CN1050999C - Silkworm medicine for antiviral silkworm diseases - Google Patents
Silkworm medicine for antiviral silkworm diseases Download PDFInfo
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- CN1050999C CN1050999C CN93110876A CN93110876A CN1050999C CN 1050999 C CN1050999 C CN 1050999C CN 93110876 A CN93110876 A CN 93110876A CN 93110876 A CN93110876 A CN 93110876A CN 1050999 C CN1050999 C CN 1050999C
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- silkworm
- medicine
- radix
- crude
- chinese
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- 241000255789 Bombyx mori Species 0.000 title claims abstract description 47
- 239000003814 drug Substances 0.000 title claims abstract description 46
- 201000010099 disease Diseases 0.000 title claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 7
- 230000000840 anti-viral effect Effects 0.000 title claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000007788 liquid Substances 0.000 claims abstract description 15
- 239000000843 powder Substances 0.000 claims abstract description 8
- 239000010231 banlangen Substances 0.000 claims abstract description 7
- 239000009636 Huang Qi Substances 0.000 claims description 6
- 241000237636 Pheretima Species 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 4
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 2
- 229940126678 chinese medicines Drugs 0.000 claims 1
- 238000000247 postprecipitation Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 4
- 235000019636 bitter flavor Nutrition 0.000 abstract description 2
- 239000003205 fragrance Substances 0.000 abstract description 2
- 244000000010 microbial pathogen Species 0.000 abstract description 2
- 240000002234 Allium sativum Species 0.000 abstract 1
- 244000061520 Angelica archangelica Species 0.000 abstract 1
- 241000950640 Calcarius Species 0.000 abstract 1
- 244000247747 Coptis groenlandica Species 0.000 abstract 1
- 235000002991 Coptis groenlandica Nutrition 0.000 abstract 1
- 241000893536 Epimedium Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000001287 Guettarda speciosa Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 241000361919 Metaphire sieboldi Species 0.000 abstract 1
- 229930195210 Ophiopogon Natural products 0.000 abstract 1
- 244000248557 Ophiopogon japonicus Species 0.000 abstract 1
- 241000972673 Phellodendron amurense Species 0.000 abstract 1
- 206010040047 Sepsis Diseases 0.000 abstract 1
- 241000316342 Taxillus Species 0.000 abstract 1
- 229940107666 astragalus root Drugs 0.000 abstract 1
- 235000018905 epimedium Nutrition 0.000 abstract 1
- 235000004611 garlic Nutrition 0.000 abstract 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 abstract 1
- 230000036737 immune function Effects 0.000 abstract 1
- 235000015096 spirit Nutrition 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 206010000269 abscess Diseases 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 235000011149 sulphuric acid Nutrition 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 235000008708 Morus alba Nutrition 0.000 description 2
- 240000000249 Morus alba Species 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 229910052573 porcelain Inorganic materials 0.000 description 2
- 239000001117 sulphuric acid Substances 0.000 description 2
- VKJGBAJNNALVAV-UHFFFAOYSA-M Berberine chloride (TN) Chemical compound [Cl-].C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 VKJGBAJNNALVAV-UHFFFAOYSA-M 0.000 description 1
- 241000255791 Bombyx Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010041954 Starvation Diseases 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000001459 mortal effect Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 239000005426 pharmaceutical component Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a medicine for silkworm, which has obvious effects for preventing and treating silkworm viral desonucleosis, malacopathia and midgut sepsis. 11 kinds of traditional Chinese medicine comprising coptis, phellodendron bark, astragalus root, garlic, radix isatidis, angelica, Chinese taxillus twig, longspur epimedium, ophiopogon root, earthworm and licorice root, which can enhance silkworm immunological functions and resist viral pathogenic microorganisms, are used as crude medicine powder; the crude medicine powder is leached into crude medicine liquid with Chinese spirits with the alcoholicity of 50%, the crude medicine liquid is blended, filtered, deposited, etc., and then, the crude medicine liquid is prepared into a brown yellow pellucid diluted alcohol solution The pellucid diluted alcohol solution contains 35 to 45% of alcohol and has alcohol fragrance and mildly bitter flavor. Every 10 ml of medicine liquid is equivalent to 0.6 g of crude medicine.
Description
The present invention relates to a kind of silkworm medicine, especially for the silkworm medicine of control viral desonucleosis, malacopathia and mesenteron abscess.
The viral silkworm medicine of silkworm is that infectiousness flacherie serious, very difficult treatment takes place generally, endangers in the domestic and international now production of breeding silkworms, its harm accounts for 70～80% of flacherie total losses, particularly viral desonucleosis, malacopathia and mesenteron abscess (are commonly called as the bright silkworm of water, the bear silkworm), the silkworm raiser has a mortal malady especially, is referred to as the cancer of silkworm.In a single day silkworm suffers from this disease, has more that existing lack of appetite body contracts, stomach breast inanition, swelling be shinny, tells diseases such as liquid dysentery, generally is difficult to cure, and causes a large amount of dead silkworms.Production brings enormous economic loss to silkworm and mulberry.At present domestic still do not have a kind of silkworm medicine and can effectively prevent and treat this kind flacherie.
In order to help numerous silkworm raisers to remove sting in one's heart, capture above-mentioned flacherie difficulty, the objective of the invention is to develop a kind of silkworm medicine of preventing and treating the viral desonucleosis of silkworm, malacopathia and mesenteron abscess fruitfully.
The silkworm medicine of the present invention's development is a ultimate principle of using the traditional Chinese medical science, the principle of herbal control human body diseases referred to prevent and treat on the flacherie, in conjunction with the practice of breeding silkworms, selecting ten plurality of Chinese such as Rhizoma Coptidis with the Chinese medicine ingredients that strengthens silkworm body immunity function and antiviral property pathogenic microorganism, the Radix Astragali, Radix Glycyrrhizae, Herba Taxilli, Radix Isatidis, Herba Epimedii, Pheretima for use is former medicated powder, extracts formulated dilute alcohol solution through scientific method.
This silkworm medicine composition (by weight percentage) is as follows:
Rhizoma Coptidis 13.5～14.4%
Cortex Phellodendri 13.5～14.4%
Bulbus Allii 13.5～14.4%
Radix Isatidis 8.6～9.0%
The Radix Astragali 6.9～7.2%
Radix Angelicae Sinensis 6.9～7.2%
Herba Taxilli 6.9～7.2%
Herba Epimedii 6.9～7.2%
Radix Ophiopogonis 6.9～7.2%
Pheretima 6.9～7.2%
Radix Glycyrrhizae 6.9～7.2%
Above-mentioned Chinese medicine total amount is processed into former medicated powder earlier, the lixiviate of reuse Chinese liquor, the time is more than one month, make the translucent original liquid of pale brown color, and then through dissolving operations such as filtration, precipitation, promptly make dilute alcohol solution, every 10ml is equivalent to crude drug in whole 0.6g, and ethanol content should be 35～45%.
This silkworm medicine is rich in aminoacid and multiple pharmaceutical component.After these medicines infiltrate the intravital viruses molecule of silkworms, can blocking virus nucleic acid and proteinic synthetic, suppress duplicating and infecting of virus, therefore, this silkworm medicine can effectively be controlled the generation of viral flacherie, and nontoxic, side effect.
After adding food this silkworm medicine, the silkworm body is strong, and flacherie is few, basic controlling the generation of viral flacherie, can make the Bombyx bombycis volume increase more than 10%.
Apply this silkworm medicine,, improve cocoon yield and quality, increase silkworm raiser and country's income, promote the development of silkworm and mulberry production to have important effect preventing and treating flacherie.
Provide embodiment below:
Example 1:
Press formula proportion and prepare Chinese medicine:
Rhizoma Coptidis 15g
Cortex Phellodendri 15g
Radix Astragali 8g
Radix Angelicae Sinensis 8g
Radix Glycyrrhizae 8g
Herba Taxilli 8g
Radix Isatidis 8g
Radix Ophiopogonis 8g
Herba Epimedii 8g
Pheretima 8g
Bulbus Allii 15g
Above-mentioned 11 flavor Chinese medicine total amounts are processed into former medicated powder earlier, reuse 50 degree Chinese liquor 1Kg lixiviates, the time is 50 days, makes the translucent original liquid of pale brown color, again through dissolve, filter, operation such as precipitation, promptly make this liquid silkworm medicine, contain alcohol amount 35～45%.For guaranteeing drug effect, should bottled sealing.
Example 2:
Prescription:
Rhizoma Coptidis 20g
Cortex Phellodendri 20g
Radix Astragali 10g
Radix Angelicae Sinensis 10g
Radix Glycyrrhizae 10g
Herba Taxilli 10g
Radix Isatidis 15g
Radix Ophiopogonis 10g
Herba Epimedii 10g
Pheretima 10g
Bulbus Allii 20g
With above-mentioned 11 flavor Chinese medicine total amounts be processed into former medicated powder earlier, reuse 50 degree Chinese liquor 1Kg are leached into pale brown color that the muddy liquid of trace is arranged, soak the body time to be not less than 40 days, through dissolve, filter, operation such as precipitation, promptly get this liquid silkworm medicine.It contains the alcohol amount is 35～45%.
Example 3:
Prescription:
Rhizoma Coptidis 25g
Cortex Phellodendri 25g
Radix Astragali 12g
Radix Angelicae Sinensis 12g
Radix Glycyrrhizae 12g
Herba Taxilli 12g
Radix Isatidis 15g
Radix Ophiopogonis 12g
Herba Epimedii 12g
Pheretima 12g
Bulbus Allii 20g
Above-mentioned Chinese medicine total amount is processed into former medicated powder earlier, reuse 50 degree Chinese liquor 1Kg lixiviates, 35 days time.Again through dissolve, filter, operation such as precipitation, promptly be made into this liquid silkworm medicine.
Check to this silkworm medicine:
This silkworm medicine is plurality of Chinese such as Rhizoma Coptidis, and through the spirit that extraction is mixed with, every 10ml is equivalent to crude drug in whole 0.6g.[character] this medicine is the clear liquid of brown yellow, ethanol fragrance is arranged, mildly bitter flavor.This medicine 2ml is got in [discriminating] (1), adds ethanol 2ml, drips 0.2% ninhydrin solution,
(100 ℃) heating is 1～2 minute in the water-bath, shows bluish violet.
(2) get this medicine 2ml, put in the test tube, add concentrated sulphuric acid 1ml, drip along the tube wall heart
Add the about 1ml of ammonia, then two liquid joints have red ring to generate.
(3) get this medicine 5ml, put in the porcelain dish, evaporate to dryness in water-bath, residue adds acetic anhydride
Several dissolvings add 2～3 of concentrated sulphuric acids immediately along the porcelain dish edge, be purple
Redness, and become pitchy rapidly.[inspection] total solid, precision are measured this medicine 25ml, place the evaporating dish of constant weight,
Evaporate to dryness in water-bath is dried to constant weight at 105 ℃, and it is many to leave over residue
In 3.0%.
Ethanol content should be 35～45%, and (Chinese Pharmacopoeia one one of version in 1985 is attached
Record 50 pages).
Other should meet every regulation (Chinese Pharmacopoeia relevant under the medicated wine item
50 pages of appendix of version in 1985).[assay] precision is measured this medicine 10ml, puts in the 25ml measuring bottle, adds hydrochloric acid solution (mol/L)
1ml adds ethanol dilution to scale; Shake up, close plug; Put in the water-bath and add
Heat 10 minutes is after the cooling, according to post layer folding method (Chinese Pharmacopoeia 1985
35 pages of appendix of version) test; Precision is drawn 5ml, places to handle
Good alumina column (internal diameter 0.9cm), neutral alumina 59, wet method dress
Post, and earlier with in the prewashing of 30.ml ethanol, wash with ethanol 35ml gradation
Take off, collect eluent, put in the 50ml measuring bottle, add ethanol dilution to carving
Degree shakes up; Precision is drawn 10ml, puts in the 50ml measuring bottle, adds sulphuric acid
Liquid (0.05mol/L) is diluted to scale, shakes up.According to spectrophotography
(31 pages of appendix of Chinese Pharmacopoeia version in 1985) is at the ripple of 3451 ± nm
Strong point measures trap, presses berberine hydrochloride (C20H18ClNO4)
(E1cml%/1cm) 728 calculates absorptance, is no less than 0.05%.[usage and consumption] diseases prevention grown silkworm: every silkworm, with 4～5 bottles of this medicines (160～200ml), with fresh cold opening
Water (the overcast and rainy Chinese liquor of using instead) is diluted to 50 times, evenly is sprayed on Folium Mori
On, feed; Play silkworm 4 ages, once a day, and until putting on an arrow.Control flacherie: every silkworm, with 3～5 bottles of this silkworm medicines, (hot weather is used with 50 degree Chinese liquor
Fresh cold boiled water is diluted to 5～10 times and is sprayed on the Folium Mori, feeds,
Continuous more than 2 times, till recovering.[storage] airtight, put shady and cool place deposits 2 years effect duration.
Claims (1)
1. the silkworm medicine of an antiviral silkworm diseases, it is made by following method:
Prescription is by weight percentage:
Rhizoma Coptidis 13.5-14.4%
Cortex Phellodendri 13.5-14.4%
Bulbus Allii 13.5-14.4%
Radix Isatidis 8.6-9.0%
Radix Astragali 6.9-7.2%
Radix Angelicae Sinensis 6.9-7.2%
Herba Taxilli 6.9-7.2%
Herba Epimedii 6.9-7.2%
Radix Ophiopogonis 6.9-7.2%
Pheretima 6.9-7.2%
Radix Glycyrrhizae 6.9-7.2%
With above-mentioned 11 flavor Chinese medicines is former medicated powder, with 50 ° of Chinese liquor lixiviates, makes original liquid, through dissolve, filtration, post precipitation, making ethanol content is 35-45%, every 10ml is equivalent to the dilute alcohol solution of crude drug in whole 0.6g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93110876A CN1050999C (en) | 1993-02-16 | 1993-02-16 | Silkworm medicine for antiviral silkworm diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93110876A CN1050999C (en) | 1993-02-16 | 1993-02-16 | Silkworm medicine for antiviral silkworm diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1075889A CN1075889A (en) | 1993-09-08 |
| CN1050999C true CN1050999C (en) | 2000-04-05 |
Family
ID=4988695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93110876A Expired - Fee Related CN1050999C (en) | 1993-02-16 | 1993-02-16 | Silkworm medicine for antiviral silkworm diseases |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1050999C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100398133C (en) * | 2006-05-09 | 2008-07-02 | 汤川 | Chinese medicine for treating silkworm disease |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5508408A (en) * | 1993-09-10 | 1996-04-16 | Ciba-Geigy Corporation | Quinoline compound |
| CN100360039C (en) * | 2003-05-07 | 2008-01-09 | 东北师范大学遗传与细胞研究所 | A kind of traditional Chinese medicine preparation with killing virus and its production process |
| WO2006093164A1 (en) * | 2005-02-28 | 2006-09-08 | Osaka Prefecture | Virus infection and proliferation inhibitor containing earthworm-derived component |
| CN101569639B (en) * | 2008-04-29 | 2011-08-31 | 四川师范大学 | Dyers woad leaf and application of extract thereof |
| CN106376530B (en) * | 2016-08-30 | 2017-09-05 | 盐城市大丰区蚕桑技术指导站 | Sericulture methods to prevent silkworm disease |
-
1993
- 1993-02-16 CN CN93110876A patent/CN1050999C/en not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| 《中成药研究》(7) 1983. 7.31 陈泉生,中药的抗衰老作用 * |
| 《山东医科大学学报》31(1) 1993. 1.31 钟蒙,抗病毒剂研究 * |
| 《山东医科大学学报》31(1) 1993. 1.31 钟蒙,抗病毒剂研究;《中成药研究》(7) 1983. 7.31 陈泉生,中药的抗衰老作用 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100398133C (en) * | 2006-05-09 | 2008-07-02 | 汤川 | Chinese medicine for treating silkworm disease |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1075889A (en) | 1993-09-08 |
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