CN1048805A - Be used to cover the treatment material of wound and skin injury and their manufacture method - Google Patents
Be used to cover the treatment material of wound and skin injury and their manufacture method Download PDFInfo
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- CN1048805A CN1048805A CN 89104813 CN89104813A CN1048805A CN 1048805 A CN1048805 A CN 1048805A CN 89104813 CN89104813 CN 89104813 CN 89104813 A CN89104813 A CN 89104813A CN 1048805 A CN1048805 A CN 1048805A
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- Prior art keywords
- oil
- emulsion
- treatment material
- wound
- carrier
- Prior art date
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- 239000000463 material Substances 0.000 title claims abstract description 30
- 208000027418 Wounds and injury Diseases 0.000 title claims abstract description 25
- 206010052428 Wound Diseases 0.000 title claims abstract description 24
- 238000000034 method Methods 0.000 title claims abstract description 16
- 208000028990 Skin injury Diseases 0.000 title claims abstract description 11
- 238000004519 manufacturing process Methods 0.000 title description 3
- 239000000839 emulsion Substances 0.000 claims abstract description 28
- 239000013543 active substance Substances 0.000 claims abstract description 5
- 239000000203 mixture Substances 0.000 claims description 26
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 21
- -1 Polyoxyethylene Polymers 0.000 claims description 19
- 239000003921 oil Substances 0.000 claims description 14
- 235000019198 oils Nutrition 0.000 claims description 14
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 13
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 11
- 239000000126 substance Substances 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 7
- 210000000582 semen Anatomy 0.000 claims description 7
- 238000007598 dipping method Methods 0.000 claims description 5
- 239000003995 emulsifying agent Substances 0.000 claims description 5
- 239000000123 paper Substances 0.000 claims description 5
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 4
- 229920002994 synthetic fiber Polymers 0.000 claims description 4
- 239000004753 textile Substances 0.000 claims description 4
- 239000005662 Paraffin oil Substances 0.000 claims description 3
- 235000019486 Sunflower oil Nutrition 0.000 claims description 3
- 229940088710 antibiotic agent Drugs 0.000 claims description 3
- 229920002545 silicone oil Polymers 0.000 claims description 3
- 239000002600 sunflower oil Substances 0.000 claims description 3
- 239000012209 synthetic fiber Substances 0.000 claims description 3
- MSJBLPVXRJMJSY-UHFFFAOYSA-N 2,6-bis(2-ethylhexyl)-7a-methyl-1,3,5,7-tetrahydroimidazo[1,5-c]imidazole Chemical compound C1N(CC(CC)CCCC)CC2(C)CN(CC(CC)CCCC)CN21 MSJBLPVXRJMJSY-UHFFFAOYSA-N 0.000 claims description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims description 2
- 238000006424 Flood reaction Methods 0.000 claims description 2
- 229930182566 Gentamicin Natural products 0.000 claims description 2
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims description 2
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 claims description 2
- 229930193140 Neomycin Natural products 0.000 claims description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 229920000297 Rayon Polymers 0.000 claims description 2
- URWAJWIAIPFPJE-UHFFFAOYSA-N Rickamicin Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(CC=C(CN)O2)N)C(N)CC1N URWAJWIAIPFPJE-UHFFFAOYSA-N 0.000 claims description 2
- 229930192786 Sisomicin Natural products 0.000 claims description 2
- 239000004098 Tetracycline Substances 0.000 claims description 2
- 239000010775 animal oil Substances 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 230000002421 anti-septic effect Effects 0.000 claims description 2
- 239000003429 antifungal agent Substances 0.000 claims description 2
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 2
- 239000000645 desinfectant Substances 0.000 claims description 2
- 229960003276 erythromycin Drugs 0.000 claims description 2
- 235000021323 fish oil Nutrition 0.000 claims description 2
- 229940050410 gluconate Drugs 0.000 claims description 2
- 229950004575 hexedine Drugs 0.000 claims description 2
- 229960000282 metronidazole Drugs 0.000 claims description 2
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims description 2
- 229960002509 miconazole Drugs 0.000 claims description 2
- 239000002480 mineral oil Substances 0.000 claims description 2
- 235000010446 mineral oil Nutrition 0.000 claims description 2
- 229960004927 neomycin Drugs 0.000 claims description 2
- 239000004006 olive oil Substances 0.000 claims description 2
- 235000008390 olive oil Nutrition 0.000 claims description 2
- 239000000419 plant extract Substances 0.000 claims description 2
- 238000006116 polymerization reaction Methods 0.000 claims description 2
- 229960005456 sisomicin Drugs 0.000 claims description 2
- URWAJWIAIPFPJE-YFMIWBNJSA-N sisomycin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC=C(CN)O2)N)[C@@H](N)C[C@H]1N URWAJWIAIPFPJE-YFMIWBNJSA-N 0.000 claims description 2
- 229960002180 tetracycline Drugs 0.000 claims description 2
- 229930101283 tetracycline Natural products 0.000 claims description 2
- 235000019364 tetracycline Nutrition 0.000 claims description 2
- 150000003522 tetracyclines Chemical class 0.000 claims description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
- 239000008158 vegetable oil Substances 0.000 claims description 2
- 229920000742 Cotton Polymers 0.000 claims 1
- 239000004258 Ethoxyquin Substances 0.000 claims 1
- DECIPOUIJURFOJ-UHFFFAOYSA-N ethoxyquin Chemical compound N1C(C)(C)C=C(C)C2=CC(OCC)=CC=C21 DECIPOUIJURFOJ-UHFFFAOYSA-N 0.000 claims 1
- 229940093500 ethoxyquin Drugs 0.000 claims 1
- 125000000219 ethylidene group Chemical group [H]C(=[*])C([H])([H])[H] 0.000 claims 1
- 230000028327 secretion Effects 0.000 abstract description 4
- 229920001983 poloxamer Polymers 0.000 description 18
- 238000012360 testing method Methods 0.000 description 9
- 239000004615 ingredient Substances 0.000 description 7
- JVKUCNQGESRUCL-UHFFFAOYSA-N 2-Hydroxyethyl 12-hydroxyoctadecanoate Chemical compound CCCCCCC(O)CCCCCCCCCCC(=O)OCCO JVKUCNQGESRUCL-UHFFFAOYSA-N 0.000 description 6
- 229920001304 Solutol HS 15 Polymers 0.000 description 6
- 230000001954 sterilising effect Effects 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 239000008389 polyethoxylated castor oil Substances 0.000 description 4
- VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 3
- 229920002700 Polyoxyl 60 hydrogenated castor oil Polymers 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 239000004744 fabric Substances 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 229920002685 Polyoxyl 35CastorOil Polymers 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 238000009954 braiding Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 210000005081 epithelial layer Anatomy 0.000 description 2
- 210000000416 exudates and transudate Anatomy 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000283977 Oryctolagus Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 125000005233 alkylalcohol group Chemical group 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical class [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229940035423 ethyl ether Drugs 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229950007687 macrogol ester Drugs 0.000 description 1
- 239000012875 nonionic emulsifier Substances 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to treatment material and method for making thereof that covering wound and skin injury are used.
Treatment material of the present invention comprises the carrier that is impregnated with a kind of nonallergic Emulsion, can choose the active substance biologically that is mixed with effective dose in this Emulsion wantonly.
Cover this treatment material adhesion wound surface on the wound, secretions is easy to infiltrate wherein, and easy-to-use.
Description
The invention relates to and be used to cover the treatment material of wound and skin injury and their manufacture method.
Have the wound of exudate and the known method on compromised skin surface according to treatment, use the Gauze of gauze belt/sheet, local dipping usually or with the oil impregnated Gauze (Jelonet of paraffin
RSmith and Nephew company product) cover, under wound also must be with the situation that biologically effective substances is treated, can directly be applied in medicine on the gauze when treating so or be applied to the wound surface place, then the wound that covers is bandaged.
The shortcoming of this known method is as follows:
-when removing binder, newborn epithelial layer sustains damage, and epithelial layer is subjected to quite serious wound in many cases;
-secretions drying in common gauze layer, the result forms hard surface, makes not porous of secretions;
-because application mode, the amount of active substance is not only on the biology of using when needing;
-can not guarantee it all is aseptic in all cases.
In order to eliminate above-mentioned shortcoming, the purpose of this invention is to provide a kind of treatment material that is used to cover wound and skin injury, this treats material
-adhesion wound,
-after treatment, can easily remove and do not have any damage and wound from the surface;
-be permeable to secretions;
-can mix with arbitrary effective substances biologically, promptly if desired, it can with water soluble, the soluble or fatty soluble effective ingredient of oil mix, therefore can guarantee to have on the surface that needs are treated the effective ingredient of optimum dosage;
-can therefore can directly use at any time with the sterile form long term store.
We find, cover one deck Emulsion on the carrier that covers wound and skin injury or with Emulsion it are flooded being applicable to, can realize the target that will reach.Described Emulsion is to be made in the presence of oil-in-water emulsifiers by the mixture of various polyoxygenated ethylidene glycol (Polyoxyethylene glycols) and oil, this emulsifying agent has extra high HLB(hydrophile-lipophile balance) value (for example HLB＞10), and wherein can choose the effective substances biologically that is mixed with effective dose wantonly.In addition, but can also control the medication and the release of the effective ingredient of optional use by this solution.
Therefore, the present invention relates to be used to cover the treatment material of wound and skin injury, this treatment material comprises:
A) carrier of being made by textile or paper material or synthetic fibers is coated with one deck or is impregnated with on this carrier:
B) have the Emulsion of following composition:
Propylene glycol 0～20%(by weight)
Polyoxygenated ethylidene glycol 5～95%(by weight)
Oil 10～25%(by weight)
Emulsifying agent 5～20%(by weight)
Can choose wantonly in this Emulsion and be mixed with:
C) the effective composition biologically of effective dose, this effective ingredient system is selected from antibiotics, antiseptic, disinfectant, antimycotic agent, biologically effectively plant extract and dermatologic.
The treatment material that the present invention is used to cover wound and skin injury can be pressed method and make: from above-mentioned b) ingredients listed, prepare Emulsion according to known method own, and can choose wantonly resulting Emulsion and c) described in the effective substances biologically of effective dose mix mutually, then with a) the above-mentioned impregnation mixture of described carrier, with the resulting packing of product, can sterilize to it when needing.
A) carrier described in can adopt the textile material of different densities braiding, and they make (for example gauze or loose fabric) by plying or filamentary yarn; Perhaps also can adopt non-woven material (for example veil fabric (Veil fabrics)), paper, sticking paper, the two all can randomly be installed with eyelet, and/or net or the thin slice made by synthetic material.
Emulsion b) the polyoxygenated ethenylidene glycol in can adopt the mixture (for example n=300～6000) of polymeric in various degree polyoxygenated ethylidene glycol, wherein the ratio of low degree polymerization and highly polymeric polyoxygenated ethylidene glycol is (1: 40)～(40: 1), is preferably (1: 1)～(20: 1).
According to the present invention, above-mentioned Emulsion b) oil phase in can be any known oil that is generally used for injection, vegetable oil (as sunflower oil, olive oil, Oleum Arachidis hypogaeae semen, Semen Lini oil, Semen Ricini wet goods) for example, animal oil (as fish oil), mineral oil (as paraffin oil), synthetic oils (as silicone oil, the wet goods of Myritol Levitol type).
According to the present invention, above-mentioned Emulsion b) emulsifying agent in can adopt the have high HLB value ion-type or the nonionic emulsifier of (for example HLB＞10), the ester of fatty alcohol ethoxylate for example, the ester of making by polyhydroxy-alcohol and fatty acid, two anhydro sorbitol-the stearates of ethyoxyl, ethylene oxide adduct is as fatty acid-macrogol ester, aliphatic alcohol-ethylene oxide adduct etc.
The oil-in-water emulsion that is used for covering the treatment material of wound and skin injury of the present invention, effective substances (this material water soluble, oil or fat) is mixed with this Emulsion, active substance can be arrived the surface that needs treatment with predetermined only dose application like this, and above-mentioned treatment can also be undertaken by the layman.
Product of the present invention can be made size and shape arbitrarily as required, for example can make 13 * 18cm, the lamellar of 5 * 6cm and 8 * 15cm.The tablet of gained places on the cardboard or on the polymer flake, and packs with metal or polymer foil, can sterilize if desired.Resulting product for the sterilization, the sealing with unit product easy to use.
Product of the present invention is highly suitable for the surface injury for the treatment of burn, ulcus cruris, having suppurative secretions, and the skin loss that various exudates are arranged, after reduction operation with wound covering, product of the present invention can be used for patient's ambulatory treatment, there are part lastingly in first aid and any material of treatment wound that needs, and for example it can be used on army, the ship or the field of traumatology.
Describe the present invention in detail with following limiting examples, following biological example proves that treatment material of the present invention is applicable to skin.
Biological example
A) skin irritation test
Test is carried out on new zealand rabbit.Slough rabbit back 5cm
2The hair of area, the Gauze that floods with each 0.5g of following example 1-10 Emulsion covers, and wraps up with binder according to common clinical manipulation.
Handle the back and removed binder in 24 and 48 hours.In each processed group of each duration of test with 3 animals.
Test shows that Gauze is removed easily in all cases, and they are moist, and skin is not caused any stimulation yet.
B) microbiology test
1) sterile test
Before carrying out the skin irritation test, check the sterilization situation of applied dipping Gauze with following method: under aseptic condition, sterilization in the sterilization tank will be placed with the Gauze of polyethylene (PE) paper tinsel parcel, and be cut into about 1/2cm with sterile scissors and pliers then
2The small pieces sheet, these small gauze sheets are placed in aseptic liquid Semen sojae atricolor casein and Saab Luo Shi (Sabouraud) culture medium cultivate.The culture that obtains is in 32 ℃ and 26 ℃ of one weeks of insulation.Check with microscope then, find that all Gauzes all are aseptic.
2) microbiology stability test
In this test, use the different antibacterial (edge pus pseudomonas and aurococcus) of two strains.This test desire proves, 72 hours of hypothesis the longest wound covering is in the time, applied material can not become the culture medium of existing these two kinds of antibacterials.
Dipping is used above-mentioned bacterial infection with material (for example arbitrary Emulsion among the example 1-10), measures the number of antibacterial in 24,28 and 72 hours later in insulation.
The above-mentioned bacterial growth of any strain is not observed in this evidence, on the contrary, and initial number of bacteria (about 10
5～10
6/ g) reduce to 0～10/g gradually.The above results shows that the Emulsion that is used to flood also has bactericidal action.
The preparation of Emulsion
Example 1
Composition:
Propylene glycol 5%
Polyoxygenated ethylidene glycol 400
（Lutrol400） 59.5%
Polyoxygenated ethylidene glycol 4000
（Lutrol4000） 8.0%
Myritol 318 20.0%
Solutol HS 15 7.5%
Example 2
Composition:
Paraffin oil 1%
Propylene glycol 10%
Lutrol 400 75%
Lutrol 4000 10%
Cremophor RH60 4%
Example 3
Composition:
Semen Lini oil 2%
Propylene glycol 4%
Lutrol 300 80%
8%
Lutrol 6000 8%
Cremophor RH60 6%
Example 4
Composition:
Propylene glycol 5%
Lutrol 300 40%
Lutrol 1540 35%
Myritol 318 10%
Cremophor EL 10%
Example 5
Composition:
Luvitol EHO 13%
Lutrol 400 59.5%
Lutrol 4000 18%
Cremophor A6 9.6%
Example 6
Composition:
Silicone oil (300CP) 5%
Lutrol 400 70%
Lutrol 1540 10%
Cremophor S9 15%
Example 7
Composition:
Semen Maydis oil 15%
Lutrol 400 55%
Lutrol 4000 10%
Solutol HS 15 20%
Example 8
Composition:
Oleum sesami 8%
Propylene glycol 2%
Lutrol 400 70%
Lutrol 1540 5%
Solutol HS 15 15%
Example 9
Composition:
Oleum Arachidis hypogaeae semen 5%
Lutrol 300 70%
Lutrol 4000 20%
Polypropylene glycol 5%
Solutol HS 15 5%
Example 10
Composition:
Sunflower oil 6%
Lutrol 300 80%
Lutrol 6000 2%
Solutol HS 15 12%
The Emulsion of above-mentioned example 1-10 can for example by the various polyoxygenated ethylidene glycol of fusion, and under agitation mix fused mass and other compositions by known method preparation itself.
The chemical constituent of the above-mentioned material of representing with trade name is as follows:
Myritol 318: sad-certain herbaceous plants with big flowers acid-triglyceride
Solutol HS15: diethylene glycol-single ethylether
Cremophor RH60: polyethylene (660)-12-hydroxyl-stearate (60)
Cremophor EL: polyoxyethylene glycerol-triricinoleic acid ester (35)
CremophorA6: the mixture of fatty alcohol ethoxylate and free alkyl alcohol
CremophorS9: Polyethylene Glycol (400)-stearate
Be used to cover the method for making of the material of wound
Example 11
Be the Gauze of placing loose braiding on the polypropylene foil with holes of 6 * 6cm to specification, with the Emulsion dipping of Gauze, cover again subsequently, be cut into small pieces and through radiation sterilization with metal forming with example 1.
Example 12
According to the preparation of the method for example 11, before being to flood, difference will be suspended in the Emulsion as the gentamycin of the effective dose of effective ingredient.
Example 13
According to the method preparation of example 11, the porous thin slice that difference is to make with synthetic (as polypropylene alkene, polyamide, viscose rayon etc.) is as carrier.
Example 14
According to the method preparation of example 12, difference is one of following ingredients of using effective dose: erythromycin, neomycin, sisomicin, tetracycline, chloro hexedine gluconate, benzalkonium chloride, miconazole or metronidazole.
Claims (7)
1, is used to cover the treatment material of wound and skin injury, it is characterized in that it contains
A) carrier of making by textile or paper or synthetic fibers, the following b of this carrier) carry out bonding or dipping,
B) Emulsion of following composition;
Propylene glycol 0～2% (by weight)
Polyoxyethylene glycol 5～95% (by weight)
Oily 10～25% (by weight)
Emulsifying agent 5～20% (by weight)
This Emulsion can be chosen wantonly and following c) mix,
C) the effective material biologically of effective dose, this active substance system is selected from antibiotics, antiseptic, disinfectant, antimycotic agent, biologically effectively plant extract and dermatologic.
2, the described treatment material of claim 1 is characterized in that, carrier is the textile of different densities a), and it is to be made by plying or filamentary yarn, preferably gauze or loose cotton goods.
3, the described treatment material of claim 1 is characterized in that, carrier a) is foraminous viscose thin slice or the net made by synthetic fibers.
4, the described treatment material of claim 1, it is characterized in that, Emulsion b) oil that contains is vegetable oil (for example sunflower oil, olive oil, Semen Maydis oil, Oleum Arachidis hypogaeae semen, Semen Lini oil), animal oil (for example fish oil), synthetic oil (for example silicone oil (10～10000cp)) or mineral oil (for example paraffin oil).
5, the described treatment material of claim 1, it is characterized in that, Emulsion b) poly-ethoxyquin ethylidene glycol is the mixture of various polymeric in various degree polyoxygenated ethylidene glycols (n=300～6000) in, and the ratio of the polymeric polyoxygenated ethylidene glycol of low degree polymerization and high level is (1: 40)～(40: 1), is preferably (1: 1)～(20: 1).
6, the described treatment material of claim 1, it is characterized in that, wherein also can choose wantonly and contain effective substances c biologically), these active substance can be selected from gentamycin, erythromycin, neomycin, sisomicin, tetracycline, chloro hexedine gluconate, benzalkonium chloride, miconazole or metronidazole.
7, the described method that is used to cover the treatment material of wound and skin injury of preparation claim 1, the method is characterized in that, each composition is mixed, preparation Emulsion b), optional with the biologically effective substances c of resulting Emulsion with effective dose) mix, this Emulsion is bonded on the carrier or with this Emulsion floods, the product that obtains is packed, can sterilize if desired.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 89104813 CN1048805A (en) | 1989-07-15 | 1989-07-15 | Be used to cover the treatment material of wound and skin injury and their manufacture method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 89104813 CN1048805A (en) | 1989-07-15 | 1989-07-15 | Be used to cover the treatment material of wound and skin injury and their manufacture method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1048805A true CN1048805A (en) | 1991-01-30 |
Family
ID=4855706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 89104813 Pending CN1048805A (en) | 1989-07-15 | 1989-07-15 | Be used to cover the treatment material of wound and skin injury and their manufacture method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1048805A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1111072C (en) * | 1996-08-02 | 2003-06-11 | 高景星 | Body-compatible antiseptic and antiphlogitic bleeding-stopping dressing and its prepn |
| CN103974680A (en) * | 2011-12-09 | 2014-08-06 | 柯惠有限合伙公司 | Non-adherent wound dressings and related methods therefor |
| CN104906627A (en) * | 2011-03-15 | 2015-09-16 | 绍兴文理学院 | Hydrophilic petrolatum gauze |
-
1989
- 1989-07-15 CN CN 89104813 patent/CN1048805A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1111072C (en) * | 1996-08-02 | 2003-06-11 | 高景星 | Body-compatible antiseptic and antiphlogitic bleeding-stopping dressing and its prepn |
| CN104906627A (en) * | 2011-03-15 | 2015-09-16 | 绍兴文理学院 | Hydrophilic petrolatum gauze |
| CN103974680A (en) * | 2011-12-09 | 2014-08-06 | 柯惠有限合伙公司 | Non-adherent wound dressings and related methods therefor |
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