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CN104306880A - 一种治疗脑血栓的中药配方 - Google Patents

一种治疗脑血栓的中药配方 Download PDF

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CN104306880A
CN104306880A CN201410503316.2A CN201410503316A CN104306880A CN 104306880 A CN104306880 A CN 104306880A CN 201410503316 A CN201410503316 A CN 201410503316A CN 104306880 A CN104306880 A CN 104306880A
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chinese medicine
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cerebral thrombosis
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朱晓岩
修晓光
侯荣耀
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Abstract

本发明公开了一种治疗脑血栓的中药配方，由以下重量份数的中药原料配制而成：石菖蒲8-11份、天麻8-10份、山萸肉7-9份、川芎9-11份、丹参10-12份、鸡内金8-10份、槐花8-11份、麦冬10-12份、白芍10-12份、牛膝10-12份、防风7-9份、白术7-12份、红花8-12份、马鞭草8-12份、活血珠8-11份、枸杞子6-9份、麦芽7-9份、胆南星7-10份、龟板6-8份、乌梢蛇5-7份和全蝎5-7份，通过本发明的中药，补气祛邪，滋养肝肾，破血逐瘀，活血通络，疏通脑脉，治疗脑血栓具有较好的效果。

Description

一种治疗脑血栓的中药配方
技术领域
本发明属于中医中药技术领域，特别涉及一种治疗脑血栓的中药配方。
背景技术
脑血栓形成是脑梗死最常见的类型。是脑动脉主干或皮质支动脉粥样硬化导致血管增厚、管腔狭窄闭塞和血栓形成，引起脑局部血流减少或供血中断，脑组织缺血缺氧导致软化坏死出现局灶性神经系统症状。
其病变范围一般为2-20毫米，其中以2-4毫米者最为多见。临床上患者多无明显症状，约有3/4的患者无病灶性神经损害症状，或仅有轻度注意力不集中、记忆力下降、轻度头痛头昏、眩晕、反应迟钝等症状。该病的诊断主要为CT或MRI检查。而轻度脑血栓如果成为多发性的，则可影响脑功能，导致智力进行性衰退，最后导致脑血管性痴呆。脑血栓形成多在安静或睡眠中发病，部分病例有短暂性脑缺血发作(TIA)前驱症状如肢体麻木无力等,突然出现偏侧上下肢麻木无力、口眼歪斜、言语不清等症状。
脑血栓的治疗主要有中、西医两种治疗方法，西医治疗主要有扩张血管剂、降压药和抗血小板凝聚剂等药物，这些药副作用较大，长期使用会给人体器官带来不同程度的伤害。中医溶栓疗法能活血化瘀、疏通脑脉，从根本上解决脑血栓的问题，毒副作用小，治后不易复发，被大多数的患者所接受。
发明内容
本发明提供一种治疗脑血栓的中药配方，补气祛邪，滋养肝肾，破血逐瘀，活血通络，疏通脑脉，治疗脑血栓具有较好的效果。
本发明的治疗脑血栓的中药配方，其特征在于由以下重量份数的中药原料配制而成：荆芥10-13份、淫羊藿8-12份、杜仲8-12份、艾叶9-14份、防风10-12份、土元8-11份、黄芪10-12份、三七10-12份、丹参10-12份、木瓜10-14份、苏木9-11份、赤芍8-10份、牛膝8-12份、郁金6-9份、独活8-11份、蒲公英7-10份、天麻6-9份、珍珠6-8份、蚯蚓6-8份和熊胆粉7-9份。
作为优选，按如下重量份数配制：荆芥12份、淫羊藿9份、杜仲9份、艾叶13份、防风11份、土元9份、黄芪11份、三七11份、丹参12份、木瓜12份、苏木10份、赤芍9份、牛膝10份、郁金8份、独活9份、蒲公英10份、天麻7份、珍珠7份、蚯蚓7份和熊胆粉8份。
本发明的中药，按下述步骤制备：
(1)按上述重量份称取荆芥、淫羊藿、杜仲、艾叶、防风、黄芪、三七、丹参、木瓜、苏木、赤芍、牛膝、郁金、独活、蒲公英和天麻放入砂锅里，然后加入饮用水，液面超出药材6-8倍量的蒸馏水，武火煮开后，改用文火煎煮2-3小时后，提取；再加入5-6倍量的蒸馏水，武火煮开后，文火煎煮2-2.5小时后，提取；最后加入3-4倍量的蒸馏水，武火煮开后，文火煎煮1.5-2小时后，提取；合并三次提取液，过滤，浓缩成40℃下相对密度为1.10-1.13的膏状；
(2)按上述重量份称取土元、珍珠、蚯蚓和熊胆粉，研末，过180目筛，备用；
(3)将步骤(1)-(2)制得的稠膏、细粉混合，制成6g蜜丸。
上述方法制备的蜜丸，每日三次、每次一粒，饭后服用。
药理分析：
荆芥：祛风；解表；透疹；止血。主感冒发热；头痛；目痒；咳嗽；咽喉肿痛；麻疹；痈肿；疮疥；衄血；吐血；便血；崩漏；产后血晕。用于感冒，头痛，麻疹，风疹，疮疡初起。炒炭治便血，崩漏，产后血晕。解表散风，透疹，消疮，止血。用于感冒，麻疹透发不畅，便血、崩漏、鼻衄。
淫羊藿：补肾壮阳，祛风除湿。治阳痿不举，偏风不遂，小便淋沥，筋骨挛急，咳嗽，病后青盲，虚火牙痛，半身不遂，腰膝无力，风湿痹痛，四肢不仁。
杜仲：味甘，性温。归肝、肾、胃经。功效补益肝肾、强筋壮骨、调理冲任、固经安胎。治疗肾阳虚引起的腰腿痛或酸软无力。肝气虚引起的胞胎不固，阴囊湿痒等症。
艾叶：味辛、苦，性温，有小毒，具有温经止血，散寒止痛，安胎、降湿杀虫的功效。
防风：味辛；甘；性微温。归经：膀胱经；肺经；脾经；肝经。功效：祛风解表、胜湿止痛、解痉、止痒。主治：外感风寒；头痛身痛；风湿痹痛；骨节酸痛；腹痛泄泻；肠风下血；破伤风；风疹瘙痒；疮疡初起。
土元：别名：可泡虫、地鳖虫、土鳖、过街、地乌龟、节节虫、臭虫母等、地鳖。性味与归经：咸，寒；有小毒。归肝经。功能与主治：破瘀血，续筋骨。用于筋骨折伤，瘀血经闭，症瘕痞块。中药功用：(1)下瘀血，消症瘕，疗折伤：用于血瘀经闭、跌打损伤及症瘕肿块。(2)散瘀止痛：用于血瘀引起的肝脾肿痛及腰肌劳损、扭伤。对心脏泵功能的作用：研究表明:，土鳖虫总生物碱给家兔静脉注射(5mg/kg、10mg/kg、15mg/kg、20mg/kg)时，对兔心脏均呈明显的负性作用,即左室收缩压、左室舒张末期压力、左室压力最大速率均降低，右心房压力升高,心电图P-R传导及心率减弱，S-T段轻度缺血改变.当用至20mg/kg以上时,心电图出现明显的S-T段缺血改变，并有室性早搏。
黄芪：性味：甘，微温；归经：归肺、脾、肝、肾经；主治：表虚自汗，多用于体虚表弱所致的自汗。如表气不固，而汗出，用黄芪配白术、防风治之，久服必效。有增强机体免疫功能、保肝、利尿、抗衰老、抗应激、降压和较广泛的抗菌作用。
三七：甘微苦，温；止血，散瘀，消肿，定痛。
丹参：性微寒，味苦，功能：祛瘀止痛，活血；具有活血化淤、理气止痛、祛淤止痛、清心除烦、凉血消痈、安神宁心之功效。临床上，复方丹参片主要用于冠心病之胸闷、心悸、面色苍白、四肢厥冷等。
木瓜：性平、微寒，味甘。归肝、脾经；功效：助消化之余还能消暑解渴、润肺止咳；平肝，舒筋，和脾，化湿；治：湿痹，脚气、霍乱、吐泻、腹痛、转筋。
苏木：甘、咸，平。归心、肝、脾经；功能主治：行血祛瘀，消肿止痛。用于经闭痛经，产后瘀阻，胸腹刺痛，外伤肿痛。
赤芍：苦，微寒。归肝经；功能主治：清热凉血，散瘀止痛。用于温毒发斑，吐血衄血，目赤肿痛，肝郁胁痛，经闭痛经，症瘕腹痛，跌扑损伤，痈肿疮疡。
牛膝：苦；酸；性平，入肝、肾经；祛风，活血祛瘀。
郁金：味辛、苦，性寒。归肝、心、肺经，具有行气化瘀、清心解郁、利胆退黄、活血止痛、行气解郁、清心凉血之用。
独活：辛、苦，微温。归肝、肾、膀胱经。祛风胜湿；散寒止痛。用于风寒湿痹；腰膝疼痛；少阴伏风头痛，头痛齿痛。
蒲公英：味甘，平，无毒；清热解毒，利尿散结。治急性乳腺炎，淋巴腺炎，瘰疬，疔毒疮肿，急性结膜炎，感冒发热，急性扁桃体炎，急性支气管炎，胃炎，肝炎，胆囊炎，尿路感染。
天麻：甘，平；入肝经；息风，定惊。治眩晕眼黑，头风头痛，肢体麻木，半身不遂，语言蹇涩，小儿惊痫动风。
珍珠：安神定惊，清热滋阴，明目，解毒；镇心定惊，适用于惊悸怔忡、癫痫惊风。清肝除翳明目，用治目赤肿痛、翳膜遮睛等眼科疾病，多外用。收敛生肌，适用于咽喉腐烂、口舌生疮、溃疡久不收口，宜外用。
蚯蚓：中药称地龙，地龙性寒味咸。其味咸，性寒。功能为清热、镇痉、止喘、利尿。主治高热狂躁、惊风抽搐、头痛目赤、喘息痰热、中风、半身不遂等病证。具有通经活络、活血化瘀、预防治疗心脑血管疾病作用。
熊胆粉：清热，平肝，明目。用于目赤肿痛，咽喉肿痛。
本发明的中药配方，选用杜仲、淫羊藿、黄芪、防风、独活，补气祛邪、补益肝肾、强筋壮骨，配伍土元、赤芍、丹参、郁金、牛膝、蚯蚓，活血化瘀；珍珠、熊胆粉、蒲公英，清热解毒、安神定惊，治疗脑血栓，标本兼治，具有更好的治疗效果。
疗效判断：
脑血栓的主要临床症状有：偏侧上下肢麻木无力、口眼歪斜、言语不清。
痊愈：肢体肌力恢复，行动正常，语言表达流利，无障碍。
好转：上下肢麻木无力改善，口眼歪斜改善。
无效：诸症无改善。
治疗结果：脑血栓患者342例，服用本发明的药物，痊愈293例，占85.7％，好转25例，占7.3％，有效率为93％。
附几例病例作进一步说明：
病例1：覃××，女，60岁，2012年8月突患右下肢无力，走路拖拉，言语不清，查体：BP155/105mmHg，神志清楚，颅神经N(-)，心肺腹无异常。CT查头颅左额叶血栓堵塞。心电图正常。住院后给予服用本发明药剂，每次1粒，每日三次，治疗14天后，下肢行走正常，语言恢复接近正常，复查BP、头颅CT、心电图、血常规无异常，痊愈出院，随访一年无复发。
病例2：赵×，女，53岁，脑血栓入院，查体BP150/90mmHg，两眼视线模糊，思维稍迟钝，CT检查颅顶、枕部阴影，心电图、血常规、肝肾功能、血脂血糖均正常，住院后给予奥扎格雷80mg，同时服用本发明药剂，每日三次，每次1粒，治疗14天，症状消失，复查头颅CT、心电图、血常规、肝肾功能、血脂血糖、均正常。继续服用本发明药剂巩固治疗14天，康复出院。
具体实施方式
实施例1
荆芥12份、淫羊藿9份、杜仲9份、艾叶13份、防风11份、土元9份、黄芪11份、三七11份、丹参12份、木瓜12份、苏木10份、赤芍9份、牛膝10份、郁金8份、独活9份、蒲公英10份、天麻7份、珍珠7份、蚯蚓7份和熊胆粉8份。
本发明的中药，按下述步骤制备：
(1)按上述重量份称取荆芥、淫羊藿、杜仲、艾叶、防风、黄芪、三七、丹参、木瓜、苏木、赤芍、牛膝、郁金、独活、蒲公英和天麻放入砂锅里，然后加入饮用水，液面超出药材6-8倍量的蒸馏水，武火煮开后，改用文火煎煮2-3小时后，提取；再加入5-6倍量的蒸馏水，武火煮开后，文火煎煮2-2.5小时后，提取；最后加入3-4倍量的蒸馏水，武火煮开后，文火煎煮1.5-2小时后，提取；合并三次提取液，过滤，浓缩成40℃下相对密度为1.10-1.13的膏状；
(2)按上述重量份称取土元、珍珠、蚯蚓和熊胆粉，研末，过180目筛，备用；
(3)将步骤(1)-(2)制得的稠膏、细粉混合，制成6g蜜丸。
上述方法制备的蜜丸，每日三次、每次一粒，饭后服用。

Claims (2)

1.一种治疗脑血栓的中药配方，其特征在于由以下重量份数的中药原料配制而成：荆芥10-13份、淫羊藿8-12份、杜仲8-12份、艾叶9-14份、防风10-12份、土元8-11份、黄芪10-12份、三七10-12份、丹参10-12份、木瓜10-14份、苏木9-11份、赤芍8-10份、牛膝8-12份、郁金6-9份、独活8-11份、蒲公英7-10份、天麻6-9份、珍珠6-8份、蚯蚓6-8份和熊胆粉7-9份。
2.根据权利要求1所述的治疗脑血栓的中药配方，其特征在于由以下重量份数的中药原料配制而成：荆芥12份、淫羊藿9份、杜仲9份、艾叶13份、防风11份、土元9份、黄芪11份、三七11份、丹参12份、木瓜12份、苏木10份、赤芍9份、牛膝10份、郁金8份、独活9份、蒲公英10份、天麻7份、珍珠7份、蚯蚓7份和熊胆粉8份。
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CN104644858A (zh) * 2015-02-02 2015-05-27 王淑玲 一种治疗脑血栓的中药制剂
CN105749222A (zh) * 2016-03-29 2016-07-13 广州暨南生物医药研究开发基地有限公司 一种含艾叶的治疗脑血栓的中药组合物及其制备方法
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