized rabbits are intravenously injected with Shanlihong Tablets, and the ethanol extract can make blood pressure drop slowly and persistently, lasting for about three hours. Various hawthorns of different species in foreign countries and domestic ones are effective for experimental arteriosclerosis. curative effect has been paid attention to.

Earthworm: cold in nature, salty in taste, returns to liver, lung, kidney channel. Efficacy and application: clearing away heat and quenching wind, clearing away heat and relieving asthma, inducing diuresis and treating stranguria, dredging meridians and activating collaterals. Liver-fire attacking upwards, conjunctival congestion, embarrassment, swelling, pain and blueness caused by wind-evil external invasion, used to clear away heat and cool the liver. Modern studies have confirmed that this product contains earthworm antipyretic alkali and earthworm toxin, which can alleviate and last spasm and lower blood pressure. In this prescription, a large dose of earthworm is used, which mainly plays a role in relieving spasm and dredging collaterals. Research has proved that renal hypertension , Rats showed a slow and lasting antihypertensive effect.

Danshen: slightly cold in nature, bitter in taste, heart-guiding, liver meridian has the effect of invigorating blood and cooling blood. In ancient times, there was a saying that "one taste of Danshen has the same effect as the four things", and it can treat all blood stasis, including cerebral apoplexy. Function, modern effects show that Salvia miltiorrhiza contains salvianolic acid, danshenin and other ingredients, which can expand peripheral blood vessels, improve microcirculation, have anticoagulant, promote fibrinolysis, inhibit platelet aggregation, and inhibit thrombosis, and can improve coronary circulation. It also has obvious effects, so this product is often used in the treatment of ischemic stroke, and it is also used to divide the heart and envelope blood.

Semen Cassiae: (nature and flavor, meridian distribution) bitter, salty, slightly cold, returns to liver and large intestine meridian. Clearing the liver and improving eyesight, opening eyesight. Red eyes, inflammation of the liver, and external invasion of wind-heat. It is used for clearing the liver and improving eyesight, dispersing wind-heat, cataracts of blue blindness, liver and kidney deficiency, fascination, dim eyesight, so as to benefit kidney water and help liver qi. Semen Cassiae clears the liver and improves eyesight, Alisma diarrhea clears heat and promotes dampness. The combination of all these has the effect of lowering blood pressure on high blood pressure and has the effect of clearing eyesight and opening eyesight for dizzy vision caused by headache and dizziness. The combination of the two can bring out the best in each other, and play the effect of nourishing the kidney water, helping the liver qi, nourishing the liver and nourishing the kidney. Compatible with Prunella vulgaris to play the role of clearing heat from the liver, and can also be used for intestinal dryness and blood dryness to facilitate constipation.

Radix Puerariae, earthworm is the monarch drug, nourishing yin and suppressing yang, calming liver and quenching wind, cassia seed, quenching wind and calming liver, can suppress liver yang, calm wind wood, strengthen heart and diuresis, clear liver and improve eyesight, relieve wind and heat dissipation, benefit kidney water , Open eyes. Prunella vulgaris, relieves internal heat, removes liver fire, governs all winds, dizziness, swelling and pain, prolapse of eyesight, compatible with Dilong and Gastrodia elata, treats headache, dizziness, wind-heat caused by internal liver-wind movement, dizziness, wind-heat, liver-yang, yin deficiency, and blood deficiency Applicable to dizziness. Eucommia ulmoides, Salvia miltiorrhiza, Chuanxiong, nourish liver dryness, nourish liver deficiency, and nourish blood level salvianolic acid together. Salvia miltiorrhiza can expand peripheral blood vessels, improve blood circulation, promote fibrinolysis, inhibit platelet aggregation, and have obvious effects on coronary circulation. It is often used in Ischemic stroke treatment.

The positive effects produced by the technical solution of the present invention are as follows: the raw material formula adopted in the present invention is excellent, low in cost, and has no toxic and side effects. Deafness and tinnitus, etc., the best effect.

The preparation process is excellent, and different extraction methods are used for medicinal materials with different properties. Earthworm is an animal medicinal material, and its main components are earthworm kinase, urokinase and other enzymes. These ingredients are all water-soluble components. It has been reported in the literature that Earthworm extract can lower blood pressure and inhibit thrombus, forming obvious thrombin outside the earthworm decoction. The effect and so on, therefore, earthworm is extracted with water; the active ingredient of gastrodia elata is gastrodin, the main active ingredient of salvia miltiorrhiza is danshensu, salvianolic acid and other medicines are all water-soluble components, so water extraction is used, but because earthworm water The extraction temperature is different from that of gastrodia elata and salvia miltiorrhiza in water, and alcohol extraction is required due to the high rate of water extraction of gastrodia elata and salvia miltiorrhiza. Therefore, Dilong is not extracted together with Gastrodia elata and other medicines of Danshen, and the effective ingredients of Ligustrazine and ferulic acid in Chuanxiong, which have strong physiological activity, are far less effective in water extraction than alcohol extraction, so Chuanxiong is extracted with alcohol.

detailed description

Embodiment one

A traditional Chinese medicine for treating hypertension, which is prepared from the following raw materials: Prunella vulgaris, Pueraria lobata, Gastrodia elata, Eucommia ulmoides, Chuanxiong, Alisma, hawthorn, earthworm, salvia miltiorrhiza, and cassia seeds. The weights of these raw materials are: 10 grams, 10 grams, 3 grams, 3 grams, 5 grams, 6 grams, 5 grams, 10 grams, 10 grams, 10 grams.

The preparation method of the enteric-coated capsules of the above-mentioned traditional Chinese medicine is as follows: after soaking the earthworm in water for 30 minutes, ultrasonically extract twice at 25°C, one time 12 times the amount for 40 minutes, the other time 10 times the amount for 40 minutes, filter the combined filtrate, 55- Concentrate under reduced pressure at 60°C to a relative density, make a 60°C extract with a density of 1.3, and set aside for later use; soak kudzu root, gastrodia elata, salvia miltiorrhiza, Prunella vulgaris, Eucommia, cassia, Alisma, and hawthorn in water for 30 minutes and then 55 ℃, ultrasonic extraction twice, one time 10 times of water for 40 minutes, the other time 8 times of water for 40 minutes, filter the combined filtrate, concentrate under reduced pressure at 55-60 ℃ to a 60 ℃ extract with a density of 1.15, add 95% ethanol , so that the alcohol content reaches 70%, let it stand overnight, the supernatant is 55-60°C, and the ethanol is recovered under reduced pressure and concentrated to the extract at 60°C with a relative density of 1.3. After 30 minutes, ultrasonically extract twice at 55°C, both times are 8 times the amount for 60 minutes, filter, combine 55-60°C extracts concentrated under reduced pressure to 60°C with a relative density of 1.3, and combine the above three parts of extracts, Add an appropriate amount of microcrystalline cellulose, stir well, mix evenly, 55-60°C, vacuum-dry, take it out, crush it, and pass it through a 20-mesh sieve to get the powder; choose the enteric-coated capsule shell and fill it with powder to make an enteric-coated capsule. Capsule 0.6g.

Embodiment two

A traditional Chinese medicine for treating hypertension, which is prepared from the following raw materials: Prunella vulgaris, Pueraria lobata, Gastrodia elata, Eucommia ulmoides, Chuanxiong, Alisma, hawthorn, earthworm, salvia miltiorrhiza, and cassia seeds. The weights of these raw materials are: 15 grams, 20 grams, 5 grams, 4 grams, 8 grams, 8 grams, 6 grams, 12 grams, 12 grams, 12 grams.

The preparation method of the enteric-coated capsules of the above-mentioned traditional Chinese medicine is as follows: after soaking the earthworm in water for 30 minutes, ultrasonically extract twice at 25°C, one time 12 times the amount for 40 minutes, the other time 10 times the amount for 40 minutes, filter the combined filtrate, 55- Concentrate under reduced pressure at 60°C to a relative density, make a 60°C extract of 1.3, store separately, and set aside; soak kudzu root, gastrodia elata, salvia miltiorrhiza, Prunella vulgaris, Eucommia, cassia, Alisma, and hawthorn in water for 30 minutes, then set aside at 55°C. Ultrasonic extraction twice, one time 10 times of water for 40 minutes, the other time 8 times of water for 40 minutes, filter the combined filtrate, concentrate under reduced pressure at 55-60 ° C to the extract at 60 ° C with a density of 1.15, add 95% ethanol to make the alcohol The content reaches 70%, stand overnight, the supernatant is 55-60°C, and the ethanol is recovered under reduced pressure and concentrated to a relative density of 1.3. Ultrasonic extraction twice at ℃, both times 8 times the amount for 60 minutes, filter, combine the extract at 55-60°C and concentrate it under reduced pressure to a relative density of 1.3 at 60°C, combine the above three parts of the extract, add microcrystalline cellulose Appropriate amount, fully stirred, mixed evenly, vacuum-dried at 55-60°C, crushed after taking out, and sieved through a 20-mesh sieve to obtain powder; choose enteric-coated capsule shells and fill them with powder to make enteric-coated capsules, 0.6g per capsule.

Embodiment three

A traditional Chinese medicine for treating hypertension, which is prepared from the following raw materials: Prunella vulgaris, Pueraria lobata, Gastrodia elata, Eucommia ulmoides, Chuanxiong, Alisma, hawthorn, earthworm, salvia miltiorrhiza, and cassia seeds. The weights of these raw materials are: 12.5 grams, 15 grams, 4 grams, 3.5 grams, 6.5 grams, 7 grams, 5~6 parts, 1 gram, 11 grams, 11 grams.

The preparation method of the enteric-coated capsules of the above-mentioned traditional Chinese medicine is as follows: after soaking the earthworm in water for 30 minutes, ultrasonically extract twice at 25°C, one time 12 times the amount for 40 minutes, the other time 10 times the amount for 40 minutes, filter the combined filtrate, 55- Concentrate under reduced pressure at 60°C to a relative density, make a 60°C extract of 1.3, store separately, and set aside; soak kudzu root, gastrodia elata, salvia miltiorrhiza, Prunella vulgaris, Eucommia, cassia, Alisma, and hawthorn in water for 30 minutes, then set aside at 55°C. Ultrasonic extraction twice, one time 10 times of water for 40 minutes, the other time 8 times of water for 40 minutes, filter the combined filtrate, concentrate under reduced pressure at 55-60 ° C to the extract at 60 ° C with a density of 1.15, add 95% ethanol to make the alcohol The content reaches 70%, stand overnight, the supernatant is 55-60°C, and the ethanol is recovered under reduced pressure and concentrated to a relative density of 1.3. Ultrasonic extraction twice at ℃, both times 8 times the amount for 60 minutes, filter, combine the extract at 55-60°C and concentrate it under reduced pressure to a relative density of 1.3 at 60°C, combine the above three parts of the extract, add microcrystalline cellulose Appropriate amount, fully stirred, mixed evenly, vacuum-dried at 55-60°C, crushed after taking out, and sieved through a 20-mesh sieve to obtain powder; choose enteric-coated capsule shells and fill them with powder to make enteric-coated capsules, 0.6g per capsule.

The treatment effect analysis is as follows:

1. General information

Hypertension, cerebral ischemia, cerebral hypoxia, hyperlipidemia, cerebral arteriosclerosis, cerebral spasm, manifested as headache, dizziness, bitter mouth, red tongue, thick and greasy tongue coating, numbness of limbs, tinnitus, deafness, blurred vision, Insomnia, high blood pressure or large blood pressure difference after blood pressure test, generally high pressure is between 120/180mmg and low pressure is between 60/70mmg, or patients with cerebral infarction combined with high blood pressure as shown by CT. Subjects and general conditions, the patients are 1289 patients with hypertension, cerebral hypoxia and cerebral ischemia co-diagnosed by my hospital, 721 males and 568 females, the youngest is 35 years old, the oldest is 80 years old, the shortest course of disease is 1 day , a maximum of 5 years.

2. Patient Selection

Generally, patients who come to our stroke department for diagnosis and treatment or cooperative consultation are selected as observation objects. Their conditions are summarized as headache, dizziness, thick and greasy tongue coating, red tongue, bitter mouth, tinnitus, deafness, irritability, sleep debt, dim vision, Patients with one side of limb weakness, numbness or sequelae of stroke and patients with high blood pressure all year round. Blood pressure above 130/80mmg.

Three, the treatment method of the present invention

Take capsules, orally three times a day, 2-3 capsules each time, after meals. Note: Pregnant women contraindicated.

4. Efficacy Evaluation Criteria

1. Efficacy standard:

Markedly effective: after taking the medicine of the present invention, headache, dizziness, tinnitus, deafness and other symptoms disappear or are obviously alleviated.

Take a turn for the better: after taking medicine of the present invention, headache, dizzy, tinnitus, irritability obviously alleviate.

Invalid: After taking the medicine of the present invention, there is still the phenomenon of blood pressure instability and repeated symptoms.

2. Diagnostic criteria

Blood pressure was stable at 130/80mmg.

5. Results

The patients in group A took the antihypertensive enteric-coated capsules prepared by the present invention, and the patients in group B took the commercially available compound apocynum tablets. The clinical trial results are as follows:

It can be seen from the above table that the treatment effect of group A is significantly better than that of group B.

6. Typical cases

1. A veteran cadre in Xinmi City, Henan Province, so-and-so, male, 75 years old, has suffered from high blood pressure for several years. Today, he has dizziness, stiff neck, numbness of left limbs, irritability, dim eyes, bitter mouth, blood pressure 160/110mmg, bitter mouth, Greasy tongue coating, normal urine and stool, poor rest, took Tianlong Jiangya Capsules for 3 days, headache and dizziness were significantly relieved, after taking the medicine for 20 days, the tongue coating was light, white, thin, headache and dizziness completely disappeared, sleep was good, after taking the medicine for 30 days, limb numbness Disappeared, blood pressure returned to 130/80mmg, took medicine continuously for 60 days, blood pressure was stable, without discomfort, took medicine for 3 courses, blood pressure was stable, without attack, blood pressure was at 130/85mmg. Return visit after 6 months, the state of an illness does not relapse, and blood pressure tends to be normal.

2. XX, male, 56 years old, Xuchang City, Henan Province, suffering from high blood pressure for more than 3 years, headache, dizziness today, cerebral infarction for 6 months, weakness of one side of limbs, bitter mouth, poor spirit, blood pressure 180/ 110mmg, vision decreased obviously, cicadas sounded in both ears, stool once every 3 days, headache and dizziness improved after taking Tianlong Jiangya Capsules for 4 days, headache, dizziness and tinnitus disappeared after 15 days, appetite increased and spirit improved, taking a course of medicine, basically Symptoms disappeared completely, blood pressure test was 145/95mmg, blood pressure stabilized at 135/85mmg after taking medicine for two courses, put an end to taking western antihypertensive drugs, return visit after 5 years, no recurrence.

Claims (2)

1. A Chinese medicine for treating hypertension, which is prepared from the following raw materials: Prunella vulgaris, Pueraria lobata, Gastrodia elata, Eucommia ulmoides, Rhizoma Chuanxiong, Alisma, hawthorn, earthworm, salvia miltiorrhiza, Semen Cassiae, and the parts by weight of these raw materials are successively : 10~15 parts, 10~20 parts, 3~5 parts, 3~4 parts, 5~8 parts, 6~8 powder, 5~6 parts, 10~12 parts, 10~12 parts, 10~12 parts . 2. A method for preparing enteric-coated capsules of traditional Chinese medicine for treating hypertension as claimed in claim 1, characterized in that: the preparation method is as follows: after soaking the earthworm in water for 30 minutes, ultrasonically extracting twice at 25°C, wherein Once 12 times the amount for 40 minutes, and another time 10 times the amount for 40 minutes, filter the combined filtrate, concentrate under reduced pressure at 55-60°C to a relative density, and make a 1.3 extract at 60°C, set aside, and set aside; Gastrodia elata, salvia miltiorrhiza, Prunella vulgaris, Eucommia ulmoides, cassia seeds, Alisma, and hawthorn were soaked in water for 30 minutes, then ultrasonically extracted twice at 55°C, one time was 10 times water for 40 minutes, the other time was 8 times water for 40 minutes, and the combined filtrate was filtered, 55 Concentrate under reduced pressure at -60°C to the 60°C extract with a density of 1.15, add 95% ethanol to make the alcohol content reach 70%, let it stand overnight, the supernatant is 55-60°C, recover the ethanol under reduced pressure and concentrate to relative The one with a density of 1.3 is the extract at 60°C, set aside for later use, and the Ligusticum chuanxiong is soaked in 60% ethanol for 30 minutes, then ultrasonically extracted twice at 55°C, both times are 8 times the amount for 60 minutes, filtered, and combined at 55-60°C Concentrate under reduced pressure to a relative density of 1.3 at 60°C extract, combine the above three parts of extract, add an appropriate amount of microcrystalline cellulose, stir well, mix evenly, vacuum dry at 55-60°C, take it out and crush it, pass 20 Mesh sieve to obtain powder; select the enteric-coated capsule shell and fill it with powder to make enteric-coated capsules.