CN104800089A - Biological fiber composite dressing - Google Patents

Abstract

A biofiber composite dressing comprising: a cloth membrane having a first surface layer and a second surface layer opposite to each other, and the cloth membrane having cloth membrane fibers; and the biological fiber membrane is provided with a third surface layer and a fourth surface layer which are opposite, and is formed by bacteria of Gluconacetobacter , the fourth surface layer is combined on the first surface layer, and a plurality of biological fibers which are wound and combined on the cloth membrane fibers extend from the fourth surface layer of the biological fiber membrane, so that the moisture retention of the dressing is improved through the biological fiber membrane, and more active ingredients can be carried.

Description

Biofiber Composite Dressing

technical field

The present invention relates to a biological fiber composite dressing, more specifically, relates to a biological fiber composite dressing applied on the skin.

Background technique

At present, in the medical field, most of the dressings used in wound care use cotton pads or gauze, but these dressings have poor antibacterial properties, a high probability of wound infection, and are prone to sticking to the wound, and are not easy to remove when changing the dressing. Shortcomings.

Later, gauze and cotton pads were replaced by non-woven dressings. The non-woven dressing has better liquid absorption capacity and can provide a moist environment to help wound repair. However, when the non-woven fabric absorbs After the liquid or moisture is gradually lost, the problem of wound sticking is also prone to occur.

On the other hand, in addition to the basic needs of life, modern people pay more attention to beauty maintenance, especially the maintenance of the face is the focus of the beauty industry, so a variety of facial mask products have been developed. The facial film of prior art is of a great variety, such as mud cream type facial film, tear-off type facial film and sheet-shaped facial film etc.

Although the mud cream mask contains maintenance ingredients or minerals, it needs to be rinsed after applying the mask. The maintenance ingredients are difficult to be absorbed by the skin, and because it contains more minerals, more preservatives must be added to prevent bacteria from entering the wet area. Grow in mud. The main components of the peel-off mask are polymer glue, water and alcohol, and it can promote skin blood circulation by raising the temperature of the skin. damage, and the peel-off mask does not add moisturizing ingredients for dryness, and it is not very suitable for dry skin. As for the sheet-shaped mask, it is mainly a single-layer sheet that absorbs effective essence, and can be used to maintain various skin types by adjusting the ingredients. Although it does not need to be rinsed after application, it does not have a cleansing effect. The above-mentioned sheet-shaped facial masks are mostly made of single-layer non-woven fabric. When users use non-woven fabrics for absorbing essence, they often use high-concentration essences due to the rapid volatilization of water in non-woven fabrics, which not only generates waste, but also cannot solve the problem of water volatilization.

Therefore, the industry has developed bio-cellulose membranes as mask products. Although bio-cellulose membranes have better moisturizing properties, the overall comfort of attachment is poor, and it is difficult to unfold the entire bio-cellulose membrane mask after using it to absorb essence. Therefore, there is still a need to develop a novel dressing product.

Contents of the invention

In view of the lack of the above-mentioned prior art, the present invention provides a biofiber composite dressing, comprising: a cloth membrane with opposite first surface layers and second surface layers, and the cloth membrane has cloth membrane fibers; The biocellulose film of the surface layer and the fourth surface layer is formed by bacteria of the genus Gluconacetobacter (Gluconacetobacter), and the fourth surface layer is combined on the first surface layer, and the fourth surface layer of the biocellulose film is extended with multiple windings Biofibres bound in the fabric membrane fibers.

In a specific embodiment, the biological fiber membrane also has a three-dimensional network structure, which is combined between the third surface layer and the fourth surface layer, wherein the density of the three-dimensional network structure is lower than that of the third surface layer and the fourth surface layer. Density, and the three-dimensional network structure extends from the fourth surface layer to the first surface layer of the cloth membrane, wherein the three-dimensional network structure is composed of a plurality of biological fibers.

Moreover, the three-dimensional network structure has a plurality of backbone fibers parallel to each other and a plurality of interlayer fibers interwoven between any two adjacent backbone fibers, and the plurality of backbone fibers and interlayer fibers are biological fibers, and the plurality of backbone fibers The diameter is greater than or equal to the diameter of the plurality of interlayer fibers. Also, the plurality of backbone fibers extend in the lengthwise or widthwise direction of the biofibrous membrane.

In yet another specific embodiment, the biofiber composite dressing further includes another biofiber film disposed on the second surface layer.

In another specific embodiment, the another bio-fiber membrane has a plurality of bio-fibres wound and combined with the cloth-membrane fiber.

The biological fiber composite dressing of the present invention has a cloth film and a biological fiber film to absorb more water or active ingredients through the biological fiber film, and because the pores of the biological fiber film are finer than the cloth film, so it has air permeability, Prevents rapid evaporation of water from the cloth film, improving the moisture retention of the dressing. Therefore, when the biofiber composite dressing of the present invention is applied on the skin, it is not necessary to absorb excessive active ingredients when used as a facial mask, which saves a lot of consumption costs for end users.

Description of drawings

Fig. 1 is the structural representation of biological fiber composite dressing of the present invention;

2A and 2B are scanning electron microscope (SEM) photos showing the biological fiber membrane composite dressing of the present invention, wherein, Figure 2A is a photo showing that the three-dimensional network structure extends to the cloth membrane, and Figure 2B is a side view showing the biological fiber membrane photo;

Fig. 3A and 3B are respectively the SEM photo showing the 500 times magnification of the biofiber composite dressing of the present invention on the biofiber membrane side and the 500 times magnification of the traditional biofiber membrane;

Fig. 4 is a schematic structural view showing that the biological fiber membrane composite dressing of the present invention has another biological fiber membrane; and

Fig. 5 shows the permeability test result of biofiber composite dressing of the present invention and commercially available traditional biofiber membrane, wherein, Fig. 5 (a) is the test result of biofiber composite dressing of the present invention, Fig. 5 (b) is commercially available traditional Test results of biocellulose membranes.

Symbol Description

1, 2 Biofiber composite dressing

10, 20 cloth film

101 Cloth film fiber

10a, 20a The first surface layer

10b, 20b Second surface layer

12, 22 Biological fiber membrane

12a Third surface layer

12b fourth surface layer

121 Three-dimensional network structure

121a backbone fiber

121b interlayer fiber

22’ Another biofiber membrane.

Detailed ways

Embodiments of the present invention are described below through specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification.

It should be noted that the structures, proportions, sizes, etc. shown in the drawings attached to this specification are only used to match the content disclosed in the specification for the understanding and reading of those skilled in the art, and are not intended to limit the implementation of the present invention. condition, so it has no technical substantive meaning, and any modification of structure, change of proportional relationship or adjustment of size shall still fall within the scope of the present invention without affecting the effect and purpose of the present invention. The disclosed technical content must be within the scope covered. At the same time, terms such as "first", "second", "third", "fourth", "upper" and "one" quoted in this specification are only for the convenience of description and are not intended to be used. To limit the practicable scope of the present invention, the change or adjustment of the relative relationship shall also be regarded as the practicable scope of the present invention without substantially changing the technical content.

The term "parallel" herein refers to a form in which a plurality of backbone fibers extend in the same direction, such as the length direction or the width direction.

The invention provides a biological fiber composite dressing, comprising: a cloth membrane with opposite first surface layers and second surface layers, and the cloth membrane has cloth membrane fibers; and a biological fiber membrane with opposite third surface layers and fourth surface layers , formed by bacteria of the genus Gluconacetobacter, and the fourth surface layer is combined with the first surface layer, and the fourth surface layer of the biological fiber membrane is extended with a plurality of biological fibers wound and combined with the cloth membrane fiber.

The cloth membrane is woven or non-woven. Generally, weaving refers to weaving through textile technology. The fabric can be woven from artificial fibers, natural fibers, or a blend of artificial fibers and natural fibers. In a specific implementation, the rayon is polyester, acrylic or nylon. The natural fiber is silk or cotton fiber.

The biocellulose film of the present invention refers to one obtained by culturing microorganisms. The present invention finds that the biofiber membrane formed by the bacterium of the genus Gluconacetobacter in a culture solution containing mannitol, peptone (peptone), yeast extract (yeast extract) and agar has multiple entanglements bound to the cloth membrane fiber of biological fibers.

In the specific example of producing biofiber membrane, the fermentation and cultivation of strains is started. At first, a culture solution is provided, which is placed in a container, and the components of the culture solution include: , and other known components, but the culture solution also needs to have a carbon source, such as mannitol, glucose, etc., other components such as peptone and yeast extract, and the weight ratio of carbon source, peptone and yeast extract can be 5: Between 1:1 and 4:1:1. Then control the pH value of the culture medium to be acidic, for example, the pH value is between 0.5 and 6, and the initial microbial concentration range can be controlled at 102 to 105/ml, and cultured at 25 to 28°C for 24 to 96 hours, and then Spread the aforementioned cloth membrane flatly in the culture solution in the container, and take out the composite dressing after 24 hours to 48 hours to obtain the biological fiber composite dressing of the present invention.

After testing, the biofiber film in the biofiber composite dressing of the present invention has a plurality of biofibers, and the amount of the biofibers per unit area is 0.005 to 0.008g/cm ² , and the diameter of the biofibers is 20 to 100nm.

In addition, after the biofiber composite dressing of the present invention is dried and then absorbs water or active ingredients, it has a rehydration rate of at least 50%, a rehydration rate of at least 60%, a rehydration rate of at least 70%, or even 91%. rehydration rate. In another aspect, the biofiber film in the biofiber composite dressing has a thickness of at least 20 μm, such as 20 to 30 μm, or such as 20 to 26 μm or 24 to 26 μm.

As shown in FIG. 1 , the biofiber composite dressing 1 of the present invention includes a cloth membrane 10 having opposite first surface layers 10 a and second surface layers 10 b ; and a biofiber membrane 12 disposed on the first surface layer 10 a. The biocellulose membrane 12 has a third surface layer 12a and a fourth surface layer 12b opposite to each other, and the fourth surface layer 12b is bonded to the first surface layer 10a.

In addition, please refer to FIG. 2A , which shows that the fourth surface layer 12 b of the biological fiber membrane 12 is extended with a plurality of biological fibers wound and combined with the cloth membrane fiber 101 .

As shown in the figure, the biological fiber membrane 12 has a three-dimensional network structure 121 extending from the fourth surface layer 12b to the first surface layer 10a of the cloth membrane 10, and the three-dimensional network structure 121 is composed of a plurality of biological fibers. Specifically, the three-dimensional network structure 121 has a plurality of backbone fibers 121a parallel to each other and a plurality of interlayer fibers 121b interwoven between any two adjacent backbone fibers 121a. The backbone fibers 121a form a three-dimensional network structure 121 . Both the backbone fiber 121a and the interlayer fiber 121b are biological fibers, and as shown in the figure, the diameter of the backbone fiber 121a is greater than or equal to the diameter of the interlayer fiber 121b. Even, it can be found that the diameter of the backbone fiber 121 a is smaller than that of the membrane fiber 101 .

Please refer to FIG. 2B , which shows a side view photo of the biofibrous membrane 12, wherein the biofibrous membrane 12 also has a plurality of backbone fibers 121a parallel to each other or extending in the length direction or width direction of the biofibrous membrane 12 and connected to the backbone. Fibers 121a interweave interlayer fibers 121b. Moreover, the three-dimensional network structure is combined between the two surface layers of the biological fiber membrane 12, and the density of the three-dimensional network structure is smaller than that of the two surface layers, such as the density of the third surface layer and the fourth surface layer. In this embodiment, the biofiber film in the biofiber composite dressing has a thickness of 20 to 30 μm.

Please refer to Figures 3A and 3B, which respectively show the 500 times magnified SEM photo of the biofiber composite dressing of the present invention on the side of the biofiber membrane and the 500 times magnified SEM photo of the traditional biofiber membrane.

As shown in Figure 3A, the biological fiber composite dressing of the present invention is flat on the biological fiber membrane side, and the strips shown in the figure are cloth film fibers below the biological fiber membrane, so the biological fiber composite dressing of the present invention is very flat on the biological fiber membrane side. flat. But the surface of the traditional biofiber membrane shown in Fig. 3B has many wrinkles. Therefore, the adhesion of the biofiber film to the skin is not good, so that the touch is affected, resulting in the problem of poor absorption of drugs or active ingredients.

As shown in Figure 4, if the cloth film 20 is in the container for a long time in the cultivation process, or the cloth film 20 is turned over, then the second surface layer 20b of the cloth film 20 also includes another biological fiber film. 22 ′, so in this embodiment, the bio-fiber composite dressing 2 includes another bio-fiber film 22 ′ in addition to the bio-fiber film 22 formed on the first surface layer 20 a.

The biological fiber composite dressing of the present invention can be applied on the skin, especially as a facial mask, so the biological fiber composite dressing can also include active ingredients or medicines. Examples of the active ingredient include moisturizers, whitening ingredients, anti-wrinkle ingredients, exfoliating ingredients, growth factors or enzymes. Adding different active ingredients can make the biofiber composite dressing of the present invention have the functions of relieving pressure and body surface massage.

Tensile strength test of biological fiber composite dressing of the present invention

The biological fiber composite dressing of the present invention is cut into the size of 15mmx15mm, and three test pieces are taken for tensile strength test, the results obtained are respectively 2113.70g/15mm, 2145.00g/15mm, 1951.90g/15mm, the average tensile strength The strength is 2070.20g/15mm.

If the same test is carried out with the traditional bio-fiber membrane, its tensile strength reaches 2607.33g/15mm. It can be seen that the softness of the biological fiber composite dressing of the present invention is better than that of the traditional biological fiber membrane.

Elongation test of biological fiber composite dressing of the present invention

In addition, the biological fiber composite dressing of the present invention was tested for elongation, and the results obtained were 21.00%, 16.20% and 16.60%, respectively, and the average elongation was 17.93%. However, in the same test with the traditional biofiber membrane, its elongation is only 5.66%. It can be seen that the elongation of the biofiber composite dressing of the present invention is obviously better, and can be extended and attached to a larger area.

Water absorption test of the biological fiber composite dressing of the present invention

Take three test pieces with a size of 100mmx15mm, pour deionized water into the water dish, keep the water temperature at 23±1°C, then touch the test piece to the water surface, and measure the water absorption height for one minute.

According to measurements, the average water absorption height of the biofiber composite dressing of the present invention is 40mm, while the average water absorption height of the traditional biofiber membrane is only 1mm, so the biofiber composite dressing of the present invention has better water absorption.

Biofiber amount test per unit area in the biofiber composite dressing of the present invention

Take the biological fiber composite dressing of the present invention, and cut it into 16 samples in the size of 5cmx5cm, and then dry it at 60°C for 10 minutes, weigh the dried samples, and take the weight of each sample after deducting the dry weight of the cloth film. The dry weight of the sample is divided by the area of the sample, and the amount of biological fiber per unit area is measured to be 0.005 to 0.008 g/cm ² .

In comparison, the amount of biofiber per unit area of commercially available conventional biofiber membranes is usually only 0.001 g/cm ² .

The rehydration rate test of the biological fiber composite dressing of the present invention

Take the biofiber composite dressing of the present invention and commercially available traditional biofiber membranes, and measure their wet weights, then dry them at 20°C for 30 minutes until the dressing and the biofiber membranes present curls and white silky fibers, then measure their dry weights. . Then, make the dressing and the biocellulose membrane contact with water for 30 minutes again, and record the weight after rehydration, divide the weight after rehydration by the weight difference between the wet weight and the dry weight to obtain the rehydration rate .

After testing, it is found that the biological fiber composite dressing of the present invention can reach at least 50%, and the highest rehydration rate can reach 91%, but the commercially available traditional biological fiber membrane cannot absorb water. The amount of biofiber is only 0.001g/cm ² , but the amount of biofiber per unit area of the biofiber film in the biofiber composite dressing of the present invention is 0.005 to 0.008g/cm ² , so it has an excellent rehydration rate.

The permeability test of biological fiber composite dressing of the present invention

Put the biofiber composite dressing of the present invention and the commercially available traditional biofiber membrane on a substrate respectively, then add an equivalent amount of dyed essence to the biofiber composite dressing of the present invention and the commercially available traditional biofiber membrane, and wait for For 10 seconds, the substrate was visually observed for penetration.

As shown in Figure 5, Figure 5 (a) is the test result of the biological fiber composite dressing of the present invention, and Figure 5 (b) is the test result of the commercially available traditional biological fiber membrane, wherein, the commercially available traditional biological fiber membrane was just dropped When using the essence, the essence diffusion effect is not good, and naturally the essence cannot be effectively penetrated into the substrate after waiting for 10 seconds, but the biofiber composite dressing of the present invention has remarkable essence diffusion and permeability.

In summary, the biological fiber composite dressing of the present invention has a cloth film and a biological fiber film to absorb more water or active ingredients through the biological fiber film, and because the pores of the biological fiber film are finer than the cloth film, it has While being air-permeable, it prevents moisture from evaporating quickly from the cloth film and improves the moisture retention of the dressing. On the other hand, when one side of the biofiber composite dressing is a cloth film, it can have both comfort and long-term moisture retention. Therefore, when the biofiber composite dressing of the present invention is applied on the skin, it is not necessary to absorb excessive active ingredients when used as a facial mask, which saves a lot of consumption costs for end users.

The above-mentioned embodiments are used to illustrate the principles and effects of the present invention, but not to limit the present invention. Any person skilled in the art can modify the above-mentioned embodiments without departing from the spirit and scope of the present invention. Therefore, the protection scope of the present invention should be listed in the claims.

Claims (21)

1. A biological fiber composite dressing, comprising: a cloth membrane having opposing first and second skin layers, and the cloth membrane has cloth membrane fibers; and The biological fiber film is formed by bacteria of the genus Gluconacetobacter, and the biological fiber film has a third surface layer and a fourth surface layer opposite, the fourth surface layer is combined with the first surface layer, and the first surface layer of the biological fiber film is The four surface layers are extended with a plurality of biofibers wound and combined with the cloth membrane fibers. 2. The biological fiber composite dressing as claimed in claim 1, characterized in that, the biological fiber film also has a three-dimensional network structure, which is combined between the third surface layer and the fourth surface layer, and the density of the three-dimensional network structure The density of the third surface layer and the fourth surface layer is smaller than that of the third surface layer, and the three-dimensional network structure extends from the fourth surface layer into the first surface layer of the cloth membrane. 3. The biological fiber composite dressing according to claim 2, wherein the three-dimensional network structure is composed of a plurality of biological fibers. 4. The biological fiber composite dressing according to claim 2, wherein the three-dimensional network structure has a plurality of backbone fibers parallel to each other and a plurality of interlayer fibers interwoven between any two adjacent backbone fibers. 5. The biological fiber composite dressing according to claim 4, wherein the diameter of the plurality of backbone fibers is greater than or equal to the diameter of the plurality of interlayer fibers. 6 . The biofiber composite dressing according to claim 4 , wherein the plurality of backbone fibers extend in the length direction or width direction of the biofiber membrane. 7. The biological fiber composite dressing according to claim 1, characterized in that, the cloth film is woven or non-woven. 8. The biological fiber composite dressing according to claim 7, characterized in that, the woven cloth is made of artificial fibers, natural fibers, or blended of artificial fibers and natural fibers. 9. The biofiber composite dressing according to claim 8, wherein the artificial fiber is polyester, acrylic or nylon. 10. The biological fiber composite dressing according to claim 8, characterized in that the natural fiber is silk or cotton fiber. 11. The biofiber composite dressing as claimed in claim 1, further comprising another biofiber film disposed on the second surface layer. 12 . The biofiber composite dressing as claimed in claim 11 , wherein the other biofiber membrane has a plurality of biofibers that are wound and bonded to the cloth membrane fibers. 13 . 13. The biofiber composite dressing of claim 1, further comprising an active ingredient or drug. 14. The biological fiber composite dressing according to claim 13, wherein the active ingredient is a moisturizing agent, a whitening ingredient, an anti-wrinkle ingredient, an exfoliating ingredient, a growth factor or an enzyme. 15. The biofiber composite dressing according to claim 1, wherein the biofiber film is formed by the bacterium of the genus Gluconacetobacter in a culture solution with mannitol, peptone, yeast extract and agar. 16 . The biofiber composite dressing according to claim 1 , wherein the biofiber film has a plurality of biofibers, and the amount of the biofibers per unit area is 0.005 to 0.008 g/cm ² . 17. The biological fiber composite dressing according to claim 16, characterized in that the diameter of the biological fiber is 20 to 100 nm. 18. The biofiber composite dressing of claim 1 having a rehydration rate of at least 50%. 19. The biofiber composite dressing of claim 18, having a rehydration rate of at least 50% to 91%. 20. The biofiber composite dressing according to claim 1, wherein the thickness of the biofiber film is at least 20 μm. 21. The biofiber composite dressing according to claim 20, characterized in that the thickness of the biofiber film is 20 to 30 μm.