CN104800261A - Clove compound mouthwash - Google Patents

Abstract

The invention discloses clove compound mouthwash, which comprises the following ingredients in percentage by mass: 0.2 to 0.4 percent of tea polyphenol, 0.5 to 1 percent of eugenol, 0.17 to 0.2 percent of pseudo-ginseng extracts (20:1), 3 to 6 percent of active ingredient stabilizing agents, 0.5 to 1 percent of active ingredient regulating agents, 0.1 to 1 percent of sweetening agents, 0.02 to 1 percent of sour agents, 2 to 5 percent of wetting agents, 0.5 to 1 percent of essence, 0.05 percent of fluoride, 0.01 to 0.4 percent of edible antiseptics and the balance deionized water, wherein the tea polyphenol, the eugenol and the pseudo-ginseng extracts are active ingredients in the mouthwash. The eugenol has the inhibition effect on the pathogenic bacteria and the fungi, a certain antioxidation effect and a certain anti-cancer effect are also achieved, the flavor is unique, the anti-bacterium and anti-oxidation effects of the tea polyphenol are also very good, the tea polyphenol is widely applied to toothpaste, the pseudo-ginseng has better blood circulation promotion and anti-inflammation effects, and a good inhibition effect is achieved on major harmful bacteria in oral cavity resident flora.

Description

A clove compound mouthwash

technical field

The invention relates to a multifunctional pure natural mouthwash with cloves, tea polyphenols and Panax notoginseng as main raw materials, belonging to the field of mouthwashes.

Background technique

With the continuous improvement of living standards in today's society, people's eating habits are gradually changing, coupled with the usual bad living habits, resulting in many oral problems, such as periodontitis, dental caries, bad breath, oral ulcers, etc. Mouthwash is a new product in the era of science and technology. Researchers have developed a variety of medicinal ingredients for the treatment of oral and throat diseases, which can directly act on the affected area, and can also eliminate mouth diseases, bad-smelling food, poor sleep, and mental stress. Mouthwash for bad breath caused by , indigestion, etc. Traditional mouthwash contains a lot of alcohol, which is harmful to the oral cavity. In order to achieve the desired effect, some products do not hesitate to add chemical synthesis reagents to improve the effect of mouthwash. This method has great impact on users. security risks. At present, the new type of plant essential oil mouthwash has natural ingredients, has the characteristics of strong permeability, non-specific sterilization, fast action, long effective action time and small side effects, and has been widely used in the field of domestic oral care products. In addition, natural Chinese medicine ingredients have other biological activities, which can enhance human immunity and prevent and treat cancer.

At present domestic development of this type of mouthwash containing natural Chinese herbal medicine components is seldom, existing relevant patents, some ingredients are too single, some lack corresponding experiments, can not guarantee the safety of mouthwash.

Contents of the invention

The object of the present invention is to provide a clove compound mouthwash, which has the effects of sterilization, caries prevention, swelling reduction, hemostasis, whitening, tooth health and breath freshening, and is safe, reliable and easy to use.

A clove compound mouthwash comprises the following components according to mass percentage:

Tea polyphenols 0.2-0.4%, eugenol 0.5-1%, Panax notoginseng extract 0.17-0.2%; tea polyphenols, eugenol, Panax notoginseng extract are active ingredients in mouthwash;

Active ingredient stabilizer 3-6%, active ingredient regulator 0.5-1%, sweetener 0.01-1%, sour agent 0.02-1%, wetting agent 2-5%, essence 0.5-1%, fluoride 0.05 %, edible preservatives 0.01-0.4%, and the rest is deionized water.

Further, in the above technical solution, the sweetener is selected from one or more of sodium saccharin, sorbitol, xylitol, fructose, and stevioside.

Further, in the above technical solution, the fluoride is selected from one or both of sodium fluoride and sodium monofluorophosphate.

Further, in the above technical solution, the sour agent is selected from one of malic acid, citric acid or tartaric acid.

Further, in the above technical solution, the active ingredient stabilizer is one of polyoxyethylene ether (40) hydrogenated castor oil, caprylic macrogolglyceride or their mixture.

Further, in the above technical solution, the active ingredient regulator is one or both of sodium lauryl sulfate and lauryl sarcosine.

Further, in the above technical solution, glycerin or sorbitol is used as the moisturizing agent.

Further, in the above technical solution, the essence adopts peacock essence and menthol.

Further, in the above technical solution, the food preservative is ethylparaben.

Above-mentioned clove compound mouthwash is prepared by the following method:

1) Stir the sweetener, sour agent and essence in water according to the above content until dissolved, then add the humectant and edible preservative into sterile water, and stir until a clear, transparent and uniformly dispersed aqueous solution;

2) Prepare eugenol mother solution: add sterile water to eugenol, heat to 30-50°C, add PEG-40, stir and dissolve until clear; obtain 40mg/mL eugenol mother solution;

Prepare tea polyphenol mother liquor: add sterile water to tea polyphenol, stir and dissolve until clear; prepare tea polyphenol mother liquor with a final concentration of 40 mg/mL;

Preparation of Panax notoginseng mother liquor: add sterile water to Panax notoginseng extract (20:1), stir and dissolve until clear; prepare Panax notoginseng extract mother liquor with a final concentration of 20 mg/mL;

Preparation of sodium fluoride mother solution: Dissolve sodium fluoride in sterile water to prepare sodium fluoride mother solution with a final concentration of 10 mg/mL;

The above four mother solutions are mixed together, and PEG-40 is added to obtain the active ingredient mother solution in mouthwash;

3) In the stirring state, slowly add the aqueous solution in step 1) to the active ingredient mother liquor prepared in step 2), stop stirring, let stand overnight, filter, and obtain the finished product after aseptic treatment.

The invention provides the use of the above mouthwash, which can be used to treat or prevent oral diseases such as periodontitis, dental caries, halitosis, oral ulcers, etc., and has the effects of whitening, strengthening teeth, clearing away heat and reducing swelling, and preventing cancer.

How to use this mouthwash: Take an appropriate amount of this product, about 10-20ml, rinse for about 30 seconds, then spit it out, no need to rinse your mouth with water.

Beneficial effect of the invention

The eugenol in the present invention has inhibitory effects on pathogenic bacteria and fungi, and also has anti-oxidation and certain anti-cancer effects, and has a unique smell. The antibacterial and anti-oxidative effects of tea polyphenols are also very good, and are widely used in In toothpaste, Panax notoginseng has a strong effect of promoting blood circulation and anti-inflammation, and has a good inhibitory effect on the main harmful bacteria in the oral resident bacteria. The present invention combines multiple components together, in addition to the function of cleaning the mouth with different mouthwashes, it also has the functions of treating or preventing oral diseases such as periodontitis, dental caries, bad breath, oral ulcers, whitening, strengthening teeth, clearing away heat and reducing swelling , The effect of preventing cancer. It has a variety of effects in the prevention and treatment of oral diseases. The mouthwash adopts natural plant ingredients, and has better safety than existing mouthwashes on the market.

Description of drawings

Fig. 1 is the inhibitory effect figure of embodiment 1 mouthwash to Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Candida albicans;

Fig. 2 is the inhibitory effect figure a of embodiment 1 mouthwash to oral bacteria;

Fig. 3 is the inhibitory effect figure b of the mouthwash of embodiment 1 on oral bacteria.

Detailed ways

The following non-limiting examples can enable those skilled in the art to understand the present invention more fully, but do not limit the present invention in any way. Eugenol, purchased from Jiangxi Cedar Natural Medicinal Vegetable Oil Co., Ltd., density 1.063-1.068g/ml; tea polyphenols, purchased from Xuancheng Baicao Plant Industry and Trade Co., Ltd.; Panax notoginseng extract (20:1) purchased in Baoji City Fangsheng Biological Development Co., Ltd.

Example 1

The clove compound mouthwash contains the following ingredients in terms of mass percentage: eugenol 1%, tea polyphenols 0.2%, Panax notoginseng extract (20:1) 0.17%, NaF 0.05%, PEG-40 3%, glycerin 5% , K12 0.5%, sorbitol 0.01%, malic acid 0.02%, menthol 0.5%, the balance of sterile water.

Preparation method, take the production of 100ml product as an example:

(1) preparation of active ingredient mother liquor,

Preparation of eugenol mother liquor: take 3.756ml eugenol (ρ=1.063～1.068g/ml), first add a small amount of sterile water, put it into a magnetic stirrer and stir while heating, the heating temperature is 40°C, gradually add PEG -40 (6 ~ 10ml) until the solution is clear, then add distilled water to 100ml. Prepare a eugenol mother solution with a final concentration of 40 mg/mL.

Preparation of tea polyphenol mother liquor: 4 g of tea polyphenols was dissolved in 100 ml of sterile water to prepare tea polyphenol mother liquor with a final concentration of 40 mg/mL.

Preparation of Panax notoginseng extract mother solution: Dissolve 2 Panax notoginseng extract (20:1) in 100ml sterile water to prepare a notoginseng extract mother solution with a final concentration of 20mg/mL.

Preparation of sodium fluoride mother solution: Dissolve 1 g of sodium fluoride in 100 ml of sterile water to prepare a sodium fluoride mother solution with a final concentration of 10 mg/mL.

(2) Take 25ml of the above eugenol mother liquor, 5ml of tea polyphenol mother liquor, 8.33ml of Panax notoginseng extract mother liquor, sodium fluoride

5ml of mother liquor, gradually add 1ml of PEG-40 until the solution is clear, and can be solubilized by ultrasound to obtain the active ingredient mother liquor mixture;

(3) Take 55.67ml of sterile water, add 5g of glycerin, 0.5g of K12, 0.01g of sorbitol, 0.02g of malic acid, 0.5g of menthol, and 0.1g of paraben, and stir until it is clear, transparent and evenly dispersed. aqueous solution;

(4) Slowly add the aqueous solution in step 1) to the active ingredient mother liquor prepared in step 2) under stirring state, after mixing evenly, stop stirring, let stand overnight, filter, and obtain the finished product after aseptic treatment .

Antibacterial Test 1

Demonstrate the antibacterial effect of the active ingredient in the mouthwash by measuring the growth curve of bacteria, the method is: aseptic operation, adopt the clove compound mouthwash in the embodiment 1 to prepare the liquid culture medium, together with the liquid culture medium without active ingredient , with the blank culture medium as the control, the initial OD value was measured at 600nm. Then take 3ml of the bacterial solution cultured for 8-12 hours, add it to the above liquid medium, measure the OD value again, and use it as the OD value of 0h, then measure the OD value every 2h, measure it again for 8h, and measure it again after 24h. The OD value obtained at each moment minus the initial absorbance value, and a curve made with these values is the bacterial growth curve.

The inhibitory effects on Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Candida albicans are shown in Table 1 and Figure 1:

Table 1 Inhibitory effect of active ingredients in clove compound mouthwash on the growth of different bacteria

The inhibitory effect on oral bacteria is shown in Figure 2 and Figure 3. Figure 2 shows the inhibitory effect of mouthwash on bacteria in a woman's oral cavity, and Figure 3 shows the inhibitory effect of mouthwash on bacteria in a man's oral cavity. The growth of oral bacteria in the liquid medium of the same volume of normal saline.

Claims (9)

1. a clove compound mouthwash, is characterized in that, comprises following composition according to mass percentage composition: Tea polyphenols 0.2-0.4%, eugenol 0.5-1%, Panax notoginseng extract (20:1) 0.17-0.2%, tea polyphenols, eugenol and Panax notoginseng extracts are active ingredients in mouthwash; active ingredients 3-6% stabilizer, 0.5-1% active ingredient regulator, 0.01-1% sweetener, 0.02-1% sour agent, 2-5% wetting agent, 0.5-1% essence, 0.05% fluoride, Edible preservatives 0.01-0.4%, the rest is deionized water. 2. according to the described clove compound mouthwash of claim 1, it is characterized in that: described sweetener is selected from one or more in sodium saccharin, sorbitol, xylitol, fructose, stevioside. 3. The clove compound mouthwash according to claim 1, wherein said fluoride is selected from one or both of sodium fluoride and sodium monofluorophosphate. 4. clove compound mouthwash according to claim 1 is characterized in that: said sour agent is selected from the one in malic acid, citric acid or tartaric acid. 5. according to the described clove compound mouthwash of claim 1, it is characterized in that: described active ingredient stabilizing agent adopts a kind of in polyoxyethylene ether (40) hydrogenated castor oil, caprylic acid polyethylene glycol glyceride or their mixture. 6. The clove compound mouthwash according to claim 1, characterized in that: the active ingredient regulator is one or both of sodium lauryl sulfate and lauryl sarcosine. 7. according to the described clove compound mouthwash of claim 1, it is characterized in that: described humectant adopts glycerin or sorbitol. 8. clove compound mouthwash according to claim 1, is characterized in that: described essence adopts peacock essence, menthol. 9. according to the described clove compound mouthwash of claim 1, it is characterized in that: described edible antiseptic is ethyl gold ester.