CN104706447A - Bionic bone trabecula lumbar vertebra fusion cage and manufacturing method thereof - Google Patents
Bionic bone trabecula lumbar vertebra fusion cage and manufacturing method thereof Download PDFInfo
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- CN104706447A CN104706447A CN201510129345.1A CN201510129345A CN104706447A CN 104706447 A CN104706447 A CN 104706447A CN 201510129345 A CN201510129345 A CN 201510129345A CN 104706447 A CN104706447 A CN 104706447A
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- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 94
- 230000004927 fusion Effects 0.000 title claims abstract description 43
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 12
- 239000011664 nicotinic acid Substances 0.000 title abstract 6
- 210000004027 cell Anatomy 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 16
- 235000001968 nicotinic acid Nutrition 0.000 claims description 16
- 239000008187 granular material Substances 0.000 claims description 15
- 238000005259 measurement Methods 0.000 claims description 12
- 239000011148 porous material Substances 0.000 claims description 12
- 239000002245 particle Substances 0.000 claims description 11
- 238000004458 analytical method Methods 0.000 claims description 8
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 210000000845 cartilage Anatomy 0.000 claims description 4
- 238000009825 accumulation Methods 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 239000011121 hardwood Substances 0.000 claims description 3
- 238000003384 imaging method Methods 0.000 claims description 3
- 210000001611 motor endplate Anatomy 0.000 claims description 3
- 230000003068 static effect Effects 0.000 claims description 3
- 210000002435 tendon Anatomy 0.000 claims description 3
- 238000012217 deletion Methods 0.000 claims description 2
- 230000037430 deletion Effects 0.000 claims description 2
- 238000010146 3D printing Methods 0.000 abstract description 4
- 230000000694 effects Effects 0.000 description 10
- 230000011164 ossification Effects 0.000 description 6
- 230000007812 deficiency Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 2
- 238000013499 data model Methods 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
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Abstract
The invention discloses a bionic bone trabecula lumbar vertebra fusion cage and a manufacturing method thereof. The bionic bone trabecula lumbar vertebra fusion cage comprises an integrated bone trabecula structure (5) composed of a fusion cage supporting column (1), a filling groove (2), a conical pointed part (3) and an artificial bone simulating structure (4), and the bone trabecula structure (5) is provided with a rear-end connecting part (6). The manufacturing method of the bionic bone trabecula lumbar vertebra fusion cage comprises the following steps that 1, original parameters of the bone trabecula are calculated; 2, a target model is established; 3, specific hole unit bodies are stacked within the boundary range of the target model disorderly, the sizes of the hole unit bodies, the distance between hole units, the sizes of ribs in the hole unit bodies, the sizes of connecting ribs between the hole unit bodies and the precision and appearance precision of the integrated bone trabecula structure are set, and finally, the original target model is deleted and the bone trabecula structure obtained after filling is reserved. According to the bionic bone trabecula lumbar vertebra fusion cage and the manufacturing method of the bionic bone trabecula lumbar vertebra fusion cage, a cancellous bone structure of a human body is simulated in the microstructure aspect through a 3D printing product, and the technical problems that according to a traditional centrum fusion cage, only the mechanical supporting function is achieved, and a formed bone can not be induced to grow are solved.
Description
Technical field
The present invention relates to human spine's lumbar surgery and merge apparatus, particularly relate to a kind of Bionics Bone girder lumbar fusion cages and preparation method thereof.
Background technology
Tradition intervertebral fusion apparatus adopts macromolecular material or metal material machining to form, and can only play the effect of physical support in human body, but exists and can not grow into by induced osteogenesis, can not reach the technological deficiency improving spinal fusion rate.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Bionics Bone girder lumbar fusion cages and preparation method thereof, overcome the shortcoming of prior art, the present invention adopts 3D printing technique, bionical in microstructure, can grow into by induced osteogenesis, reach the effect improving spinal fusion rate.
Technical problem to be solved by this invention is achieved through the following technical solutions:
A kind of Bionics Bone girder lumbar fusion cages, comprises the overall trabecular bone structure of fusion device support column, filling slot, tapered tip portion, manual imitation bone structure formation;
Described trabecular bone structure is provided with rear connecting portion.
Described filling slot is filled with spongy bone and bone; Described Grafting Cancellous Bone Bolt girder is graininess.
Described fusion device support column has the effect supporting and fill, and described filling slot is for filling spongy bone and bone; Described tapered tip portion is conducive to squeezing into vertebral body position; Described manual imitation bone structure is the structure after filling; The rear end entity of described rear connecting portion, for connecting holding apparatus, easy to usely squeezes into vertebral body.
Present invention also offers described a kind of Bionics Bone girder lumbar fusion cages manufacture method, comprise the following steps:
(1) raw bone girder parameter measurement:
Waist 2 to waist 7 vertebral body is carried out to the CT helical scanning of full vertebral body;
Choose the cross-section and nearly 3mm place of motor end plate, the center of vertebral body and carry out totally three the aspect imagings of 1mm thickness upper, middle and lower;
The process that threshold value is 250HU pixel is carried out to the image obtained, the image pixel lower than 250HU is hidden, produce gray scale figure; Further binary conversion treatment, makes image transform into bianry image;
Establish with the other target measurement district opening graphical analysis, vertebral body center, line length of going forward side by side is calibrated;
Adopt particle quantitative system, the input of image adopts shooting mode;
Grafting Cancellous Bone Bolt girder granule in described image is defined as granule;
By measuring, calculating the bone trabecular average pore size of lumbar vertebra spongy bone and porosity and bone trabecular structure, finally drawing the bone trabecular average pore size of lumbar vertebra and voidage;
(2) object module is set up:
Use Three-dimensional Design Software UG, design the model of the bone trabecula fusion device done of drawing up; After microcomputer modelling, 3D prints, and then on 3D printing device, produces product;
(3) unordered accumulation specific hole cell cube in the bounds of object module; The size of dowel, overall trabecular bone structure precision and outward appearance precision between distance between the size of setting hole cell cube, hole unit, the size of hole cell cube interior tendon, hole cell cube;
Finally delete original object module, retain the trabecular bone structure after filling.
The CT helical scanning condition of described full vertebral body is 120KV, 210mA, 1 cycle per second;
Described establishment opens 10mm so that vertebral body center is other, 400mm altogether
2the target measurement district of graphical analysis, and length calibration;
Described employing particle quantitative system, image shows resolution 1024 × 1024 × 8bit, the dynamic static graphics capture card that 1M hardwood is deposited, and the input of image adopts shooting mode, and resolution is 625 lines, 50/second; Adopt full-automatic function.
The index of described graphical analysis comprises: girder amounts of particles in (1) target measurement district; (2) girder particle diameter; (3) girder granule average major axis; (4) girder granule average minor axis; (5) the average flexibility of girder granule.
Need after described formation bone trabecula body to measure micro-pore diameter, overall porosity, if cannot meet the demands, then need to redesign parameter, refill, remeasure after completing;
The original object module of described last deletion, retains the trabecular bone structure after filling, then adds compact texture, be final cartilage pad bone trabecula model.
Described photographic head model is the CCD-MTV-1881CB of Min Tron.
The present invention adopts technique scheme to have following technique effect:
Overcome the effect that traditional intervertebral fusion apparatus can only play physical support in human body, but exist and can not grow into by induced osteogenesis, the technological deficiency improving spinal fusion rate can not be reached.Adopt 3D printing technique, bionical in microstructure, can grow into by induced osteogenesis, reach and improve the effect of spinal fusion rate.
Accompanying drawing explanation
Fig. 1 is hole cell cube figure of the present invention
Fig. 2 is the hole cell cube design sketch after the present invention fills
Fig. 3 is after Fig. 2 shown pores cell parameters of the present invention has set, the trabecular bone structure formed after deleting original filling objective body
The final cartilage pad bone trabecula model of Fig. 4 for being formed after the interpolation of trabecular bone structure shown in Fig. 3 of the present invention compact texture
Wherein, 1-fusion device support column, 2-filling slot, 3-tapered tip portion, 4-manual imitation bone structure, 5-trabecular bone structure, 6-rear connecting portion
Detailed description of the invention
A kind of Bionics Bone girder lumbar fusion cages as shown in Figure 1, Figure 2, Figure 3, Figure 4, comprises the overall trabecular bone structure 5 of fusion device support column 1, filling slot 2, tapered tip portion 3, manual imitation bone structure 4 formation; Described trabecular bone structure 5 is provided with rear connecting portion 6.Described fusion device support column 1 has the effect supporting and fill, and described filling slot 2 is for filling spongy bone and bone; Described tapered tip portion 3 is conducive to squeezing into vertebral body position; Described manual imitation bone structure is the structure after filling; The rear end entity of described rear connecting portion 6, for connecting holding apparatus, easy to usely squeezes into vertebral body.
Described Bionics Bone girder lumbar fusion cages manufacture method, comprises the following steps:
(1) raw bone girder parameter measurement:
Waist 2 to waist 7 vertebral body is carried out to the CT helical scanning of full vertebral body, condition is 120KV, 210mA, 1 cycle per second; Choose the cross-section and nearly 3mm place of motor end plate, the center of vertebral body and carry out totally three the aspect imagings of 1mm thickness upper, middle and lower; The process that threshold value is 250HU is carried out to the image obtained, the image pixel lower than 250HU is hidden, produce gray scale figure, adopt the binary conversion treatment function of this machine further, make image transform into bianry image.
Establish and open 10mm so that vertebral body center is other, 400mm altogether
2the target measurement district of graphical analysis, and length calibration.Adopt TJTY-300V1.0 particle quantitative system, image shows resolution 1024 × 1024 × 8bit, the dynamic static graphics capture card that 1M hardwood is deposited, the input of image adopts shooting mode, photographic head model is the CCD-MTV-1881CB of Min Tron, and its resolution is 625 lines, 50/second.Adopt its full-automatic function to reduce the interference of subjective factors.Grafting Cancellous Bone Bolt girder granule in image is defined as granule.The index of graphical analysis comprises: girder amounts of particles (Total Number of Objects, TNO) in (1) target measurement district; (2) girder particle diameter (Mean Diameter, MD); (3) girder granule average major axis (Mean Max-Axis, MMA); (4) girder granule average minor axis (Mean Min-Axis, MNA); (5) the average flexibility of girder granule (Thin-D).
By measuring, calculating the bone trabecular average pore size of lumbar vertebra spongy bone and porosity and bone trabecular structure, finally drawing the bone trabecular average pore size of lumbar vertebra and voidage.Aperture is at 400-600um, and porosity is 70%.
(2) object module is set up
Use Three-dimensional Design Software UG, design the model of the bone trabecula fusion device done of drawing up, as depicted in figs. 1 and 2.
(3) unordered accumulation specific hole cell cube in the bounds of object module, the size of dowel and overall trabecular bone structure precision, outward appearance precision between distance between the size of setting hole cell cube, hole unit, the size of hole cell cube interior tendon, hole cell cube, finally delete original object module, retain the trabecular bone structure after filling.
The performance indications of product of the present invention: (1) porosity is not less than 70%, pore diameter range 400-600 μm: the present invention with human body spongy bone for data model, between each parameter region of Accurate Measurement Grafting Cancellous Bone Bolt girder, by adjustment bone trabecula aperture, porosity, bone trabecula diameter technological parameter, realize control to bone fusion device pore structure, make porosity be not less than 70%, aperture 400-600 μm.
(2) EBM technology shaping strength is not less than 50MPa: by controlling bone trabecula micropore structure, guarantees that the fusion device compressive strength after molding making is not less than 50MPa.This performance overcomes the effect that traditional intervertebral fusion apparatus can only play physical support in human body, but exists and can not grow into by induced osteogenesis, can not reach the technological deficiency improving spinal fusion rate.The present invention is bionical in microstructure, can grow into by induced osteogenesis, reaches and improves the technique effect of spinal fusion rate.
Effect after as shown in Figure 1 and Figure 2 hole cell cube being filled; After parameter setting completes as shown in Figure 3, namely form trabecular bone structure after deleting original filling objective body, need after forming bone trabecula body to measure micro-pore diameter, overall porosity, if cannot meet the demands, then need to redesign parameter, refill, remeasure after completing; Add compact texture shown in Fig. 4, be final cartilage pad bone trabecula model.
Claims (9)
1. a Bionics Bone girder lumbar fusion cages, comprises fusion device support column (1), overall trabecular bone structure (5) that filling slot (2), tapered tip portion (3), manual imitation bone structure (4) are formed.
2. a kind of Bionics Bone girder lumbar fusion cages according to claim 1, is characterized in that: described trabecular bone structure (5) is provided with rear connecting portion (6).
3. a kind of Bionics Bone girder lumbar fusion cages according to claim 1 and 2, is characterized in that: described filling slot (2) is filled with spongy bone and bone; Described Grafting Cancellous Bone Bolt girder is graininess.
4. a kind of Bionics Bone girder lumbar fusion cages manufacture method of claim 1-3, comprises the following steps: print about 3D
(1) raw bone girder parameter measurement:
The full vertebral body of lumbar vertebra is carried out to the CT helical scanning of full vertebral body;
Choose the cross-section and nearly 3mm place of motor end plate, the center of vertebral body and carry out totally three the aspect imagings of 1mm thickness upper, middle and lower;
The process that threshold value is 250HU pixel is carried out to the image obtained, the image pixel lower than 250HU is hidden, produce gray scale figure; Further binary conversion treatment, makes image transform into bianry image;
Establish with the other target measurement district opening graphical analysis, vertebral body center, line length of going forward side by side is calibrated;
Adopt particle quantitative system, the input of image adopts shooting mode;
Grafting Cancellous Bone Bolt girder granule in described image is defined as granule;
By measuring, calculating the bone trabecular average pore size of lumbar vertebra spongy bone and porosity and bone trabecular structure, finally drawing the bone trabecular average pore size of lumbar vertebra and voidage;
(2) object module is set up:
Use Three-dimensional Design Software UG designs the model of the bone trabecula fusion device done of drawing up;
(3) unordered accumulation specific hole cell cube in the bounds of object module; The size of dowel, overall trabecular bone structure precision and outward appearance precision between distance between the size of setting hole cell cube, hole unit, the size of hole cell cube interior tendon, hole cell cube;
Finally delete original object module, retain the trabecular bone structure after filling.
5. a kind of Bionics Bone girder lumbar fusion cages manufacture method according to claim 4,
The CT helical scanning condition of described full vertebral body is 120KV, 210mA, 1 cycle per second;
Described establishment opens 10mm so that vertebral body center is other, 400mm altogether
2the target measurement district of graphical analysis, and length calibration;
Described employing particle quantitative system, image shows resolution 1024 × 1024 × 8bit, the dynamic static graphics capture card that 1M hardwood is deposited, and the input of image adopts shooting mode, and resolution is 625 lines, 50/second; Adopt full-automatic function.
6. a kind of Bionics Bone girder lumbar fusion cages manufacture method according to claim 4 or 5,
The index of described graphical analysis comprises: girder amounts of particles in (1) target measurement district; (2) girder particle diameter; (3) girder granule average major axis; (4) girder granule average minor axis; (5) the average flexibility of girder granule.
7. a kind of Bionics Bone girder lumbar fusion cages manufacture method according to claim 6, needs after described formation bone trabecula body to measure micro-pore diameter, overall porosity, if cannot meet the demands, then needs to redesign parameter, refill, remeasures after completing.
8. a kind of Bionics Bone girder lumbar fusion cages manufacture method according to claim 4, the original object module of described last deletion, retains the trabecular bone structure after filling, then adds compact texture, be final cartilage pad bone trabecula model.
9. a kind of Bionics Bone girder lumbar fusion cages manufacture method according to claim 5, described photographic head model is the CCD-MTV-1881CB of Min Tron.
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Cited By (6)
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| CN105662660A (en) * | 2016-01-13 | 2016-06-15 | 李鹏 | 3D printing bionic bone trabecular structure lumbar vertebra fusion device, manufacturing method and application |
| CN109124833A (en) * | 2018-11-08 | 2019-01-04 | 北京爱康宜诚医疗器材有限公司 | Artificial dentata |
| CN109550968A (en) * | 2018-12-27 | 2019-04-02 | 杭州电子科技大学 | A method of human body lumbar fusion cages are prepared using 3D printing technique |
| CN111529134A (en) * | 2020-04-29 | 2020-08-14 | 陕西增材制造研究院有限责任公司 | Multi-hole interbody fusion cage and processing method thereof |
| CN113081405A (en) * | 2021-04-08 | 2021-07-09 | 新疆大学 | Artificial vertebral body and manufacturing method thereof |
| US20240123116A1 (en) * | 2022-10-12 | 2024-04-18 | Globus Medical, Inc. | Thermoresponsive or Shear-Thinning Injectable Gel Compositions for Treatment of Arthritis |
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| CN111529134A (en) * | 2020-04-29 | 2020-08-14 | 陕西增材制造研究院有限责任公司 | Multi-hole interbody fusion cage and processing method thereof |
| CN113081405A (en) * | 2021-04-08 | 2021-07-09 | 新疆大学 | Artificial vertebral body and manufacturing method thereof |
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| US20240123116A1 (en) * | 2022-10-12 | 2024-04-18 | Globus Medical, Inc. | Thermoresponsive or Shear-Thinning Injectable Gel Compositions for Treatment of Arthritis |
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Effective date of registration: 20151116 Address after: 102200, Changping District Beijing science and Technology Park, super Road, No. 37, building 5, north two Applicant after: Beijing Zhongnuo Hengkang Biotechnology Co., Ltd. Address before: 100029 Haidian District, Beijing on the road to information on the international entrepreneurship Park No. 2 D Dong 707D Applicant before: Li Peng |
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Application publication date: 20150617 |