CN105411871A - 复方药物牙膏 - Google Patents
复方药物牙膏 Download PDFInfo
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- CN105411871A CN105411871A CN201510916722.6A CN201510916722A CN105411871A CN 105411871 A CN105411871 A CN 105411871A CN 201510916722 A CN201510916722 A CN 201510916722A CN 105411871 A CN105411871 A CN 105411871A
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- combination
- acid
- medicinal toothpaste
- zinc
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- 229940034610 toothpaste Drugs 0.000 title claims abstract description 32
- 239000000606 toothpaste Substances 0.000 title claims abstract description 32
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- CUCUKLJLRRAKFN-UHFFFAOYSA-N 7-Hydroxy-(S)-usnate Chemical compound CC12C(=O)C(C(=O)C)C(=O)C=C1OC1=C2C(O)=C(C)C(O)=C1C(C)=O CUCUKLJLRRAKFN-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229940004858 usnic acid Drugs 0.000 claims abstract description 20
- ICTZCAHDGHPRQR-UHFFFAOYSA-N usnic acid Natural products OC1=C(C)C(O)=C(C(C)=O)C2=C1C1(C)C(O)=C(C(=O)C)C(=O)C=C1O2 ICTZCAHDGHPRQR-UHFFFAOYSA-N 0.000 claims abstract description 20
- WEYVVCKOOFYHRW-UHFFFAOYSA-N usninic acid Natural products CC12C(=O)C(C(=O)C)=C(O)C=C1OC1=C2C(O)=C(C)C(O)=C1C(C)=O WEYVVCKOOFYHRW-UHFFFAOYSA-N 0.000 claims abstract description 20
- VVOAZFWZEDHOOU-UHFFFAOYSA-N magnolol Chemical compound OC1=CC=C(CC=C)C=C1C1=CC(CC=C)=CC=C1O VVOAZFWZEDHOOU-UHFFFAOYSA-N 0.000 claims abstract description 18
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 claims abstract description 14
- 229960000401 tranexamic acid Drugs 0.000 claims abstract description 14
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 150000007524 organic acids Chemical class 0.000 claims abstract description 13
- 239000011701 zinc Substances 0.000 claims abstract description 13
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 13
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000002131 composite material Substances 0.000 claims description 20
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- 235000013599 spices Nutrition 0.000 claims description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
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- 239000011230 binding agent Substances 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- 239000004094 surface-active agent Substances 0.000 claims description 9
- 239000000080 wetting agent Substances 0.000 claims description 9
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 6
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 6
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- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 6
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 6
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical group C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 3
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 3
- BHWMZEPWQUFLLQ-HSHFZTNMSA-N (2R)-2-hydroxypropanoic acid zinc Chemical compound [Zn].C[C@@H](O)C(O)=O BHWMZEPWQUFLLQ-HSHFZTNMSA-N 0.000 claims description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 3
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- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- 229920002907 Guar gum Polymers 0.000 claims description 3
- 235000006679 Mentha X verticillata Nutrition 0.000 claims description 3
- 235000002899 Mentha suaveolens Nutrition 0.000 claims description 3
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 3
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 3
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 3
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- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 3
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 3
- YGZOLUSJFYDOMD-UHFFFAOYSA-N [Na].CC12C(=O)C(C(=O)C)C(=O)C=C1OC1=C2C(O)=C(C)C(O)=C1C(C)=O Chemical group [Na].CC12C(=O)C(C(=O)C)C(=O)C=C1OC1=C2C(O)=C(C)C(O)=C1C(C)=O YGZOLUSJFYDOMD-UHFFFAOYSA-N 0.000 claims description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 3
- 229910021502 aluminium hydroxide Inorganic materials 0.000 claims description 3
- 229940024545 aluminum hydroxide Drugs 0.000 claims description 3
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 claims description 3
- 239000000605 aspartame Substances 0.000 claims description 3
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 3
- 235000010357 aspartame Nutrition 0.000 claims description 3
- 229960003438 aspartame Drugs 0.000 claims description 3
- 235000010233 benzoic acid Nutrition 0.000 claims description 3
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- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- 235000010216 calcium carbonate Nutrition 0.000 claims description 3
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims description 3
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 3
- 229940043256 calcium pyrophosphate Drugs 0.000 claims description 3
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- 235000010418 carrageenan Nutrition 0.000 claims description 3
- 239000000679 carrageenan Substances 0.000 claims description 3
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- 235000019821 dicalcium diphosphate Nutrition 0.000 claims description 3
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 3
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 claims description 3
- 235000013399 edible fruits Nutrition 0.000 claims description 3
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 235000009569 green tea Nutrition 0.000 claims description 3
- 239000000665 guar gum Substances 0.000 claims description 3
- 235000010417 guar gum Nutrition 0.000 claims description 3
- 229960002154 guar gum Drugs 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 3
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 3
- 235000013336 milk Nutrition 0.000 claims description 3
- 239000008267 milk Substances 0.000 claims description 3
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- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 239000011591 potassium Substances 0.000 claims description 3
- 229910052700 potassium Inorganic materials 0.000 claims description 3
- 239000004302 potassium sorbate Substances 0.000 claims description 3
- 235000010241 potassium sorbate Nutrition 0.000 claims description 3
- 229940069338 potassium sorbate Drugs 0.000 claims description 3
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 3
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 3
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- 229940005550 sodium alginate Drugs 0.000 claims description 3
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 3
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- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 3
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- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 3
- 239000000230 xanthan gum Substances 0.000 claims description 3
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 3
- 229960002675 xylitol Drugs 0.000 claims description 3
- 239000011746 zinc citrate Substances 0.000 claims description 3
- 235000006076 zinc citrate Nutrition 0.000 claims description 3
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- 239000011670 zinc gluconate Substances 0.000 claims description 3
- 235000011478 zinc gluconate Nutrition 0.000 claims description 3
- 229960000306 zinc gluconate Drugs 0.000 claims description 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 10
- 230000002195 synergetic effect Effects 0.000 abstract description 7
- 206010018276 Gingival bleeding Diseases 0.000 abstract description 5
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 abstract description 4
- 208000002064 Dental Plaque Diseases 0.000 abstract description 2
- 206010061218 Inflammation Diseases 0.000 abstract description 2
- 208000007117 Oral Ulcer Diseases 0.000 abstract description 2
- 208000002399 aphthous stomatitis Diseases 0.000 abstract description 2
- 210000004195 gingiva Anatomy 0.000 abstract description 2
- 230000023597 hemostasis Effects 0.000 abstract description 2
- 230000008961 swelling Effects 0.000 abstract description 2
- 208000024891 symptom Diseases 0.000 abstract description 2
- SIZDUQQDBXJXLQ-UHFFFAOYSA-N 2-(3-acetyl-2,2-dimethylcyclobutyl)acetic acid Chemical compound CC(=O)C1CC(CC(O)=O)C1(C)C SIZDUQQDBXJXLQ-UHFFFAOYSA-N 0.000 abstract 1
- 206010015150 Erythema Diseases 0.000 abstract 1
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- 241000894006 Bacteria Species 0.000 description 2
- 208000006558 Dental Calculus Diseases 0.000 description 2
- 230000001408 fungistatic effect Effects 0.000 description 2
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- 208000000412 Avitaminosis Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010021135 Hypovitaminosis Diseases 0.000 description 1
- 208000005888 Periodontal Pocket Diseases 0.000 description 1
- 241000605862 Porphyromonas gingivalis Species 0.000 description 1
- 241000605861 Prevotella Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
本发明涉及一种复方药物牙膏，其以摩擦剂、保湿剂和去离子水为主要成分，并且至少添加有氨甲环酸、有机酸锌、松萝酸和/或松萝酸盐的组合。本案采用氨甲环酸、松罗酸和/或松罗酸盐、锌离子联合使用的方式，使牙膏具有很强的止血、抗菌、抗炎功能，能快速防止牙龈出血，有效缓解牙龈红肿、口腔溃疡、牙菌斑等症状；同时，引入的厚朴酚能与上述配方产生协效作用，进一步提高牙膏的抗菌止血效果。
Description
技术领域
本发明涉及一种牙膏，具体涉及一种复方药物牙膏。
背景技术
牙龈炎是常见的牙周组织疾病，是由于不注意口腔卫生，牙齿受到牙齿周围食物残渣、细菌等物结成的软质的牙垢和硬质的牙石所致的长期刺激，以及不正确的刷牙习惯，维生素缺乏等原因所造成。全国35岁～44岁年龄段人群牙周健康率为14.5％，城市高于农村，女性高于男性，西部地区最高；牙龈出血检出率为77.3％，人均有牙龈出血的牙数为8.77颗，女性高于男性，城乡无差异，中部地区最高；牙周袋检出率为40.9％，城市低于农村，男性高于女性，中部地区最高；附着丧失等于或4毫米的检出率为38.9％，男性高于女性，城乡无差异，东部地区最高。
目前市场上也存在一些质量参差不齐的药物牙膏，但有些牙膏的抑菌效果较差，无法真正实现抗菌消炎的功效。
发明内容
针对现有技术的不足之处，本发明的目的在于提供一种复方药物牙膏，其能起到快速防止牙龈出血，有效抑制口腔细菌的目的。
本发明的技术方案概述如下：
一种复方药物牙膏，其以摩擦剂、保湿剂和去离子水为主要成分，并且至少添加有氨甲环酸、有机酸锌、松萝酸和/或松萝酸盐的组合。
优选的是，所述的复方药物牙膏，其中，所述氨甲环酸的含量为0.01～1wt％。
优选的是，所述的复方药物牙膏，其中，所述有机酸锌的含量为0.01～5wt％，所述有机酸锌选自柠檬酸锌、葡萄糖酸锌、左旋乳酸锌或其组合。
优选的是，所述的复方药物牙膏，其中，所述松萝酸和松萝酸盐的总含量为0.01～10wt％，所述松萝酸盐选自松萝酸钠、松萝酸钾或其组合。
优选的是，所述的复方药物牙膏，其中，所述摩擦剂选自碳酸钙、磷酸氢钙、焦磷酸钙、水合硅石、氢氧化铝或其组合；所述摩擦剂的含量为10～30wt％；
所述保湿剂选自甘油、山梨醇、丙二醇、聚乙二醇或其组合；所述保湿剂的含量为30～50wt％。
优选的是，所述的复方药物牙膏，其中，还包括粘合剂、表面活性剂、甜味剂、香精、清凉剂和防腐剂。
优选的是，所述的复方药物牙膏，其中，所述粘合剂选自瓜尔胶、卡拉胶、黄原胶、羧甲基纤维素钠、硅酸镁铝、海藻酸钠、纤维素胶或其组合；所述粘合剂的含量为0.2～1.5wt％；
所述表面活性剂选自月桂醇硫酸酯钠或十二烷基硫酸钠；所述表面活性剂的含量为1～5wt％；
所述甜味剂选自糖精、糖精钠、阿斯巴甜、甜菊糖、三氯蔗糖、木糖醇或其组合；所述甜味剂的含量为0.1～0.5wt％；
所述香料选自薄荷香料、留兰香料、绿茶香料、牛奶香精、水果类香料或其组合；所述香料的含量为0.1～0.5wt％；
所述清凉剂选自冰片、薄荷脑或其组合；所述清凉剂的含量为0.1～0.8wt％；
所述防腐剂选自苯甲酸、苯甲酸钠、山梨酸、山梨酸钾、尼泊金甲酯、尼泊金丙酯、尼泊金丁酯或其组合；所述防腐剂的含量为0.05～0.5wt％。
优选的是，所述的复方药物牙膏，其中，还包括0.05～0.2wt％的厚朴酚。
本发明的有益效果是：本案采用氨甲环酸、松罗酸和/或松罗酸盐、锌离子联合使用的方式，使牙膏具有很强的止血、抗菌、抗炎功能，能快速防止牙龈出血，有效缓解牙龈红肿、口腔溃疡、牙菌斑等症状；同时，引入的厚朴酚能与上述配方产生协效作用，进一步提高牙膏的抗菌止血效果。
具体实施方式
下面结合实施例对本发明做进一步的详细说明，以令本领域技术人员参照说明书文字能够据以实施。
本案提出一实施例的复方药物牙膏，其以摩擦剂、保湿剂和去离子水为主要成分，并且至少添加有氨甲环酸、有机酸锌、松萝酸和/或松萝酸盐的组合。松萝酸和/或松萝酸盐的意思是单一的松萝酸或单一的松萝酸盐或松萝酸+松萝酸盐的任意比组合。氨甲环酸、有机酸锌、松萝酸和/或松萝酸盐是一个密不可分的有机整体，这些成分之间能够相互促进产生协效作用，共同提高牙膏的抗菌止血能力，例如，氨甲环酸能够协同提高锌离子和松萝酸或松萝酸盐结合后的抗菌性能；锌离子和松萝酸或松萝酸盐也能协同提高氨甲环酸的凝血止血性能。并且，这几种成分的含量应被限定，具体如下：
在上述实施例中，氨甲环酸的含量优选为0.01～1wt％。
在上述实施例中，有机酸锌的含量优选为0.01～5wt％，有机酸锌优选选自柠檬酸锌、葡萄糖酸锌、左旋乳酸锌或其组合。
在上述实施例中，松萝酸和松萝酸盐的总含量优选为0.01～10wt％，总含量中可以全部是松萝酸或全部是松萝酸盐，或是松萝酸+松萝酸盐的任意比组合，松萝酸盐优选选自松萝酸钠、松萝酸钾或其组合。
若上述几种成分中的某一个成分的含量超出限定的范围，或者删去其中的某一个成分或多出另一个新的药物成分，都将导致牙膏的抑菌效果和止血效果下降。
在上述实施例中，摩擦剂优选选自碳酸钙、磷酸氢钙、焦磷酸钙、水合硅石、氢氧化铝或其组合；摩擦剂的含量优选为10～30wt％；
保湿剂优选选自甘油、山梨醇、丙二醇、聚乙二醇或其组合；保湿剂的含量优选为30～50wt％。
作为本案另一实施例，其中，还包括粘合剂、表面活性剂、甜味剂、香精、清凉剂和防腐剂。
其中，粘合剂选自瓜尔胶、卡拉胶、黄原胶、羧甲基纤维素钠、硅酸镁铝、海藻酸钠、纤维素胶或其组合；粘合剂的含量为0.2～1.5wt％；
表面活性剂选自月桂醇硫酸酯钠或十二烷基硫酸钠；表面活性剂的含量为1～5wt％；
甜味剂选自糖精、糖精钠、阿斯巴甜、甜菊糖、三氯蔗糖、木糖醇或其组合；甜味剂的含量为0.1～0.5wt％；
香料选自薄荷香料、留兰香料、绿茶香料、牛奶香精、水果类香料或其组合；香料的含量为0.1～0.5wt％；
清凉剂选自冰片、薄荷脑或其组合；清凉剂的含量为0.1～0.8wt％；
防腐剂选自苯甲酸、苯甲酸钠、山梨酸、山梨酸钾、尼泊金甲酯、尼泊金丙酯、尼泊金丁酯或其组合；防腐剂的含量为0.05～0.5wt％。
作为本案又一实施例，其中，还包括0.05～0.2wt％的厚朴酚。厚朴酚能够协同提高氨甲环酸、有机酸锌、松萝酸和/或松萝酸盐的抗菌能力，但厚朴酚的协效作用也需要被协效体高度的完整性，缺少氨甲环酸、有机酸锌、松萝酸和/或松萝酸盐中的任何一种或者这些成分中的任意一种含量超出优选的范围，都将导致其协效作用降低，甚至消失。若牙膏中仅含有厚朴酚一种成分，其所展现出的抗菌止血功能十分微弱；厚朴酚的含量也应受到限制，超出优选的范围，会使得它的协效作用受到影响。
表一列出不同实施例和对比例的具体成分及其含量，其中各成分之外的余量为去离子水，各成分与去离子水的总和为100％，表一中略去了去离子水。
表一
本案选取牙龈卟啉单胞菌、中间普雷沃氏菌、粘性放线菌、大肠杆菌、金黄色葡萄球菌这五种菌并参考GB15979-2002附录C3进行抗菌实验。
表二列出了实施例1、2和对比例1、2的抗菌实验结果。
表二
表三列出了实施例3、4和对比例3、4的抗菌实验结果。
表三
尽管本发明的实施方案已公开如上，但其并不仅仅限于说明书和实施方式中所列运用，它完全可以被适用于各种适合本发明的领域，对于熟悉本领域的人员而言，可容易地实现另外的修改，因此在不背离权利要求及等同范围所限定的一般概念下，本发明并不限于特定的细节和这里示出的实施例。
Claims (8)
1.一种复方药物牙膏，其特征在于，其以摩擦剂、保湿剂和去离子水为主要成分，并且至少添加有氨甲环酸、有机酸锌、松萝酸和/或松萝酸盐的组合。
2.根据权利要求1所述的复方药物牙膏，其特征在于，所述氨甲环酸的含量为0.01～1wt％。
3.根据权利要求1所述的复方药物牙膏，其特征在于，所述有机酸锌的含量为0.01～5wt％，所述有机酸锌选自柠檬酸锌、葡萄糖酸锌、左旋乳酸锌或其组合。
4.根据权利要求1所述的复方药物牙膏，其特征在于，所述松萝酸和松萝酸盐的总含量为0.01～10wt％，所述松萝酸盐选自松萝酸钠、松萝酸钾或其组合。
5.根据权利要求1所述的复方药物牙膏，其特征在于，所述摩擦剂选自碳酸钙、磷酸氢钙、焦磷酸钙、水合硅石、氢氧化铝或其组合；所述摩擦剂的含量为10～30wt％；
所述保湿剂选自甘油、山梨醇、丙二醇、聚乙二醇或其组合；所述保湿剂的含量为30～50wt％。
6.根据权利要求1所述的复方药物牙膏，其特征在于，还包括粘合剂、表面活性剂、甜味剂、香精、清凉剂和防腐剂。
7.根据权利要求6所述的复方药物牙膏，其特征在于，所述粘合剂选自瓜尔胶、卡拉胶、黄原胶、羧甲基纤维素钠、硅酸镁铝、海藻酸钠、纤维素胶或其组合；所述粘合剂的含量为0.2～1.5wt％；
所述表面活性剂选自月桂醇硫酸酯钠或十二烷基硫酸钠；所述表面活性剂的含量为1～5wt％；
所述甜味剂选自糖精、糖精钠、阿斯巴甜、甜菊糖、三氯蔗糖、木糖醇或其组合；所述甜味剂的含量为0.1～0.5wt％；
所述香料选自薄荷香料、留兰香料、绿茶香料、牛奶香精、水果类香料或其组合；所述香料的含量为0.1～0.5wt％；
所述清凉剂选自冰片、薄荷脑或其组合；所述清凉剂的含量为0.1～0.8wt％；
所述防腐剂选自苯甲酸、苯甲酸钠、山梨酸、山梨酸钾、尼泊金甲酯、尼泊金丙酯、尼泊金丁酯或其组合；所述防腐剂的含量为0.05～0.5wt％。
8.根据权利要求1所述的复方药物牙膏，其特征在于，还包括0.05～0.2wt％的厚朴酚。
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