CN104397006A - Water-treated polyhexamethylene guanidine hydrochloride sterilizing agent and preparation method thereof - Google Patents
Water-treated polyhexamethylene guanidine hydrochloride sterilizing agent and preparation method thereof Download PDFInfo
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- CN104397006A CN104397006A CN201410684057.8A CN201410684057A CN104397006A CN 104397006 A CN104397006 A CN 104397006A CN 201410684057 A CN201410684057 A CN 201410684057A CN 104397006 A CN104397006 A CN 104397006A
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- water
- hydrochloride
- hexamethylene
- guanidine hydrochloride
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 60
- -1 polyhexamethylene guanidine hydrochloride Polymers 0.000 title claims abstract description 39
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 239000003206 sterilizing agent Substances 0.000 title abstract 8
- NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 claims abstract description 70
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims abstract description 62
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims abstract description 28
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 claims abstract description 25
- 229960000789 guanidine hydrochloride Drugs 0.000 claims abstract description 24
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 21
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 21
- JBIROUFYLSSYDX-UHFFFAOYSA-M benzododecinium chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 JBIROUFYLSSYDX-UHFFFAOYSA-M 0.000 claims abstract description 15
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000002270 dispersing agent Substances 0.000 claims abstract description 11
- 239000003112 inhibitor Substances 0.000 claims abstract description 11
- 238000006116 polymerization reaction Methods 0.000 claims abstract description 11
- 230000000844 anti-bacterial effect Effects 0.000 claims description 40
- 239000003899 bactericide agent Substances 0.000 claims description 34
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims description 20
- RVZPDKXEHIRFPM-UHFFFAOYSA-N tert-butyl n-(6-aminohexyl)carbamate Chemical compound CC(C)(C)OC(=O)NCCCCCCN RVZPDKXEHIRFPM-UHFFFAOYSA-N 0.000 claims description 20
- 238000006243 chemical reaction Methods 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 14
- 238000010792 warming Methods 0.000 claims description 14
- 229910000358 iron sulfate Inorganic materials 0.000 claims description 13
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 13
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 7
- 230000004044 response Effects 0.000 claims description 7
- WJUMWVJBOZKPPU-UHFFFAOYSA-N 2,3-bis(6-methylheptyl)-N-phenylaniline Chemical compound C(CCCCC(C)C)C=1C(=C(C=CC1)NC1=CC=CC=C1)CCCCCC(C)C WJUMWVJBOZKPPU-UHFFFAOYSA-N 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 5
- 229960004025 sodium salicylate Drugs 0.000 claims description 5
- 229920002367 Polyisobutene Polymers 0.000 claims description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical class [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- SRENRFDRXNVMKN-UHFFFAOYSA-N n-butyl-n-phenylaniline Chemical class C=1C=CC=CC=1N(CCCC)C1=CC=CC=C1 SRENRFDRXNVMKN-UHFFFAOYSA-N 0.000 claims description 4
- 239000011593 sulfur Substances 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 230000002070 germicidal effect Effects 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 abstract description 30
- 241000894006 Bacteria Species 0.000 abstract description 19
- 230000009965 odorless effect Effects 0.000 abstract description 9
- 241000588724 Escherichia coli Species 0.000 abstract description 8
- 241000228212 Aspergillus Species 0.000 abstract description 7
- 241000607142 Salmonella Species 0.000 abstract description 7
- 241000191967 Staphylococcus aureus Species 0.000 abstract description 7
- 230000001154 acute effect Effects 0.000 abstract description 7
- 229920001971 elastomer Polymers 0.000 abstract description 7
- 229910052751 metal Inorganic materials 0.000 abstract description 7
- 239000002184 metal Substances 0.000 abstract description 7
- 229920003023 plastic Polymers 0.000 abstract description 7
- 239000004033 plastic Substances 0.000 abstract description 7
- 239000005060 rubber Substances 0.000 abstract description 7
- 239000000344 soap Substances 0.000 abstract description 7
- 230000009967 tasteless effect Effects 0.000 abstract description 7
- 238000012360 testing method Methods 0.000 abstract description 7
- 230000007797 corrosion Effects 0.000 abstract description 2
- 238000005260 corrosion Methods 0.000 abstract description 2
- 241000222122 Candida albicans Species 0.000 abstract 1
- 241000588652 Neisseria gonorrhoeae Species 0.000 abstract 1
- 241000228143 Penicillium Species 0.000 abstract 1
- 229940095731 candida albicans Drugs 0.000 abstract 1
- RUTXIHLAWFEWGM-UHFFFAOYSA-H iron(3+) sulfate Chemical compound [Fe+3].[Fe+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O RUTXIHLAWFEWGM-UHFFFAOYSA-H 0.000 abstract 1
- 229910000360 iron(III) sulfate Inorganic materials 0.000 abstract 1
- 231100000614 poison Toxicity 0.000 abstract 1
- 230000007096 poisonous effect Effects 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
- 238000005303 weighing Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 11
- 231100000252 nontoxic Toxicity 0.000 description 9
- 230000003000 nontoxic effect Effects 0.000 description 9
- 230000002045 lasting effect Effects 0.000 description 8
- 241000588653 Neisseria Species 0.000 description 6
- 241000228150 Penicillium chrysogenum Species 0.000 description 6
- 206010040880 Skin irritation Diseases 0.000 description 6
- 239000004744 fabric Substances 0.000 description 6
- 230000010354 integration Effects 0.000 description 6
- 230000036556 skin irritation Effects 0.000 description 6
- 231100000475 skin irritation Toxicity 0.000 description 6
- 241000251468 Actinopterygii Species 0.000 description 5
- 241000195493 Cryptophyta Species 0.000 description 5
- 230000001590 oxidative effect Effects 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 230000003115 biocidal effect Effects 0.000 description 4
- 239000003139 biocide Substances 0.000 description 4
- 239000000498 cooling water Substances 0.000 description 4
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 241000251511 Holothuroidea Species 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 241000143060 Americamysis bahia Species 0.000 description 2
- 241000238557 Decapoda Species 0.000 description 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 2
- 229920000289 Polyquaternium Polymers 0.000 description 2
- 239000004902 Softening Agent Substances 0.000 description 2
- 241000607598 Vibrio Species 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000004043 dyeing Methods 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 229960000304 folic acid Drugs 0.000 description 2
- 239000011724 folic acid Substances 0.000 description 2
- 235000019152 folic acid Nutrition 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 238000007639 printing Methods 0.000 description 2
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- 230000003134 recirculating effect Effects 0.000 description 2
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- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 1
- VYVKAVOEYGTNNY-UHFFFAOYSA-N C(CCCCCCCCCCC)C1=C(C([N+](C)(C)CCCCCCCCCCCCCCCC)(C)C)C=CC=C1 Chemical compound C(CCCCCCCCCCC)C1=C(C([N+](C)(C)CCCCCCCCCCCCCCCC)(C)C)C=CC=C1 VYVKAVOEYGTNNY-UHFFFAOYSA-N 0.000 description 1
- ZKQDCIXGCQPQNV-UHFFFAOYSA-N Calcium hypochlorite Chemical compound [Ca+2].Cl[O-].Cl[O-] ZKQDCIXGCQPQNV-UHFFFAOYSA-N 0.000 description 1
- QDHHCQZDFGDHMP-UHFFFAOYSA-N Chloramine Chemical class ClN QDHHCQZDFGDHMP-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
- 102000011931 Nucleoproteins Human genes 0.000 description 1
- 108010061100 Nucleoproteins Proteins 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 229920002413 Polyhexanide Polymers 0.000 description 1
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 description 1
- 241000607594 Vibrio alginolyticus Species 0.000 description 1
- 206010047400 Vibrio infections Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000002216 antistatic agent Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 230000031709 bromination Effects 0.000 description 1
- 238000005893 bromination reaction Methods 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- RCTYPNKXASFOBE-UHFFFAOYSA-M chloromercury Chemical compound [Hg]Cl RCTYPNKXASFOBE-UHFFFAOYSA-M 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 239000003398 denaturant Substances 0.000 description 1
- 230000001877 deodorizing effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- FMSYTQMJOCCCQS-UHFFFAOYSA-L difluoromercury Chemical compound F[Hg]F FMSYTQMJOCCCQS-UHFFFAOYSA-L 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 238000005189 flocculation Methods 0.000 description 1
- 230000016615 flocculation Effects 0.000 description 1
- 229960004198 guanidine Drugs 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 229910000474 mercury oxide Inorganic materials 0.000 description 1
- UKWHYYKOEPRTIC-UHFFFAOYSA-N mercury(ii) oxide Chemical compound [Hg]=O UKWHYYKOEPRTIC-UHFFFAOYSA-N 0.000 description 1
- 150000002736 metal compounds Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000002332 oil field water Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 108091092562 ribozyme Proteins 0.000 description 1
- 239000013535 sea water Substances 0.000 description 1
- 239000010802 sludge Substances 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- SEEPANYCNGTZFQ-UHFFFAOYSA-N sulfadiazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CC=N1 SEEPANYCNGTZFQ-UHFFFAOYSA-N 0.000 description 1
- 229960004306 sulfadiazine Drugs 0.000 description 1
- 229960002135 sulfadimidine Drugs 0.000 description 1
- QPPBRPIAZZHUNT-UHFFFAOYSA-N sulfamerazine Chemical compound CC1=CC=NC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 QPPBRPIAZZHUNT-UHFFFAOYSA-N 0.000 description 1
- ASWVTGNCAZCNNR-UHFFFAOYSA-N sulfamethazine Chemical compound CC1=CC(C)=NC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 ASWVTGNCAZCNNR-UHFFFAOYSA-N 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000012209 synthetic fiber Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000009941 weaving Methods 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The application discloses a water-treated polyhexamethylene guanidine hydrochloride sterilizing agent and a preparation method thereof. The water-treated polyhexamethylene guanidine hydrochloride sterilizing agent is prepared by weighing and uniformly mixing guanidine hydrochloride, hexamethylene diamine, hexamethylenediamine, polyethylene glycol, water, methylbenzene, a polymerization inhibitor, sulphonic acid, maleic anhydride, N-t-butyloxycarboryl-1,6-diamino hexane, a dispersing agent, ferric sulfate, methacrylic acid, dodecyl dimethyl benzyl ammonium chloride and methyl acrylate according to parts by weight. The water-treated polyhexamethylene guanidine hydrochloride sterilizing agent is 100% soluble in water, has no volatility, can be completely neutralized with soaps, and has no pollution to environment; the integral of an acute skin irritancy test is 0, and the water-treated polyhexamethylene guanidine hydrochloride sterilizing agent is colorless, non-poisonous, odorless and tasteless, and has no corrosion to metal, rubber and plastic; the sterilizing rate to escherichia coli, staphylococcus aureus, candida albicans, neisseria gonorrhoeae, penicillium, aspergillus, saprophytic bacteria and salmonella is 100%, when the water-treated polyhexamethylene guanidine hydrochloride sterilizing agent is placed at 50-60 DEG C for a month, the sterilizing rate is 98-100%, when the water-treated polyhexamethylene guanidine hydrochloride sterilizing agent is placed at 40-50 DEG C for half a year, the sterilizing rate is 97.5-99.5%, and when the water-treated polyhexamethylene guanidine hydrochloride sterilizing agent is placed at the room temperature for 1-2 years, the sterilizing rate is 95-99%.
Description
Technical field
The application belongs to environmental protection reagent process field, particularly relates to a kind of nontoxic, bactericidal effect significant water treatment poly (hexamethylene) hydrochloride bactericide and preparation method thereof.
Background technology
Water treatment biocide is also known as Biocidal algae-killing agent, mud remover or the agent of anti-soil mud.One class can suppress growing, to prevent from forming microorganism viscosity mud, to the chemicals that system works the mischief of bacterium algae and microorganism in water.Comprise oxidizing bactericide, as chlorine, clorox, bleaching powder, ozone, chloramines etc.; Non oxidizing bactericide, as dodecyl dimethyl benzyl ammonium chloride, bromination dodecyl dimethyl hexadecyldimethyl benzyl ammonium, dithiocyano-methane etc.; Heavy metal compound, as mercury oxide, mercury chloride, mercuric fluoride etc.; Foundry loam bactericide, as rosin amine, hydrogen peroxide, again guanidine polymer etc.Wherein quaternary ammonium salt non oxidizing bactericide effect is best, often has the multiple effects such as sterilization, stripping, inhibition concurrently, has been widely used in the aspects such as oil field water, industrial colling.
1227 is a kind of cationic surfactants, belong to non oxidizing bactericide, there is wide spectrum, efficiently sterilization algae removal ability, effectively can control bacterium algae propagation and foundry loam growth in water, and there is good sludge stripping effect and certain dispersion, osmosis, have simultaneously certain to deoil, deodorizing capability and corrosion inhibition.1227 toxicity are little, without accumulation property toxicity, and soluble in water, do not affect by the water hardness, therefore be widely used in, in the recirculating cooling water system of the industries such as oil, chemical industry, electric power, weaving, growing in order to controlled circulation cooling water system bacterium algae, having special efficacy to stabilized.1227 biocide mildewcide and softening agent, antistatic additive, emulsifier, the conditioners etc. that can be used as textile printing and dyeing industry.
Polyquaternium flocculation bactericide belongs to strong cation high molecular polymer, has good solubility property, belong to non oxidizing bactericide flocculant in water.Be widely used in, in the recirculating cooling water system of the industries such as oil, chemical industry, electric power, growing in order to controlled circulation cooling water system bacterium algae, having special efficacy to killing Escherichia coli.Polyquaternium bactericide flocculant can be used as biocide mildewcide and softening agent, antistatic additive, emulsifier, the conditioner etc. of textile printing and dyeing industry, can also be used for washing industry as surfactant etc.
Environment-friendly type macromolecule polymer disinfection sanitizer---polyhexamethylene guanide, has broad-spectrum; Valid density is low; Speed of action is fast; Stable in properties; Premium properties soluble in water; Can use at normal temperatures; For a long time antibacterial, have no side effect; Non-corrosiveness; Colourless, odorless; Nontoxic; Do not fire, not quick-fried, use safety; Moderate; Convenient transportation, can be described as best bactericide.In fact, this product is a kind of environment-friendly multipurpose new polymers, in industrial, agriculture, medical and daily life, have purposes extremely widely.
This product is a kind of high molecular polymer, the noxious bacterias such as the Gram negative bacterium in seawater, floating vibrios, vibrio parahaemolytious, vibrio alginolyticus can be killed rapidly, to sea cucumber and other aquatic products because bacterial various disease has good preventive and therapeutic action.
This product is also applicable to the disease such as various red mouth, rotten eye, gill rot, the black gill, the yellow gill that fishes and shrimps cause because of baculoviral, also can be used for clearing up the shrimp pond fish pool, decomposes feed refuse, fish excrement etc., purifies water, and prevents effect that sea cucumber, fish, shrimp are ill.In water circulation processing procedure, add this product, can algal grown be controlled, the ecosystem in natural equilibrium sea cucumber pond, fishes and shrimps pond.
Guanidine hydrochloride, proterties white or micro-yellow block.Be used as the intermediate of medicine, agricultural chemicals, other organic synthesis thing of dye well, be the important source material manufacturing sulfa drugs and folic acid, also can be used as the antistatic agent of synthetic fibers.Guanidine hydrochloride is the important source material manufacturing sulphadiazine, sulfamethyldiazine, sulfamethazine and folic acid, as the strong denaturant extracted in cell total rna experiment.Guanidine hydrochloride solution solubilized protein, causes cell structure to be destroyed, and nucleoprotein secondary structure is destroyed, and disintegrate down from nucleic acid, in addition, RNA enzyme can by reductant deactivations such as guanidine hydrochlorides.And universal along with humanity concept, and the formation of novel harmonious society, design a kind of nontoxic, odorless, bactericidal effect are remarkable and long-acting lasting water treatment poly (hexamethylene) hydrochloride bactericide and preparation method thereof is very important.
Summary of the invention
the technical problem solved:
The application, for above-mentioned technical problem, provides a kind of water treatment poly (hexamethylene) hydrochloride bactericide and preparation method thereof, solves that existing water treatment anti-microbial agents is volatile, bactericidal effect is poor, is insoluble in water and the technical problem such as bactericidal effect is not lasting.
technical scheme:
A kind of water treatment poly (hexamethylene) hydrochloride bactericide, the raw materials by weight portion proportioning of described water treatment poly (hexamethylene) hydrochloride bactericide is as follows: guanidine hydrochloride 100 parts; Hexamethylene diamine 2-18 part; Hexamethylene diamine 10-30 part; Polyethylene glycol 25-45 part; Water 5-45 part; Toluene 5-15 part; Polymerization inhibitor 0.5-2.5 part; Sulfonic acid 0.5-2.5 part; Maleic anhydride 15-35 part; N-tertbutyloxycarbonyl-1,6-diamino hexane is 30-50 part; Dispersant 1-20 part; Iron sulfate is 5-25 part; Methacrylic acid 1-20 part; Dodecyl benzyl dimethyl ammonium chloride 5-15 part; Methyl acrylate is 15-25 part.
As a preferred technical solution of the present invention: the raw materials by weight portion proportioning of described water treatment poly (hexamethylene) hydrochloride bactericide is as follows: guanidine hydrochloride 100 parts; Hexamethylene diamine 6-14 part; Hexamethylene diamine 15-25 part; Polyethylene glycol 30-40 part; Water 15-35 part; Toluene 8-12 part; Polymerization inhibitor 1-2 part; Sulfonic acid 1-2 part; Maleic anhydride 20-30 part; N-tertbutyloxycarbonyl-1,6-diamino hexane is 35-45 part; Dispersant 5-15 part; Iron sulfate is 10-20 part; Methacrylic acid 5-15 part; Dodecyl benzyl dimethyl ammonium chloride 7-13 part; Methyl acrylate is 16-24 part.
As a preferred technical solution of the present invention: the raw materials by weight portion proportioning of described water treatment poly (hexamethylene) hydrochloride bactericide is as follows: guanidine hydrochloride 100 parts; Hexamethylene diamine 10 parts; Hexamethylene diamine 20 parts; Polyethylene glycol 35 parts; 25 parts, water; Toluene 10 parts; Polymerization inhibitor 1.5 parts; Sulfonic acid 1.5 parts; Maleic anhydride 25 parts; N-tertbutyloxycarbonyl-1,6-diamino hexane is 40 parts; Dispersant 10 parts; Iron sulfate is 15 parts; Methacrylic acid 10 parts; Dodecyl benzyl dimethyl ammonium chloride 10 parts; Methyl acrylate is 20 parts.
As a preferred technical solution of the present invention: described polymerization inhibitor adopts di-iso-octyldiphenylamine or butyl diphenylamines.
As a preferred technical solution of the present invention: described dispersant adopts alkyl sodium salicylate or sulfur phosphorization polyisobutylene titanate salt.
As a preferred technical solution of the present invention: the preparation method of described water treatment poly (hexamethylene) hydrochloride bactericide, comprises the steps:
The first step: take guanidine hydrochloride, hexamethylene diamine, hexamethylene diamine, polyethylene glycol, water, toluene, polymerization inhibitor, sulfonic acid, maleic anhydride, N-tertbutyloxycarbonyl-1,6-diamino hexane, dispersant, iron sulfate, methacrylic acid, dodecyl benzyl dimethyl ammonium chloride and methyl acrylate according to parts by weight proportioning;
Second step: guanidine hydrochloride, hexamethylene diamine, polyethylene glycol and toluene are put into four-hole boiling flask and is heated to 60-80 DEG C, stirs 5-10min;
3rd step: add ethylenediamine, sulfonic acid, maleic anhydride and N-tertbutyloxycarbonyl-1,6-diamino hexane, be warming up to 150 DEG C, reaction 4-6h;
4th step: be warming up to 160-170 DEG C, reaction 10-12h, stops heating, when question response thing temperature is down to 80 DEG C, adds water and surplus stock, stirs 50-90min, obtains poly (hexamethylene) hydrochloride bactericide.
beneficial effect:
A kind of water treatment poly (hexamethylene) hydrochloride bactericide of the present invention and preparation method thereof adopts above technical scheme compared with prior art, there is following technique effect: 1, product 100% is water-soluble, volatility is 0, neutralizes completely, environmentally safe with soap class; 2, nonirritant, acute skin irritation test integration is 0 point, colourless, nontoxic, odorless, tasteless, and non-corrosiveness is all corrosion-free to metal, rubber, plastics, cloth; 3, bactericidal effect is good, to Escherichia coli, staphylococcus aureus, white chain pearl bacterium, gonococcus, Penicillium notatum, Aspergillus, saprophytic bacteria and salmonella, and sterilizing rate 100%; 4, effect is lasting, places one month for 50-60 DEG C, and place half a year, sterilizing rate 97.5-99.5% for sterilizing rate 98-100%, 40-50 DEG C, ambient temperatare puts 1-2, sterilizing rate 95-99%; With low cost, simple to operate, in building-up process, no waste mine produces, and the widespread production not division of history into periods can replace current material.
Embodiment
embodiment 1:
Guanidine hydrochloride 100 parts is taken according to parts by weight proportioning; Hexamethylene diamine 2 parts; Hexamethylene diamine 10 parts; Polyethylene glycol 25 parts; 5 parts, water; Toluene 5 parts; Butyl diphenylamines 0.5 part; Sulfonic acid 0.5 part; Maleic anhydride 15 parts; N-tertbutyloxycarbonyl-1,6-diamino hexane is 30 parts; Alkyl sodium salicylate 1 part; Iron sulfate is 5 parts; Methacrylic acid 1 part; Dodecyl benzyl dimethyl ammonium chloride 5 parts; Methyl acrylate is 15 parts.
Guanidine hydrochloride, hexamethylene diamine, polyethylene glycol and toluene are put into four-hole boiling flask and is heated to 60 DEG C, stir 5min, add ethylenediamine, sulfonic acid, maleic anhydride and N-tertbutyloxycarbonyl-1,6-diamino hexane, be warming up to 150 DEG C, reaction 4h.
Be warming up to 160 DEG C, reaction 10h, stops heating, when question response thing temperature is down to 80 DEG C, adds water and surplus stock, stirs 50min, obtains poly (hexamethylene) hydrochloride bactericide.
Product 100% is water-soluble, and volatility is 0, neutralizes completely, environmentally safe with soap class; Acute skin irritation test integration is 0 point, colourless, nontoxic, odorless, tasteless, all corrosion-free to metal, rubber, plastics, cloth; To Escherichia coli, staphylococcus aureus, white chain pearl bacterium, gonococcus, Penicillium notatum, Aspergillus, saprophytic bacteria and salmonella, sterilizing rate 100%; Effect is lasting, places one month for 50 DEG C, sterilizing rate 98%, and place half a year for 40 DEG C, sterilizing rate 97.5%, ambient temperatare puts 1 year, sterilizing rate 95%.
embodiment 2:
Guanidine hydrochloride 100 parts is taken according to parts by weight proportioning; Hexamethylene diamine 18 parts; Hexamethylene diamine 30 parts; Polyethylene glycol 45 parts; 45 parts, water; Toluene 15 parts; Butyl diphenylamines 2.5 parts; Sulfonic acid 2.5 parts; Maleic anhydride 35 parts; N-tertbutyloxycarbonyl-1,6-diamino hexane is 50 parts; Alkyl sodium salicylate 20 parts; Iron sulfate is 25 parts; Methacrylic acid 20 parts; Dodecyl benzyl dimethyl ammonium chloride 15 parts; Methyl acrylate is 25 parts.
Guanidine hydrochloride, hexamethylene diamine, polyethylene glycol and toluene are put into four-hole boiling flask and is heated to 80 DEG C, stir 10min, add ethylenediamine, sulfonic acid, maleic anhydride and N-tertbutyloxycarbonyl-1,6-diamino hexane, be warming up to 150 DEG C, reaction 6h.
Be warming up to 170 DEG C, reaction 12h, stops heating, when question response thing temperature is down to 80 DEG C, adds water and surplus stock, stirs 90min, obtains poly (hexamethylene) hydrochloride bactericide.
Product 100% is water-soluble, and volatility is 0, neutralizes completely, environmentally safe with soap class; Acute skin irritation test integration is 0 point, colourless, nontoxic, odorless, tasteless, all corrosion-free to metal, rubber, plastics, cloth; To Escherichia coli, staphylococcus aureus, white chain pearl bacterium, gonococcus, Penicillium notatum, Aspergillus, saprophytic bacteria and salmonella, sterilizing rate 100%; Effect is lasting, places one month for 52 DEG C, sterilizing rate 98.5%, and place half a year for 43 DEG C, sterilizing rate 98%, ambient temperatare puts 1 year, sterilizing rate 96%.
embodiment 3:
Guanidine hydrochloride 100 parts is taken according to parts by weight proportioning; Hexamethylene diamine 6 parts; Hexamethylene diamine 15 parts; Polyethylene glycol 30 parts; 15 parts, water; Toluene 8 parts; Di-iso-octyldiphenylamine 1 part; Sulfonic acid 1 part; Maleic anhydride 20 parts; N-tertbutyloxycarbonyl-1,6-diamino hexane is 35 parts; Alkyl sodium salicylate 5 parts; Iron sulfate is 10 parts; Methacrylic acid 5 parts; Dodecyl benzyl dimethyl ammonium chloride 7 parts; Methyl acrylate is 16 parts.
Guanidine hydrochloride, hexamethylene diamine, polyethylene glycol and toluene are put into four-hole boiling flask and is heated to 65 DEG C, stir 6min, add ethylenediamine, sulfonic acid, maleic anhydride and N-tertbutyloxycarbonyl-1,6-diamino hexane, be warming up to 150 DEG C, reaction 4.5h.
Be warming up to 163 DEG C, reaction 10.5h, stops heating, when question response thing temperature is down to 80 DEG C, adds water and surplus stock, stirs 60min, obtains poly (hexamethylene) hydrochloride bactericide.
Product 100% is water-soluble, and volatility is 0, neutralizes completely, environmentally safe with soap class; Acute skin irritation test integration is 0 point, colourless, nontoxic, odorless, tasteless, all corrosion-free to metal, rubber, plastics, cloth; To Escherichia coli, staphylococcus aureus, white chain pearl bacterium, gonococcus, Penicillium notatum, Aspergillus, saprophytic bacteria and salmonella, sterilizing rate 100%; Effect is lasting, places one month for 55 DEG C, sterilizing rate 99%, and place half a year for 45 DEG C, sterilizing rate 98.5%, ambient temperatare puts 2 years, sterilizing rate 97%.
embodiment 4:
Guanidine hydrochloride 100 parts is taken according to parts by weight proportioning; Hexamethylene diamine 14 parts; Hexamethylene diamine 25 parts; Polyethylene glycol 40 parts; 35 parts, water; Toluene 12 parts; Di-iso-octyldiphenylamine 2 parts; Sulfonic acid 2 parts; Maleic anhydride 30 parts; N-tertbutyloxycarbonyl-1,6-diamino hexane is 45 parts; Sulfur phosphorization polyisobutylene titanate salt 15 parts; Iron sulfate is 20 parts; Methacrylic acid 15 parts; Dodecyl benzyl dimethyl ammonium chloride 13 parts; Methyl acrylate is 24 parts.
Guanidine hydrochloride, hexamethylene diamine, polyethylene glycol and toluene are put into four-hole boiling flask and is heated to 75 DEG C, stir 9min, add ethylenediamine, sulfonic acid, maleic anhydride and N-tertbutyloxycarbonyl-1,6-diamino hexane, be warming up to 150 DEG C, reaction 5.5h.
Be warming up to 167 DEG C, reaction 11.5h, stops heating, when question response thing temperature is down to 80 DEG C, adds water and surplus stock, stirs 80min, obtains poly (hexamethylene) hydrochloride bactericide.
Product 100% is water-soluble, and volatility is 0, neutralizes completely, environmentally safe with soap class; Acute skin irritation test integration is 0 point, colourless, nontoxic, odorless, tasteless, all corrosion-free to metal, rubber, plastics, cloth; To Escherichia coli, staphylococcus aureus, white chain pearl bacterium, gonococcus, Penicillium notatum, Aspergillus, saprophytic bacteria and salmonella, sterilizing rate 100%; Effect is lasting, places one month for 58 DEG C, sterilizing rate 99.5%, and place half a year for 47 DEG C, sterilizing rate 99%, ambient temperatare puts 2 years, sterilizing rate 98%.
embodiment 5:
Guanidine hydrochloride 100 parts is taken according to parts by weight proportioning; Hexamethylene diamine 10 parts; Hexamethylene diamine 20 parts; Polyethylene glycol 35 parts; 25 parts, water; Toluene 10 parts; Di-iso-octyldiphenylamine 1.5 parts; Sulfonic acid 1.5 parts; Maleic anhydride 25 parts; N-tertbutyloxycarbonyl-1,6-diamino hexane is 40 parts; Sulfur phosphorization polyisobutylene titanate salt 10 parts; Iron sulfate is 15 parts; Methacrylic acid 10 parts; Dodecyl benzyl dimethyl ammonium chloride 10 parts; Methyl acrylate is 20 parts.
Guanidine hydrochloride, hexamethylene diamine, polyethylene glycol and toluene are put into four-hole boiling flask and is heated to 70 DEG C, stir 8min, add ethylenediamine, sulfonic acid, maleic anhydride and N-tertbutyloxycarbonyl-1,6-diamino hexane, be warming up to 150 DEG C, reaction 5h.
Be warming up to 165 DEG C, reaction 11h, stops heating, when question response thing temperature is down to 80 DEG C, adds water and surplus stock, stirs 60min, obtains poly (hexamethylene) hydrochloride bactericide.
Product 100% is water-soluble, and volatility is 0, neutralizes completely, environmentally safe with soap class; Acute skin irritation test integration is 0 point, colourless, nontoxic, odorless, tasteless, all corrosion-free to metal, rubber, plastics, cloth; To Escherichia coli, staphylococcus aureus, white chain pearl bacterium, gonococcus, Penicillium notatum, Aspergillus, saprophytic bacteria and salmonella, sterilizing rate 100%; Effect is lasting, places one month for 60 DEG C, sterilizing rate 100%, and place half a year for 50 DEG C, sterilizing rate 99.5%, ambient temperatare puts 2 years, sterilizing rate 99%.
Composition all components in above embodiment all can business be bought.
Above-described embodiment is just for setting forth content of the present invention, instead of restriction, and any change therefore in the implication suitable with claims of the present invention and scope, all should think to be included in the scope of claims.
Claims (6)
1. a water treatment poly (hexamethylene) hydrochloride bactericide, is characterized in that the raw materials by weight portion proportioning of described water treatment poly (hexamethylene) hydrochloride bactericide is as follows: guanidine hydrochloride 100 parts; Hexamethylene diamine 2-18 part; Hexamethylene diamine 10-30 part; Polyethylene glycol 25-45 part; Water 5-45 part; Toluene 5-15 part; Polymerization inhibitor 0.5-2.5 part; Sulfonic acid 0.5-2.5 part; Maleic anhydride 15-35 part; N-tertbutyloxycarbonyl-1,6-diamino hexane is 30-50 part; Dispersant 1-20 part; Iron sulfate is 5-25 part; Methacrylic acid 1-20 part; Dodecyl benzyl dimethyl ammonium chloride 5-15 part; Methyl acrylate is 15-25 part.
2. a kind of water treatment poly (hexamethylene) hydrochloride bactericide according to claim 1, proportioning is as follows by weight: guanidine hydrochloride 100 parts to it is characterized in that described water treatment poly (hexamethylene) hydrochloride material of germicide; Hexamethylene diamine 6-14 part; Hexamethylene diamine 15-25 part; Polyethylene glycol 30-40 part; Water 15-35 part; Toluene 8-12 part; Polymerization inhibitor 1-2 part; Sulfonic acid 1-2 part; Maleic anhydride 20-30 part; N-tertbutyloxycarbonyl-1,6-diamino hexane is 35-45 part; Dispersant 5-15 part; Iron sulfate is 10-20 part; Methacrylic acid 5-15 part; Dodecyl benzyl dimethyl ammonium chloride 7-13 part; Methyl acrylate is 16-24 part.
3. a kind of water treatment poly (hexamethylene) hydrochloride bactericide according to claim 1, is characterized in that the raw materials by weight portion proportioning of described water treatment poly (hexamethylene) hydrochloride bactericide is as follows: guanidine hydrochloride 100 parts; Hexamethylene diamine 10 parts; Hexamethylene diamine 20 parts; Polyethylene glycol 35 parts; 25 parts, water; Toluene 10 parts; Polymerization inhibitor 1.5 parts; Sulfonic acid 1.5 parts; Maleic anhydride 25 parts; N-tertbutyloxycarbonyl-1,6-diamino hexane is 40 parts; Dispersant 10 parts; Iron sulfate is 15 parts; Methacrylic acid 10 parts; Dodecyl benzyl dimethyl ammonium chloride 10 parts; Methyl acrylate is 20 parts.
4. a kind of water treatment poly (hexamethylene) hydrochloride bactericide according to claim 1, is characterized in that: described polymerization inhibitor adopts di-iso-octyldiphenylamine or butyl diphenylamines.
5. a kind of water treatment poly (hexamethylene) hydrochloride bactericide according to claim 1, is characterized in that: described dispersant adopts alkyl sodium salicylate or sulfur phosphorization polyisobutylene titanate salt.
6. a preparation method for water treatment poly (hexamethylene) hydrochloride bactericide described in claim 1, is characterized in that, comprise the steps:
The first step: take guanidine hydrochloride, hexamethylene diamine, hexamethylene diamine, polyethylene glycol, water, toluene, polymerization inhibitor, sulfonic acid, maleic anhydride, N-tertbutyloxycarbonyl-1,6-diamino hexane, dispersant, iron sulfate, methacrylic acid, dodecyl benzyl dimethyl ammonium chloride and methyl acrylate according to parts by weight proportioning;
Second step: guanidine hydrochloride, hexamethylene diamine, polyethylene glycol and toluene are put into four-hole boiling flask and is heated to 60-80 DEG C, stirs 5-10min;
3rd step: add ethylenediamine, sulfonic acid, maleic anhydride and N-tertbutyloxycarbonyl-1,6-diamino hexane, be warming up to 150 DEG C, reaction 4-6h;
4th step: be warming up to 160-170 DEG C, reaction 10-12h, stops heating, when question response thing temperature is down to 80 DEG C, adds water and surplus stock, stirs 50-90min, obtains poly (hexamethylene) hydrochloride bactericide.
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