CN105092354B - A kind of high flux pre-treatment instrument for the residual extraction of medicine - Google Patents

Abstract

The invention discloses a high-throughput pretreatment instrument for extracting drug residues, and aims to provide a pretreatment instrument with convenient operation, high work efficiency, and the ability to simultaneously operate multiple samples and obtain sample extracts. It includes a vortex oscillator, a frame, a horizontal guide rail set on the frame, a slide seat slidably set on the horizontal guide rail, a clamping device located under the slide seat and a clamping device set on the slide seat for lifting The lifting cylinder, the clamping device includes a support plate, a mounting seat located below the support plate, a vertical connecting rod connecting the supporting plate and the mounting seat, and a pressure plate that can be lifted up and down along the vertical connecting rod; the mounting seat is provided with several The first vertical installation through hole, the first vertical installation through hole is inserted with a liquid storage cylinder, the outer surface of the liquid storage cylinder is above the mounting seat and a first annular stopper is provided; the vortex oscillator is located below the mounting seat.

Description

A high-throughput pretreatment instrument for drug residue extraction

technical field

The invention relates to a treatment device for drug residue extraction liquid, in particular to a high-throughput pre-processing instrument for drug residue extraction.

Background technique

With the improvement of people's living standards, while the production and consumption of aquatic products have greatly increased, the quality of aquatic products has also attracted more and more attention. How to test the quality of aquatic products is a problem that consumers are very concerned about. According to relevant food regulations and food inspection requirements, aquatic products need to pass sensory inspection, physical inspection, chemical inspection and other tests to ensure the quality and safety of aquatic products.

At present, the extraction steps of sample extracts for aquatic product testing usually include the following steps: first, mash the aquatic product to be tested and put it into the sample tube, and add a certain amount of organic solvent into the sample tube; The oscillator homogenizes the sample in the sample tube to dissolve the residual drug in the aquatic product into the organic solvent; then the residue in the sample tube is filtered by centrifugation or filtration to obtain the sample extract. The current operation process of this sample extraction solution is cumbersome, time-consuming and labor-intensive, and only one sample tube can be operated at a time, which leads to a large amount of time spent in actual detection of a large number of samples.

Contents of the invention

The purpose of the present invention is to overcome the deficiencies in the prior art and provide a high-throughput pretreatment instrument for drug residue extraction that is easy to operate, high in work efficiency, and capable of operating multiple samples at the same time and obtaining sample extracts .

Technical scheme of the present invention is:

A high-throughput pretreatment instrument for extracting drug residues, comprising a vortex oscillator, a frame, a horizontal guide rail arranged on the frame, a sliding seat slidably arranged on the horizontal guide rail, and a device located under the sliding seat. The clamping device and the lifting cylinder for lifting and lowering the clamping device are arranged on the sliding seat. The clamping device includes a support plate, a mounting seat located below the support plate, a vertical connecting rod connecting the support plate and the mounting seat, and a The straight connecting rod lifts up and down the pressure plate; the mounting base is provided with a number of first vertical installation through holes, the first vertical installation through holes are inserted with a liquid storage cylinder, the lower end of the liquid storage cylinder is located below the mounting base, The upper end of the liquid cylinder is located above the mounting seat, and a first annular stopper is provided on the outer surface of the liquid storage cylinder above the mounting seat; the pressure plate is provided with a first guide sleeve that can slide along the vertical connecting rod, and the first guide A set bolt is provided on the sleeve to fix the first guide sleeve on the vertical connecting rod; the vortex oscillator is located under the mounting seat. The structure of this scheme can carry out the homogenization operation on multiple samples at the same time, and the operation is convenient and the working efficiency is high.

Preferably, it also includes an extraction liquid separation device, the liquid extraction separation device includes vacuum equipment, a main box with a sealed inner cavity, a circular placement through hole and a connected airtight structure arranged on the top surface of the main box; The main box is located directly below the placement through hole and is provided with a number of extraction liquid collection cylinders corresponding to the liquid storage cylinder; the connected airtight structure includes an installation groove arranged on the inner side of the placement through hole, and is arranged in the installation groove. an inflatable sealing ring and a pressure conversion cylinder; the inner cavity of the pressure conversion cylinder is composed of a first cavity and a second cavity connected to each other, and the inner diameter of the first cavity is greater than the inner diameter of the second cavity; The first cavity is provided with a first piston body, the second cavity is provided with a second piston body, and the first piston body and the second piston body are connected through a first connecting rod, and the pressure conversion cylinder One end close to the first piston body is open, and one end close to the second piston body is closed; a first limit block is provided on the inner side of the first cavity, and the first limit block and the second piston body are located on the first piston. On the opposite sides of the body, the second cavity is provided with a first pre-tightened compression spring that can make the first piston body lean against the first limit block, and the first pre-tightened compression spring and the first piston body are located at the first position. Two opposite sides of the piston body; a first connection port and a second connection port are provided on the outer side of the pressure conversion cylinder, the first connection port communicates with the first cavity, and the first connection port is located on the first piston body Between the second piston body; the second connection port communicates with the second cavity, and the second connection port and the first piston body are located on opposite sides of the second piston body; the outer surface of the main box is provided with a second Three connection ports and a suction port, the inflatable sealing ring is provided with an inflation and exhaust nozzle, the first connection port is connected to the third connection port through a first communication pipe, and the second connection port is connected to the third connection port. The filling and exhaust nozzles are connected through the second communication pipe, and the vacuum equipment and the suction port are connected through the third communication pipe; the upper and lower ends of the liquid storage cylinder are open, and the liquid storage cylinder The edge of the upper port is provided with an air guide gap, and the lower part of the liquid storage cylinder is provided with a filter membrane interlayer; the mounting seat is cylindrical, and the outer diameter of the mounting seat is smaller than the inner diameter of the placement through hole, and the first vertical mounting through hole and A first sealing ring is arranged between the liquid containing cylinders.

The structure of this scheme can filter multiple samples at the same time to obtain the sample extract, which is convenient to operate and high in work efficiency.

On the other hand, in the actual use process, since the mounting base needs to be frequently inserted into the placement through hole/taken out, the sealing ring between the placement through hole and the mounting base is easy to loosen and a gap is generated, resulting in external The gas enters the inner cavity of the main box, which affects the filtration of the sample extraction solution; this solution is improved to solve this problem, and effectively solves the problem of insufficient negative pressure in the vacuum cavity caused by the poor seal between the placement through hole and the mounting seat, which affects the Problems with filtration of sample extracts.

Due to the pressure conversion between the first piston body and the second piston body, the inner chamber of the cylinder communicates with the inner chamber of the main box body through the first communication pipe, and the cross-sectional area of the first piston body is larger than that of the second piston body. Cross-sectional area; therefore, during the vacuuming process, the air pressure between the first piston body and the second piston body decreases, so that the second piston body moves toward the second limit block, so that the gas in the pressure conversion cylinder passes through the second piston body. The two connecting pipes are pressed into the inner cavity of the inflatable sealing ring to expand the inflatable sealing ring, thereby ensuring that the inflatable sealing ring forms a reliable seal between the filter cartridge and the through hole; As the pressure increases, the air pressure in the annular inflatable inner chamber of the inflatable sealing ring also increases, thereby further ensuring that the inflatable sealing ring forms a reliable seal between the filter cartridge and the through hole, effectively solving the problem of frequent Take it out for cleaning and sample loading, so that the sealing ring between the placement through hole and the filter cartridge is loose and a gap is generated, which affects the sealing reliability between the filter cartridge and the placement through hole, and as the negative pressure in the inner cavity of the main box increases , it is often prone to the problem of poor sealing between the placement through hole and the filter cartridge. On the other hand, when the sample extraction liquid is filtered, the vacuuming equipment is turned off, and the pressure in the inner cavity of the main box is restored at this time, so that the first piston body and the second piston body are reset under the action of the first pre-tightened compression spring. When the inflatable sealing ring shrinks, the installation seat can be taken out smoothly to ensure the normal operation of the equipment.

Preferably, a fourth connection port communicating with the first cavity is provided on the outer side of the pressure conversion cylinder, and the fourth connection port is located between the first piston body and the second piston body, and the fourth connection port is An electromagnetic switch valve is provided; a fifth connection port communicating with the second cavity is provided on the outer side of the pressure conversion cylinder, and the fifth connection port and the first piston body are located on opposite sides of the second piston body. An electromagnetic switch valve is provided at the fifth connection port; a sixth connection port communicating with the inner cavity of the main box is provided on the outer side of the main box, and an electromagnetic switch valve is provided at the sixth connection port.

Preferably, a second limiting block is provided on the inner side of the second cavity, and the second limiting block is located between the second piston body and the second connection port.

Preferably, a one-way valve device is provided in the lower port of the liquid storage cylinder, and the one-way valve device is located under the filter membrane interlayer. The second sealing ring on the inner side of the boss, the vertical valve sleeve arranged in the liquid storage cylinder and above the annular boss, the valve stem that can be slidably arranged in the vertical valve sleeve and the circular ring that is arranged at the lower end of the valve stem Valve plate, the valve sleeve is connected with the liquid storage cylinder through a connecting rod, the outer surface of the valve stem is located above the valve sleeve with a second annular stopper, and the valve stem is located between the valve sleeve and the circular valve plate There is a second compression spring that can make the second annular stopper abut against the valve sleeve, and when the second annular stopper is abutted against the valve sleeve, the second sealing ring is abutted against the circular valve plate on the outer side of the extraction liquid collection tube; a vertical ejector pin is provided in the extraction liquid collection tube, and the vertical ejector pin is connected with the extraction liquid collection tube through a connecting rod, and the upper end of the vertical ejector pin is located above the extraction liquid collection tube; The upper edge of the outer surface of the mounting seat is provided with a third annular stopper; when the mounting seat is inserted into the placement through hole, and the third annular stopper is against the top surface of the main box, the vertical push rod will Lift up the circular valve plate and make the circular valve plate be positioned above the annular boss. The one-way valve device of this solution can prevent the liquid in the liquid storage cylinder from flowing out, and at the same time cooperate with the vertical ejector rod in the liquid collection collection cylinder to ensure that the residue in the sample tube is filtered to obtain the sample extract during the filtration process.

As a preference, a placement frame is provided in the main box, and a horizontal placement plate is provided on the placement shelf; several second vertical installation through holes are provided on the horizontal placement plate, and the extraction liquid collection tube is inserted in the corresponding The second vertical installation through hole, and the outer surface of the extraction liquid collection cylinder above the second vertical installation through hole is provided with a third annular stopper.

As a preference, the horizontal guide rail is provided with a third limit stop and a fourth limit stop, the slide seat is located between the third limit stop and the fourth limit stop, and when the slide seat abuts against When the third limit stop is on, the installation seat is located directly above the vortex oscillator; when the sliding seat abuts against the fourth limit stop, the installation seat is located directly above the placement through hole.

Preferably, the sliding seat is provided with a second vertical guide sleeve, and a vertical guide rod is arranged inside the second vertical guide sleeve, and the lower end of the vertical guide rod is connected with the support plate.

Preferably, the oscillating plate of the vortex oscillator is provided with a rubber pad or a sponge pad, and the rubber pad or the sponge pad is located above the oscillating plate.

The beneficial effects of the invention are: it has the characteristics of convenient operation, high working efficiency, and the ability to simultaneously operate multiple samples and obtain sample extracts.

Description of drawings

Fig. 1 is a schematic diagram of the structure of the high-throughput pretreatment apparatus for drug residue extraction of the present invention.

Fig. 2 is a partial enlarged view of A in Fig. 1 .

Fig. 3 is a partial enlarged view of B in Fig. 2 .

Fig. 4 is a schematic structural view of the liquid extraction and separation device of the present invention.

Fig. 5 is a schematic diagram of the structure of the high-throughput pretreatment device for extracting drug residues in the working process of the present invention.

FIG. 6 is a partially enlarged view at point C in FIG. 5 .

FIG. 7 is a partial enlarged view at D in FIG. 5 .

In the figure: horizontal guide rail 1, third limit stop 1a, fourth limit stop 1b; clamping device 2, sliding seat 21, vertical guide rod 22, lifting cylinder 23, support plate 24, vertical connecting rod 25, the pressure plate 26, the mounting seat 27, the liquid cylinder 28, the first guide sleeve 29, the set bolt 210, the third annular stopper 211, the first sealing ring 212, the air guide gap 213, the first annular stopper 214, The first vertical installation through hole 215, the filter membrane interlayer 216, the annular boss 217, the second sealing ring 218, the circular valve plate 219, the valve stem 220, the second compression spring 221, the vertical valve sleeve 222, the second Ring block 223; vortex oscillator 3, oscillating plate 31, rubber pad 32; extraction liquid separation device 4, main box 41, suction port 42, sixth connection port 43, placement through hole 44, placement rack 45 , a horizontally placed plate 46, an extraction liquid collection cylinder 47, a third annular stopper 48, a vertical ejector rod 49; a connected airtight structure 5, a pressure conversion cylinder 51, a fifth connection port 52, and a first preloaded compression spring 53, the second cavity 54, the second limit block 55, the second piston body 56, the fourth connection port 57, the first cavity 58, the first piston body 59, the first limit block 510, the second connection port 511 , the first connection port 512 , the second communication pipe 513 , the first communication pipe 514 , the third connection port 515 , and the inflatable sealing ring 516 .

detailed description

Below in conjunction with accompanying drawing and specific embodiment the present invention is described in further detail:

As shown in Fig. 1, a kind of high-flux pretreatment instrument that is used for drug residue extraction comprises vortex oscillator 3, frame, the horizontal guide rail 1 that is arranged on the frame, the slide seat that can be slidably arranged on the horizontal guide rail 21. The clamping device 2 located under the sliding seat, the lifting cylinder 23 and the extracting liquid separation device 4 are arranged on the sliding seat for lifting and lowering the clamping device. The frame is also provided with a horizontal moving cylinder for promoting the slide seat. A third limit block 1a and a fourth limit block 1b are arranged on the horizontal guide rail. The sliding seat is located between the third limit stopper and the fourth limit stopper. The vortex oscillator and the extraction liquid separation device are located under the horizontal guide rail, and the vortex oscillator and the extraction liquid separation device are distributed along the horizontal guide rail.

As shown in Figure 1 and Figure 2, the clamping device includes a support plate 24, a mounting seat 27 located below the support plate, a vertical connecting rod 25 connecting the supporting plate and the mounting seat, and a pressure plate 26 that can be lifted up and down along the vertical connecting rod . The vortex shaker is located under the mount. The oscillating plate 31 of the vortex oscillator is provided with a rubber pad 32 or a sponge pad, and the rubber pad or the sponge pad is located above the oscillating plate. When the sliding seat abuts against the third limit stopper, the mounting seat is located directly above the vortex oscillator. The sliding seat is provided with a second vertical guide sleeve. A vertical guide rod 22 is arranged inside the second vertical guide sleeve. The lower end of the vertical guide rod is connected with the support plate. The piston rod of the lift cylinder is connected with the support plate. The pressing plate is provided with a first guide sleeve 29 that can slide along the vertical connecting rod, and the first guide sleeve is provided with a set bolt 210 that can fix the first guide sleeve on the vertical connecting rod. The first guide sleeve is provided with horizontal screw holes penetrating through the inner and outer surfaces of the first guide sleeve, and the set bolts are arranged in the horizontal screw holes.

The mount has a cylindrical shape. A third annular stopper 211 is provided on the upper edge of the outer surface of the mounting base. The mounting base is provided with a plurality of first vertical mounting through holes 215 . The first vertical installation through hole is a round hole. A liquid containing cylinder 28 is inserted into the first vertical installation through hole. The liquid holding cylinder is cylindrical. The upper and lower ends of the liquid containing cylinder are open. The edge of the upper port of the liquid storage cylinder is provided with an air guiding gap 213 . The lower part of the liquid storage cylinder is provided with a filter membrane interlayer 216 . The filter membrane interlayer is close to the lower end of the liquid storage cylinder. The lower end of the liquid storage cylinder is located below the installation seat, the upper end of the liquid storage cylinder is located above the installation seat, and a first annular stopper 214 is provided on the outer surface of the liquid storage cylinder above the installation seat. A first sealing ring 212 is provided between the first vertical installation through hole and the liquid storage cylinder. The first sealing ring is installed in the sealing ring groove on the inner side of the first vertical installation through hole. The liquid storage cylinder can be taken out from the first vertical installation through hole, which is convenient for adding samples and cleaning.

As shown in Fig. 2 and Fig. 3, a check valve device is arranged in the lower port of the liquid holding cylinder. The one-way valve device is located below the filter membrane septum. The one-way valve device includes an annular boss 217 arranged on the inner side of the liquid containing cylinder, a second sealing ring 218 arranged on the inner surface of the annular boss, a vertical valve arranged in the liquid containing cylinder and above the annular boss. Sleeve 222, the valve rod 220 that can slide to be arranged in the vertical valve sleeve and the circular valve plate 219 that is arranged on the lower end of valve rod. The valve sleeve is connected with the liquid storage cylinder through the connecting rod. A second annular stopper 223 is provided on the outer surface of the valve stem above the valve sleeve. A second compression spring 221 is provided on the valve stem between the valve sleeve and the circular valve plate to make the second annular stopper abut against the valve sleeve. When the second annular stopper abuts against the valve sleeve, the second sealing ring abuts against the outer surface of the circular valve plate, and forms a sealing structure between the annular boss and the circular valve plate.

As shown in Fig. 1, Fig. 4 and Fig. 5, the liquid extraction and separation device includes vacuum pumping equipment, a main box body 41 with an airtight inner cavity, a circular placement through hole 44 and a communication type that are arranged on the top surface of the main box body. Airtight structure5. The vacuum equipment is an air pump. The outer diameter of the mounting seat is smaller than the inner diameter of the placement through hole. When the sliding seat abuts against the fourth limit stopper, the mounting seat is located directly above the placement through hole.

A plurality of extracting liquid collecting tubes 47 corresponding to the liquid containing tubes are arranged in the main box directly below the placement through hole. A placement frame 45 is provided in the main casing. The placing frame is provided with a horizontal placing plate 46 . A plurality of second vertical installation through holes are arranged on the horizontally placed plate. The extraction liquid collection cylinder is inserted into the corresponding second vertical installation through hole, and a third annular stopper 48 is provided on the outer surface of the extraction liquid collection cylinder above the second vertical installation through hole. The extraction liquid collection cylinder is cylindrical, and the inner diameter of the extraction liquid collection is larger than the inner diameter of the liquid storage cylinder. A vertical push rod 49 is arranged in the extraction liquid collection cylinder, and the vertical push rod is connected with the extraction liquid collection cylinder through a connecting rod. The upper end of the vertical push rod is located above the extraction liquid collection cylinder.

As shown in Figure 5, Figure 6, and Figure 7, when the mounting seat is inserted in the placement through hole, and the third annular stopper is against the top surface of the main box; the vertical ejector rod will jack up the circular valve plate , and make the circular valve plate above the annular boss.

The communicating airtight structure includes an installation groove arranged on the inner side of the through hole, an inflatable sealing ring 516 and a pressure conversion cylinder 51 arranged in the installation groove. The inner cavity of the pressure conversion cylinder is stepped. The inner cavity of the pressure conversion cylinder is composed of a first cavity 58 and a second cavity 54 which communicate with each other, and the inner diameter of the first cavity is larger than the inner diameter of the second cavity. A first piston body 59 is disposed in the first cavity. A second piston body 56 is arranged in the second cavity, and the first piston body and the second piston body are connected by a first connecting rod. One end close to the first piston body is open on the pressure conversion cylinder body, and one end close to the second piston body is closed. A first limiting block 510 is disposed on the inner side of the first cavity, and the first limiting block and the second piston body are located on opposite sides of the first piston body. A second limiting block 55 is disposed on the inner side of the second cavity, and the second limiting block is located between the second piston body and the second connection port. The second cavity is provided with a first pre-tightened compression spring 53 that can make the first piston body lean against the first limit block, and the first pre-tightened compression spring and the first piston body are located on opposite sides of the second piston body .

A first connection port 512 and a second connection port 511 are provided on the outer side of the pressure conversion cylinder. The first connection port communicates with the first cavity, and the first connection port is located between the first piston body and the second piston body. The second connection port communicates with the second cavity, and the second connection port and the first piston body are located on opposite sides of the second piston body. A third connection port 515 and a suction port 42 are provided on the outer side of the main box. A fourth connection port 57 communicating with the first cavity is provided on the outer side of the pressure conversion cylinder, and the fourth connection port is located between the first piston body and the second piston body. The fourth connecting port is provided with an electromagnetic switch valve. A fifth connection port 52 communicating with the second cavity is provided on the outer side of the pressure conversion cylinder, and the fifth connection port and the first piston body are located on opposite sides of the second piston body. The fifth connecting port is provided with an electromagnetic switch valve. A sixth connection port 43 communicating with the inner cavity of the main box is provided on the outer surface of the main box. The sixth connection port is provided with an electromagnetic switch valve. The inflatable sealing ring is provided with an inflatable exhaust nozzle. The first connection port is connected to the third connection port through a first communication pipe 514 . The second connection port is connected with the inflation nozzle through the second communication pipe 513 . The vacuum equipment is connected with the suction port through a third communication pipe.

The specific working process of the high-throughput pretreatment instrument for drug residue extraction of the present invention is as follows:

First, add the crushed aquatic products and the organic solvent into the liquid storage cylinder together.

Second, press the pressing plate against the upper port of each liquid storage cylinder, and fix the pressing plate through the set bolt.

Third, make the sliding seat abut against the third limit stopper, at this time, the mounting seat is located directly above the vortex oscillator; then, the lifting cylinder drives the support plate, the pressure plate, the mounting seat and the liquid storage cylinder to move down, and Make the lower end of the liquid storage cylinder lean against the rubber pad or sponge pad of the vortex oscillator; then, the vortex oscillator works to homogenize multiple samples at the same time.

Fourth, the lifting cylinder drives the supporting plate, the pressing plate, the mounting seat and the liquid storage cylinder to move upward.

Fifth, the sliding seat moves along the horizontal guide rail, and makes the sliding seat abut against the fourth limit stopper, and at this time, the mounting seat is located directly above the placement through hole.

Sixth, the lifting cylinder drives the support plate, the pressure plate, the mounting seat and the liquid storage cylinder to move down, so that the mounting seat is inserted into the through hole until the third annular stopper is against the top surface of the main box; at this time, the vertical The push rod will jack up the circular valve plate and make the circular valve plate be positioned above the annular boss.

Seventh, close the electromagnetic switch valves at the fourth, fifth and sixth connection ports, and open the vacuum equipment to vacuum the inner cavity of the main box;

As shown in Fig. 4, Fig. 5 and Fig. 6, since the communicating cylinder inner chamber between the first piston body and the second piston body communicates with the inner chamber of the main box through the first communicating pipe, and the first piston The cross-sectional area of the first piston body is larger than that of the second piston body; therefore, the air pressure between the first piston body and the second piston body decreases during the vacuuming process, so that the second piston body moves toward the second stopper , so that the gas in the connecting cylinder is pressed into the annular inflatable inner chamber of the inflatable sealing ring through the second connecting pipe, so that the inflatable sealing ring expands, thereby ensuring that the inflatable sealing ring is between the mounting seat and the through hole Forms a reliable seal.

During this process, the sample extraction liquid in the liquid storage cylinder passes through the filter membrane interlayer and flows into the corresponding extraction liquid collection cylinder.

Eighth, after the sample extraction solution to be filtered in the filter cartridge is filtered, the vacuum equipment is closed, and the electromagnetic switch valves at the fourth, fifth and sixth connection ports are opened at the same time, so that the first piston body and the The second piston body is reset under the action of the pre-tightened compression spring, and the residue can be repeatedly extracted as required, or prepared for the next filtration

Ninth, drive the support plate, the pressure plate, the mounting seat and the liquid storage cylinder through the lifting cylinder; then, take out the extraction liquid collection cylinder, so as to obtain the sample extraction liquid to be tested.

Claims (8)

1. A high-throughput pretreatment instrument for extracting drug residues, comprising a vortex oscillator, characterized in that it comprises a frame, a horizontal guide rail arranged on the frame, and a sliding seat that is slidably arranged on the horizontal guide rail , the clamping device located under the slide seat and the lifting cylinder arranged on the slide seat for lifting and lowering the clamping device, the clamping device includes a support plate, a mounting seat located below the support plate, and a vertical shaft connecting the support plate and the mounting seat Straight connecting rods and a pressure plate that can be lifted up and down along the vertical connecting rods; the mounting base is provided with a number of first vertical installation through holes, and a liquid storage cylinder is inserted in the first vertical installation through holes, and the liquid storage cylinder The lower end is located below the installation seat, the upper end of the liquid storage cylinder is located above the installation seat, and the outer surface of the liquid storage cylinder is above the installation seat and a first annular stopper is provided; the pressure plate is provided with a first stop that can slide along the vertical connecting rod. A guide sleeve, and the first guide sleeve is provided with a set bolt that can fix the first guide sleeve on the vertical connecting rod; the vortex oscillator is located below the mounting seat; It also includes an extraction liquid separation device, the extraction liquid separation device includes vacuum equipment, a main box with a closed inner cavity, a circular placement through hole and a connected airtight structure arranged on the top surface of the main box; Located directly below the placement through hole, there are several extraction liquid collection cylinders corresponding to the liquid storage cylinder; the connected airtight structure includes an installation groove arranged on the inner side of the placement through hole, and an inflatable Sealing ring and pressure conversion cylinder; The inner cavity of the pressure conversion cylinder is composed of a first cavity and a second cavity which communicate with each other, and the inner diameter of the first cavity is larger than the inner diameter of the second cavity; the first cavity is provided with a first piston body, the second cavity is provided with a second piston body, and the first piston body and the second piston body are connected through a first connecting rod, and the pressure conversion cylinder is opened at one end close to the first piston body, close to One end of the second piston body is closed; A first limit block is provided on the inner side of the first cavity, and the first limit block and the second piston body are located on the opposite sides of the first piston body, and the second cavity is provided to make the first piston body leaning against the first preloaded compression spring on the first limit block, and the first preloaded compression spring and the first piston body are located on opposite sides of the second piston body; A first connection port and a second connection port are provided on the outer side of the pressure conversion cylinder, the first connection port communicates with the first cavity, and the first connection port is located between the first piston body and the second piston body ; The second connection port communicates with the second cavity, and the second connection port and the first piston body are located on opposite sides of the second piston body; the outer side of the main box is provided with a third connection port and a suction port , the inflatable sealing ring is provided with an inflation nozzle, the first connection port is connected to the third connection port through a first communication pipe, and the second connection port is connected to the inflation nozzle through The second communication pipeline is connected, and the vacuum device is connected to the suction port through a third communication pipeline; The upper and lower ends of the liquid storage cylinder are open, the edge of the upper port of the liquid storage cylinder is provided with an air guide gap, and the lower part of the liquid storage cylinder is provided with a filter membrane interlayer; the mounting seat is cylindrical, and the outer diameter of the mounting seat is Smaller than the inner diameter of the placement through hole, a first sealing ring is provided between the first vertical installation through hole and the liquid storage cylinder. 2. A high-throughput pre-processing instrument for extracting drug residues according to claim 1, wherein a fourth connection connected to the first cavity is provided on the outer side of the pressure conversion cylinder port, and the fourth connection port is located between the first piston body and the second piston body, the fourth connection port is provided with an electromagnetic switch valve; The fifth connection port, and the fifth connection port and the first piston body are located on the opposite sides of the second piston body, the fifth connection port is provided with an electromagnetic switch valve; The sixth connection port communicating with the internal cavity, the sixth connection port is provided with an electromagnetic switch valve. 3. A high-throughput pre-processing instrument for extracting drug residues according to claim 1, wherein a second limiting block is provided on the inner side of the second cavity, and the second limiting block Located between the second piston body and the second connection port. 4. A high-throughput pre-processing instrument for extracting drug residues according to claim 1, wherein a check valve device is arranged in the lower port of the liquid holding cylinder, and the check valve device is located at Below the filter membrane interlayer, the one-way valve device includes an annular boss arranged on the inner surface of the liquid storage cylinder, and a second sealing ring arranged on the inner surface of the annular boss, which is arranged in the liquid storage cylinder and above the annular boss The vertical valve sleeve of the vertical valve sleeve can slide the valve stem arranged in the vertical valve sleeve and the circular valve plate arranged at the lower end of the valve stem. The valve sleeve is connected with the liquid storage cylinder through the connecting rod, and the outer surface of the valve stem A second annular stopper is provided above the valve sleeve, and a second compression spring is provided on the valve rod between the valve sleeve and the circular valve plate to make the second annular stopper lean against the valve sleeve, and When the second annular stopper is against the valve sleeve, the second sealing ring is against the outer surface of the circular valve plate; A vertical ejector rod is arranged in the extraction liquid collection cylinder, and the vertical ejector rod is connected with the extraction liquid collection cylinder through a connecting rod, and the upper end of the vertical ejector rod is located above the extraction liquid collection cylinder; The upper edge of the upper edge is provided with a third ring stop; when the mounting base is inserted into the placement through hole, and the third ring stop is against the top surface of the main box, the vertical push rod will jack up the circular valve plate, and make the circular valve plate above the annular boss. 5. according to claim 1 or 2 or 3 or 4 described a kind of high-throughput pretreatment instrument for drug residue extraction, it is characterized in that, the described main box body is provided with a placement frame, and the placement frame is provided with There is a horizontal plate; the horizontal plate is provided with a number of second vertical installation through holes, the extraction liquid collection tube is inserted in the corresponding second vertical installation through hole, and the outer surface of the extraction liquid collection tube is located A third annular stopper is arranged above the second vertical installation through hole. 6. A high-throughput pretreatment instrument for drug residue extraction according to claim 1 or 2 or 3 or 4, wherein the horizontal guide rail is provided with a third limit stopper and a fourth limit stopper. limit stopper, the sliding seat is located between the third limit stopper and the fourth limit stopper, and when the slide seat abuts against the third limit stopper, the mounting seat is in the position of vortex oscillation directly above the device; when the sliding seat abuts against the fourth limit stopper, the mounting seat is located directly above the placement through hole. 7. A high-throughput pre-treatment instrument for drug residue extraction according to claim 1 or 2 or 3 or 4, characterized in that, the slide seat is provided with a second vertical guide sleeve, the second A vertical guide rod is arranged inside the vertical guide sleeve, and the lower end of the vertical guide rod is connected with the support plate. 8. according to claim 1 or 2 or 3 or 4 described a kind of high-throughput pretreatment instrument for drug residue extraction, it is characterized in that, the oscillating plate of the vortex oscillator is provided with a rubber pad or Sponge pads, and rubber pads or sponge pads are located above the oscillating plate.