CN105296340B - A kind of intestinal contents fractions extraction element - Google Patents

Abstract

The invention provides a device for extracting some components of intestinal contents, which comprises a base, a support, a vibration device arranged on the support, an extraction container movably connected with the vibration device, and a negative pressure device connected with the extraction container. The beneficial effects of the invention are: the invention integrates the preparation of feces suspension to the extraction of feces bacteria, is convenient to operate and is easy to accept by medical personnel, and improves the quality of feces bacteria and the effect of curing diseases.

Description

A device for extracting some components of intestinal contents

This case is a divisional application. The invention name of the original application is: a device for extracting target components of intestinal contents. The filing date of the original application is: 2014-09-19, and the application number of the original application is: 201410484215.5.

technical field

The invention relates to a medical extraction device, in particular to a device for extracting some components of intestinal contents.

Background technique

The contents of the human gastrointestinal tract include food residues, flora, parasite eggs and other active components, as well as body fluid components secreted by the intestinal tract, foreign bodies and liquids that enter the intestinal tract for various reasons, and endoscopic Finely divided tumor tissue that has been resected but is not easy to remove directly. In the clinical and research process, to distinguish and obtain the components for these purposes, only rely on effective instrument-assisted separation. The flora in the normal human intestinal tract has been considered a special organ in the human body, and fecal transplantation is considered a special organ transplant. There are about 1,000 to 1,050 species of bacteria in the gut. At present, the functions of most of these bacteria and the mechanism by which different bacteria work organically are still unclear. Recently, modern medicine has increasingly recognized the important role of intestinal bacteria in the human body, and has taken maintaining or rebuilding the normal intestinal flora of the human body as an important treatment for many diseases. Commonly used probiotic drugs and food are just one or several kinds of bacteria in the intestine, which are specially cultured in vitro, and then packaged according to a certain amount. However, because the number and types of bacteria incorporated into the human gut are very limited, their therapeutic value is also limited. In recent years, fecal microbiota transplantation has gradually gained attention, especially for infection-related diseases that are ineffective in the treatment of commonly used antibiotics and other drugs, and its therapeutic value is particularly important, especially for infection-related diseases that are ineffective in the treatment of commonly used antibiotics and other drugs. Therapeutic value is particularly important, such as the treatment of antibiotic-associated diarrhea, refractory inflammatory bowel disease, refractory irritable bowel syndrome, immune-related refractory diarrhea, obesity, food allergy, depression intestinal symptoms, fatty liver, etc. .

Since the development of science, although there have been a few studies on the delivery of fecal suspension or fecal suspension into the gastrointestinal tract through colonoscopy, gastroscope nasogastric tube, jejunal tube, capsules, etc. Extraction needs to dilute the feces into a fecal suspension first, and then put the suspension into a filter device to filter, filter out parasites such as eggs, and only retain useful flora. It is difficult to accept visually, olfactorily, and psychologically, and the operation is cumbersome. To ensure the activity of fecal bacteria, the extraction process must be completed quickly. However, it is difficult to complete the extraction of fecal bacteria within an hour with the existing extraction device. , it is difficult to ensure the quality of fecal bacteria.

Contents of the invention

The purpose of the present invention is to provide a device for extracting some components of intestinal contents which is integrated from the preparation of feces suspension to the extraction of fecal bacteria, which is convenient to operate and easy to accept by medical personnel.

The present invention is achieved through the following measures: a device for extracting target components of intestinal contents, comprising a base, a support, a vibrating device arranged on the support, an extraction container movably connected with the vibrating device, and a Negative pressure device connected to the container;

The extraction container includes an upper end surface and a lower end surface, the upper end surface is provided with a liquid inlet with a sealing cover, and the side wall of the extraction container near the lower end surface is provided with a The liquid outlet is located between the liquid inlet and the liquid outlet. The extraction container is provided with several stages of filter membranes whose apertures gradually decrease from top to bottom. Between two adjacent stages of the filter membranes There is an interval, and a liquid outlet pipe with a sealing cover is arranged on the side wall of the extraction container between the adjacent two stages of the filter membrane;

A sealing partition is arranged between the filter membrane of the first stage and the liquid inlet, and the sealing partition includes an upper fixed plate and a lower movable plate with through holes, and the lower movable plate is also provided with There is a protrusion corresponding to the position of the through hole of the upper fixing plate and capable of sealing the through hole. The upper end surface of the protrusion is a hemispherical surface; A bit net, there is an interval between the limiting net and the filter membrane of the first stage;

The central position of the bottom surface of the extraction container is provided with a strip-shaped protrusion, and the side wall of the bottom surface is provided with two center-symmetric limiting protrusions; the central position of the upper end surface of the vibration device is provided with a circular concave platform, so that The central position of the circular concave table is provided with a bar-shaped movable block, the lower end surface of the strip-shaped movable block is provided with a spring, and the side wall of the circular concave table is provided with an arc used in conjunction with the position-limiting protrusion. The arc-shaped slot is open at one end and closed at the other end.

The vibrating device includes a rotating shaft arranged on the support through bearings, two cams symmetrically arranged on the rotating shaft and a vibrating bottom plate capable of moving up and down along the support.

Two opposite sides of the vibrating bottom plate are provided with rollers, and the bracket is provided with a limit chute corresponding to the rollers; in order to better keep the vibrating bottom plate moving up and down horizontally, the rollers and the The above-mentioned limiting chute can be provided with many pairs.

The lower surface of the vibrating bottom plate is provided with a U-shaped roller used in cooperation with the cam.

One end of the rotating shaft passes through the bracket and is provided with a handle.

A circular groove with an air hole is arranged on the sealing cover of the extraction container, and an air valve cover hinged with the sealing cover is arranged in the circular groove.

Wherein, preferably, the extraction container can also be directly fixed on the vibrating device; namely: a device for extracting target components of intestinal contents, comprising a base, a bracket, a vibrating device arranged on the bracket, and a vibrating device fixed on the An extraction container on the vibrating device and a negative pressure device connected to the extraction container;

The extraction container includes an upper end surface and a lower end surface, the upper end surface is provided with a liquid inlet with a sealing cover, and the side wall of the extraction container near the lower end surface is provided with a The liquid outlet is located between the liquid inlet and the liquid outlet. The extraction container is provided with several stages of filter membranes whose pore diameters gradually decrease from top to bottom. Between two adjacent stages of the filter membranes There is an interval, and a liquid outlet pipe with a sealing cover is arranged on the side wall of the extraction container between the adjacent two stages of the filter membrane;

A sealing partition is arranged between the filter membrane of the first stage and the liquid inlet, and the sealing partition includes an upper fixed plate and a lower movable plate with through holes, and the lower movable plate is also provided with There is a protrusion corresponding to the position of the through hole of the upper fixing plate and capable of sealing the through hole. The upper end surface of the protrusion is a hemispherical surface; There is a space between the limiting net and the filter membrane of the first stage.

The vibrating device includes a rotating shaft arranged on the support through bearings, two cams symmetrically arranged on the rotating shaft and a vibrating bottom plate capable of moving up and down along the support.

Two opposite sides of the vibrating bottom plate are provided with rollers, and the support is provided with limiting chute corresponding to the rollers.

The lower surface of the vibrating bottom plate is provided with a U-shaped roller used in cooperation with the cam.

One end of the rotating shaft passes through the bracket and is provided with a handle.

A circular groove with an air hole is arranged on the sealing cover of the extraction container, and an air valve cover hinged with the sealing cover is arranged in the circular groove.

Among them, preferably, a device for extracting some components of intestinal contents, including an extraction container and a negative pressure device connected to the extraction container;

The extraction container includes an upper end surface and a lower end surface, the upper end surface is provided with a liquid inlet with a sealing cover, and the side wall of the extraction container near the lower end surface is provided with a The liquid outlet is located between the liquid inlet and the liquid outlet. The extraction container is provided with several stages of filter membranes whose apertures gradually decrease from top to bottom. Between two adjacent stages of the filter membranes There is an interval, and a liquid outlet pipe with a sealing cover is arranged on the side wall of the extraction container between the adjacent two stages of the filter membrane;

A sealing partition is arranged between the filter membrane of the first stage and the liquid inlet, and the sealing partition includes an upper fixed plate and a lower movable plate with through holes, and the lower movable plate is also provided with There is a protrusion corresponding to the position of the through hole of the upper fixing plate and capable of sealing the through hole, the upper end surface of the protrusion is a hemispherical surface; the side wall of the extraction container located below the sealing partition A limiting net is arranged on the top, and there is an interval between the limiting net and the filter membrane of the first stage.

A circular groove with an air hole is arranged on the sealing cover of the extraction container, and an air valve cover hinged with the sealing cover is arranged in the circular groove.

The beneficial effects of the present invention are: the present invention is integrated from the preparation of feces suspension to the extraction of fecal bacteria, easy to operate and easy to accept by medical personnel, and improves the quality and curative effect of fecal bacteria; Add diluent (such as physiological saline or milk, etc.) to the extraction container, and quickly cover the sealing cover. At this time, the upper fixed plate of the sealed partition is closely connected with the lower movable plate, and the extraction container is shaken manually (the shaking force of the hand is insufficient The lower movable plate is separated from the upper fixed plate), so that the feces and the diluent are well mixed to obtain a fecal suspension, and then the air valve cover on the sealing cover of the extraction container is opened, and the negative pressure device is turned on. At this time, the sealing partition Under the action of negative pressure, the lower movable plate quickly breaks away from the upper fixed plate and falls on the limit net. Under the action of negative pressure, the feces suspension passes through the filter membrane step by step, and the filter membrane selects different pore sizes according to requirements. film, and finally get the desired target component, open the sealing cap of the liquid outlet tube, and suck out the target component through the syringe.

Description of drawings

Fig. 1 is a schematic structural diagram of Embodiment 1 of the present invention.

Fig. 2 is a schematic structural view of the bottom surface of the extraction container in Example 1 of the present invention.

Fig. 3 is a schematic structural diagram of a vibrating bottom plate in Embodiment 1 of the present invention.

Fig. 4 is a sectional view taken along line A-A of Fig. 3 .

Fig. 5 is a schematic structural diagram of Embodiment 2 of the present invention.

Fig. 6 is a schematic structural diagram of Embodiment 3 of the present invention.

Fig. 7 is a schematic structural view of the sealing cover of the liquid outlet pipe in Embodiment 1-3 of the present invention.

Fig. 8 is a schematic structural view of the sealing cover on the upper end surface of the extraction container in Example 1-3 of the present invention.

Wherein, reference signs are: 1. base; 2. bracket; 3. rotating shaft; 4. liquid outlet; 5. extraction container; 6. sealing cover of liquid outlet pipe; 7. filter membrane; ; 9, protrusion; 10, through hole; 11, sealing cover; 12, upper fixed plate; 13, lower movable plate; 14, vibrating bottom plate; 15, roller; 16, handle; 17, U-shaped roller; 18, cam; 19. Cover core; 20. Cap; 21. Air valve cover; 22. Air hole sealing protrusion; 23. Air hole; 24. Strip protrusion; 25. Limit protrusion; 26. Strip movable block; 27. Arc slot ; 28, circular concave platform; 29, spring.

Detailed ways

In order to clearly illustrate the technical features of the solution, the solution will be described below through specific implementation modes.

Example 1

Referring to Fig. 1-Fig. 4, Fig. 7 and Fig. 8, the present invention is a device for extracting target components of intestinal contents, comprising a base 1, a support 2, a vibration device arranged on the support 2, and an extraction device movably connected with the vibration device. The container 5 and the negative pressure device connected with the extraction container 5, the extraction container 5 includes an upper end surface and a lower end surface, the upper end surface is provided with a liquid inlet with a sealing cover 11, and the side wall of the extraction container 5 near the lower end surface is provided with a The liquid outlet 4 connected with the negative pressure device is located between the liquid inlet and the liquid outlet 4, and the extraction container 5 is provided with several filter membranes 7 whose pore diameters gradually decrease from top to bottom, and two adjacent filter membranes There is an interval between 7, and the side wall of the extraction container 5 between adjacent two-stage filter membranes 7 is provided with a liquid outlet pipe with a sealing cover (i.e. the sealing cover 6 of the liquid outlet pipe); wherein, the extraction device 5 can be used from The vibration device is taken off; the negative pressure device is a prior art, and will not be repeated here.

The vibrating device includes a rotating shaft 3 arranged on the support 2 through bearings, two cams 18 symmetrically arranged on the rotating shaft 3 and a vibrating bottom plate 14 that can move up and down along the supporting frame 2; the opposite sides of the vibrating bottom plate 14 are provided with rollers 15. The bracket 2 is provided with a limit chute corresponding to the roller 15; the lower surface of the vibrating bottom plate 14 is provided with a U-shaped roller 17 used in conjunction with the cam 18; one end of the rotating shaft 3 passes through the bracket 2 and is provided with a handle 16.

A sealing partition is arranged between the first-stage filter membrane 7 and the liquid inlet. The sealing partition includes an upper fixed plate 12 and a lower movable plate 13 with through holes 10. The lower movable plate 13 is also provided with a The position of the through hole 10 of the fixed plate 12 is corresponding and can seal the protrusion 9 of the through hole 10. The upper end surface of the protrusion 9 is a hemispherical surface; the side wall of the extraction container 5 under the sealing partition is provided with a limit net 8, a limit net There is an interval between 8 and the first stage filter membrane 7.

The central position of the bottom surface of the extraction container 5 is provided with a bar-shaped protrusion 24, and the side wall of the bottom surface is provided with two center-symmetrical position-limiting protrusions 25; The central position of the strip-shaped movable block 26 is provided with a spring 29 on the lower end surface of the strip-shaped movable block 26. The side wall of the circular concave table 28 is provided with an arc-shaped draw-in groove 27 used in conjunction with the limit protrusion 25. One end of the shaped card slot 27 is open and the other end is closed. That is, when the extracting container 5 is rotated, the position-limiting protrusion 25 just enters the arc-shaped card slot 27, and the rotation stops to a certain extent. At this time, the extracting device 5 is connected to the vibration base plate 14.

The sealing cover of the extraction container 5 is provided with a circular groove with an air hole 23, and an air valve cover 21 hinged with the sealing cover is arranged in the circular groove, and the air valve cover 21 is provided with an air hole corresponding to the air hole 23. The sealing protrusion 22; the outlet pipe is provided with an internal thread, and the sealing cover 6 of the liquid outlet pipe includes a cap 20 and a cover core 19, and the cover core 19 is provided with an external thread used in conjunction with the internal thread.

During use, the extraction container 5 is fixed on the vibrating device (the strip-shaped protrusion 24 at the bottom of the extraction container 5 is aligned with the strip-shaped movable block 26 of the vibrating bottom plate 14, pressed down and rotated, and the position-limiting protrusion 25 just snaps into the arc. card slot 27), put the feces just taken into the extraction container 5, and add diluent (such as physiological saline or milk, etc.), and quickly cover the sealing cover 11, and at this time, the upper fixed plate 12 of the sealing partition and the The lower movable plate 13 is tightly connected, and the handle 16 of the vibrating device is manually shaken, and the extraction container 5 vibrates up and down under the drive of the vibrating device (the vibration force of the vibrating device is not enough to make the lower movable plate 13 separate from the upper fixed plate 12), so that the excrement and diluent Mix well to obtain the feces suspension, then open the air valve cover 21 on the sealing cover 11 of the extraction container 5, and open the negative pressure device. At this time, the lower movable plate 13 of the sealing partition is quickly Detach from the upper fixed plate 12 and drop on the limit net 8. Under the effect of negative pressure, the feces suspension passes through the filter membrane 7 step by step. The filter membrane 7 selects filter membranes with different pore sizes according to requirements, and finally obtains the desired For the target component, open the sealing cap 6 of the outlet tube, and suck out the target component through the syringe.

Example 2

Referring to Fig. 5, Fig. 7 and Fig. 8, the present invention is a device for extracting target components of intestinal contents, comprising a base 1, a support 2, a vibration device arranged on the support 2, an extraction container 5 fixedly connected with the vibration device and A negative pressure device connected to the extraction container 5, the extraction container 5 includes an upper end surface and a lower end surface, the upper end surface is provided with a liquid inlet with a sealing cover 11, and the side wall of the extraction container 5 near the lower end surface is provided with a The liquid outlet 4 connected to the device is located between the liquid inlet and the liquid outlet 4. The extraction container 5 is provided with several stages of filter membranes 7 whose apertures gradually decrease from top to bottom. There are intervals, and the side wall of the extraction container 5 between adjacent two-stage filter membranes 7 is provided with a liquid outlet pipe with a sealing cover (ie, the sealing cover 6 of the liquid outlet pipe); wherein, the negative pressure device is a prior art, I won't repeat them here.

The vibrating device includes a rotating shaft 3 arranged on the support 2 through bearings, two cams 18 symmetrically arranged on the rotating shaft 3 and a vibrating bottom plate 14 that can move up and down along the supporting frame 2; the opposite sides of the vibrating bottom plate 14 are provided with rollers 15. The bracket 2 is provided with a limit chute corresponding to the roller 15; the lower surface of the vibrating bottom plate 14 is provided with a U-shaped roller 17 used in conjunction with the cam 18; one end of the rotating shaft 3 passes through the bracket 2 and is provided with a handle 16.

A sealing partition is arranged between the first-stage filter membrane 7 and the liquid inlet. The sealing partition includes an upper fixed plate 12 and a lower movable plate 13 with through holes 10. The lower movable plate 13 is also provided with a The position of the through hole 10 of the fixed plate 12 is corresponding and can seal the protrusion 9 of the through hole 10. The upper end surface of the protrusion 9 is a hemispherical surface; the side wall of the extraction container 5 under the sealing partition is provided with a limit net 8, a limit net There is an interval between 8 and the first stage filter membrane 7.

The sealing cover of the extraction container 5 is provided with a circular groove with an air hole 23, and an air valve cover 21 hinged with the sealing cover is arranged in the circular groove, and the air valve cover 21 is provided with an air hole corresponding to the air hole 23. The sealing protrusion 22; the outlet pipe is provided with an internal thread, and the sealing cover 6 of the liquid outlet pipe includes a cap 20 and a cover core 19, and the cover core 19 is provided with an external thread used in conjunction with the internal thread.

When in use, put the feces just taken into the extraction container 5, and add a diluent (such as physiological saline or milk, etc.), and quickly cover the sealing cover 11. At this time, the upper fixed plate 12 and the lower movable plate of the sealing partition 13 are closely connected, manually shake the handle 16 of the vibrating device, and the extraction container 5 vibrates up and down under the drive of the vibrating device (the vibrating force of the vibrating device is not enough to make the lower movable plate 13 separate from the upper fixed plate 12), so that the excrement and diluent are well separated Mix to obtain feces suspension, then open the air valve cover 21 on the sealing cover 11 of the extraction container 5, and open the negative pressure device. plate 12, and drop on the limiting net 8, under the effect of negative pressure, the feces suspension passes through the filter membrane 7 step by step, and the filter membrane 7 selects filter membranes with different pore sizes according to the requirements, and finally obtains the desired target component. Open the sealing cover 6 of the liquid outlet pipe, and suck out the target component through the syringe.

Example 3

Referring to Fig. 6, Fig. 7 and Fig. 8, the present invention is an extraction device for target components of intestinal contents, comprising an extraction container 5 and a negative pressure device connected to the extraction container 5, the extraction container 5 includes an upper end surface and a lower end surface, and the upper end surface The end surface is provided with a liquid inlet with a sealing cover 11, and the side wall of the extraction container 5 close to the lower end surface is provided with a liquid outlet 4 that can be connected to a negative pressure device, and the extraction container is located between the liquid inlet and the liquid outlet 4. 5 is provided with several stages of filter membranes 7 whose pore diameters decrease step by step from top to bottom, there is an interval between adjacent two-stage filter membranes 7, and the side wall of the extraction container 5 between adjacent two-stage filter membranes 7 is provided with A liquid outlet pipe with a sealing cover (that is, the sealing cover 6 of the liquid outlet pipe); wherein, the extraction device 5 can be removed from the vibrating device; the negative pressure device is a prior art, and will not be repeated here.

A sealing partition is arranged between the first-stage filter membrane 7 and the liquid inlet, and the sealing partition includes an upper fixed plate 12 and a lower movable plate 13 with through holes 10, and the lower movable plate 13 is also provided with a The position of the through hole 10 of the fixed plate 12 is corresponding and can seal the protrusion 9 of the through hole 10. The upper end surface of the protrusion 9 is a hemispherical surface; the side wall of the extraction container 5 under the sealing partition is provided with a limit net 8, a limit net There is an interval between 8 and the first stage filter membrane 7.

The sealing cover of the extraction container 5 is provided with a circular groove with an air hole 23, and an air valve cover 21 hinged with the sealing cover is arranged in the circular groove, and the air valve cover 21 is provided with an air hole corresponding to the air hole 23. The sealing protrusion 22; the outlet pipe is provided with an internal thread, and the sealing cover 6 of the liquid outlet pipe includes a cap 20 and a cover core 19, and the cover core 19 is provided with an external thread used in conjunction with the internal thread.

When in use, put the feces just taken into the extraction container 5, and add a diluent (such as physiological saline or milk, etc.), and quickly cover the sealing cover 11. At this time, the upper fixed plate 12 and the lower movable plate of the sealing partition 13 are tightly connected, and the extraction container 5 is manually shaken (the strength of the hand shaking is not enough to make the lower movable plate 13 separate from the upper fixed plate 12), so that the feces and the diluent are well mixed to obtain a feces suspension, and then the sealing cover of the extraction container 5 The air valve cover 21 on the 11 is opened, and the negative pressure device is opened. At this time, the lower floor movable plate 13 of the sealing partition breaks away from the upper floor fixed plate 12 very quickly under the effect of negative pressure, and falls on the spacer net 8. Under the action of negative pressure, the feces suspension passes through the filter membrane 7 step by step, and the filter membrane 7 selects filter membranes with different pore sizes according to the requirements, and finally obtains the desired target component, opens the sealing cover 6 of the liquid outlet pipe, and sucks out the target component through the syringe That's it.

The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included in the protection of the present invention. within range.

Claims (2)

1. a kind of intestinal contents fractions extraction element, including extraction vessel and the negative pressure dress that is connected with the extraction vessel Put；

The extraction vessel includes upper surface and lower surface, and the upper surface is provided with the inlet with closure, close to institute The liquid outlet that is provided with and can be connected with the negative pressure device in the side wall of extraction vessel described in lower surface is stated, positioned at the feed liquor Some levels filter membrane that from top to bottom aperture reduces step by step is provided with the extraction vessel between mouth and the liquid outlet, it is adjacent There is interval between filter membrane described in two-stage, be provided with and carry in the side wall of the extraction vessel between filter membrane described in adjacent two-stage The drain pipe of closure；

Sealing dividing plate is provided between filter membrane described in the first order and the inlet, the sealing dividing plate includes carrying The upper strata fixed plate and lower floor's portable plate of through hole, the through hole position with the upper strata fixed plate is additionally provided with lower floor's portable plate Projection corresponding and that the through hole can be sealed is put, the upper surface of the projection is hemisphere face；Under the sealing dividing plate Limited location net is set in the side wall of Fang Suoshu extraction vessels, has interval between filter membrane described in the spacing net and the first order.

2. intestinal contents fractions extraction element according to claim 1, set on the closure of the extraction vessel It is equipped with leachy circular groove, the air valve cap being hinged with the closure is provided with the circular groove.