CN104906132B - A kind of plaster for preventing and treating lamb stomatitis - Google Patents

Abstract

This invention discloses and it is a kind of prevent and treat lamb stomatitis plaster, consist of the following compositions：25~75ml of the tincture of iodine, 25~75ml of glycerol, 1~3g of menthol, 1~3g of xanthan gum, 25~75ml of pure water.After mixing the tincture of iodine and menthol mixed solution with glycerol, then mixes with the jelly of xanthan gum and both obtained.The present invention mainly as lamb stomatitis external application prevention and treatment, can anti-inflammatory, analgesic, it is antipruritic, promote blood circulation, mitigate edema, to bacterium, virus have killing effect.

Description

A plaster preparation for preventing and treating lamb stomatitis

technical field

The invention belongs to the technical field of veterinary medicine, and in particular relates to a plaster preparation for preventing and treating lamb stomatitis.

Background technique

Mouth stomatitis is an inflammation of the surface and deep tissues of the oral mucosa. In the pathological process, the oral mucosa and gums are inflamed, which can make it difficult for sick sheep to eat and chew, salivation clears the mouth, and pain sensitivity increases. Simple local inflammation and secondary systemic reactions are common clinically. Newborn lambs mainly rely on breastfeeding for nutrition within a week. After a week, as the lambs grow up, they begin to imitate ewes to eat feed and bite objects of various shapes. However, because the skin and mucous membranes of the mouth of newborn lambs are particularly delicate, they are very easy to be injured and damaged, and stomatitis will occur after infection. Once infected with stomatitis, sick sheep show loss of appetite, salivation in the mouth, slow chewing, reluctance to eat because of pain, and sometimes secondary halitosis. If the sick sheep cannot be treated in time, the sick sheep will have loss of appetite or even no appetite, reduced rumination, dull and messy coat, and gradually become emaciated, and eventually the sick lamb will starve to death.

At present, in the production of sheep, some disinfectants are mainly used to prevent and treat lamb stomatitis. For mild stomatitis, the mouth can be washed with 0.1% Ravenul or 0.1% potassium permanganate solution, or rinsed with 2% alum; When erosion and exudation occur, rinse with 2% alum; when oral mucosa has ulcers, use iodine glycerin, 5% iodine tincture, gentian violet solution, sulfonamide ointment, tetracycline ointment, etc. to rub the affected part; When the sheep's body temperature rises, penicillin, streptomycin, etc. can be used for intramuscular injection, twice a day, for 3 to 5 consecutive days, and sulfa drugs can also be taken or injected.

In the process of using the above methods to prevent and treat lamb stomatitis, it was found that some of the above-mentioned commonly used disinfectants are not easy to adhere to the diseased part, let alone form a protective cover on the diseased part, so that they cannot be used on the diseased part. Stay for a long time to exert the drug effect, and the curative effect is slow; other ointments such as sulfonamides and tetracyclines are irritating to lambs due to their bitter taste, and they are prone to drug resistance when used frequently. The use of antibiotics can easily lead to problems such as drug resistance (resistance) and breeding drug residues exceeding the standard, and even affect the mammary gland development of ewes, which does not meet the needs of animal welfare, the development of pollution-free aquaculture, and the production of green aquatic products. .

Contents of the invention

Aiming at the technical defects existing in the prevention and treatment of lamb stomatitis in the prior art, the purpose of the present invention is to provide a low-cost, easy-to-use and effective ointment for the prevention and treatment of lamb stomatitis, and the preparation method of the ointment. The ointment prepared by the present invention The practical application effect is good, the cost is low, easy to process and produce, and has a good market prospect.

The present invention is specifically realized through the following technical solutions:

A plaster preparation for preventing and treating lamb stomatitis, which consists of the following components: 25-75ml of tincture of iodine, 25-75ml of glycerin, 1-3g of menthol, 1-3g of xanthan gum, and 25-75ml of purified water.

The mass concentration of iodine in the described iodine tincture is 20g/L, i.e. 2% iodine tincture.

The ointment is mainly used for treating lamb stomatitis from birth to 60 days of age.

The plaster preparation for preventing and treating lamb stomatitis is prepared by the following method:

1) dissolving 1-3g of menthol in 25-75ml of tincture of iodine with a concentration of 2% to obtain an iodine-menthol solution;

2) Measure 25-75ml of glycerin and mix with the iodine-menthol solution made in step (1) to obtain a mixed solution;

3) Weigh 1-3g of xanthan gum and dissolve it in 25-75ml of water, fully dissolve to obtain jelly;

4) Thoroughly mix the mixed solution obtained in step (2) with the jelly produced in step (3).

Preferably, a plaster preparation for preventing and treating lamb stomatitis is composed of the following components: 50ml of tincture of iodine, 50ml of glycerin, 2g of menthol, 2g of xanthan gum, and 50ml of purified water.

The mass concentration of iodine in the described iodine tincture is 20g/L, i.e. 2% iodine tincture.

The ointment is mainly used for treating lamb stomatitis from birth to 60 days of age.

The plaster preparation for preventing and treating lamb stomatitis is prepared by the following method:

1) dissolving 2g menthol in 50ml concentration of 2% iodine tincture to obtain iodine tincture menthol solution;

2) Measure the glycerin of 50ml and mix with the iodine tincture menthol solution made in step (1) to obtain a mixed solution;

3) Weigh 2g of xanthan gum and dissolve it in 50ml of water, fully dissolve to obtain jelly;

4) Thoroughly mix the mixed solution obtained in step (2) with the jelly produced in step (3).

The tincture of iodine in the ointment of the present invention, tincture of iodine is commonly called as iodine wine, is generally called tincture of iodine in medicine, is the antiseptic antiseptic used for skin infection and disinfection, is the 2% solution that is made by dissolving iodine and potassium iodide in alcohol. Its mechanism of action is to denature and kill bacterial proteins, and it has a killing effect on bacteria and viruses. The function of iodine tincture is mainly used for disinfection of the skin, before injection, and the surgical site.

Glycerin, glycerol is a colorless, sweet, clear, viscous liquid, odorless, with a warm sweet taste, commonly known as glycerin, which can absorb moisture from the air, and is a component of many skin care products.

Menthol, a chemical agent, is extracted from the leaves and stems of peppermint. It is a white crystal with a molecular formula of C ₁₀ H ₂₀ O. It is the main component of peppermint and peppermint essential oils. In the world, India is the major producer of natural peppermint. Both menthol and racemic menthol can be used as toothpaste; perfume; flavoring agent for beverages and candies. It is used as a stimulant in medicine, acting on the skin or mucous membranes, and has a cooling and antipruritic effect; it can be used as a carminative when taken orally, for headaches and nose; pharynx; laryngitis, etc. Its esters are used in fragrances and medicines. Menthol can selectively stimulate the cold receptors of human skin or mucous membranes, produce cold reflection and cold sensation, and cause skin and mucous membrane blood vessels to constrict (actually the skin remains normal); in addition, it can also cause contraction of blood vessels in deep tissues, resulting in Therapeutic effect. External use can reduce inflammation, relieve pain, relieve itching, promote blood circulation, reduce edema, etc.

Xanthan gum, also known as xanthan gum, xanthan gum, and xanthomonas polysaccharide, is a monospore polysaccharide produced by the fermentation of Pseudoxanthomonas, which is produced by Xanthomonas campestris spp. The main raw material, through aerobic fermentation bioengineering technology, cuts 1,6-glucosidic bonds, opens branched chains, and then presses 1,4-bonds to form an acidic extracellular heteropolysaccharide composed of straight chains. Xanthan gum is an extracellular microbial polypond produced by the intoxication of sugars by Xanthomonas bacteria. Due to its special macromolecular structure and colloidal properties, it has multiple functions, and can be used as an emulsifier, stabilizer, gel thickener, wetting agent, film forming agent, etc. Xanthan gum, known as "industrial monosodium glutamate", is currently the world's largest microbial polysaccharide with a wide range of uses. In pharmaceutical products, it can be used as a setting agent, suspending agent, and moisturizing agent. It has the functions of thickening, adhesion, and lubrication, and can improve the adhesion of ointments and has good dispersibility.

The beneficial effects of the present invention are: the ointment of the present invention is mainly used for clearing heat and detoxifying, can reduce inflammation, relieve pain, relieve itching, promote blood circulation, reduce edema, and have a killing effect on bacteria and viruses. Lamb stomatitis has a significant curative effect. Simultaneously, the ointment of the present invention is convenient to use, has long-acting effects, is convenient and simple, has a simple preparation process, and is easy to popularize and use.

Detailed ways

The present invention will be further described below in conjunction with the embodiments. The following descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention to other forms. Changes to equivalent embodiments with equivalent changes. Any simple modifications or equivalent changes made to the following embodiments according to the technical essence of the present invention without departing from the solution content of the present invention fall within the protection scope of the present invention.

Example 1

A plaster preparation for preventing and treating lamb stomatitis, which consists of the following components: 50ml of tincture of iodine, 50ml of glycerin, 2g of menthol, 2g of xanthan gum, and 50ml of purified water.

Prepared by:

1) dissolving 2g menthol in 50ml concentration of 2% iodine tincture to obtain iodine tincture menthol solution;

2) Measure the glycerin of 50ml and mix with the iodine tincture menthol solution made in step (1) to obtain a mixed solution;

3) Weigh 2g of xanthan gum and dissolve it in 50ml of water, fully dissolve to obtain jelly;

4) Thoroughly mix the mixed solution obtained in step (2) with the jelly produced in step (3).

Example 2

A plaster preparation for preventing and treating lamb stomatitis, which consists of the following components: 25ml of tincture of iodine, 75ml of glycerin, 1g of menthol, 3g of xanthan gum, and 25ml of purified water.

Prepared by:

1) 1g of menthol is dissolved in 25ml of iodine tincture with a concentration of 2%, to obtain iodine tincture of menthol;

2) Measure the glycerol of 75ml and mix with the iodine tincture menthol solution made in step (1) to obtain a mixed solution;

3) Weigh 3g of xanthan gum and dissolve it in 25ml of water, fully dissolve to obtain jelly;

4) Thoroughly mix the mixed solution obtained in step (2) with the jelly produced in step (3).

Example 3

A plaster preparation for preventing and treating lamb stomatitis, which consists of the following components: 75ml of tincture of iodine, 25ml of glycerin, 3g of menthol, 1g of xanthan gum, and 75ml of purified water.

Prepared by:

1) dissolving 3g menthol in 75ml concentration of 2% iodine tincture to obtain iodine tincture menthol solution;

2) Measure 25ml of glycerin and mix with the iodine tincture menthol solution made in step (1) to obtain a mixed solution;

3) Weigh 1g of xanthan gum and dissolve it in 75ml of water, fully dissolve to obtain jelly;

4) Thoroughly mix the mixed solution obtained in step (2) with the jelly produced in step (3).

The therapeutic effect of the ointment of the present invention will be further described below in conjunction with specific examples.

Embodiment 4 therapeutic effect experiment

In a milk goat farm in Laoshan District, Qingdao City, Shandong Province, lambs were selected from birth to 60 days old, and 200 lambs diagnosed with stomatitis were selected as treatment objects, and 200 randomly selected lambs with stomatitis were selected. Lamb is divided into 4 groups (embodiment 1 group, embodiment 2 groups, embodiment 3 groups and control group), every group of 50, wherein embodiment 1～3 groups use the plaster obtained from embodiment 1～3 of the present invention to carry out respectively. For treatment, apply it on the affected area at night, and change the dressing once a day; the control group is treated with western medicine, grinding 25 tablets of metronidazole each with a net weight of 0.2g into powder, mixing it into 30ml of warm water for stirring, and finally adding 70ml of glycerin Mix and prepare a metronidazole-glycerin mixture with a concentration of 0.5%, rinse the oral cavity of the sick sheep with 0.2% potassium permanganate, and rub the metronidazole-glycerin mixture on the affected part, once a day in the morning and evening. The cure rate and cure time of each group of sheep were observed and recorded, and the results are shown in Table 1.

Efficacy Judgment Criteria:

Recovery: After 1 week of treatment, the sheep's oral symptoms disappeared, they could eat normally, and their body temperature returned to normal.

Effective: The oral symptoms of affected sheep basically disappeared, the food intake increased compared with before treatment, and the body temperature returned to normal.

Ineffective: After 1 week of treatment, the affected sheep still had oral symptoms, and their body temperature was high, and their food intake did not increase.

Table 1 Treatment effect statistics

group Example 1 Example 2 Example 3 control group get well 49 45 46 30 efficient 1 4 4 11

invalid 0 1 0 9 Days of recovery 3 3 3 7

As can be seen from the data of table 1: plaster of the present invention is obviously better than western medicine treatment group to amniotic stomatitis therapeutic effect, and treatment experiment is obviously shorter than matched group simultaneously, illustrates that plaster of the present invention has obvious effect on long-acting and absorption of medicine.

Embodiment 5 control effect experiment

Randomly select 200 healthy lambs just after birth in a dairy goat farm in Laoshan District, Qingdao City, Shandong Province, and divide the 200 lambs selected at random into 4 groups (embodiment 1 group, embodiment 2 groups, embodiment 3 groups and contrast) Group), every group of 50, wherein embodiment 1～3 groups use respectively the plaster gained in the embodiment of the present invention 1～3 to carry out prevention and treatment, apply once in the sheep lip every night; Control group does not use any medicine, after 10 consecutive days, Get the disease material suspension of goats, and inoculate the sheep of embodiment group 1, embodiment group 2, embodiment group 3 and control group in the mucous membrane scratches of the sheep lips, observe and record the incidence rate of each group of sheep, and the results are shown in Table 2 shown.

Table 2 Statistical data of preventive effect

group Example 1 Example 2 Example 3 control group total 50 50 50 50 number of infections 1 2 3 48 Morbidity 2% 4% 6% 96% protection rate 98% 96% 94% 4%

From the data in Table 2, it can be seen that the traditional Chinese medicine composition of the present invention has an obvious preventive effect on stomatitis.

Claims (5)

1. A plaster preparation for preventing and treating lamb stomatitis, characterized in that: it is composed of the following components: iodine tincture 25～75ml, glycerin 25～75ml, menthol 1～3g, xanthan gum 1～3g, purified water 25～75ml. 2. A kind of plaster preparation for preventing and treating lamb stomatitis according to claim 1, characterized in that: it consists of the following components: iodine tincture 50ml, glycerin 50ml, menthol 2g, xanthan gum 2g, purified water 50ml. 3. A kind of plaster preparation for preventing and treating lamb stomatitis according to claim 1 or 2, characterized in that: the mass concentration of iodine in the described iodine tincture is 20g/L. 4. The application of the plaster preparation according to claim 1 or 2 in the preparation of medicines for treating lamb stomatitis, characterized in that: the lamb is a lamb within 60 days after birth. 5. a kind of plaster preparation for preventing and treating lamb stomatitis according to claim 1 and 2, is characterized in that: described plaster preparation is prepared by the following method: 1) Dissolving holenol in iodine tincture with a concentration of 2% to obtain iodine menthol solution; 2) Measure glycerin and mix with the iodine tincture menthol solution prepared in step (1) to obtain a mixed solution; 3) Weigh xanthan gum and dissolve it in water, fully dissolve to obtain jelly; 4) Thoroughly mix the mixed solution obtained in step (2) with the jelly made in step (3).