CN104815068A - Cefalexin ointment and preparation method thereof - Google Patents
Cefalexin ointment and preparation method thereof Download PDFInfo
- Publication number
- CN104815068A CN104815068A CN201510275471.8A CN201510275471A CN104815068A CN 104815068 A CN104815068 A CN 104815068A CN 201510275471 A CN201510275471 A CN 201510275471A CN 104815068 A CN104815068 A CN 104815068A
- Authority
- CN
- China
- Prior art keywords
- parts
- cefalexin
- ointment
- constant temperature
- viscous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 title claims abstract description 59
- 229940106164 cephalexin Drugs 0.000 title claims abstract description 59
- 239000002674 ointment Substances 0.000 title claims abstract description 55
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000003814 drug Substances 0.000 claims abstract description 58
- 229940079593 drug Drugs 0.000 claims abstract description 21
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 18
- 239000002994 raw material Substances 0.000 claims abstract description 18
- 238000000605 extraction Methods 0.000 claims description 42
- 239000000706 filtrate Substances 0.000 claims description 36
- 238000003756 stirring Methods 0.000 claims description 24
- 229940056582 human hair preparation Drugs 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 19
- 239000000758 substrate Substances 0.000 claims description 19
- 239000013521 mastic Substances 0.000 claims description 18
- 239000000284 extract Substances 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 13
- 239000000843 powder Substances 0.000 claims description 12
- 238000010792 warming Methods 0.000 claims description 12
- 239000004480 active ingredient Substances 0.000 claims description 8
- -1 Crinis Carbonisatus Chemical compound 0.000 claims description 6
- 229940031955 anhydrous lanolin Drugs 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 6
- 230000000694 effects Effects 0.000 abstract description 20
- 238000000034 method Methods 0.000 abstract description 20
- 206010053615 Thermal burn Diseases 0.000 abstract description 13
- 208000003455 anaphylaxis Diseases 0.000 abstract description 5
- 208000024891 symptom Diseases 0.000 abstract description 5
- 206010002198 Anaphylactic reaction Diseases 0.000 abstract description 3
- 230000036783 anaphylactic response Effects 0.000 abstract description 3
- 150000001875 compounds Chemical class 0.000 abstract description 3
- 230000007547 defect Effects 0.000 abstract description 3
- 238000002347 injection Methods 0.000 abstract description 3
- 239000007924 injection Substances 0.000 abstract description 3
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 231100000419 toxicity Toxicity 0.000 abstract description 3
- 230000001988 toxicity Effects 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 240000005729 Cylindropuntia imbricata Species 0.000 abstract 1
- 235000001427 Cylindropuntia imbricata Nutrition 0.000 abstract 1
- 244000269722 Thea sinensis Species 0.000 abstract 1
- 241001278775 Veronicastrum Species 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- 229940126678 chinese medicines Drugs 0.000 abstract 1
- 230000000249 desinfective effect Effects 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 229940126673 western medicines Drugs 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 44
- 239000000047 product Substances 0.000 description 21
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 201000010099 disease Diseases 0.000 description 11
- 230000001737 promoting effect Effects 0.000 description 11
- 230000003203 everyday effect Effects 0.000 description 7
- 238000007689 inspection Methods 0.000 description 7
- 231100000614 poison Toxicity 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 239000003440 toxic substance Substances 0.000 description 6
- 206010030113 Oedema Diseases 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 210000003205 muscle Anatomy 0.000 description 5
- 238000007789 sealing Methods 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 241001478240 Coccus Species 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 230000003115 biocidal effect Effects 0.000 description 4
- 238000005469 granulation Methods 0.000 description 4
- 230000003179 granulation Effects 0.000 description 4
- 206010025482 malaise Diseases 0.000 description 4
- 230000001338 necrotic effect Effects 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 229930186147 Cephalosporin Natural products 0.000 description 3
- 229930182555 Penicillin Natural products 0.000 description 3
- 230000001139 anti-pruritic effect Effects 0.000 description 3
- 239000003908 antipruritic agent Substances 0.000 description 3
- 229940124587 cephalosporin Drugs 0.000 description 3
- 150000001780 cephalosporins Chemical class 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 230000000857 drug effect Effects 0.000 description 3
- 206010022000 influenza Diseases 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 231100000241 scar Toxicity 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- 241000588624 Acinetobacter calcoaceticus Species 0.000 description 2
- 206010002199 Anaphylactic shock Diseases 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 2
- 241000606124 Bacteroides fragilis Species 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 2
- 241000588921 Enterobacteriaceae Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000605909 Fusobacterium Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 241000588653 Neisseria Species 0.000 description 2
- 108010087702 Penicillinase Proteins 0.000 description 2
- 241000588770 Proteus mirabilis Species 0.000 description 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 2
- 206010039424 Salivary hypersecretion Diseases 0.000 description 2
- 241000607142 Salmonella Species 0.000 description 2
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 2
- 241000607764 Shigella dysenteriae Species 0.000 description 2
- 241000607762 Shigella flexneri Species 0.000 description 2
- 208000008630 Sialorrhea Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 241000194017 Streptococcus Species 0.000 description 2
- 241000193998 Streptococcus pneumoniae Species 0.000 description 2
- 208000033809 Suppuration Diseases 0.000 description 2
- 241000282898 Sus scrofa Species 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 208000002352 blister Diseases 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 210000002216 heart Anatomy 0.000 description 2
- 230000002949 hemolytic effect Effects 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 210000000003 hoof Anatomy 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000004811 liquid chromatography Methods 0.000 description 2
- 208000004396 mastitis Diseases 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229950009506 penicillinase Drugs 0.000 description 2
- 150000002960 penicillins Chemical class 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 230000001047 pyretic effect Effects 0.000 description 2
- 229940007046 shigella dysenteriae Drugs 0.000 description 2
- 206010040872 skin infection Diseases 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 1
- 229930182837 (R)-adrenaline Natural products 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 101100515516 Arabidopsis thaliana XI-H gene Proteins 0.000 description 1
- 201000008283 Atrophic Rhinitis Diseases 0.000 description 1
- 241000193738 Bacillus anthracis Species 0.000 description 1
- 208000031868 Calculus ureteric Diseases 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 208000012353 Contagious Pleuropneumonia Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010013700 Drug hypersensitivity Diseases 0.000 description 1
- 241000194033 Enterococcus Species 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010017564 Fusobacterium infections Diseases 0.000 description 1
- 206010054787 Haemorrhoidal haemorrhage Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241001062009 Indigofera Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010024238 Leptospirosis Diseases 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 206010028846 Necrobacillosis Diseases 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 206010035148 Plague Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010039088 Rhinitis atrophic Diseases 0.000 description 1
- 208000004078 Snake Bites Diseases 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 241000295644 Staphylococcaceae Species 0.000 description 1
- 208000000014 Ureteral Calculi Diseases 0.000 description 1
- 206010046793 Uterine inflammation Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 201000007691 actinomycosis Diseases 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 238000004500 asepsis Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 201000005311 drug allergy Diseases 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 229960005139 epinephrine Drugs 0.000 description 1
- 238000010812 external standard method Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 230000002962 histologic effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004968 inflammatory condition Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229960003085 meticillin Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 238000011580 nude mouse model Methods 0.000 description 1
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 208000000143 urethritis Diseases 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a cefalexin ointment and a preparation method thereof. The ointment comprises the following components in parts by weight: 2-5 parts of cefalexin, 5-10 parts of carbonized human hair, 20-25 parts of tea leaves, 2-5 parts of borneol, 25-30 parts of herb of villosulous veronicastrum, 25-30 parts of cholla stem and 60-80 parts of matrixes. The preparation method of the ointment comprises the following steps: preparing materials, and extracting, crushing, mixing and sub-packaging effective components of the traditional Chinese medicine raw materials. The cefalexin ointment disclosed by the invention can be used for overcoming the defect of anaphylaxis caused by oral administration or injection medication, can be used for treating burns and scalds by using a Chinese and western medicine combination process, ensures that Chinese and western medicines have synergistic effects, can be used for rapidly and effectively relieving uncomfortable symptoms of the burns and scalds, and can also be used for curing the burns and scalds from the source; the cefalexin ointment is quick in curative effect and good in treatment effect, can be used for clearing heat and removing toxicity, can also be used for sterilizing, disinfecting and curing the burns and scalds within a short time, and ensures that diseased sites can be recovered to a state before illness; and the compound ointment disclosed by the invention is small in toxic or side effect, safe in medication and convenient to use.
Description
Technical field
The present invention relates to a kind of ointment formulation and preparation method, is specifically a kind of cefalexin ointment machin preparation method.
Background technology
Cefalexin belongs to first generation cephalosporin, is broad-spectrum antibiotic class medicine.Streptococcus pneumoniae, Hemolytic streptococcus, product or not produce the staphylococcic most of bacterial strain of penicillinase responsive to this product.This product has better antibacterial action to neisseria, but the sensitivity of hemophilus influenza to this product is poor; This product has certain antibacterial action to part escherichia coli, proteus mirabilis, salmonella and shigella dysenteriae.All the other enterobacteriaceae lactobacteriaceaes, acinetobacter calcoaceticus, Pseudomonas aeruginosa, bacteroides fragilis all present drug resistance to this product.Fusobacterium and Wei Rong coccus are generally responsive to this product, and anaerobism gram positive coccus is to this product medium sensitivity.Cefalexin is mainly used to gram positive bacteria and negative microbial infections, as influenza, the caused high heat of septic (41 ~ 43 DEG C) or the consecutive low temperature (less than 37 DEG C) such as hueppe's disease, streptococcicosis, pig erysipelas, anthrax, blackleg, malignant edema, actinomycosis, Swine Necrobacillosis, leptospirosis, dyspepsia, happiness drink cold water, walking drowsiness without god is turned lame, ear and become indigo plant, shed tears.Be used for the treatment of various inflammatory condition simultaneously, as: contagious pleuropneumonia, lung plague pneumonia, atrophic rhinitis, reproductive and respiratory syndrome, mastitis, metritis, stomatitis, urethritis, mouth hoof fester, sialorrhea is more than, raw pus gathers in a sore.
Must inquire that before application this product patient is to cephalosporins, penicillins and other drug allergy histories in detail, penicillin medicine anaphylactic shock history person is had to apply this product, other patients must be noted that when applying this product that the chance that cephalosporins and penicillins exist Cross-reactivity about has 5% ~ 7%, need be cautious use of under close observation.Once generation anaphylaxis, medicine of stopping using immediately.As there is anaphylactic shock, must rescue on the spot immediately, comprising the measure such as application keeping airway patency, oxygen uptake and epinephrine, glucocorticoid.
Current this product is mainly oral medicine, does not have medicine for external use, treatment topical disorders as mouth hoof fester, sialorrhea is more than, raw pus gathers in a sore etc. can only select other antibiotic medicine or oral medicine.If have anaphylaxis to this medicine, can not oral medicine.
Summary of the invention
The present invention seeks to the defect not having local application for cefalexin, propose a kind of cefalexin ointment that locally can be used for the treatment of burn, scald; This ointment treating both the principal and secondary aspects of a disease, can effectively antiinflammatory, subside a swelling, relieve the pain, antipruritic, promote wound healing, cure illness position in the short time, also there is the effect of the necrotic tissue and promoting muscle growing that disappears, make illness position comparatively fast return to not ill before state.
The present invention seeks to be realized by following technical scheme:
A kind of cefalexin ointment, the composition of this ointment and parts by weight comprise cefalexin 2 ~ 5 parts, Crinis Carbonisatus 5 ~ 10 parts, Folium Camelliae sinensis 20 ~ 25 parts, Borneolum Syntheticum 2 ~ 5 parts, Herba veronicastri villosuli 25 ~ 30 parts, Radix et Caulis Opuntiae Dillenii 25 ~ 30 parts, substrate 60 ~ 80 parts.
Further, described a kind of cefalexin ointment, the composition of this ointment and parts by weight comprise cefalexin 3 parts, Crinis Carbonisatus 8 parts, Folium Camelliae sinensis 23 parts, Borneolum Syntheticum 3 parts, Herba veronicastri villosuli 27 parts, Radix et Caulis Opuntiae Dillenii 28 parts, substrate 70 parts.
Further, described a kind of cefalexin ointment, the composition of substrate and parts by weight comprise anhydrous lanolin 40 ~ 45 parts, Oleum sesami 30 ~ 35 parts.
Effect of each effective ingredient is:
Cefalexin: be broad-spectrum antibiotic class medicine, except Enterococcus, methicillin-resistant Staphylococci, streptococcus pneumoniae, Hemolytic streptococcus, product or not produce the staphylococcic most of bacterial strain of penicillinase responsive to this product.This product has better antibacterial action to neisseria, but the sensitivity of hemophilus influenza to this product is poor; This product has certain antibacterial action to part escherichia coli, proteus mirabilis, salmonella and shigella dysenteriae.All the other enterobacteriaceae lactobacteriaceaes, acinetobacter calcoaceticus, Pseudomonas aeruginosa, bacteroides fragilis all present drug resistance to this product.Fusobacterium and Wei Rong coccus are generally responsive to this product, and anaerobism gram positive coccus is to this product medium sensitivity.
Crinis Carbonisatus: repercussive, hemostasis, endures cream external application hemostasia and promoting granulation.Crinis Carbonisatus decoct has comparatively high inhibition effect to staphylococcus aureus, Bacillus typhi, paratyphoid bacillus A and shigella flexneri.
Folium Camelliae sinensis: removing summer-heat pyretic toxicity, sharp skin infection and granulation promoting.
Borneolum Syntheticum: acrid in the mouth, hardship, be slightly cold; GUIXIN, liver, lung meridian; Delicate fragrance a surname is loose, has the effect of refreshment of having one's ideas straightened out.
Herba veronicastri villosuli: row water, dissipating blood stasis, detumescence, removing toxic substances.Harness the river swollen, dysuria, hepatitis, menoxenia, treats carbuncle sore and swells, traumatic injury, burn.
Radix et Caulis Opuntiae Dillenii: bitter in the mouth, cool in nature.Enter the heart, lung, stomach three warp.Effect promoting flow of QI and blood, heat-clearing and toxic substances removing.Cure mainly heart peratodynia, mass in the abdomen, dysentery, hemorrhoidal bleeding, cough, laryngalgia, lung abscess, acute mastitis, furuncle, burn, snakebite.
Present invention also offers a kind of preparation method of cefalexin ointment, concrete steps are as follows:
1) get the raw materials ready according to each composition of cefalexin ointment and parts by weight;
2) extraction of raw material of Chinese medicine pharmaceutically active ingredient: the pure water adding raw material of Chinese medicine medicine parts by weight 10 times in constant temperature extraction pot, open and stir, by Folium Camelliae sinensis, Herba veronicastri villosuli adds in constant temperature extraction pot, reacting liquid temperature in constant temperature extraction pot is warming up to 95 ~ 100 DEG C of constant temperature and extracts 30min, through 16 layers of filtered through gauze, filter to get filtrate a, in constant temperature extraction pot, again add the pure water of raw material of Chinese medicine medicine parts by weight 10 times, open and stir, filtering residue is added in constant temperature extraction pot, reacting liquid temperature in constant temperature extraction pot is warming up to 95 ~ 100 DEG C of constant temperature and extracts 30min, through 16 layers of filtered through gauze, filter to get filtrate b, merging filtrate a, b obtains filtrate A, by filtrate A pressure be-0.06 ~-0.08Mpa, temperature is concentrated into thick viscous solution B under being 45 ~ 50 DEG C of conditions, when the relative density of viscous solution B is 45 DEG C 1.12 ~ 1.18, viscous solution B is cooled to room temperature for subsequent use,
3) cefalexin, Crinis Carbonisatus, Borneolum Syntheticum are pulverized 200 mesh sieves respectively and obtain fine drug powder C; Radix et Caulis Opuntiae Dillenii is squeezed the juice, pressure be-0.06 ~-0.08Mpa, temperature is concentrated into thick viscous solution D under being 40 ~ 45 DEG C of conditions, when the relative density of viscous solution D is 45 DEG C 1.08 ~ 1.12, viscous solution D is cooled to room temperature for subsequent use;
4) substrate is added in constant temperature agitator tank, open and stir, substrate is heated to 50 DEG C, in constant temperature agitator tank, add step 2 successively) gained viscous solution B, step 3) gained viscous solution D and fine drug powder C, the rear 50 DEG C of constant temperature 20min that stir obtain mastic, mastic E are cooled to room temperature E for subsequent use;
5) by step 4) gained mastic E subpackage is for subsequent use.
The using method of a kind of cefalexin ointment of the present invention: be applied to affected part, every day 3 ~ 4 times, or follow the doctor's advice.
Storage: shading, sealing, cool dark place are preserved.
Beneficial effect of the present invention:
1, cefalexin has the effect of bactericidal antiphlogistic, is broad-spectrum antibiotic class medicine.Folium Camelliae sinensis: removing summer-heat pyretic toxicity, sharp skin infection and granulation promoting.Crinis Carbonisatus: repercussive, hemostasis, endure cream external application hemostasia and promoting granulation, decoct has comparatively high inhibition effect to staphylococcus aureus, Bacillus typhi, paratyphoid bacillus A and shigella flexneri.Delicate fragrance a surname is loose, and Borneolum Syntheticum has the effect of refreshment of having one's ideas straightened out.Herba veronicastri villosuli: row water, dissipating blood stasis, detumescence, removing toxic substances.Radix et Caulis Opuntiae Dillenii: promoting flow of QI and blood, heat-clearing and toxic substances removing.
2, burn mainly refers to skin and/or mucosa, refer generally to heating power, comprise the histologic lesion that hydrothermal solution, steam, high-temperature gas, flame, hot metal liquid or solid etc. are caused, severe patient also can injure subcutaneous and/or sub-mucosal tissues, as muscle, bone, joint even internal organs.Scald is by the caused tissue injury such as hydrothermal solution, steam, is the one of heat injury.Contained by this ointment, Borneolum Syntheticum can reduce the malaise symptoms of disease sites, improves the compliance of patient.The combined sterilizing effect of cefalexin, Crinis Carbonisatus, can make disease sites inflammation disappear, and prevents the further deterioration of the disease sites state of an illness, contributes to the recovery of disease sites.Folium Camelliae sinensis, Radix et Caulis Opuntiae Dillenii have the effect of heat-clearing and toxic substances removing, can reduce the malaise symptoms of disease sites, improve the compliance of patient.Crinis Carbonisatus, Herba veronicastri villosuli, Radix et Caulis Opuntiae Dillenii have the effect of blood circulation promoting and blood stasis dispelling, not only can promote the absorption of other drug, can also promote the healing of wound, Crinis Carbonisatus, Folium Camelliae sinensis disappear the effect of necrotic tissue and promoting muscle growing can make disease sites return to not ill before state, preventing from scar.
3, raw material of Chinese medicine pharmaceutically active ingredient is conducive to the absorption of disease sites after extracting and works.95 ~ 100 DEG C of constant temperature extract 30min, can reach and farthest extract Effective Component of Chinese Medicine, extract twice, basic by extracts active ingredients out, remain undrawn active constituent content seldom need not continue to extract, if it is high to continue to extract gained effective ingredient impurity content, drug effect is low.Relative energy-saving while thickening temperature selected by the present invention and pressure condition can keep drug effect preferably.Substrate heating-up temperature and constant temperature time can effectively make each composition of this ointment dissolve each other and keep good drug effect.
4, medicine for external use directly acts on local, and untoward reaction is less, is easily accepted by doctor and patient, and medicine for external use acts on local, and without systemic adverse reactions, safety is good.A kind of cefalexin ointment of the present invention, is used for the topical therapeutic of burn and scald for the first time as medicine for external use using cefalexin.Overcome oral or injecting drug use and there is hypersensitive defect, adopt the method treatment burn and scald of Chinese medicine and western medicine mixture, Chinese medicine and western medicine synergism, while the malaise symptoms effectively alleviating burn and scald fast, burn and scald can be cured from root.Each effective ingredient synergism, curative effect is fast, and therapeutic effect is good, not only can heat clearing away, removing toxic substances, can also to sterilize, antiinflammatory.This ointment has detumescence, relieves the pain, antipruritic, promote wound healing, the necrotic tissue and promoting muscle growing that disappears, do not stay the effect of pigment, preventing from scar, can cure burn and scald in short time, make disease sites return to not ill front state, this compound ointment toxic and side effects is little, drug safety, easy to use.
Detailed description of the invention
According to following embodiment, the present invention may be better understood.But those skilled in the art will readily understand, concrete material proportion, process conditions and result thereof described by embodiment only should can not limit the present invention described in detail in claims yet for illustration of the present invention.
Embodiment 1
A kind of cefalexin ointment, the composition of this ointment and parts by weight comprise cefalexin 3 parts, Crinis Carbonisatus 8 parts, Folium Camelliae sinensis 23 parts, Borneolum Syntheticum 3 parts, Herba veronicastri villosuli 27 parts, Radix et Caulis Opuntiae Dillenii 28 parts, anhydrous lanolin 40 parts, Oleum sesami 30 parts.
A preparation method for cefalexin ointment, comprises the following steps:
1) get the raw materials ready according to each composition according to claim 1 and parts by weight;
2) extraction of raw material of Chinese medicine pharmaceutically active ingredient: add 700 parts of pure water in constant temperature extraction pot, open and stir, by Folium Camelliae sinensis, Herba veronicastri villosuli adds in constant temperature extraction pot, reacting liquid temperature in constant temperature extraction pot is warming up to 95 ~ 100 DEG C of constant temperature and extracts 30min, through 16 layers of filtered through gauze, filter to get filtrate a, again in constant temperature extraction pot, add 700 parts of pure water, open and stir, filtering residue is added in constant temperature extraction pot, reacting liquid temperature in constant temperature extraction pot is warming up to 95 ~ 100 DEG C of constant temperature and extracts 30min, through 16 layers of filtered through gauze, filter to get filtrate b, merging filtrate a, b obtains filtrate A, by filtrate A pressure be-0.06 ~-0.08Mpa, temperature is concentrated into thick viscous solution B under being 45 ~ 50 DEG C of conditions, when the relative density of viscous solution B is 45 DEG C 1.12 ~ 1.18, viscous solution B is cooled to room temperature for subsequent use,
3) cefalexin, Crinis Carbonisatus, Borneolum Syntheticum are pulverized 200 mesh sieves respectively and obtain fine drug powder C; Radix et Caulis Opuntiae Dillenii is squeezed the juice, through 16 layers of filtered through gauze, filter gained filtrate pressure be-0.06 ~-0.08Mpa, temperature be concentrated under being 40 ~ 45 DEG C of conditions thick must viscous solution D, when the relative density of viscous solution D is 45 DEG C 1.08 ~ 1.12, viscous solution D is cooled to room temperature for subsequent use;
4) substrate is added in constant temperature agitator tank, open and stir, substrate is heated to 50 DEG C, in constant temperature agitator tank, add step 2 successively) gained viscous solution B, step 3) gained viscous solution D and fine drug powder C, the rear 50 DEG C of constant temperature 20min that stir obtain mastic E, mastic E are cooled to room temperature for subsequent use;
5) by step 4) gained mastic E subpackage is for subsequent use.
The using method of a kind of cefalexin ointment of the present invention: be applied to affected part, every day 3 ~ 4 times, or follow the doctor's advice.
Storage: shading, sealing, cool dark place are preserved.
Inspection method:
Granularity checks: get appropriate test sample, and be coated with straticulation, thin layer area is equivalent to coverslip area, altogether Fig. 3 sheet, checks, all must not detect the particle being greater than 180um according to granularity and particle size distribution method (pharmacopeia 2010 editions annex IX E first methods).
Sterility test: check according to pharmacopeia 2010 editions annex XI H items, positive control pipe well-grown, negative control pipe asepsis growth.
Assay: measure according to high performance liquid chromatography (pharmacopeia 2010 editions annex VD).
Chromatograph regulates and system suitability: be filler with octadecylsilane chemically bonded silica; With water-methanol-3.86% sodium acetate solution-4% acetum (742:240:15:3) for mobile phase; Determined wavelength is 254nm; Get need testing solution appropriate, heat 60 minutes in 80 DEG C of water-baths, cooling, gets 20ul injection liquid chromatography, and record chromatogram, the separating degree at cefalexin peak and other impurities peak should meet the requirements.
Algoscopy: get this product in right amount, accurately weighed (being about equivalent to cefalexin 10mg), put in separatory funnel, mobile phase is appropriate, and shake well makes dissolving, then is diluted to scale with mobile phase, shakes up; Filter, precision measures subsequent filtrate 10ml, puts in 50ml volumetric flask, is diluted to scale with mobile phase, shake up, and precision measures 10ml injection liquid chromatography record chromatogram; Separately get cefalexin reference substance appropriate, be measured in the same method.Both obtained with calculated by peak area by external standard method.
Transdermal absorption checks: this inspection method skin: nude mice skin.
This inspection method instrument: do skin permeation test in vitro with skin permeation test in vitro instrument, measures medicine cefalexin transit dose by HPLC, represents with relative amount %.
Test method: measure according to " Chinese Pharmacopoeia " version (two) annex XD drug release determination method the 3rd method in 2010, all sample at 1h, 2h, 4h, 8h.
Embodiment 2
A kind of cefalexin ointment, the composition of this ointment and parts by weight comprise cefalexin 2 parts, Crinis Carbonisatus 5 parts, Folium Camelliae sinensis 20 parts, Borneolum Syntheticum 2 parts, Herba veronicastri villosuli 25 parts, Radix et Caulis Opuntiae Dillenii 25 parts, anhydrous lanolin 30 parts, Oleum sesami 30 parts.
A preparation method for cefalexin ointment, comprises the following steps:
1) get the raw materials ready according to each composition according to claim 1 and parts by weight;
2) extraction of raw material of Chinese medicine pharmaceutically active ingredient: add 600 parts of pure water in constant temperature extraction pot, open and stir, by Folium Camelliae sinensis, Herba veronicastri villosuli adds in constant temperature extraction pot, reacting liquid temperature in constant temperature extraction pot is warming up to 95 ~ 100 DEG C of constant temperature and extracts 30min, through 16 layers of filtered through gauze, filter to get filtrate a, again in constant temperature extraction pot, add 600 parts of pure water, open and stir, filtering residue is added in constant temperature extraction pot, reacting liquid temperature in constant temperature extraction pot is warming up to 95 ~ 100 DEG C of constant temperature and extracts 30min, through 16 layers of filtered through gauze, filter to get filtrate b, merging filtrate a, b obtains filtrate A, by filtrate A pressure be-0.06 ~-0.08Mpa, temperature is concentrated into thick viscous solution B under being 45 ~ 50 DEG C of conditions, when the relative density of viscous solution B is 45 DEG C 1.12 ~ 1.18, viscous solution B is cooled to room temperature for subsequent use,
3) cefalexin, Crinis Carbonisatus, Borneolum Syntheticum are pulverized 200 mesh sieves respectively and obtain fine drug powder C; Radix et Caulis Opuntiae Dillenii is squeezed the juice, through 16 layers of filtered through gauze, filter gained filtrate pressure be-0.06 ~-0.08Mpa, temperature be concentrated under being 40 ~ 45 DEG C of conditions thick must viscous solution D, when the relative density of viscous solution D is 45 DEG C 1.08 ~ 1.12, viscous solution D is cooled to room temperature for subsequent use;
4) substrate is added in constant temperature agitator tank, open and stir, substrate is heated to 50 DEG C, in constant temperature agitator tank, add step 2 successively) gained viscous solution B, step 3) gained viscous solution D and fine drug powder C, the rear 50 DEG C of constant temperature 20min that stir obtain mastic E, mastic E are cooled to room temperature for subsequent use;
5) by step 4) gained mastic E subpackage is for subsequent use.
The using method of a kind of cefalexin ointment of the present invention: be applied to affected part, every day 3 ~ 4 times, or follow the doctor's advice.
Storage: shading, sealing, cool dark place are preserved.
Inspection method is with embodiment 1.
Embodiment 3
A kind of cefalexin ointment, the composition of this ointment and parts by weight comprise cefalexin 5 parts, Crinis Carbonisatus 10 parts, Folium Camelliae sinensis 25 parts, Borneolum Syntheticum 5 parts, Herba veronicastri villosuli 30 parts, Radix et Caulis Opuntiae Dillenii 30 parts, anhydrous lanolin 45 parts, Oleum sesami 35 parts.
A preparation method for cefalexin ointment, comprises the following steps:
1) get the raw materials ready according to each composition according to claim 1 and parts by weight;
2) extraction of raw material of Chinese medicine pharmaceutically active ingredient: add 800 parts of pure water in constant temperature extraction pot, open and stir, by Folium Camelliae sinensis, Herba veronicastri villosuli adds in constant temperature extraction pot, reacting liquid temperature in constant temperature extraction pot is warming up to 95 ~ 100 DEG C of constant temperature and extracts 30min, through 16 layers of filtered through gauze, filter to get filtrate a, again in constant temperature extraction pot, add 800 parts of pure water, open and stir, filtering residue is added in constant temperature extraction pot, reacting liquid temperature in constant temperature extraction pot is warming up to 95 ~ 100 DEG C of constant temperature and extracts 30min, through 16 layers of filtered through gauze, filter to get filtrate b, merging filtrate a, b obtains filtrate A, by filtrate A pressure be-0.06 ~-0.08Mpa, temperature is concentrated into thick viscous solution B under being 45 ~ 50 DEG C of conditions, when the relative density of viscous solution B is 45 DEG C 1.12 ~ 1.18, viscous solution B is cooled to room temperature for subsequent use,
3) cefalexin, Crinis Carbonisatus, Borneolum Syntheticum are pulverized 200 mesh sieves respectively and obtain fine drug powder C; Radix et Caulis Opuntiae Dillenii is squeezed the juice, through 16 layers of filtered through gauze, filter gained filtrate pressure be-0.06 ~-0.08Mpa, temperature be concentrated under being 40 ~ 45 DEG C of conditions thick must viscous solution D, when the relative density of viscous solution D is 45 DEG C 1.08 ~ 1.12, viscous solution D is cooled to room temperature for subsequent use;
4) substrate is added in constant temperature agitator tank, open and stir, substrate is heated to 50 DEG C, in constant temperature agitator tank, add step 2 successively) gained viscous solution B, step 3) gained viscous solution D and fine drug powder C, the rear 50 DEG C of constant temperature 20min that stir obtain mastic E, mastic E are cooled to room temperature for subsequent use;
5) by step 4) gained mastic E subpackage is for subsequent use.
The using method of a kind of cefalexin ointment of the present invention: be applied to affected part, every day 3 ~ 4 times, or follow the doctor's advice.
Storage: shading, sealing, cool dark place are preserved.
Inspection method is with embodiment 1.
Embodiment 4
A kind of cefalexin ointment, the composition of this ointment and parts by weight comprise cefalexin 4 parts, Crinis Carbonisatus 9 parts, Folium Camelliae sinensis 24 parts, Borneolum Syntheticum 4 parts, Herba veronicastri villosuli 26 parts, Radix et Caulis Opuntiae Dillenii 27 parts, anhydrous lanolin 42 parts, Oleum sesami 35 parts.
A preparation method for cefalexin ointment, comprises the following steps:
1) get the raw materials ready according to each composition according to claim 1 and parts by weight;
2) extraction of raw material of Chinese medicine pharmaceutically active ingredient: add 770 parts of pure water in constant temperature extraction pot, open and stir, by Folium Camelliae sinensis, Herba veronicastri villosuli adds in constant temperature extraction pot, reacting liquid temperature in constant temperature extraction pot is warming up to 95 ~ 100 DEG C of constant temperature and extracts 30min, through 16 layers of filtered through gauze, filter to get filtrate a, again in constant temperature extraction pot, add 770 parts of pure water, open and stir, filtering residue is added in constant temperature extraction pot, reacting liquid temperature in constant temperature extraction pot is warming up to 95 ~ 100 DEG C of constant temperature and extracts 30min, through 16 layers of filtered through gauze, filter to get filtrate b, merging filtrate a, b obtains filtrate A, by filtrate A pressure be-0.06 ~-0.08Mpa, temperature is concentrated into thick viscous solution B under being 45 ~ 50 DEG C of conditions, when the relative density of viscous solution B is 45 DEG C 1.12 ~ 1.18, viscous solution B is cooled to room temperature for subsequent use,
3) cefalexin, Crinis Carbonisatus, Borneolum Syntheticum are pulverized 200 mesh sieves respectively and obtain fine drug powder C; Radix et Caulis Opuntiae Dillenii is squeezed the juice, through 16 layers of filtered through gauze, filter gained filtrate pressure be-0.06 ~-0.08Mpa, temperature be concentrated under being 40 ~ 45 DEG C of conditions thick must viscous solution D, when the relative density of viscous solution D is 45 DEG C 1.08 ~ 1.12, viscous solution D is cooled to room temperature for subsequent use;
4) substrate is added in constant temperature agitator tank, open and stir, substrate is heated to 50 DEG C, in constant temperature agitator tank, add step 2 successively) gained viscous solution B, step 3) gained viscous solution D and fine drug powder C, the rear 50 DEG C of constant temperature 20min that stir obtain mastic E, mastic E are cooled to room temperature for subsequent use;
5) by step 4) gained mastic E subpackage is for subsequent use.
The using method of a kind of cefalexin ointment of the present invention: be applied to affected part, every day 3 ~ 4 times, or follow the doctor's advice.
Storage: shading, sealing, cool dark place are preserved.
Inspection method is with embodiment 1.
Check result:
Check result is analyzed:
Conform with the regulations according to the ointment granularity inspection of this method gained cefalexin and sterility test, content is minimum is 94.51%, illustrates that the preparation method of this ointment is proper.
Transdermal absorption check result:
Interpretation of result: as can be seen from check result, cefalexin ointment medicament absorptance of the present invention is comparatively thorough, and effective rate of utilization is high.
Pharmacodynamic analysis of the present invention:
1) foundation of rats after burn model: Wistar cleaning grade healthy white rat 20, in modeling proxima luce (prox. luc) with 8%Na
2s alcoholic solution loses hair or feathers.During modeling, by cream solid ethanol uniform application in the district that burns in advance, application area is consistent with pre-burn surface area, and light immediately and timing, the burn time is 15 seconds.There is edema in burn district and surrounding, edema transudate accumulates between epidermis and corium, forms vesicle.
2) bum model Mus is divided into 2 groups, smears affected part with the ointment prepared by embodiments of the invention 1 for the 1st group, every day 4 times, smear affected part, every day 4 times with the burn ointment that market is bought for the 2nd group.
3) medication Ureteral Calculus result:
Latter 2 minutes mices start to become quiet in 1st group: the 1st medicine-feeding, and pain obviously alleviates; Treat the 2nd day edema area and vesicle district obviously reduces; Treat the 3rd day substantially anhydrous bleb district; Treat the 5th day burned part to be almost recovered; Treat burned part recovery from illness in the 7th day, only have the burned part color of 1 rat slightly darker than non-burned part.
Latter 3 minutes mices start to become quiet in 2nd group: the 1st medicine-feeding, and pain obviously alleviates; Treat the 2nd day edema area and vesicle district obviously reduces; Treat the 4th day substantially anhydrous bleb district; Treat the 7th day burned part to be almost recovered; Treat burned part recovery from illness in the 10th day, only have the burned part color of 2 rat slightly darker than non-burned part.
As can be seen from therapeutic outcome, a kind of cefalexin ointment of the present invention effectively can alleviate the malaise symptoms of burn and scald fast, and curative effect is fast, and therapeutic effect is good.This ointment has detumescence, relieves the pain, antipruritic, promote wound healing, the necrotic tissue and promoting muscle growing that disappears, do not stay the effect of pigment, preventing from scar, can cure burn and scald in short time, make disease sites return to not ill front state, this compound ointment toxic and side effects is little, drug safety, easy to use.
Above-described embodiment is only be described the preferred embodiment of the present invention; not scope of the present invention is limited; under not departing from the present invention and designing the prerequisite of spirit; the various distortion that those of ordinary skill in the art make technical scheme of the present invention and improvement, all should fall in protection domain that claims of the present invention determines.
Claims (4)
1. a cefalexin ointment, is characterized in that, the composition of this ointment and parts by weight comprise cefalexin 2 ~ 5 parts, Crinis Carbonisatus 5 ~ 10 parts, Folium Camelliae sinensis 20 ~ 25 parts, Borneolum Syntheticum 2 ~ 5 parts, Herba veronicastri villosuli 25 ~ 30 parts, Radix et Caulis Opuntiae Dillenii 25 ~ 30 parts, substrate 60 ~ 80 parts.
2. a kind of cefalexin ointment according to claim 1, is characterized in that, the composition of this ointment and parts by weight comprise cefalexin 3 parts, Crinis Carbonisatus 8 parts, Folium Camelliae sinensis 23 parts, Borneolum Syntheticum 3 parts, Herba veronicastri villosuli 27 parts, Radix et Caulis Opuntiae Dillenii 28 parts, substrate 70 parts.
3. a kind of cefalexin ointment according to claim 1 and 2, is characterized in that, the composition of substrate and parts by weight comprise anhydrous lanolin 30 ~ 45 parts, Oleum sesami 30 ~ 35 parts.
4. a preparation method for cefalexin ointment, is characterized in that, comprises the following steps:
1) get the raw materials ready according to each composition according to claim 1 and parts by weight;
2) extraction of raw material of Chinese medicine pharmaceutically active ingredient: the pure water adding raw material of Chinese medicine medicine parts by weight 10 times in constant temperature extraction pot, open and stir, by Folium Camelliae sinensis, Herba veronicastri villosuli adds in constant temperature extraction pot, reacting liquid temperature in constant temperature extraction pot is warming up to 95 ~ 100 DEG C of constant temperature and extracts 30min, through 16 layers of filtered through gauze, filter to get filtrate a, in constant temperature extraction pot, again add the pure water of raw material of Chinese medicine medicine parts by weight 10 times, open and stir, filtering residue is added in constant temperature extraction pot, reacting liquid temperature in constant temperature extraction pot is warming up to 95 ~ 100 DEG C of constant temperature and extracts 30min, through 16 layers of filtered through gauze, filter to get filtrate b, merging filtrate a, b obtains filtrate A, by filtrate A pressure be-0.06 ~-0.08Mpa, temperature is concentrated into thick viscous solution B under being 45 ~ 50 DEG C of conditions, when the relative density of viscous solution B is 45 DEG C 1.12 ~ 1.18, viscous solution B is cooled to room temperature for subsequent use,
3) cefalexin, Crinis Carbonisatus, Borneolum Syntheticum are pulverized 200 mesh sieves respectively and obtain fine drug powder C; Radix et Caulis Opuntiae Dillenii is squeezed the juice, through 16 layers of filtered through gauze, filter gained filtrate pressure be-0.06 ~-0.08Mpa, temperature be concentrated under being 40 ~ 45 DEG C of conditions thick must viscous solution D, when the relative density of viscous solution D is 45 DEG C 1.08 ~ 1.12, viscous solution D is cooled to room temperature for subsequent use;
4) substrate is added in constant temperature agitator tank, open and stir, substrate is heated to 50 DEG C, in constant temperature agitator tank, add step 2 successively) gained viscous solution B, step 3) gained viscous solution D and fine drug powder C, the rear 50 DEG C of constant temperature 20min that stir obtain mastic E, mastic E are cooled to room temperature for subsequent use;
5) by step 4) gained mastic E subpackage is for subsequent use.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510275471.8A CN104815068A (en) | 2015-05-26 | 2015-05-26 | Cefalexin ointment and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510275471.8A CN104815068A (en) | 2015-05-26 | 2015-05-26 | Cefalexin ointment and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104815068A true CN104815068A (en) | 2015-08-05 |
Family
ID=53725711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510275471.8A Pending CN104815068A (en) | 2015-05-26 | 2015-05-26 | Cefalexin ointment and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104815068A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106864A (en) * | 2015-09-25 | 2015-12-02 | 青岛海之源智能技术有限公司 | Cefalexin compound capsule and preparation method thereof |
| CN105126031A (en) * | 2015-09-25 | 2015-12-09 | 青岛海之源智能技术有限公司 | Composite cefalexin sustained tablet and preparation method thereof |
| CN105148193A (en) * | 2015-09-25 | 2015-12-16 | 青岛海之源智能技术有限公司 | Cefalexin compound effervescent tablet and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1125139A (en) * | 1995-12-06 | 1996-06-26 | 张金安 | Antiphlogistic analgesic ointment for treating burn |
| CN1336202A (en) * | 2001-03-18 | 2002-02-20 | 胡毅飞 | Ointment specially for treating dermatosis |
| CN1676127A (en) * | 2004-04-01 | 2005-10-05 | 肖春林 | Dry-wet integrated external-application formulation for treating burn and empyrosis |
-
2015
- 2015-05-26 CN CN201510275471.8A patent/CN104815068A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1125139A (en) * | 1995-12-06 | 1996-06-26 | 张金安 | Antiphlogistic analgesic ointment for treating burn |
| CN1336202A (en) * | 2001-03-18 | 2002-02-20 | 胡毅飞 | Ointment specially for treating dermatosis |
| CN1676127A (en) * | 2004-04-01 | 2005-10-05 | 肖春林 | Dry-wet integrated external-application formulation for treating burn and empyrosis |
Non-Patent Citations (6)
| Title |
|---|
| 南京中医药大学编著: "《中药大辞典》", 31 March 2006, 上海科学技术出版社 * |
| 周先稠主编: "《茶与健康》", 31 October 2014, 中国科学技术大学出版社 * |
| 师海波等主编: "《最新临床药物手册》", 31 January 2013, 军事医学科学出版社 * |
| 李芳等: "先锋霉素粉剂外用治疗中小面积烧伤2例", 《中原医刊》 * |
| 樊裕琴等: "中西医结合治疗小面积烫伤52例", 《陕西中医》 * |
| 高学敏等主编: "《临床中药学》", 31 January 2006, 河北科学技术出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106864A (en) * | 2015-09-25 | 2015-12-02 | 青岛海之源智能技术有限公司 | Cefalexin compound capsule and preparation method thereof |
| CN105126031A (en) * | 2015-09-25 | 2015-12-09 | 青岛海之源智能技术有限公司 | Composite cefalexin sustained tablet and preparation method thereof |
| CN105148193A (en) * | 2015-09-25 | 2015-12-16 | 青岛海之源智能技术有限公司 | Cefalexin compound effervescent tablet and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104983989A (en) | Traditional Chinese medicine drug for treating dysmenorrheal and gel paste and preparation method thereof | |
| JP2021516696A (en) | Chinese herbal medicine composition, Chinese herbal medicine combination preparation and its preparation method and application | |
| CN104815068A (en) | Cefalexin ointment and preparation method thereof | |
| CN104258278A (en) | Gushangling (for bone injury) spray | |
| CN102429976A (en) | A Chinese medicinal ointment for treating burn and scald, and its preparation method | |
| CN107412366A (en) | Chinese medicine composition antibacterial for skin pruritus and preparation method thereof | |
| CN114177231B (en) | Antipyretic pharmaceutical composition, antipyretic gel and preparation method | |
| CN106822321B (en) | Application of Curcuma water of traumatology in preparing medicine for treating keratosis pilaris | |
| CN105168629A (en) | Traditional Chinese medicine gel for treating qi-stagnation and blood stasis type decubitus | |
| WO2018161890A1 (en) | Application of berberine in preparing drug for treating acute soft tissue injury | |
| CN104547251B (en) | A kind of navel patch and preparation method for treating chordapsus | |
| CN103948709B (en) | Palace, a kind of Uygur medicine heat seal Meikang suppository and preparation method thereof | |
| CN1217683C (en) | Prescription of lotion for treating pile and fistula and its preapring process | |
| CN105267516A (en) | Plaster for skin surface local anesthesia | |
| CN113144061A (en) | Cough-relieving traditional Chinese medicine external preparation and preparation method thereof | |
| CN112587616A (en) | Oil for lithospermum and preparation method thereof | |
| CN111920883A (en) | External preparation for treating herpes zoster and preparation method thereof | |
| CN116327828B (en) | Lithospermum and peony seed oil spray film for light and medium burns and scalds and preparation method thereof | |
| CN110384785A (en) | A kind of external application Chinese medicine medical fluid and preparation method thereof for treating virus flu | |
| CN103006986B (en) | Traditional Chinese medicine for treating children cough and preparation method of external use patch thereof | |
| CN111358927B (en) | Pujiang medicinal composition and application thereof | |
| CN100355437C (en) | Medicine for treating scald and burn and preparing method | |
| CN102697928B (en) | Preparation method for medicine composition for treating traumatic injury | |
| CN101406579A (en) | Novel use of pinellia | |
| CN1084748A (en) | Quick results arthritis dressing and manufacture method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150805 |