CN1048157A - A kind of preparation technology of medical pelletron - Google Patents
A kind of preparation technology of medical pelletron Download PDFInfo
- Publication number
- CN1048157A CN1048157A CN 89104306 CN89104306A CN1048157A CN 1048157 A CN1048157 A CN 1048157A CN 89104306 CN89104306 CN 89104306 CN 89104306 A CN89104306 A CN 89104306A CN 1048157 A CN1048157 A CN 1048157A
- Authority
- CN
- China
- Prior art keywords
- pelletron
- infection
- polymethyl methacrylate
- preparation technology
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 238000005516 engineering process Methods 0.000 title claims abstract description 14
- 239000003814 drug Substances 0.000 claims abstract description 16
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229940093265 berberine Drugs 0.000 claims abstract description 14
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims abstract description 14
- 239000000843 powder Substances 0.000 claims abstract description 12
- 229940079593 drug Drugs 0.000 claims abstract description 9
- 208000015181 infectious disease Diseases 0.000 claims abstract description 9
- 239000000178 monomer Substances 0.000 claims abstract description 7
- 239000000203 mixture Substances 0.000 claims abstract description 6
- 206010031256 Osteomyelitis chronic Diseases 0.000 claims abstract description 4
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 4
- 206010062255 Soft tissue infection Diseases 0.000 claims abstract description 3
- 238000012546 transfer Methods 0.000 claims abstract description 3
- 238000013461 design Methods 0.000 claims description 5
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 3
- 238000011109 contamination Methods 0.000 claims description 2
- 208000014674 injury Diseases 0.000 claims description 2
- 230000008733 trauma Effects 0.000 claims description 2
- 206010016717 Fistula Diseases 0.000 abstract description 4
- 208000027418 Wounds and injury Diseases 0.000 abstract description 4
- 230000003890 fistula Effects 0.000 abstract description 4
- 239000011159 matrix material Substances 0.000 abstract description 4
- 208000002565 Open Fractures Diseases 0.000 abstract description 3
- 230000004071 biological effect Effects 0.000 abstract description 3
- 230000002265 prevention Effects 0.000 abstract description 3
- 238000007711 solidification Methods 0.000 abstract description 3
- 230000008023 solidification Effects 0.000 abstract description 3
- 238000001356 surgical procedure Methods 0.000 abstract description 3
- 206010002198 Anaphylactic reaction Diseases 0.000 abstract description 2
- 230000036783 anaphylactic response Effects 0.000 abstract description 2
- 208000003455 anaphylaxis Diseases 0.000 abstract description 2
- 230000000699 topical effect Effects 0.000 abstract description 2
- 230000000472 traumatic effect Effects 0.000 abstract description 2
- 231100000957 no side effect Toxicity 0.000 abstract 1
- 239000011049 pearl Substances 0.000 description 12
- 210000004185 liver Anatomy 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 3
- 229930182566 Gentamicin Natural products 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 231100000252 nontoxic Toxicity 0.000 description 3
- 230000003000 nontoxic effect Effects 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 206010000269 abscess Diseases 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000680 avirulence Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000003792 cranial nerve Anatomy 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
A kind of preparation technology of medical pelletron.The preparation method that belongs to the topical drug of bone, surgery use.Adopt the Chinese medicine berberine powder as the active drug composition, with polymethyl methacrylate polymer and monomer whose as solidification matrix.And the shape of pearl in the pelletron is processed into sphere, ellipse or with holes according to the wound surface needs.Thereby, pelletron with prepared of the present invention proves the prevention infection that is applicable to chronic osteomyelitis, traumatic infection, deep soft tissue's infection, fistula, sinus tract and compound fracture through using, biological activity is stable, human body is had no side effect and anaphylaxis, be convenient to transfer to and can make slow release or localized mass is released type according to the state of an illness.
Description
A kind of preparation technology of medical pelletron, the preparation technology of the topical drug that genus bone, surgery use.
At present, at bone, surgery clinically, be used for chronic osteomyelitis, trauma infection contamination, abscess and cut fistula, sinus tract behind the row, the pelletron of cases such as compound fracture prevention infection treatment is made as raw material by antibiotics, polymethyl methacrylate polymer and polymethyl methacrylate monomer.For example, celebrate big pelletron, use gentamycin, polymethyl methacrylate polymer and monomer as raw material.
Pour a fixed mold after the stirring into,, make a string pelletron that strings spherical pearl by stainless steel silk through solidifying.They are placed to focal zone, the antibiotics in the pelletron then, for example: gentamycin, obtain discharging, form high local concentrations killing perilesional antibacterial, and can play drainage.But in the technology of existing preparation pelletron, the antibiotics of used active drug composition all is Western medicine, all has certain poison to pay effect, and for example: gentamycin has infringement to liver, kidney and the 8th pair of cranial nerve, and human body is easily irritated, biologically active labile.And the cost of material height with existing prepared causes pelletron to cost an arm and a leg, for example: celebrate about 11 yuan/every string of big pelletron.
The present invention seeks to develop nontoxic pair of effect of a kind of preparation, do not have irritated reaction, the cheap new technology that is suitable for the spacetabs type pelletron of clinical practice.
In order to realize the foregoing invention purpose, the present invention adopts berberine powder as the active drug composition, with polymethyl methacrylate polymer and monomer whose as solidification matrix.Because berberine be a kind of known, through clinical practice proof staphylococcus aureus, Hemolytic streptococcus, colibacillus, green dense liver bacterium etc. are all had the Chinese medicine of sterilization and bacteriostasis, biological activity is stable, to nontoxic pair of reaction of human body, does not have irritated reaction.Concrete preparation is that berberine powder is mixed with polymethyl methacrylate polymer and polymethyl methacrylate monomer, transfer to dough period not, pour into by pelletron shape need design, giving of preparing and be embedded with in the mould wiry that human body is not reacted, solidify, the demoulding forms.In addition, have finite concentration in order to guarantee the Rhizoma Coptidis in the pelletron, simultaneously berberine powder can be combined with solidification matrix is good, during preparation, the proportioning of berberine powder and polymethyl methacrylate polymer is 0.5: 2-5: the 1(weight ratio)
For the multiple special shape wound surface of suitable administration's human body, so that extract after operation, the shape of each pearl can be processed by spherical or ellipse garden shape in the pelletron.
In order to adapt to the different needs of wound, can carry out different boring processing on each pearl in pelletron, can bore one or more hole, Kong Yue is many, and the medicine star of Shi Fanging is many more at short notice.
Be described further below in conjunction with embodiment and accompanying drawing thereof:
Embodiment 1: at first, by requirement shown in Figure 1 design and give molding jig, mould is that two halves close up, 21 in the hole that pearl 2 matches in total shape and the pelletron, and in mould, lay 1 one of the stainless steel silks that diameter is 0.6mm.
Again refining berberine powder 5g of 100 purposes and polymethyl methacrylate polymer 10g mix homogeneously, measure polymethyl methacrylate monomer 10ml, add in the above-mentioned blended powder, the limit edged is transferred, be stirred to and be dough period not, pour in the die cavity of the above-mentioned mould for preparing, two halves close up again, and pressurize outside mould, mixture demoulding after solidifying 4～6 hours in the die cavity, remove unnecessary burr, illustration 2 in kind according to shown in a string pelletron, have the spherical pearl that 21 diameters are 7mm.
Embodiment 2: the medicine, chemical compound and the preparation method that contain in Mould design preparation process and the pelletron are all identical with embodiment 1, and different is:
1. the match ratio of berberine powder and polymethyl methacrylate polymer is 0.5: 2.
2. the hole in the die cavity is an ellipse garden shape.Make the pearl 2 of the pelletron of making be ellipse garden shape shown in Figure 3, its major axis 7mm, minor axis are 5mm, totally 26.
Embodiment 3: the medicine, chemical compound and the preparation method that contain in Mould design preparation process and the pelletron are all identical with embodiment 1, and the pearl shape is identical with embodiment 1 or 2, and different is:
1. be drilled with several holes 3 at the short-axis direction of pearl 2 as shown in Figure 4.
2. the match ratio of berberine powder and polymethyl methyl ester is 5: 1.
The present invention prepares the technology of pelletron owing to used berberine as active drug, thereby biological activity is stable, to nontoxic pair of effect of human body and anaphylaxis.So and since the berberine powder be scattered in the coralliform micropore of solid matrix equably among berberine can slowly release.With the made product of the technology of above-mentioned example 1, measure proof through the measuring degree and in external 37 ℃ ± 0.5 ℃ normal saline medium, still have drug release after 50 days; Through animal (rabbit) evidence,, there is not inflammatory cell infiltration to the heart, lung, liver, kidney and local all untoward reaction such as avirulence, allergy yet; The tangible bacteriostasis that staphylococcus aureus, colibacillus, green dense liver bacterium, B-mode chain pearl bacterium etc. is all had the long period through the bacteriostatic test proof.From in October, 88, all obtained good therapeutic effect in the prevention of treatment chronic osteomyelitis, fistula, sinus tract, deep soft tissue's infection, traumatic infection and open fracture infection through clinical practice.Because the pearl in embodiment 2 technologies is ellipse garden shape, so when being used for the myelitic dead space of fistula or sinus tract or part and being elongated shape, be convenient to extract.Owing to have the wound that several holes can be used for actute infection, example on the pearl of the pelletron in embodiment 3 technologies: abscess is cut row's postoperative soft tissue actute infection etc., is beneficial to the medicine rapid release and forms high local concentrations.Owing to cost of material among the present invention is low, preparation technology is simple again, thereby the cost price of every string (26 pearls) is 0.20～0.30 a yuan/string.
Claims (2)
1, a kind of preparation technology who is used for the treatment of the pelletron of treatment usefulness behind chronic osteomyelitis, trauma infection contamination, deep soft tissue's infection and bone, the surgical operation, with active drug and polymethyl methacrylate polymer and polymethyl methacrylate monomer is that raw material mixes, transfer to dough period not, pour into by giving of preparing of pelletron shape need design and be embedded with in the mould wiry that human body is not reacted, solidify, the demoulding forms, and it is characterized in that: use berberine powder as the active drug composition.
2, according to the preparation technology of claim 1 described medical pelletron, it is characterized in that: the proportioning of berberine powder and polymethyl methacrylate polymer is 0.5: 2-5: the 1(weight ratio).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 89104306 CN1048157A (en) | 1989-06-21 | 1989-06-21 | A kind of preparation technology of medical pelletron |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 89104306 CN1048157A (en) | 1989-06-21 | 1989-06-21 | A kind of preparation technology of medical pelletron |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1048157A true CN1048157A (en) | 1991-01-02 |
Family
ID=4855507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 89104306 Pending CN1048157A (en) | 1989-06-21 | 1989-06-21 | A kind of preparation technology of medical pelletron |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1048157A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1050048C (en) * | 1993-07-10 | 2000-03-08 | 宋爱民 | Jiedufugugao adhesive plaster for medullitis |
| CN1060056C (en) * | 1994-12-04 | 2001-01-03 | 崔树闰 | "Guyankang" adhesive plaster for curing osteomyelitis |
| CN102429493A (en) * | 2011-07-21 | 2012-05-02 | 刘振躬 | Carbon healthcare mattress and processing method |
| CN104207829A (en) * | 2014-09-03 | 2014-12-17 | 吉林大学 | Antibiotic bone cement chain bead manufacturer and method |
| US10080688B2 (en) | 2012-10-16 | 2018-09-25 | Surmodics, Inc. | Wound packing device and method |
| US10201457B2 (en) | 2014-08-01 | 2019-02-12 | Surmodics, Inc. | Wound packing device with nanotextured surface |
-
1989
- 1989-06-21 CN CN 89104306 patent/CN1048157A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1050048C (en) * | 1993-07-10 | 2000-03-08 | 宋爱民 | Jiedufugugao adhesive plaster for medullitis |
| CN1060056C (en) * | 1994-12-04 | 2001-01-03 | 崔树闰 | "Guyankang" adhesive plaster for curing osteomyelitis |
| CN102429493A (en) * | 2011-07-21 | 2012-05-02 | 刘振躬 | Carbon healthcare mattress and processing method |
| US10080688B2 (en) | 2012-10-16 | 2018-09-25 | Surmodics, Inc. | Wound packing device and method |
| US10201457B2 (en) | 2014-08-01 | 2019-02-12 | Surmodics, Inc. | Wound packing device with nanotextured surface |
| CN104207829A (en) * | 2014-09-03 | 2014-12-17 | 吉林大学 | Antibiotic bone cement chain bead manufacturer and method |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |