CN104398431B - It is a kind of to treat Chinese medicine extract product of chloasma and preparation method thereof - Google Patents
It is a kind of to treat Chinese medicine extract product of chloasma and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of treat Chinese medicine extract product of chloasma and preparation method thereof, it is prepared from by the raw medicinal material of 1.0 3.5 parts of winter folium mori extract, 1.0 2.4 parts of peony seed oil of weight proportion.Traditional Chinese medicine is combined by the present invention with the processing technology of modernization, is obtained the cosmetics that can be used to smear, is improve the health-care effect of the utilization rate and medicine of Chinese medicine extract, be more applicable for the development of the modernization of Chinese medicine and big health-oriented products.
Description
Technical field
The present invention relates to a kind of treat Chinese medicine extract product of chloasma and preparation method thereof, more particularly to utilize Chinese medicine
The method that extract makes health product or cosmetics, belongs to pharmaceutical technology field.
Background technology
Human body face mottle is a kind of clinically common skin outer layer surface symptoms, and men and women may occur in which, especially women
In the majority, particularly married femle is more common, and it is in that symmetric figure is filbert indefinite to dark brown, shape size which betides face,
It is an impediment to face appearance.It is broadly divided into various pigmented lesions such as freckle, chloasma, skin melanopathy.Chloasma is commonly called as
" butterfly spot ", " chloasma hepaticum " or " cyasma ".Face is occurred mainly in, based on cheekbone portion, buccal, nose, forehead, chin portion.For side
The patch of the unclear brown in boundary or black, mostly symmetry.The appearance of chloasma is most relevant with endocrine, especially and female
The estrogen level of property is relevant, menoxenia, gestation, takes contraceptive or liver function is bad and chronic nephropathy is all likely to occur Huang
Brown patch.
At present, more people are selected using tcm product eliminating chloasma, and to be directed to enanthrope in tcm product,
It is more effective by the therapeutic modality for adjusting Whole Body state.Wherein face is treated as CN201010276230.2 discloses one kind
Medicine of portion's chloasma and preparation method thereof, is made with 35 kinds of medicines such as Folium Mori, Flos Chrysanthemi, Radix Trichosanthis, Ilex purpurea Hassk.[I.chinensis Sims, Radix Rehmanniae；
CN201210455001.6 discloses a kind of troche of health products for speckle dispelling and preparation method thereof, is with Radix Bupleuri, Radix Angelicae Sinensis, river
13 kinds of Chinese crude drugs such as rhizome of chuanxiong, Flos Carthami, Folium Mori are made；CN201110441115.0 discloses a kind of compound natural with spot-removing function
Plant extract and preparation method and application, the compound natural plant extract is by 50～100 parts of Folium Mori, Radix Glycyrrhizae 30～60
1～35 part of part, 10～50 parts of Radix Scutellariae and Folium Vaccinii vitis-idaeae are made.These compositionss or compound preparation medical material species are various, and step is complicated, slightly
The careless mistake that can cause drug matching, it is not high to the availability of effective component extracts in addition, and production cost is larger.
CN201310240904.7 discloses a kind of skin care oil of containing peony oil and preparation method thereof, is using peony oil and octanoic acid/last of the ten Heavenly stems
Acid glycerol three ester, ring five dimethyl silicone polymer, 1,2- pentanediols 1-12 and skin care oil made by other adjuvants, the skin care oil
Metabolism can be improved, delay skin aging process has crease-resistant, moisturizing whitening function, therefore can mitigate the impact of chloasma；
CN201410298231.5 discloses a kind of moisturizing speckle dispelling wrinkle removing eye patch and preparation method thereof, and its active layer is by Chinese gooseberry seed
Oil, peony seed oil, Oleum Camelliae, almond oil, antioxidant, glycerol, isopropyl myristate, essence are prepared from, and change eye patch tool
There are the multi-efficiencies such as moisturizing, speckle dispelling, wrinkle removing.The above-mentioned research for Folium Mori, peony seed oil speckle dispelling has a lot, but utilizes medical material
Research of the effective component extracts to the treatment or health care of specified disease is few, not yet finds for winter folium mori extract and seed of Flos Moutan
Oil makes cosmetics jointly, and the research for eliminating chloasma is reported.
The content of the invention
For above the deficiencies in the prior art, research worker of the present invention is through substantial amounts of experiment, there is provided a kind of stability
Good, Chinese medicine extract product for the treatment of chloasma that absorption is abundant, curative effect is high, nonirritant and preparation method thereof.
The primary and foremost purpose of the present invention is to disclose a kind of Chinese medicine extract product for treating chloasma.
It is achieved through the following technical solutions：
A kind of Chinese medicine extract product for treating chloasma, by weight, be with winter folium mori extract 1.0-3.5 parts,
Peony seed oil 1.0-2.4 parts are prepared from for raw medicinal material.
Further, the Chinese medicine extract product is with winter folium mori extract 1.5-3.0 parts, peony seed oil 1.5-2.0
Part is prepared from for raw medicinal material.
Wherein, the preparation method of Chinese medicine extract is as follows：
1) winter folium mori extract：Winter folium mori is taken, the removal of impurity is gone, plus 6-10 times is measured water reflux, extract, 1-3 time, each 1-3 is little
When, filtering, merging filtrate, concentrating under reduced pressure are subsequently adding 3-5 times and measure 60-85% ethanol, stir into thick paste, stand
12-24 hours, filter, decompression filtrate recycling ethanol, and when being condensed into 60 DEG C, relative density is the thick paste of 1.10-1.30, is obtained final product
Winter folium mori extract；
2) peony seed oil：Shell, dried seed of Flos Moutan, be ground into 60-100 mesh, add boiling range for 60-90 DEG C of oil
The liquid ratio of ether, the petroleum ether and seed of Flos Moutan is 5-10ml/g, is put in processor for ultrasonic wave after mix homogeneously, adjusts power
For 200-300W, temperature 40-60 DEG C, after supersound process 20-40min, solvent mixture and residue, recovered under reduced pressure oil are separated
Ether, is dried to constant mass, obtains final product peony seed oil.
The Chinese medicine extract product of the treatment chloasma, by winter folium mori extract and peony seed oil is auxiliary with suitable
Material mixing, makes cosmetics.
Further, the cosmetics are soft capsule, and by weight, its prescription proportioning is as follows：
Winter folium mori extract 1-3.5 parts, peony seed oil 1-2.4 parts, Polyethylene Glycol 4-10 parts, Margarita powder 1-12 parts, dimension life
Plain E oil 0.2-1.0 parts, Jojoba oil 0.1-0.5 parts, hyaluronate sodium 0.1-0.2 parts, carbomer 0.3-0.9 parts, deionized water
80-100 parts.
Further, the cosmetics are facial cream, and by weight, its prescription proportioning is as follows：
Winter folium mori extract 1.0-3.5 parts, peony seed oil 1.0-2.4 parts, moisturizing ingredient 50-80 parts, emulsifying agent 25-50
Part, Mel 3-6 parts, vaseline 5-15 parts.
Above-mentioned moisturizing ingredient is selected from one or more of glycerol, hyaluronic acid or aminoacid；It is preferred that moisturizing ingredient is glycerol, glass
The mixture of uric acid, aminoacid, its mass ratio are 5：3：2.
Another object of the present invention is the preparation method of the Chinese medicine extract product for disclosing this treatment chloasma.
The preparation method of wherein soft capsule is：
1) preparation of extract：
Winter folium mori extract：Winter folium mori is taken, the removal of impurity is gone, plus 6-10 times is measured water reflux, extract, 1-3 time, each 1-3 hours,
Filter, merging filtrate, concentrating under reduced pressure are subsequently adding 3-5 times and measure 60-85% ethanol, stir into thick paste, stand 12-
24 hours, filter, decompression filtrate recycling ethanol, and relative density is the thick paste of 1.10-1.30 when being condensed into 60 DEG C, obtains final product winter Mulberry
Leaf extract；
Peony seed oil：Shell, dried seed of Flos Moutan, be ground into 60-100 mesh, add boiling range for 60-90 DEG C of oil
The liquid ratio of ether, the petroleum ether and seed of Flos Moutan is 5-10ml/g, is put in processor for ultrasonic wave after mix homogeneously, adjusts power
For 200-300W, temperature 40-60 DEG C, after supersound process 20-40min, solvent mixture and residue, recovered under reduced pressure oil are separated
Ether, gained solid drying obtain final product peony seed oil to constant mass；
2) preparation of soft capsule：
Take fibroin, carbomer and deionized water and/min speed homogenizing 15-20 minutes are turned with 1500-2500, and heat
To 75-85 DEG C ,/min insulated and stirred 20-30min is turned with 40-50 then, A phase solution is obtained；Take vitamin E oil, peony seed oil, suddenly
Bar oil, turns/min speed homogenizing 5-10 minutes with 3000-3500, and is heated to 85-95 DEG C suddenly, then turns/min guarantors with 40-50
Temperature stirring 10-20min, obtains B phase solution；A phases solution is added in B phase solution, after 75-85 DEG C of emulsifying homogeneous 10-15 minute, drop
Temperature is added swelling uniform Margarita powder and hyaluronate sodium in advance to stir evenly, is cooled to 45-50 DEG C, adds winter folium mori to 55-60 DEG C
Extract, turns/min speed with 40-60, stirs 25-40min, is cooled to room temperature, by soft capsule preparation method, swelling with prior
Soft capsule material after deaeration makes soft capsule.
The preparation method of wherein facial cream is：
1) preparation of extract：
Winter folium mori extract：Winter folium mori is taken, the removal of impurity is gone, plus 6-10 times is measured water reflux, extract, 1-3 time, each 1-3 hours,
Filter, merging filtrate, concentrating under reduced pressure are subsequently adding 3-5 times and measure 60-85% ethanol, stir into thick paste, stand 12-
24 hours, filter, decompression filtrate recycling ethanol, and relative density is the thick paste of 1.10-1.30 when being condensed into 60 DEG C, obtains final product winter Mulberry
Leaf extract；
Peony seed oil：Shell, dried seed of Flos Moutan, be ground into 60-100 mesh, add boiling range for 60-90 DEG C of oil
The liquid ratio of ether, the petroleum ether and seed of Flos Moutan is 5-10ml/g, is put in processor for ultrasonic wave after mix homogeneously, adjusts power
For 200-300W, temperature 40-60 DEG C, after supersound process 20-40min, solvent mixture and residue, recovered under reduced pressure oil are separated
Ether, gained solid drying obtain final product peony seed oil to constant mass；
2) preparation of facial cream：Take step 1) obtained in winter folium mori extract, after spray drying extract dried cream powder, mistake
200 mesh sieves, sequentially add peony seed oil, moisturizing ingredient, emulsifying agent, Mel and vaseline by formula ratio, after mix homogeneously, carry
Refining, obtains target product.
Compared with prior art, the crude drug that the present invention is adopted, effect are as follows with mechanism：
Winter folium mori extract：The Folium Mori that winter folium mori is late fall to early winter to be harvested Jing after frost, also known as Folium Mori, clinically recognize
It is good for Jing frost person's matter, it is conventional Chinese medicine, there is dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving, is mainly used in wind heat sense
Emit, or pulmonary has hot and suffocating, or Liver Channel has mesh mist epiphora induced by wind caused by heat etc..In winter folium mori rich in crude protein, dietary fiber,
The nutritional labeling such as the several mineral materials such as magnesium, zinc, ferrum and 18 kinds of aminoacid, with solution spasm, resisting pathogenic microbes, antiinflammatory, drop
The pharmacological actions such as blood glucose, blood fat, blood pressure and diuresis.
Peony seed oil：Peony seed oil is the oils and fatss that human nutrition is best suitable in the oils and fatss for being found so far, wherein many
Unsaturated fatty acid --- linolenic acid (category ω -3 are serial) content, more than 40%, is 140 times of olive oil.It is difficult oxide deposition
At positions such as human vas wall, heart coronary arteries.With blood circulation promoting and blood stasis dispelling, anti-inflammation and sterilization, promote cell regeneration, activation tip god
Jing, lowering blood pressure and blood fat, fat-reducing etc. are acted on, and external can eliminate pigmentation with looks improving and the skin nourishing, reduce wrinkle, make skin fine and smooth
It is bright and clean, high resilience.Also to treat oral ulcer, rhinitis, arthritis, dermatosiss (include comedo, tinea pedis, trick cast off a skin, on
Fiery foaming, eczema, redness, pain etc. of itching) there is good efficacy.
The traditional Chinese medical science thinks that the brown maculeses cause of disease is hepatic depression and blood deficiency, the heresy of wind heat is strongly fragrant caused by channels, and to sum up, the present invention utilizes matter
Good winter folium mori extract, its dispelling wind and heat pathogens, effect collocation peony seed oil blood circulation promoting and blood stasis dispelling of liver heat removing and eyesight improving, the work of anti-inflammation and sterilization
With, pigmentation, light speckle U.S. face can be effectively eliminated, the product utilization Du Genggao of acquisition is made, drug effect is more significantly.
For product of the present invention, applicant carried out substantial amounts of experimental study, specific as follows：
Experiment 1：Clinical observation test-prescription proportioning the screening of extract eliminating chloasma of the present invention, pigmentation effect
1.1 sample
Sample 1：Method according to embodiment 1 makes extract, takes winter folium mori extract 10g, peony seed oil 25ml, mixing
Uniformly, conventionally make soft capsule 100；
Sample 2：Method according to embodiment 2 makes extract, takes winter folium mori extract 30g, peony seed oil 75ml, mixing
Uniformly, conventionally make soft capsule 100；
Sample 3：Method according to embodiment 1 makes extract, takes winter folium mori extract 20g, peony seed oil 50ml, mixing
Uniformly, conventionally make soft capsule 100；
Control sample 1：Compound natural plant extract I obtained in CN201110441115.0 embodiments 1, according to conventional side
Method makes soft capsule 100.
Control sample 2：Winter folium mori extract 40g, peony seed oil 100ml, mix homogeneously conventionally make flexible glue
100, capsule, wherein extract are prepared by 1 preparation method of embodiment；
Control sample 3：Winter folium mori extract 6g, peony seed oil 20ml, mix homogeneously conventionally make soft capsule
100, wherein extract is prepared by 1 preparation method of embodiment.
1.2 subjects：Women, 18～60 years old age, the different chloasma 140 of Head And Face perusal visible level
Example, without symptoms such as any sufferings.
1.3 test method
140 patient with chloasma are randomly divided into into 7 groups, treatment group, matched group and blank control group, 20 per group, averagely
34.98 ± 5.23 years old age, course of disease 2-10, the basic condition of 6 groups of experimenters, age, the course of disease there are no significant difference have
Comparability.
6 groups of samples of the above, are opening soft capsule when in use, directly smear face, respectively use 1 sooner or later, continuously make
With 30 days, pregnant and lying-in women, menorrhagia person's disabling, experimenter stopped using other speckle dispelling products during taking medicine.
Blank control group does not use any medicine for removing speckle.
1.3.1 before and after observation and treatment speckle size, mottle shade change
With length and width of the same chloasma of tape measure before and after tested, mottle area is calculated；According to the Chinese Academy of Sciences
Institute of Geography development and design, what Mapping Press published for 1992《Practical standard colour atla》Brown (Y+M+ in (first edition)
BK is yellow+pinkish red+black folded color) colour atla for the chloasma depth criterion：I (15,20,5), II (30,40,10), III
(40、60、15)。
Freckle effect judges
(1) it is effective：Chloasma color substantially shoals, and area is reduced>1/3, do not produce new chloasma；
(2) effectively：Chloasma lighter, area reduce≤1/3, do not produce new chloasma；
(3) it is invalid：Chloasma color and area are without significant change.
1.3.2 curative effect index and untoward reaction before and after observation and treatment, and detect activity of SOD in serum and MDA contents.
SOD is determined using yellow crash cry of certain animals enzymatic measurement, and MDA is determined and used thiobarbituricacidα- method.
1.4 result of the test
1.4.1 freckle effect result of the test, is shown in Table 1.
As a result show：Continuously using inventive samples after 30 days, the color of the chloasma of Head And Face substantially shoals experimenter
Until disappearing, mottle area is reduced significantly, more than 85.0% experimenter's mottle area be reduced beyond the 1/3 of primary colors speckle area with
On, wherein the chloasma of 65% experimenter (i.e. 13 experimenters) is wholly absent, and does not observe that new chloasma occurs, this
The total effective rate of invention reaches more than 95.0%.Compared with 1 group of control, effect of the present invention is more preferable；Other low extract consumption
Compare that 3 groups of effects are undesirable, the effect of high consumption does not increase, and consumption is too high had both increased production cost, be also easily caused product
Toxic and side effects.Therefore extract amount ranges of the present invention and preparation method are selected, the sample of acquisition is more satisfactory.
In addition, during testing, sample 1-3 experimenter illustrates the present invention without any anaphylaxiss and other untoward reaction
Extract has no adverse effects to human body.And it is experimenter's healthy looking, exquisiteness, ruddy glossy, illustrate the extract tool of the present invention
There are speckle dispelling, U.S. face.
Experiment 2：Product research
2.1 health care soft capsule
Method 1：Winter folium mori extract 1.5g, peony seed oil 2.0g prepared by Example 1, are sufficiently mixed and grind to form suspension
Liquid, in adding carbomer and the solution after deionized water homogenizing, then according to prepared by conventional soft capsule preparation method, obtains 100
Sample A；
Method 2：Winter folium mori extract 1.5g, peony seed oil 2.0g prepared by Example 1, add 0.2g in peony seed oil
The abundant intimate mixing of vitamin E oil, the mixed powder for adding winter folium mori extract 1.5g, Margarita powder 6g colloids to wear into, stirs
Afterwards, prepare according to conventional soft capsule preparation method, obtain 100 sample B；
Method 3：Prepare according to 4 method of the embodiment of the present invention, obtain 100 sample C.
As a result：Sample obtained in above-mentioned 3 kinds of methods, by skin test, sample A quality is rougher, have minimal irritation sense；
Sample B adds vitamin E oil and Margarita powder, whitening and moist degree to increase, but moisturizing degree and fine and smooth sense be not high；Sample C
Matter is gentle, mastic is uniform, fine and smooth, it is easy to smear, and absorbs rapid, non-greasy, and moistens degree, the satisfaction of whitening degree.Therefore selecting party
Method 3 carries out the preparation of soft capsule.
2.2 speckle dispelling facial creams
Method 1：Winter folium mori extract 1.5g, peony seed oil 2.0g prepared by Example 1, add glycerol 80g, emulsifying agent
25g, vaseline 10g, after mix homogeneously, refine, obtain sample A；
Method 2：Winter folium mori extract 1.5g, peony seed oil 2.0g prepared by Example 1, add moisturizing ingredient 80g (sweet
Oily 40g, hyaluronic acid 40g), emulsifying agent 30g, vaseline 10g, after mix homogeneously, refine, obtain sample B；
Method 3：Winter folium mori extract 1.5g, peony seed oil 2.0g prepared by Example 1, add moisturizing ingredient 80g (sweet
Oily 40g, hyaluronic acid 24g, amino acid/11 6g), emulsifying agent 40g, vaseline 5g, after mix homogeneously, refine, obtain sample C；
Method 4：Winter folium mori extract 1.5g, peony seed oil 2.0g prepared by Example 1, add moisturizing ingredient 80g (sweet
Oily 40g, hyaluronic acid 24g, amino acid/11 6g), emulsifying agent 35g, Mel 5g, vaseline 10g, after mix homogeneously, refine, obtain sample
Product D.
As a result：, by skin test, sample A insufficient formabilities are partially dry and not easy to apply for above-mentioned sample；Sample B quality is more equal
It is even, it is more easy to apply, but moisturizing degree is not high；Sample C properties are gentle, mastic is uniform, it is easy to smear, but white body viscosity is slightly worse, and skin
Skin sense of touch is slightly worse；Sample D is fine and smooth gently, tend to smear out absorption, non-greasy, and moistens degree satisfaction.Therefore system of selection 4 carries out face
The preparation of frost.
Experiment 3, product quality research
Soft capsule obtained in the scheme of Example 4-5, numbered samples 1-2；Facial cream obtained in the scheme of embodiment 6-7,
Numbered samples 3-4；Every group of 10 people of sample is tested, and with character texture, zest, absorbability etc. as index, investigates product
Quality.
Experimental result shows：After experimenter uses soft capsule and facial cream, there is skin in 24 hours after use in no one
The untoward reaction such as twinge, redness；Product is fine and smooth gently, tend to smear out absorption, non-greasy, and moistens degree satisfaction.
From data above, extract of the present invention and its made by cosmetics, eliminating chloasma works well, and stingless
Sharp property and toxicity, investigate through curative effect, safety, product quality etc., and corresponding index meets the expected requirements, and illustrates the present invention
Formula is reasonable in design, and preparation method is simply controllable, has a good application prospect.
Specific embodiment
Embodiment 1：It is prepared by extract
1) winter folium mori extract：Winter folium mori is taken, the removal of impurity is gone, plus 8 times of amount water reflux, extract, 2 times, 2 hours every time, filter,
Merging filtrate, concentrating under reduced pressure are subsequently adding 4 times of 75% ethanol of amount, stir, stand 24 hours, filter into thick paste, filter
Liquid decompression recycling ethanol, and when being condensed into 60 DEG C, relative density is 1.20 thick paste, obtains final product winter folium mori extract；
2) peony seed oil：Shell, dried seed of Flos Moutan, be ground into 80 mesh, add boiling range for 60-90 DEG C of petroleum ether,
The liquid ratio of the petroleum ether and seed of Flos Moutan is 9ml/g, is put in processor for ultrasonic wave after mix homogeneously, adjusts power and is
250W, temperature 50 C, after supersound process 30min, separate solvent mixture and residue, and recovered under reduced pressure petroleum ether is dried to quality
It is constant, obtain final product peony seed oil.
Embodiment 2：It is prepared by extract
1) winter folium mori extract：Winter folium mori is taken, the removal of impurity is gone, plus 6 times of amount water reflux, extract, 3 times, 1 hour every time, filter,
Merging filtrate, concentrating under reduced pressure are subsequently adding 5 times of 60% ethanol of amount, stir, stand 18 hours, filter into thick paste, filter
Liquid decompression recycling ethanol, and when being condensed into 60 DEG C, relative density is 1.10 thick paste, obtains final product winter folium mori extract；
2) peony seed oil：Shell, dried seed of Flos Moutan, be ground into 60 mesh, add boiling range for 60-90 DEG C of petroleum ether,
The liquid ratio of the petroleum ether and seed of Flos Moutan is 10ml/g, is put in processor for ultrasonic wave after mix homogeneously, adjusts power and is
200W, temperature 60 C, after supersound process 20min, separate solvent mixture and residue, and recovered under reduced pressure petroleum ether is dried to quality
It is constant, obtain final product peony seed oil.
Embodiment 3：It is prepared by extract
1) winter folium mori extract：Winter folium mori is taken, the removal of impurity is gone, plus 10 times are measured water reflux, extract, 3 hours, filtered, merge filter
Liquid, concentrating under reduced pressure are subsequently adding 3 times of 85% ethanol of amount, stir, stand 12 hours, filter, filtrate decompression into thick paste
Ethanol is reclaimed, and relative density is 1.30 thick paste when being condensed into 60 DEG C, obtains final product winter folium mori extract；
2) peony seed oil：Shell, dried seed of Flos Moutan, be ground into 100 mesh, add boiling range for 60-90 DEG C of petroleum ether,
The liquid ratio of the petroleum ether and seed of Flos Moutan is 5ml/g, is put in processor for ultrasonic wave after mix homogeneously, adjusts power and is
300W, 40 DEG C of temperature, after supersound process 40min, separate solvent mixture and residue, and recovered under reduced pressure petroleum ether is dried to quality
It is constant, obtain final product peony seed oil.
Embodiment 4：It is prepared by soft capsule
Formula：Winter folium mori extract 1.0g, peony seed oil 2.4g, Polyethylene Glycol 4.0g, Margarita powder 12g, vitamin E oil
0.2g, Jojoba oil 0.5g, hyaluronate sodium 0.1g, carbomer 0.9g, deionized water 80g
Preparation method：1) preparation of extract：Prepare according to embodiment 1-3 either method；
2) preparation of soft capsule：
Fibroin, carbomer and deionized water are taken with 2500 turns/min speed homogenizing 15 minutes, and is heated to 85 DEG C, so
Afterwards with 40 turns/min insulated and stirred 30min, A phase solution is obtained；Take vitamin E oil, peony seed oil, Jojoba oil, with 3500 turns/
Min speed homogenizing 5 minutes, and 95 DEG C are heated to, then with 40 turns/min insulated and stirred 20min, obtain B phase solution；By A phase solution
In adding B phase solution, 75 DEG C of emulsifying homogeneous were cooled to 60 DEG C after 15 minutes, added in advance swelling uniform Margarita powder and transparent
Matter acid sodium is stirred evenly, and is cooled to 50 DEG C, is added winter folium mori extract, with 40 turns/min speed, is stirred 40min, is cooled to room temperature, presses
Soft capsule material after soft capsule preparation method, with prior swelling deaeration makes soft capsule.
Embodiment 5：It is prepared by soft capsule
Formula：Winter folium mori extract 3.5g, peony seed oil 1.0g, Polyethylene Glycol 10.0g, Margarita powder 1.0g, vitamin E oil
1.0g, Jojoba oil 0.1g, hyaluronate sodium 0.2g, carbomer 0.3g, deionized water 100g
Preparation method：1) preparation of extract：Prepare according to embodiment 1-3 either method；
2) preparation of soft capsule：
Fibroin, carbomer and deionized water are taken with 1500 turns/min speed homogenizing 20 minutes, and is heated to 75 DEG C, so
Afterwards with 50 turns/min insulated and stirred 20min, A phase solution is obtained；Take vitamin E oil, peony seed oil, Jojoba oil, with 3000 turns/
Min speed homogenizing 10 minutes, and 85 DEG C are heated to, then with 50 turns/min insulated and stirred 10min, obtain B phase solution；A is mixed
During liquid adds B phase solution, 85 DEG C of emulsifying homogeneous were cooled to 55 DEG C after 10 minutes, added in advance swelling uniform Margarita powder and thoroughly
Bright matter acid sodium is stirred evenly, and is cooled to 45 DEG C, is added winter folium mori extract, with 60 turns/min speed, is stirred 25min, is cooled to room temperature,
Soft capsule is made by the soft capsule material after soft capsule preparation method, with prior swelling deaeration.
Embodiment 6：The preparation of facial cream
Formula：Winter folium mori extract 1.0g, peony seed oil 2.4g, moisturizing ingredient 50g (glycerol：Hyaluronic acid：Aminoacid=5：
3：2), emulsifying agent 50g, Mel 3g, vaseline 15g
Preparation method：1) preparation of extract：Prepare according to embodiment 1-3 either method；
2) preparation of facial cream：Take step 1) obtained in winter folium mori extract, after spray drying extract dried cream powder, mistake
200 mesh sieves, sequentially add peony seed oil, moisturizing ingredient, emulsifying agent, Mel and vaseline by formula ratio, after mix homogeneously, carry
Refining, obtains target product.
Embodiment 7：The preparation of facial cream
Formula：Winter folium mori extract 3.5g, peony seed oil 1.0g, moisturizing ingredient 80g (glycerol：Hyaluronic acid：Aminoacid=5：
3：2), emulsifying agent 25g, Mel 6g, vaseline 5g
Preparation method：1) preparation of extract：Prepare according to embodiment 1-3 either method；
2) preparation of facial cream：Take step 1) obtained in winter folium mori extract, after spray drying extract dried cream powder, mistake
200 mesh sieves, sequentially add peony seed oil, moisturizing ingredient, emulsifying agent, Mel and vaseline by formula ratio, after mix homogeneously, carry
Refining, obtains target product.
Claims (5)
1. a kind of Chinese medicine extract product for treating chloasma, by weight, is by raw medicinal material winter folium mori extract, Paeonia suffruticosa
Seed oil makes cosmetics soft capsule by formula as below amount with adjuvant：
Winter folium mori extract 1-3.5 parts, peony seed oil 1-2.4 parts, Polyethylene Glycol 4-10 parts, Margarita powder 1-12 parts, vitamin E oil
0.2-1.0 parts, Jojoba oil 0.1-0.5 parts, hyaluronate sodium 0.1-0.2 parts, carbomer 0.3-0.9 parts, deionized water 80-
100 parts.
2. a kind of Chinese medicine extract product for treating chloasma, by weight, be by winter folium mori extract, peony seed oil with it is auxiliary
Material makes cosmetics facial cream by formula as below amount：
Winter folium mori extract 1.0-3.5 parts, peony seed oil 1.0-2.4 parts, moisturizing ingredient 50-80 parts, emulsifying agent 25-50 parts, honeybee
Sweet 3-6 parts, vaseline 5-15 parts；
The moisturizing ingredient is glycerol, hyaluronic acid, the mixture of aminoacid, and its mass ratio is 5：3：2.
3. the Chinese medicine extract product of the treatment chloasma described in claim 1 or 2, is characterized in that, calculate in parts by weight, be
It is prepared from winter folium mori extract 1.5-3.0 parts, peony seed oil 1.5-2.0 parts as raw medicinal material.
4. the Chinese medicine extract product for the treatment of chloasma according to claim 1, is characterized in that, the preparation of the soft capsule
Method is：
1) preparation of extract：
Winter folium mori extract：Winter folium mori is taken, the removal of impurity is gone, plus 6-10 times is measured water reflux, extract, 1-3 time, each 1-3 hours, mistake
Filter, merging filtrate, concentrating under reduced pressure are subsequently adding 3-5 times and measure 60-85% ethanol, stir into thick paste, stand 12-24
Hour, filter, decompression filtrate recycling ethanol, and relative density is the thick paste of 1.10-1.30 when being condensed into 60 DEG C, obtains final product winter folium mori
Extract；
Peony seed oil：Shell, dried seed of Flos Moutan, be ground into 60-100 mesh, add boiling range for 60-90 DEG C of petroleum ether, institute
The liquid ratio for stating petroleum ether and seed of Flos Moutan is 5-10ml/g, is put in processor for ultrasonic wave after mix homogeneously, adjusts power and is
200-300W, temperature 40-60 DEG C, after supersound process 20-40min, separate solvent mixture and residue, recovered under reduced pressure petroleum ether,
Gained solid drying obtains final product peony seed oil to constant mass；
2) preparation of soft capsule：
Take carbomer and deionized water and/min speed homogenizing 15-20 minutes are turned with 1500-2500, and be heated to 75-85 DEG C, then
/ min insulated and stirred 20-30min is turned with 40-50, A phase solution is obtained；Vitamin E oil, peony seed oil, Jojoba oil are taken, with 3000-
3500 turns/min speed homogenizing 5-10 minutes, and 85-95 DEG C is heated to ,/min insulated and stirred 10-20min is turned with 40-50 then,
Obtain B phase solution；A phases solution is added in B phase solution, after 75-85 DEG C of emulsifying homogeneous 10-15 minute, 55-60 DEG C is cooled to, plus
Enter advance swelling uniform Margarita powder and hyaluronate sodium is stirred evenly, be cooled to 45-50 DEG C, add winter folium mori extract, with 40-60
Turn/min speed, stir 25-40min, be cooled to room temperature, by the soft capsule after soft capsule preparation method, with prior swelling deaeration
Capsule material makes soft capsule.
5. the Chinese medicine extract product for the treatment of chloasma according to claim 2, is characterized in that, the preparation side of the facial cream
Method is：
1) preparation of extract：
Winter folium mori extract：Winter folium mori is taken, the removal of impurity is gone, plus 6-10 times is measured water reflux, extract, 1-3 time, each 1-3 hours, mistake
Filter, merging filtrate, concentrating under reduced pressure are subsequently adding 3-5 times and measure 60-85% ethanol, stir into thick paste, stand 12-24
Hour, filter, decompression filtrate recycling ethanol, and relative density is the thick paste of 1.10-1.30 when being condensed into 60 DEG C, obtains final product winter folium mori
Extract；
Peony seed oil：Shell, dried seed of Flos Moutan, be ground into 60-100 mesh, add boiling range for 60-90 DEG C of petroleum ether, institute
The liquid ratio for stating petroleum ether and seed of Flos Moutan is 5-10ml/g, is put in processor for ultrasonic wave after mix homogeneously, adjusts power and is
200-300W, temperature 40-60 DEG C, after supersound process 20-40min, separate solvent mixture and residue, recovered under reduced pressure petroleum ether,
Gained solid drying obtains final product peony seed oil to constant mass；
2) preparation of facial cream：Take step 1) obtained in winter folium mori extract, after spray drying extract dried cream powder, cross 200 mesh
Sieve, sequentially adds peony seed oil, moisturizing ingredient, emulsifying agent, Mel and vaseline by formula ratio, after mix homogeneously, refines, obtains
Target product.
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| CN106580839B (en) * | 2016-04-25 | 2019-10-11 | 山东省农业科学院农产品研究所 | A kind of peony seed protein smear mask and preparation method thereof |
| CN108670925A (en) * | 2018-07-07 | 2018-10-19 | 佛山文森特知识产权服务有限公司 | Plant composition with white-skinned face function |
| CN109771611A (en) * | 2019-03-08 | 2019-05-21 | 中山火炬职业技术学院 | Pharmaceutical composition for treating chloasma as well as preparation method and application thereof |
| CN110433094A (en) * | 2019-08-27 | 2019-11-12 | 广东锦玛绿色食品科技有限公司 | A kind of cosmetics and preparation method thereof with skin nti-freckle repair function |
| CN112089656A (en) * | 2020-09-04 | 2020-12-18 | 珠海市康栢生物科技有限公司 | Cosmetic composition and application thereof |
| CN113952256A (en) * | 2021-11-01 | 2022-01-21 | 山西农业大学 | A kind of barrier cream containing peony seed oil and preparation method thereof |
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