CN104800189A - Starch plant hollow capsule - Google Patents
Starch plant hollow capsule Download PDFInfo
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- CN104800189A CN104800189A CN201510242699.7A CN201510242699A CN104800189A CN 104800189 A CN104800189 A CN 104800189A CN 201510242699 A CN201510242699 A CN 201510242699A CN 104800189 A CN104800189 A CN 104800189A
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- starch
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- 239000002775 capsule Substances 0.000 title claims abstract description 95
- 229920002472 Starch Polymers 0.000 title claims abstract description 76
- 239000008107 starch Substances 0.000 title claims abstract description 72
- 235000019698 starch Nutrition 0.000 title claims abstract description 72
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 238000002360 preparation method Methods 0.000 claims abstract description 20
- 239000008367 deionised water Substances 0.000 claims abstract description 16
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 16
- 239000000835 fiber Substances 0.000 claims abstract description 10
- 239000003814 drug Substances 0.000 claims abstract description 6
- 235000013305 food Nutrition 0.000 claims abstract 2
- 241000196324 Embryophyta Species 0.000 claims description 61
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 9
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 9
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 9
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 9
- 240000003183 Manihot esculenta Species 0.000 claims description 6
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 claims description 6
- 239000004014 plasticizer Substances 0.000 claims description 6
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 5
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 5
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 5
- 229940100486 rice starch Drugs 0.000 claims description 5
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 4
- 229920002678 cellulose Polymers 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 4
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 3
- 235000010418 carrageenan Nutrition 0.000 claims description 3
- 239000000679 carrageenan Substances 0.000 claims description 3
- 229920001525 carrageenan Polymers 0.000 claims description 3
- 229940113118 carrageenan Drugs 0.000 claims description 3
- 239000003086 colorant Substances 0.000 claims description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 3
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims description 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 3
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 claims description 2
- 244000247812 Amorphophallus rivieri Species 0.000 claims description 2
- 235000001206 Amorphophallus rivieri Nutrition 0.000 claims description 2
- 229920002261 Corn starch Polymers 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 229920002148 Gellan gum Polymers 0.000 claims description 2
- 229920002581 Glucomannan Polymers 0.000 claims description 2
- 244000017020 Ipomoea batatas Species 0.000 claims description 2
- 235000002678 Ipomoea batatas Nutrition 0.000 claims description 2
- 229920002752 Konjac Polymers 0.000 claims description 2
- 235000004431 Linum usitatissimum Nutrition 0.000 claims description 2
- 240000006240 Linum usitatissimum Species 0.000 claims description 2
- 244000275012 Sesbania cannabina Species 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims description 2
- 238000007796 conventional method Methods 0.000 claims description 2
- 239000008120 corn starch Substances 0.000 claims description 2
- 235000010492 gellan gum Nutrition 0.000 claims description 2
- 239000000216 gellan gum Substances 0.000 claims description 2
- 229940046240 glucomannan Drugs 0.000 claims description 2
- 239000000252 konjac Substances 0.000 claims description 2
- 235000010485 konjac Nutrition 0.000 claims description 2
- 239000003605 opacifier Substances 0.000 claims description 2
- 229920001592 potato starch Polymers 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- 239000000230 xanthan gum Substances 0.000 claims description 2
- 235000010493 xanthan gum Nutrition 0.000 claims description 2
- 229940082509 xanthan gum Drugs 0.000 claims description 2
- 239000002994 raw material Substances 0.000 abstract description 16
- 239000000126 substance Substances 0.000 abstract description 3
- 239000004615 ingredient Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 description 5
- 235000019322 gelatine Nutrition 0.000 description 5
- 235000019890 Amylum Nutrition 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 239000003292 glue Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000001828 Gelatine Substances 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000007902 hard capsule Substances 0.000 description 2
- YIXJRHPUWRPCBB-UHFFFAOYSA-N magnesium nitrate Chemical compound [Mg+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O YIXJRHPUWRPCBB-UHFFFAOYSA-N 0.000 description 2
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 239000004368 Modified starch Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 239000002156 adsorbate Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 235000012489 doughnuts Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229960003943 hypromellose Drugs 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Jellies, Jams, And Syrups (AREA)
- General Preparation And Processing Of Foods (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to a capsule widely applied to industry of food, medicine and health care products, in particular to a starch plant hollow capsule. The starch plant hollow capsule mainly comprises the following ingredients in parts by weight: 50 to 80 parts of natural starch and 10 to 50 parts of plant fiber and 50 to 90 parts of deionized water; then, a conventional process for preparing the hollow capsule is adopted for preparation. Various hydrophilic groups are contained in a chemical structure of the plant fiber added to the starch plant hollow capsule, and higher water-holding power is realized, so that the prepared capsule has better water preservation performance. In addition, the starch hollow capsule prepared from the raw materials has the advantages of low friability and good disintegrating property.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of starch plant Capsules.
Background technology
Tradition gelatine capsule is made up of gelatin, G & W.Meet aldehydes medicine due to gelatin easily cross-linking reaction to occur and make aldehydes drug inactivation, and the drug substance contents making the unsuitable easy moisture absorption of filling of gelatine capsule and react with capsule material.In recent years, " toxic capsule " constantly comes into the market, and causes the fear of numerous consumer, causes the great attention of society and government.And plant capsule is because of its practicality, good safety, stronger stability and be subject to pursuing of consumer without cross-linking reaction widely.The plant capsule produced both at home and abroad at present has two kinds: hypromellose Capsules and general polysaccharide empty capsule.But all there is the drawback that cost is higher, popularization is more difficult in these two kinds of capsules.And starch plant Capsules has the advantages such as with low cost, better performances, has very wide application prospect.
Patent CN 103191433 disclose a kind of utilize plant amylum to be raw material safe Capsules and preparation technology, the plant amylum of 320 grams will be added in the pure water of 1L, after stirring and dissolving, adopt doughnut membrane filtration to remove impurity and obtain plant amylum liquid, carrageenan is added in 1L pure water, two kinds of solution are merged, and stir, gelatinizing in 90 DEG C of water-baths, adds dodecane level sodium sulfonate 0.5g, edible glycerol 10 parts, medicinal pigment 2g, dips in glue after stirring, and then 38-40 DEG C is dried 1h, come unstuck, obtain the safe Capsules of plant amylum.
Patent CN 103638001 discloses a kind of vegetative hard capsule and preparation method thereof, this invention is mixed with water the thickening agent of the modified starch of 60-80 weight portion, 1-2 weight portion, the plasticizer of 20-40 weight portion, obtain dispersion liquid, by dispersion liquid heating for dissolving, temperature controls at 70-85 DEG C, then mould dips in glue, 40-50 DEG C of oven dry, cutting and fit and obtained vegetative hard capsule.
Summary of the invention
The object of the invention is to overcome that fragility in existing starch capsule is poor, disintegration length, the defect such as poor water retention property, provide a kind of starch hollow capsule raw material components, use starch to replace gelatin, not only reduce the cost of Capsules, and substantially increase the safety of capsule.In addition, in this capsule, with the addition of Plant fiber, make capsule have good retentiveness.
Invention broadly provides a kind of starch plant Capsules, primarily of native starch 50-80 part, Plant fiber 10-50 part and deionized water 50-90 part, then the conventional technique preparing Capsules is adopted to prepare and obtain, it is characterized in that, described Plant fiber is mainly selected from one in carboxymethyl cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, Pericarpium Citri grandis cellulose or combination.Preferred Pericarpium Citri grandis cellulose.
Further, described starch plant Capsules, native starch is selected from one in rice starch, corn starch, tapioca, sweet potato starch, pea starch, green starch or combination.
Further, described starch plant Capsules, its component can also comprise plasticizer, and plasticizer is selected from one in edible glycerol, sorbitol or combination, preferred edible glycerol.
Further, described starch plant Capsules, its component can also comprise one in carrageenan in plant gum, Konjac glucomannan, gellan gum, xanthan gum, flax gum, sesbania gum or combination.
Further, described starch plant Capsules, can also comprise video or the acceptable opacifier of medicine, coloring agent, odor mask in its component, the total amount of these additives must not exceed 1.0% of starch hollow capsule gross weight.
Further, described starch plant Capsules, can select the preparation method of conventional hollow capsule and obtain.The preparation method of described conventional hollow capsule, is and most widely usedly in industry is stained with glue method.
Beneficial effect
(1) this starch plant Capsules with the addition of Plant fiber, owing to containing multiple hydrophilic group in the chemical constitution of Plant fiber, there is stronger retention ability, make the capsule water-retaining property of preparation better, and due to the characteristic of Plant fiber self, entering in body self can also harmful substance in adsorbate, plays a driving role to gastrointestinal digestion.
(2) this starch plant Capsules, friability is lower, and disintegration is shorter.
Specific embodiment
Embodiment 1
Rice starch 50 parts, carboxymethyl cellulose 10 parts are dissolved in the deionized water of 50 parts, the preparation method of conventional hollow capsule is adopted to obtain starch plant Capsules above-mentioned raw materials mixed liquor, prepared starch plant Capsules carries out friability and test disintegration, and investigates its water retention property.
Embodiment 2
Rice starch 60 parts, hydroxyethyl-cellulose 30 parts are dissolved in the deionized water of 70 parts, the preparation method of conventional hollow capsule is adopted to obtain starch plant Capsules above-mentioned raw materials mixed liquor, prepared starch plant Capsules carries out friability and test disintegration, and investigates its water retention property.
Embodiment 3
Rice starch 80 parts, carboxymethyl cellulose 50 parts are dissolved in the deionized water of 90 parts, the preparation method of conventional hollow capsule is adopted to obtain starch plant Capsules above-mentioned raw materials mixed liquor, prepared starch plant Capsules carries out friability and test disintegration, and investigates its water retention property.
Embodiment 4
Tapioca 50 parts, hydroxypropyl cellulose 10 parts are dissolved in the deionized water of 60 parts, the preparation method of conventional hollow capsule is adopted to obtain starch plant Capsules above-mentioned raw materials mixed liquor, prepared starch plant Capsules carries out friability and test disintegration, and investigates its water retention property.
Embodiment 5
Tapioca 70 parts, hydroxypropyl methylcellulose 20 parts are dissolved in the deionized water of 70 parts, the preparation method of conventional hollow capsule is adopted to obtain starch plant Capsules above-mentioned raw materials mixed liquor, prepared starch plant Capsules carries out friability and test disintegration, and investigates its water retention property.
Embodiment 6
Tapioca 80 parts, hydroxypropyl cellulose 35 parts are dissolved in the deionized water of 85 parts, the lemon yellow (coloring agent) of 1.5 parts is added in above-mentioned solution, the preparation method of conventional hollow capsule is adopted to obtain starch plant Capsules above-mentioned raw materials mixed liquor, prepared starch plant Capsules carries out friability and test disintegration, and investigates its water retention property.
Embodiment 7
Pea starch 55 parts, carboxymethyl cellulose 25 parts are dissolved in the deionized water of 60 parts, the preparation method of conventional hollow capsule is adopted to obtain starch plant Capsules above-mentioned raw materials mixed liquor, prepared starch plant Capsules carries out friability and test disintegration, and investigates its water retention property.
Embodiment 8
Pea starch 60 parts, carboxymethyl cellulose 40 parts are dissolved in the deionized water of 65 parts, 5 parts of glycerol (plasticizer) are added in above-mentioned solution, the preparation method of conventional hollow capsule is adopted to obtain starch plant Capsules above-mentioned mixed liquor, prepared starch plant Capsules carries out friability and test disintegration, and investigates its water retention property.
Embodiment 9
Pea starch 75 parts, hydroxypropyl methylcellulose 45 parts are dissolved in the deionized water of 90 parts, the preparation method of conventional hollow capsule is adopted to obtain starch plant Capsules above-mentioned raw materials mixed liquor, prepared starch plant Capsules carries out friability and test disintegration, and investigates its water retention property.
Embodiment 10
Green starch 60 parts, carboxymethyl cellulose 45 parts are dissolved in the deionized water of 65 parts, the preparation method of conventional hollow capsule is adopted to obtain starch plant Capsules above-mentioned raw materials mixed liquor, prepared starch plant Capsules carries out friability and test disintegration, and investigates its water retention property.
Embodiment 11
Green starch 60 parts, carboxymethyl cellulose 45 parts are dissolved in the deionized water of 65 parts, the preparation method of conventional hollow capsule is adopted to obtain starch plant Capsules above-mentioned raw materials mixed liquor, prepared starch plant Capsules carries out friability and test disintegration, and investigates its water retention property.
Embodiment 12
Tapioca 70 parts, Pericarpium Citri grandis cellulose 20 parts are dissolved in the deionized water of 70 parts, the preparation method of conventional hollow capsule is adopted to obtain starch plant Capsules above-mentioned raw materials mixed liquor, prepared starch plant Capsules carries out friability and test disintegration, and investigates its water retention property.
Comparative example
Pea starch 55 parts, carboxymethyl cellulose 25 parts are dissolved in the deionized water of 60 parts, the preparation method of conventional hollow capsule is adopted to obtain starch plant Capsules above-mentioned raw materials mixed liquor, prepared starch plant Capsules carries out friability and test disintegration, and investigates its water retention property.
Disintegration tests: carry out inspection disintegration according to " Chinese Pharmacopoeia " 2010 editions two annex, take water as medium, temperature is 37 DEG C, adds baffle plate test.Criterion is the whole disintegrate in 20min of all capsules.
Friability test: according to " Chinese Pharmacopoeia " 2010 editions two, get starch hollow capsule 50 in surface plate, put into the exsiccator filling magnesium nitrate saturated solution, put 25 DEG C ± 1 DEG C constant temperature 24 hours, take out, put into by grain the glass tubing stood upright on plank respectively immediately, circular counterweight is freely fallen from the glass mouth of pipe, whether break depending on capsule, if any breaking, must not more than 5.
Respectively get the soft capsule that raw material described in above-described embodiment is made, and to appearance character, the burst test of starch hollow capsule and detect disintegration, the results are shown in Table 1, water retention property test result is in table 2.
Table 1 starch plant Capsules friability, disintegration investigate result
Table 2 starch plant Capsules water retention property investigates result
Claims (6)
1. a starch plant Capsules, primarily of native starch 50-80 part, Plant fiber 10-50 part and deionized water 50-90 part, then the conventional technique preparing Capsules is adopted to prepare and obtain, it is characterized in that, described Plant fiber is mainly selected from one in carboxymethyl cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, Pericarpium Citri grandis cellulose or combination.
2. starch plant Capsules according to claim 1, is characterized in that, described native starch is selected from one in rice starch, corn starch, tapioca, sweet potato starch, pea starch, green starch or combination.
3. starch plant Capsules according to claim 1, is characterized in that, its component can also comprise plasticizer, and plasticizer is selected from one in edible glycerol, sorbitol or combination, preferred edible glycerol.
4. starch plant Capsules according to claim 1, is characterized in that, its component can also comprise one in carrageenan in plant gum, Konjac glucomannan, gellan gum, xanthan gum, flax gum, sesbania gum or combination.
5. starch plant Capsules according to claim 1, is characterized in that, can also comprise food or the acceptable opacifier of medicine, coloring agent, odor mask in its component, the total amount of these additives must not exceed 1.0% of starch hollow capsule gross weight.
6. starch plant Capsules according to claim 1, is characterized in that, can select the preparation method of conventional hollow capsule and obtain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510242699.7A CN104800189B (en) | 2015-05-13 | 2015-05-13 | A kind of starch plant Capsules |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510242699.7A CN104800189B (en) | 2015-05-13 | 2015-05-13 | A kind of starch plant Capsules |
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| Publication Number | Publication Date |
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| CN104800189A true CN104800189A (en) | 2015-07-29 |
| CN104800189B CN104800189B (en) | 2018-03-06 |
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Cited By (5)
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| CN105769811A (en) * | 2016-05-05 | 2016-07-20 | 夏放军 | Empty starch capsule and preparation method thereof |
| CN105919978A (en) * | 2016-04-28 | 2016-09-07 | 湖南尔康制药股份有限公司 | Preparation method of amoxicillin microsphere slow-release capsule |
| CN105997930A (en) * | 2016-07-04 | 2016-10-12 | 安顺济世科技有限公司 | Empty capsule and soft capsule based on modified starch |
| CN108542966A (en) * | 2018-05-22 | 2018-09-18 | 湖北康科德生物科技有限公司 | A kind of hard capsule and preparation method thereof of relieving the effect of alcohol of plant formula |
| CN110090202A (en) * | 2019-06-10 | 2019-08-06 | 哈尔滨坤丰生物工程有限公司 | A kind of pea hydroxypropyl carboxy methyl starch hollow capsule and preparation method |
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| CN105997930A (en) * | 2016-07-04 | 2016-10-12 | 安顺济世科技有限公司 | Empty capsule and soft capsule based on modified starch |
| CN108542966A (en) * | 2018-05-22 | 2018-09-18 | 湖北康科德生物科技有限公司 | A kind of hard capsule and preparation method thereof of relieving the effect of alcohol of plant formula |
| CN110090202A (en) * | 2019-06-10 | 2019-08-06 | 哈尔滨坤丰生物工程有限公司 | A kind of pea hydroxypropyl carboxy methyl starch hollow capsule and preparation method |
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