CN105407870A - Organogel composition and organogel mask pack produced by using same - Google Patents
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Abstract
Description
技术领域technical field
本发明涉及有机凝胶组合物及其制备的有机凝胶面膜,更具体地涉及一种有机凝胶组合物,其中悬浮在该有机凝胶中的活性成分具有良好的经表皮的吸收,以及使用该有机凝胶组合物制备的有机凝胶面膜。The present invention relates to an organogel composition and an organogel facial mask prepared therefrom, more particularly to an organogel composition, wherein the active ingredients suspended in the organogel have good absorption through the epidermis, and use An organogel facial mask prepared from the organogel composition.
背景技术Background technique
术语“有机凝胶”最初用于描述具体水包油反向微乳液凝胶的概念(瑞斯(Luisi)等的《胶体与聚合物科学(Colloid&PolymerScience)》,1990,268卷,第356-374页)。The term "organogel" was originally used to describe the concept of specific oil-in-water inverse microemulsion gels (Colloid & Polymer Science, 1990, Vol. 268, pp. 356-374 by Luisi et al. Page).
现在,该术语包括胶凝的体系,主要是含有由富含磷脂酰胆碱的卵磷脂稳定化的两个不互溶相的氢化的体系(威廉姆(Williman)等的《药学科学期刊(JournalofPharmaceuticalScience)》,1992,81卷,第871-874页和斯切其普诺夫(Schchipunov)等的《凝胶期刊(ColloidJournal)》,1995,57卷,第556-560页)。有机凝胶具有与皮肤结构相似的薄片相,其特征在于,凝胶的获取不需要胶凝剂。The term now includes gelled systems, primarily hydrogenated systems containing two immiscible phases stabilized by phosphatidylcholine-rich lecithin (Journal of Pharmaceutical Science by William et al. ", 1992, Vol. 81, pp. 871-874 and Schchipunov et al., "Colloid Journal", 1995, Vol. 57, pp. 556-560). Organogels have a lamellar phase similar in structure to the skin, characterized in that gelling agents are not required for the acquisition of the gel.
有机凝胶,特别是卵磷脂有机凝胶,由于其具有与皮肤相似的薄片结构而具有对皮肤的亲和性,同时也可在很长一段时间内在皮肤上保持保湿效果。因此,有机凝胶已在各种美容组合物中使用。Organogels, especially lecithin organogels, have affinity for the skin due to their skin-like lamella structure, while also maintaining a moisturizing effect on the skin for a long period of time. Accordingly, organogels have been used in various cosmetic compositions.
韩国专利第0843155号公开了含有由具有卵磷脂-有机凝胶结构的卵磷脂凝胶稳定化的维生素C的皮肤美白的美容组合物。Korean Patent No. 0843155 discloses a skin whitening cosmetic composition containing vitamin C stabilized by a lecithin gel having a lecithin-organogel structure.
此外,韩国专利第0824212号公开了含有通过在有机凝胶中收集而稳定化的胎盘的皮肤保护美容组合物。In addition, Korean Patent No. 0824212 discloses a skin protection cosmetic composition containing placenta stabilized by collecting it in an organogel.
预计改善的有机凝胶组合物对于面膜是有用的,在该凝胶组合物中悬浮在有机凝胶中的活性成分能容易且快速地递送。Improved organogel compositions in which active ingredients suspended in an organogel can be delivered easily and rapidly are expected to be useful for facial masks.
发明内容Contents of the invention
技术问题technical problem
本发明的一个方面提供了一种有机凝胶组合物,其活性成分能容易地经表皮的吸收。One aspect of the present invention provides an organogel composition, the active ingredient of which is easily absorbed through the epidermis.
本发明的另一个方面提供了采用上述有机凝胶组合物制备的有机凝胶面膜。Another aspect of the present invention provides an organogel mask prepared by using the above-mentioned organogel composition.
技术方案Technical solutions
根据本发明的一个方面,有机凝胶组合物包含油、油胶凝剂、多元醇、水、胶凝聚合物和活性成分。According to one aspect of the invention, an organogel composition comprises oil, an oil gelling agent, a polyol, water, a gelling polymer and an active ingredient.
根据本发明的另一个方面,有机凝胶面膜是使用上述有机凝胶组合物制备的。According to another aspect of the present invention, an organogel facial mask is prepared using the above-mentioned organogel composition.
有益效果Beneficial effect
根据本发明的有机凝胶组合物具有的有机凝胶结构由于其薄片结构(与皮肤的结构相似)而与皮肤具有改善的亲和性,因此活性成分可容易且快速地递送。此外,本发明的有机凝胶组合物具有相对高的油含量,因此各种油质的活性成分可容易递送,皮肤水分可保持很长一段时间,从而减少了皮肤的水分流失。The organogel composition according to the present invention has an organogel structure that has improved affinity with the skin due to its sheet structure (similar to that of the skin), so active ingredients can be delivered easily and quickly. In addition, the organogel composition of the present invention has a relatively high oil content, so various oil-based active ingredients can be easily delivered, and skin moisture can be maintained for a long time, thereby reducing skin moisture loss.
最佳实施方式best practice
根据本发明的一个方面,提供一种有机凝胶组合物,在该组合物中,悬浮在有机凝胶中的活性成分可容易地被经表皮的吸收。According to one aspect of the present invention, there is provided an organogel composition in which an active ingredient suspended in an organogel can be easily absorbed transepidermally.
更具体地,根据本发明,有机凝胶组合物包含油、油胶凝剂、多元醇、水、胶凝聚合物和活性成分。More specifically, according to the present invention, an organogel composition comprises oil, an oil gelling agent, a polyol, water, a gelling polymer and an active ingredient.
可用于本发明的油可为选自下组中的至少一种:肉豆蔻酸异丙酯、月桂酸乙酯、肉豆蔻酸乙酯、棕榈酸异丙酯、环戊烷、环辛烷、反式十氢化萘、正戊烷、正己烷、正十六烷、三丙胺、1,7-辛二烯、月桂酸丁酯、环十二烷、二丁基醚、异辛烷、正辛烷、三丁胺、三异丁基胺、多元醇酯、甘油三酯、甘油二酯、甘油单酯、甘油二酯和脂肪酸酯,此外,可以是选自下组的至少一种或多种的混合物:酯油,例如辛酸/癸酸甘油三酯、丁二醇二辛酸酯/二癸酸酯、三异辛酸甘油脂(triethylhexanoin)、乙基己酸十六烷基酯、肉豆蔻酸异丙酯、辛基十二烷醇;烃油,例如液体石蜡、矿脂、氢化聚癸烯、鲨烯;蜡,例如微晶蜡、蜂蜡、羊毛脂蜡;天然油,例如霍霍巴油(jojobaoil)、鳄梨油、杏仁油、橄榄油、芝麻油、麦胚芽油、红花油、山茶油、蓖麻油、葡萄籽油、茶籽油(Camelliasinensisseedoil)、澳洲坚果油、椰子油、玫瑰果油、硬化油、摩洛哥坚果油(arganoil)、沙棘油(Hippophaerhamnoidesoil)、刺阿干树仁油(Arganiaspinosakerneloil)、薰衣草油;硅油,例如环甲硅油、苯基三甲硅油(phenyltrimethicone)、环戊硅氧烷、二甲聚硅氧烷,但不限于前述种类。优选使用的是酯油,例如辛酸/癸酸甘油三酯、丁二醇二辛酸酯/二癸酸酯、甘油三(乙基己酸)酯、乙基己酸十六烷基酯、肉豆蔻酸异丙酯、辛基十二烷醇。The oil that can be used in the present invention may be at least one selected from the group consisting of isopropyl myristate, ethyl laurate, ethyl myristate, isopropyl palmitate, cyclopentane, cyclooctane, Trans-decalin, n-pentane, n-hexane, n-hexadecane, tripropylamine, 1,7-octadiene, butyl laurate, cyclododecane, dibutyl ether, isooctane, n-octyl Alkanes, tributylamine, triisobutylamine, polyol esters, triglycerides, diglycerides, monoglycerides, diglycerides and fatty acid esters, in addition, may be at least one or more selected from the following group Mixture of species: ester oils such as caprylic/capric triglyceride, butylene glycol dicaprylate/dicaprate, triethylhexanoin, cetyl ethylhexanoate, myristate isopropyl ester, octyldodecanol; hydrocarbon oils such as liquid paraffin, petrolatum, hydrogenated polydecene, squalene; waxes such as microcrystalline wax, beeswax, lanolin wax; natural oils such as jojoba oil (jojoba oil), Avocado Oil, Almond Oil, Olive Oil, Sesame Oil, Wheat Germ Oil, Safflower Oil, Camellia Oil, Castor Oil, Grape Seed Oil, Camelliasinensissedoil, Macadamia Oil, Coconut Oil, Rosehip Oils, hardened oils, argan oil, Hippophaerhamnoides oil, Argania spinosa kernel oil, lavender oil; silicone oils such as cyclomethicone, phenyltrimethicone, cyclopentasiloxane alkanes, dimethicone, but not limited to the aforementioned types. Preferably used are ester oils such as caprylic/capric triglyceride, butylene glycol dicaprylate/dicaprate, tri(ethylhexanoate), cetyl ethylhexanoate, meat Isopropyl myristate, Octyldodecanol.
以用于面膜的有机凝胶组合物的总重量为基准计,所述油的含量可为5-45重量%,更优选为10-30重量%。如果以用于面膜的有机凝胶组合物的总重量为基准计,所述油的含量低于10重量%,油的含量太低不能形成所需的有机凝胶组合物,且可能减少所需的活性成分的经表皮的吸收。如果油的含量高于45重量%,那么油从水相分离,很难形成最终的面膜。Based on the total weight of the organogel composition for facial masks, the content of the oil may be 5-45% by weight, more preferably 10-30% by weight. If the content of the oil is less than 10% by weight, based on the total weight of the organogel composition for facial masks, the oil content is too low to form the desired organogel composition and may reduce the Transdermal absorption of active ingredients. If the content of the oil is higher than 45% by weight, the oil is separated from the water phase and it is difficult to form the final mask.
油胶凝剂可以是选自下组的至少一种:卵磷脂、普朗尼克卵磷脂(Pluroniclecithin)、脂肪酸山梨醇酯、明胶、L-赖氨酸、柠檬烯和聚乙烯,并且可使用它们的混合物。The oil gelling agent may be at least one selected from the group consisting of lecithin, pluroniclecithin, fatty acid sorbitol ester, gelatin, L-lysine, limonene and polyethylene, and their mixture.
以用于面膜的有机凝胶组合物的总重量为基准计,所述油胶凝剂的含量可为0.1-10重量%,更优选为3-7重量%。如果以用于面膜的有机凝胶组合物的总重量为基准计,所述油胶凝剂的含量低于0.1重量%,会存在油从水相分离的问题。如果油胶凝剂的含量高于10重量%,会存在导致有机凝胶低弹性的问题。Based on the total weight of the organogel composition for facial masks, the content of the oil gelling agent may be 0.1-10% by weight, more preferably 3-7% by weight. If the content of the oil gelling agent is less than 0.1% by weight based on the total weight of the organogel composition for facial masks, there may be a problem of separation of oil from the water phase. If the content of the oil gelling agent is higher than 10% by weight, there is a problem of causing low elasticity of the organogel.
可用于本发明的多元醇与水一起作为溶剂。所述多元醇可以是选自下组的至少一种:甘油、乙二醇、丙二醇、二丙二醇和丁二醇或它们的混合物。The polyols useful in the present invention are used together with water as a solvent. The polyhydric alcohol may be at least one selected from the group consisting of glycerin, ethylene glycol, propylene glycol, dipropylene glycol, and butanediol, or mixtures thereof.
以有机凝胶组合物的总重量为基准计,所述多元醇的含量可为0.5-35重量%,更优选为5-15重量%。如果多元醇的含量低于0.5重量%,则胶凝聚合物很难被分散。如果多元醇的含量高于35重量%,那么水的含量就相对低,从而凝胶的强度会随时间而降低,并且在皮肤上的粘性特征会过度增加。Based on the total weight of the organogel composition, the content of the polyol may be 0.5-35% by weight, more preferably 5-15% by weight. If the content of the polyol is less than 0.5% by weight, the gelled polymer is hardly dispersed. If the polyol content is higher than 35% by weight, the water content is relatively low, so that the strength of the gel decreases with time and the sticky characteristics on the skin increase excessively.
在本发明中,有机凝胶中的水表示剩余量。也就是说,添加的水的量来获得总量为100重量%的组成。可分段式添加水,以这种方式添加水,除了水以外的其它组分会容易地溶解。In the present invention, the water in the organogel represents the remaining amount. That is, the amount of water added to obtain a composition whose total amount is 100% by weight. Water may be added in stages, and in such a manner that other components other than water dissolve easily.
所述胶凝聚合物是选自下组的至少一种或多种的混合物:天然糖,例如半乳甘露聚糖胶、葡甘露聚糖、瓜尔胶、刺槐豆胶、普朗尼克(Pluronic)、琼脂、藻胶、角叉菜胶、黄原胶、胞外多糖、明胶、甲基纤维素、纤维素、羧甲基纤维素和羟乙基纤维素;和亲水性胶凝剂,例如聚丙烯酸酯或其盐、聚甲基丙烯酸酯、羧基乙烯基聚合物、聚乙烯醇、聚丙烯酰胺、聚环氧乙烷、聚乙烯亚胺和聚乙烯基吡咯烷酮。The gelling polymer is a mixture of at least one or more selected from the group consisting of natural sugars such as galactomannan gum, glucomannan, guar gum, locust bean gum, Pluronic ), agar, algin, carrageenan, xanthan gum, gelatin, gelatin, methylcellulose, cellulose, carboxymethylcellulose, and hydroxyethylcellulose; and hydrophilic gelling agents, Examples include polyacrylates or salts thereof, polymethacrylates, carboxyvinyl polymers, polyvinyl alcohols, polyacrylamides, polyethylene oxides, polyethyleneimines, and polyvinylpyrrolidones.
以本发明的有机凝胶组合物的总重量为基准计,所述胶凝聚合物的含量可为0.1-10重量%,更优选为0.5-5重量%。以有机凝胶组合物的总重量为基准计,如果水溶性聚合物的含量低于0.1重量%,可形成凝胶,但该凝胶可能具有高强度和低弹性,并因此减少与皮肤的粘附性。如果所述聚合物含量高于20重量%,由于凝胶可能会松散、断裂并具有低弹性而很难制备凝胶。Based on the total weight of the organogel composition of the present invention, the content of the gelling polymer may be 0.1-10% by weight, more preferably 0.5-5% by weight. If the content of the water-soluble polymer is less than 0.1% by weight based on the total weight of the organogel composition, a gel may be formed, but the gel may have high strength and low elasticity, and thus reduce adhesion to the skin attachment. If the polymer content is higher than 20% by weight, it is difficult to prepare a gel because the gel may loosen, break and have low elasticity.
在本发明中,可添加至少两种胶凝聚合物以获得交联的基质。当所述基质用作美容皮肤膜时,优选保留有机凝胶的形状。In the present invention, at least two gelling polymers may be added to obtain a crosslinked matrix. When the matrix is used as a cosmetic skin film, it is preferable to retain the shape of the organogel.
最优选地,可将至少一种选自下组的支化的聚合物:半乳甘露聚糖胶、葡甘露聚糖、瓜尔胶、刺槐豆胶和普朗尼克,与至少一种选自下组的电解聚合物:琼脂、藻胶、角叉菜胶、黄原胶、胞外多糖和明胶进行混合。Most preferably, at least one branched polymer selected from the group consisting of galactomannan gum, glucomannan, guar gum, locust bean gum and pluronic, and at least one selected from The electrolytic polymers of the following group: agar, algin, carrageenan, xanthan gum, gellan and gelatin were mixed.
所述电解胶凝聚合物使本发明的组合物在室温(约20℃)下,优选在0-30℃下保持凝胶状态。所述支化的胶凝聚合物使本发明的有机凝胶在较高的温度(为10-50℃,优选为接近人体温度的约30-40℃)下流动,从而所述有机凝胶可有效地应用于皮肤。The electrolytic gelling polymer keeps the composition of the present invention in a gel state at room temperature (about 20°C), preferably at 0-30°C. The branched gelling polymers allow the organogels of the present invention to flow at elevated temperatures (between 10-50°C, preferably about 30-40°C close to human body temperature), so that the organogels can Effectively applied to the skin.
以组合物的总重量为基质计,支化的胶凝聚合物和电解胶凝聚合物的含量可分别为0.05-10重量%和0.05-5重量%。如果它们的含量偏离了这些范围,可能不能形成凝胶,或者凝胶可能不能在较高的温度下流动。The content of the branched gelling polymer and the electrolytic gelling polymer may be 0.05-10% by weight and 0.05-5% by weight, respectively, based on the total weight of the composition as the matrix. If their content deviates from these ranges, the gel may not be formed, or the gel may not flow at higher temperatures.
在本发明的组合物中,如果需要,所述胶凝聚合物可与至少一种选自丙烯酸类聚合物、苯乙烯类聚合物和它们的混合物的交联剂混合。例如,所述交联剂可以是选自下组的一种或两种或更多种:丙烯酸钠/丙烯酸C10-30烷基酯交联共聚物(crosspolymer)或丙烯酸钾/丙烯酸C10-30烷基酯交联共聚物、丙烯酸酯/丙烯酸乙基己酯/HEMA/苯乙烯共聚物、丁烯/乙烯/苯乙烯共聚物、丙烯酸铵/甲基苯乙烯/苯乙烯共聚物、苯乙烯/VP共聚物和苯乙烯/丙烯酸酯共聚物。In the composition of the present invention, if desired, the gelling polymer may be mixed with at least one crosslinking agent selected from the group consisting of acrylic polymers, styrenic polymers and mixtures thereof. For example, the crosslinking agent may be one or two or more selected from the group consisting of sodium acrylate/C10-30 alkyl acrylate crosspolymer (crosspolymer) or potassium acrylate/C10-30 alkyl acrylate Acrylate cross-linked copolymer, acrylate/ethylhexyl acrylate/HEMA/styrene copolymer, butene/ethylene/styrene copolymer, ammonium acrylate/methylstyrene/styrene copolymer, styrene/VP copolymers and styrene/acrylate copolymers.
当加入交联剂时,其用于改善本发明的有机凝胶的物理性质,同时促进薄膜形成,从而提高与皮肤的粘附性并且有效地保持水分。此外,交联剂可用于赋予柔软的感觉。以所述有机凝胶组合物的总重量为基准计,所述交联剂可添加0.01-5重量%。When a crosslinking agent is added, it serves to improve the physical properties of the organogel of the present invention while promoting film formation, thereby improving adhesion to the skin and effectively retaining moisture. Additionally, crosslinkers can be used to impart a soft feel. Based on the total weight of the organogel composition, the crosslinking agent can be added in an amount of 0.01-5 wt%.
此外,可在用作面膜的有机凝胶组合物中使用的活性成分可以是选自下组的至少一种:视黄醇、棕榈酸视黄酯、乙酸视黄酯、视黄酸、辅酶Q10、弹性蛋白、胶原、透明质酸、神经酰胺、胶原、咖啡因、壳聚糖、抗坏血酸、抗坏血酸葡糖苷、α-红没药醇、生育酚、醋酸生育酚、熊果苷、烟酰胺、腺苷、维生素A醋酸酯(retinolacetate,)、维生素A、D和E以及其它天然提取物,优选为它们的混合物。In addition, the active ingredient usable in the organogel composition used as a face mask may be at least one selected from the group consisting of retinol, retinyl palmitate, retinyl acetate, retinoic acid, coenzyme Q10 , elastin, collagen, hyaluronic acid, ceramide, collagen, caffeine, chitosan, ascorbic acid, ascorbyl glucoside, α-bisabolol, tocopherol, tocopheryl acetate, arbutin, niacinamide, adenocarcinamide Glycosides, retinolacetate, vitamins A, D and E and other natural extracts, preferably mixtures thereof.
当用根据本发明的用于面膜的有机凝胶组合物制备面膜时,特别地,可大大改善油质组分(例如醋酸生育酚、维生素A醋酸酯、维生素A、D和E、神经酰胺、辅酶Q10和α-红没药醇)的经表皮的吸收。When a facial mask is prepared with the organogel composition for facial mask according to the present invention, in particular, oily components (such as tocopheryl acetate, vitamin A acetate, vitamins A, D and E, ceramide, Transdermal absorption of coenzyme Q10 and α-bisabolol).
所述天然提取物或多种提取物可以是至少一种选自下组的提取物:芦荟、绿茶、人参、红参、焦木酸、松针、银杏叶、蜂胶、桑叶、蚕、蜗牛粘液、卡卡杜李(kakaduplum)、卡姆果(camucamu)、阿萨伊棕榈(acaipalm)、角鲨烷、鱼子酱、椰菜、蓝莓、金缕梅、金虎尾、小球藻、山竹果、番石榴、日本山樱(Japanesecorneliancherry)、胡萝卜、咖啡豆、金缕梅、螺旋藻、鲑鱼籽、山胡椒(Linderaglauca)、巨藻、海带、马齿苋、石莼、琼脂、桑树根、覆盆子、野生浆果、羊栖菜(hijiki)、马尾草、火绒草、甘菊、薰衣草、薄荷、桉树、蜜蜂花、牛至、茶树、黄芩(Scutellaria)、鱼腥草(Houttuyniacordata)、沙棘和香橼。The natural extract or multiple extracts may be at least one extract selected from the group consisting of aloe vera, green tea, ginseng, red ginseng, pyroligneous acid, pine needles, ginkgo biloba, propolis, mulberry leaves, silkworm, snail mucus , kakaduplum, camucamu, acaipalm, squalane, caviar, broccoli, blueberry, witch hazel, acerola, chlorella, mangosteen, Guava, Japanese cornelian cherry, Carrot, Coffee Bean, Witch Hazel, Spirulina, Salmon Roe, Linderaglauca, Kelp, Kelp, Purslane, Ulva, Agar, Mulberry Root, Raspberry , wild berries, hijiki, horsetail, edelweiss, chamomile, lavender, peppermint, eucalyptus, melissa, oregano, tea tree, skullcap (Scutellaria), houttuynia cordata, sea buckthorn, and citron.
以组合物的总重量为基准计,所述活性成分的含量可为0.05-10重量%,更优选为2-5重量%。以组合物的总重量为基准计,如果活性成分的含量低于10重量%,那么美容皮肤的效果低。如果活性成分的含量高于20重量%,可能发生皮肤刺激。Based on the total weight of the composition, the content of the active ingredient may be 0.05-10% by weight, more preferably 2-5% by weight. If the content of the active ingredient is less than 10% by weight based on the total weight of the composition, the skin beautifying effect is low. If the content of the active ingredient is higher than 20% by weight, skin irritation may occur.
此外,根据应用,如果需要,可加入其它添加剂,例如pH调节剂,如柠檬酸、氢氧化钾和精氨酸盐;防腐剂,如对羟基苯甲酸酯类,具体为对羟基苯甲酸甲酯、对羟基苯甲酸丙酯和苯氧乙醇;金属离子封闭剂,如2NaEDTA;以及保湿剂,如甜菜碱、山梨糖醇、1,2-己二醇和赤藓糖醇。In addition, depending on the application, other additives such as pH adjusters such as citric acid, potassium hydroxide and arginine salts; preservatives such as parabens, specifically methylparaben, may be added if necessary , propylparaben, and phenoxyethanol; metal ion blockers, such as 2NaEDTA; and humectants, such as betaine, sorbitol, 1,2-hexanediol, and erythritol.
以本发明的有机凝胶组合物的总重量为基准计,所述添加剂的含量可为0.01-10重量%,更优选为0.05-5重量%。Based on the total weight of the organogel composition of the present invention, the content of the additive may be 0.01-10% by weight, more preferably 0.05-5% by weight.
根据本发明的有机凝胶组合物由于其薄片结构(与皮肤相似)而与皮肤具有改善的亲和性,因此活性成分可容易且快速地从有机凝胶向皮肤递送。此外,根据本发明的有机凝胶具有相对高的油含量,因此各种油质的活性成分可容易递送,皮肤水分可保持很长一段时间,从而减少了皮肤的水分流失。The organogel composition according to the present invention has improved affinity with the skin due to its lamellar structure (similar to skin), so active ingredients can be easily and quickly delivered from the organogel to the skin. In addition, the organogel according to the present invention has a relatively high oil content, so various oil-based active ingredients can be easily delivered, and skin moisture can be maintained for a long time, thereby reducing skin moisture loss.
使用本发明的有机凝胶组合物的面膜可通过以下方法制备:The facial mask using organogel composition of the present invention can be prepared by the following method:
首先,如果需要,将添加剂混合在水中,并将该混合物在约70-80℃下加热以溶解这些组分。向该混合物中加入另一种混合物,在所述另一种混合物中加入了胶凝聚合物、皮肤美容组分和多元醇并溶解在剩余水中,将得到的新混合物搅拌以获得均匀溶液。如果需要,还可加入交联剂。如果温度低于70℃,组分可能不能完全溶解在水中。如果温度高于80℃,一些添加剂或天然组分可能具有差的稳定性。First, additives are mixed in water, if necessary, and the mixture is heated at about 70-80°C to dissolve the components. To this mixture is added another mixture in which the gelling polymer, skin cosmetic component and polyol are added and dissolved in the remaining water, and the resulting new mixture is stirred to obtain a homogeneous solution. A crosslinking agent can also be added if desired. If the temperature is lower than 70°C, the components may not be completely dissolved in water. Some additives or natural components may have poor stability if the temperature is higher than 80°C.
当制备本发明的有机凝胶时,加入的水达到某个量以获得总量100重量%的组合物。可分段式添加水,以这种方式添加水每种组分会容易地溶解。When preparing the organogel of the present invention, water is added up to a certain amount to obtain a total composition of 100% by weight. The water can be added in portions in such a way that each component readily dissolves.
将在约70-80℃下分别向其中加入油和油胶凝剂的混合物逐滴加入混合的溶液中,以制备有机凝胶溶液。如果需要,还可加入添加剂例如防腐剂。如果混合温度低于70℃,水相和油相不能容易地混合,可能很难制备有机凝胶。如果温度高于80℃,水相和油相中的材料可能具有差的稳定性。A mixture to which oil and an oil gelling agent were respectively added at about 70-80° C. was added dropwise to the mixed solution to prepare an organogel solution. Additives such as preservatives may also be added, if desired. If the mixing temperature is lower than 70 °C, the water phase and the oil phase cannot be mixed easily, and it may be difficult to prepare organogels. If the temperature is higher than 80°C, the materials in the water and oil phases may have poor stability.
将得到的有机凝胶溶液涂覆在支持物上随后冷却至室温,随后将其成形成需要的形式以制备面膜。The obtained organogel solution was coated on a support followed by cooling to room temperature, and then shaped into a desired form to prepare a facial mask.
所述支持物可以是尼龙、人造丝、无纺织物等,较优选的是网眼织物。The support can be nylon, rayon, non-woven fabric, etc., more preferably mesh fabric.
将有机凝胶面膜成形成具有所需要的符合人体的部分,例如脸、眼睛下部、面颊、下巴和颈部的形式,以获得最终的面膜。此外,可用薄膜保护有机凝胶面膜的两面。The organogel mask is shaped to have the desired conformal parts, such as the face, under the eyes, cheeks, chin and neck, to obtain the final mask. In addition, both sides of the organogel mask can be protected with a thin film.
用于涂覆在支持物上的有机凝胶组合物的厚度可为0.01-50mm。如果厚度小于0.01mm,当粘附到皮肤上时由于其减少的厚度凝胶可能会断开,且凝胶中活性成分的量太少不足以将它们递送到皮肤。如果厚度大于50mm,凝胶太厚,与皮肤的粘附性减少。The thickness of the organogel composition for coating on the support may be 0.01-50mm. If the thickness is less than 0.01 mm, the gel may break due to its reduced thickness when adhered to the skin, and the amount of active ingredients in the gel is too small to deliver them to the skin. If the thickness is greater than 50mm, the gel is too thick and the adhesion to the skin is reduced.
下文中,将参照具体实施例详细地描述本发明。通过举例帮助理解本发明的方式包括以下实施例,但它们并不用于限制本发明的范围。Hereinafter, the present invention will be described in detail with reference to specific examples. The following examples are included by way of example to help understanding of the present invention, but they are not intended to limit the scope of the present invention.
发明实施方式Embodiment of the invention
实施例Example
1.有机凝胶面膜的制备1. Preparation of Organogel Mask
实施例1和2Examples 1 and 2
首先,在第一纯化水中混合EDTA2Na、甜菜碱和对羟基苯甲酸甲酯并加热至约75-80℃以溶解这些组分。向其中加入在第二纯化水中混合有烟酰胺、丁二醇、甘油、角叉菜胶和刺槐豆胶的溶液并混合。对于实施例1和2,每种组分的含量在表1中显示。First, EDTA2Na, betaine and methylparaben were mixed in first purified water and heated to about 75-80°C to dissolve these components. A solution of niacinamide, butylene glycol, glycerin, carrageenan, and locust bean gum mixed in second purified water was added thereto and mixed. For Examples 1 and 2, the content of each component is shown in Table 1.
分别地,在75-80℃下在搅拌所述溶液的同时向所述溶液中逐滴加入辛酸/癸酸甘油三酯(MCT)、卵磷脂和对羟基苯甲酸丙酯的混合物以制备有机凝胶溶液。Separately, a mixture of caprylic/capric triglyceride (MCT), lecithin and propylparaben was added dropwise to the solution while stirring the solution at 75-80° C. to prepare organic gelatin. glue solution.
将所述有机凝胶溶液涂覆在人造网眼织物的两面,并成形成所需要的形式以制备有机凝胶面膜。The organogel solution is coated on both sides of the artificial mesh fabric, and shaped into a required form to prepare an organogel mask.
表1Table 1
实施例3和4Examples 3 and 4
首先,在第一纯化水中混合EDTA2Na、山梨糖醇、对羟基苯甲酸甲酯和丙烯酸钠/丙烯酸C10-30烷基酯交联共聚物,并加热至约75-80℃以溶解这些组分。向上述混合物中加入溶液并混合,该溶液包含在第二纯化水中混合的醋酸生育酚、甘油、角叉菜胶和刺槐豆胶。对于实施例3和4,每种组分的含量在表2中显示。First, EDTA2Na, sorbitol, methylparaben, and sodium acrylate/C10-30 alkyl acrylate crosscopolymer were mixed in first purified water and heated to about 75-80°C to dissolve these components. A solution comprising tocopheryl acetate, glycerin, carrageenan, and locust bean gum mixed in a second purified water was added to the above mixture and mixed. For Examples 3 and 4, the content of each component is shown in Table 2.
分别地,在75-80℃下在搅拌所述溶液的同时向所述溶液中逐滴加入丁二醇二辛酸酯/二癸酸酯和卵磷脂的混合物或三异辛酸甘油脂和卵磷脂的混合物以制备有机凝胶溶液。Separately, a mixture of butanediol dicaprylate/dicaprate and lecithin or glyceryl triisocaprylate and lecithin was added dropwise to the solution at 75-80°C while stirring the solution mixture to prepare an organogel solution.
将所述有机凝胶溶液涂覆在人造网眼织物的两面,并成形成所需要的形式以制备有机凝胶面膜。The organogel solution is coated on both sides of the artificial mesh fabric, and shaped into a required form to prepare an organogel mask.
表2Table 2
实施例5和6Examples 5 and 6
首先,在第一纯化水中混合EDTA2Na、山梨糖醇、丁烯/乙烯/苯乙烯共聚物和对羟基苯甲酸甲酯并加热至约75-80℃以溶解这些组分。向上述混合物中加入溶液并混合,该溶液包含在第二纯化水中混合的α-红没药醇、甘油、角叉菜胶和葡甘露聚糖。对于实施例5和6,每种组分的含量在表3中显示。First, EDTA2Na, sorbitol, butene/ethylene/styrene copolymer and methylparaben were mixed in first purified water and heated to about 75-80°C to dissolve these components. A solution comprising alpha-bisabolol, glycerin, carrageenan and glucomannan mixed in a second purified water was added to the above mixture and mixed. For Examples 5 and 6, the content of each component is shown in Table 3.
分别地,在75-80℃下在搅拌所述溶液的同时向所述溶液中逐滴加入十六基乙基己酸酯和卵磷脂的混合物或者肉豆蔻酸异丙酯和普朗尼克卵磷脂的混合物以制备有机凝胶溶液。A mixture of cetylethylhexanoate and lecithin or isopropyl myristate and pluronic lecithin were added dropwise to the solution at 75-80°C while stirring the solution mixture to prepare an organogel solution.
将所述有机凝胶溶液涂覆在人造网眼织物的两面,并成形成所需要的形式以制备有机凝胶面膜。The organogel solution is coated on both sides of the artificial mesh fabric, and shaped into a required form to prepare an organogel mask.
表3table 3
实施例7和8Examples 7 and 8
首先,在第一纯化水中混合EDTA2Na、山梨糖醇、丁烯/乙烯/苯乙烯共聚物和对羟基苯甲酸甲酯并加热至约75-80℃以溶解这些组分。向上述混合物中加入在溶液并混合,该溶液包含第二纯化水中混合的α-红没药醇、甘油、葡甘露聚糖和胶凝糖或角叉菜胶。对于实施例7和8,每种组分的含量在表4中显示。First, EDTA2Na, sorbitol, butene/ethylene/styrene copolymer and methylparaben were mixed in first purified water and heated to about 75-80°C to dissolve these components. A solution comprising alpha-bisabolol, glycerin, glucomannan and gellan or carrageenan mixed in a second purified water is added to the above mixture and mixed. For Examples 7 and 8, the content of each component is shown in Table 4.
分别地,在75-80℃下在搅拌所述溶液的同时向所述溶液中逐滴加入十六基乙基己酸酯和卵磷脂的混合物或肉豆蔻酸异丙酯和普朗尼克卵磷脂的混合物以制备有机凝胶溶液。A mixture of cetylethylhexanoate and lecithin or isopropyl myristate and pluronic lecithin were added dropwise to the solution at 75-80°C while stirring the solution mixture to prepare an organogel solution.
将所述有机凝胶溶液涂覆在人造网眼织物的两面,并成形成所需要的形式以制备有机凝胶面膜。The organogel solution is coated on both sides of the artificial mesh fabric, and shaped into a required form to prepare an organogel mask.
表4Table 4
比较例1和2Comparative Examples 1 and 2
首先,在第一纯化水中混合EDTA2Na、甜菜碱和对羟基苯甲酸甲酯并加热至约75-80℃以溶解这些组分。向上述混合物中加入溶液并混合,该溶液包含在第二纯化水中混合的醋酸生育酚、甘油、刺槐豆胶和角叉菜胶。对于比较例1和2,每种组分的含量在表5中显示。First, EDTA2Na, betaine and methylparaben were mixed in first purified water and heated to about 75-80°C to dissolve these components. A solution comprising tocopheryl acetate, glycerin, locust bean gum and carrageenan mixed in a second purified water was added to the above mixture and mixed. For Comparative Examples 1 and 2, the content of each component is shown in Table 5.
分别地,在75-80℃下在搅拌所述溶液的同时向所述溶液中逐滴加入MCT、卵磷脂和对羟基苯甲酸丙酯的混合物以制备有机凝胶溶液。Separately, a mixture of MCT, lecithin, and propylparaben was added dropwise to the solution while stirring the solution at 75-80° C. to prepare an organogel solution.
将所述有机凝胶溶液涂覆在人造网眼织物的两面,并成形成所需要的形式以制备有机凝胶面膜。The organogel solution is coated on both sides of the artificial mesh fabric, and shaped into a required form to prepare an organogel mask.
表5table 5
有机凝胶面膜的物理性质的评价Evaluation of Physical Properties of Organogel Masks
测量在实施例和比较例中制备的有机凝胶面膜的物理性质,并在下表中显示结果。The physical properties of the organogel masks prepared in Examples and Comparative Examples were measured, and the results are shown in the following table.
(1)保湿效果的评价(1) Evaluation of moisturizing effect
将制备的有机凝胶切割成直径为10mm的圆形,测量其初始重量。然后,将其粘附在20个健康女性的上臂内侧。随后,剥离后,测量制备的有机凝胶的重量。计算两个重量之间的差值。为了防止水分蒸发,将具有与有机凝胶同样尺寸的乙烯树脂安全地覆盖在该有机凝胶上。The prepared organogel was cut into a circle with a diameter of 10 mm, and its initial weight was measured. Then, it was adhered to the inner upper arms of 20 healthy women. Subsequently, after peeling off, the weight of the prepared organogel was measured. Calculates the difference between two weights. To prevent moisture from evaporating, a vinyl resin having the same dimensions as the organogel is securely covered on the organogel.
为了评价保留的水分量,用皮肤水分测试仪(Corneometer)CM825(德国C&K公司(Courage+KhazakaElectronicGmbH,Germany))测量在粘附有有机凝胶的皮肤区域上的保湿效果,所述皮肤水分测试仪能无创测量体内水容量。此外,用皮肤水分流失测试仪(Tewarmeter)TM210(德国C&K公司)测量水分损失量(g/m2h),所述皮肤水分流失测试仪可测量经表皮的水分损失(TEWL)。In order to evaluate the amount of moisture retained, the moisturizing effect on the skin area to which the organogel was adhered was measured with a Corneometer CM825 (Courage+Khazaka Electronic GmbH, Germany), which Non-invasive measurement of body water volume. In addition, the amount of water loss (g/m 2 h) was measured with a Tewarmer TM210 (C&K, Germany), which can measure transepidermal water loss (TEWL).
测量在每20个女性身上进行,计算从这些女性得到的平均值。结果见表6。Measurements were carried out on every 20 females and the average value obtained from these females was calculated. The results are shown in Table 6.
(2)皮肤刺激的评价(2) Evaluation of skin irritation
将有机凝胶切割成直径为10mm的圆形,并将其粘附到20位健康女性的上臂内侧。随后,24小时后,将其剥离,根据以下标准用肉眼评价皮肤状况。结果见表6。The organogel was cut into a circle with a diameter of 10 mm and adhered to the inner upper arms of 20 healthy women. Then, after 24 hours, it was peeled off, and the skin condition was visually evaluated according to the following criteria. The results are shown in Table 6.
没有刺激 no stimulation
○:轻微刺激○: Slight irritation
□:红疹□:Rash
Δ:红疹和水肿Δ:Rash and edema
X:红疹、水肿和水泡X: rash, edema and blisters
(3)稳定性(变色、凝胶强度、相分离)的评价(3) Evaluation of stability (discoloration, gel strength, phase separation)
在25℃下将有机凝胶放在环境空气中,在此期间根据以下标准在60分钟、5小时、10小时和24小时时用肉眼测量该有机凝胶的物理变化。结果见表6。The organogel was placed in ambient air at 25°C, during which time the physical changes of the organogel were measured with the naked eye at 60 minutes, 5 hours, 10 hours and 24 hours according to the following criteria. The results are shown in Table 6.
保持的状态 maintained state
○:变色、凝胶强度(变弱)、相分离少于总区域的10%○: discoloration, gel strength (weakening), phase separation less than 10% of the total area
□:变色、凝胶强度(变弱)、相分离少于总区域的30%□: discoloration, gel strength (weakening), phase separation less than 30% of the total area
Δ:变色、凝胶强度(变弱)、相分离少于总区域的50%Δ: discoloration, gel strength (weakening), phase separation less than 50% of the total area
X:变色、凝胶强度(变弱)、相分离少于总区域的80%X: discoloration, gel strength (weakening), phase separation less than 80% of the total area
表6Table 6
如表6所示,证明了根据本发明的实施例1-4具有良好的保湿效果,低皮肤刺激和高稳定性。相反,比较例1的保湿效果不够,皮肤刺激较高且稳定性较低,由于比较例2不可能制备凝胶,因此不能测量比较例2的物理性质。As shown in Table 6, it is proved that Examples 1-4 according to the present invention have good moisturizing effect, low skin irritation and high stability. On the contrary, the moisturizing effect of Comparative Example 1 was insufficient, the skin irritation was high and the stability was low, and the physical properties of Comparative Example 2 could not be measured because it was impossible to prepare a gel.
经表皮的吸收的评价Evaluation of Transdermal Absorption
用无毛小鼠的皮肤在体内进行皮肤传送测试。将实施例3和4以及比较例1的样品各48微升施用到老鼠的15.0mm直径的皮肤表面。用经表皮的吸收器(HansonMicroetteTM)通过液相色谱计量24小时后传送的醋酸生育酚的量。结果见表7。如表7中所示,证明根据本发明的实施例3和4的经表皮的吸收优于比较例1的经表皮的吸收。Skin delivery tests were performed in vivo using the skin of hairless mice. 48 microliters each of the samples of Examples 3 and 4 and Comparative Example 1 were applied to the skin surface of the mouse with a diameter of 15.0 mm. Transdermal absorbers (Hanson Microette ™ ) to measure the amount of tocopheryl acetate delivered after 24 hours by liquid chromatography. The results are shown in Table 7. As shown in Table 7, it was demonstrated that the transdermal absorption of Examples 3 and 4 according to the present invention was superior to that of Comparative Example 1.
表7Table 7
(5)皱纹改善的评价(5) Evaluation of wrinkle improvement
将在实施例3和4以及比较例1中制备的有机凝胶以20mm的环形形式每天2次均匀地粘附在40-60位20岁女性的眼睛周围。该测试总共进行3个月,同时测量鱼尾纹。将在实施例3或4中制备的有机凝胶施用在左眼,将在比较例1中制备的组合物施用在右眼。The organogels prepared in Examples 3 and 4 and Comparative Example 1 were evenly adhered around the eyes of 40-60 20-year-old women twice a day in the form of a 20 mm ring. The test was run for a total of 3 months while crow's feet were measured. The organogel prepared in Example 3 or 4 was applied to the left eye, and the composition prepared in Comparative Example 1 was applied to the right eye.
3个月后,用肉眼评价皱纹的改善(用4级测定:相对于对照例没有改善、轻微改善、适度改善和显著改善)。结果见表8。After 3 months, the improvement of wrinkles was visually evaluated (determined on 4 scales: no improvement, slight improvement, moderate improvement and significant improvement compared to the control). The results are shown in Table 8.
表8Table 8
此外,在将有机凝胶重复施用到眼睛周围之前和之后,通过成像分析法测量皱纹的深度(μm)。结果(皱纹深度减小)见表9。In addition, the depth (μm) of wrinkles was measured by imaging analysis before and after repeated application of the organogel around the eyes. Results (reduction in wrinkle depth) are shown in Table 9.
表9Table 9
如表8和9所示,证明根据本发明制备的有机凝胶具有良好的经表皮的吸收和皱纹改善效果。As shown in Tables 8 and 9, it is proved that the organogel prepared according to the present invention has good transepidermal absorption and wrinkle improving effect.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080226616A1 (en) * | 2005-07-07 | 2008-09-18 | Jens Schulz | Emulsifier Combination for Cosmetics |
| WO2013055041A1 (en) * | 2011-10-11 | 2013-04-18 | 주식회사 제닉 | Emulsified hydrogel composition and a production method therefor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7157093B1 (en) * | 1997-12-05 | 2007-01-02 | 3M Innovative Properties Company | Oil cleaning sheets for makeup |
| KR101040509B1 (en) * | 2008-12-31 | 2011-06-16 | 주식회사 코리아나화장품 | Water-in-oil cosmetic composition of sherbet-balm type |
| KR101320297B1 (en) * | 2011-10-26 | 2013-10-22 | 주식회사 제닉 | Adhesive composition for transdermal absorption comprising rice powder and method for preparing the same |
| KR101384999B1 (en) * | 2012-05-04 | 2014-04-14 | 주식회사 제닉 | Organogel Composition and Organogel Mask Pack using Thereof |
-
2013
- 2013-07-25 CN CN201380078473.7A patent/CN105407870A/en active Pending
- 2013-07-25 WO PCT/KR2013/006666 patent/WO2015012424A1/en not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080226616A1 (en) * | 2005-07-07 | 2008-09-18 | Jens Schulz | Emulsifier Combination for Cosmetics |
| WO2013055041A1 (en) * | 2011-10-11 | 2013-04-18 | 주식회사 제닉 | Emulsified hydrogel composition and a production method therefor |
Non-Patent Citations (1)
| Title |
|---|
| SWARBRICK J.等: "《制剂技术百科全书》", 31 January 2009 * |
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Application publication date: 20160316 |