CN104171407A - Application of sodium butyrate to preparation of feed or feed additive of promoting flaudio-videoonoid secretion - Google Patents
Application of sodium butyrate to preparation of feed or feed additive of promoting flaudio-videoonoid secretion Download PDFInfo
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- CN104171407A CN104171407A CN201410370480.0A CN201410370480A CN104171407A CN 104171407 A CN104171407 A CN 104171407A CN 201410370480 A CN201410370480 A CN 201410370480A CN 104171407 A CN104171407 A CN 104171407A
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- sodium butyrate
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- MFBOGIVSZKQAPD-UHFFFAOYSA-M sodium butyrate Chemical compound [Na+].CCCC([O-])=O MFBOGIVSZKQAPD-UHFFFAOYSA-M 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 230000028327 secretion Effects 0.000 title claims abstract description 10
- 239000003674 animal food additive Substances 0.000 title abstract description 4
- 230000001737 promoting effect Effects 0.000 title abstract description 4
- 241001465754 Metazoa Species 0.000 claims abstract description 7
- 235000014590 basal diet Nutrition 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- 238000009472 formulation Methods 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract description 28
- 102000004877 Insulin Human genes 0.000 abstract description 14
- 108090001061 Insulin Proteins 0.000 abstract description 14
- 229940125396 insulin Drugs 0.000 abstract description 14
- 229930192334 Auxin Natural products 0.000 abstract description 5
- 239000002363 auxin Substances 0.000 abstract description 5
- 210000004369 blood Anatomy 0.000 abstract description 5
- 239000008280 blood Substances 0.000 abstract description 5
- SEOVTRFCIGRIMH-UHFFFAOYSA-N indole-3-acetic acid Chemical compound C1=CC=C2C(CC(=O)O)=CNC2=C1 SEOVTRFCIGRIMH-UHFFFAOYSA-N 0.000 abstract description 5
- 239000011248 coating agent Substances 0.000 abstract description 3
- 238000000576 coating method Methods 0.000 abstract description 3
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- 238000003786 synthesis reaction Methods 0.000 abstract description 2
- 239000003405 delayed action preparation Substances 0.000 abstract 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 20
- 238000012360 testing method Methods 0.000 description 14
- 230000035611 feeding Effects 0.000 description 11
- 238000012545 processing Methods 0.000 description 10
- 238000000034 method Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 235000005911 diet Nutrition 0.000 description 4
- 230000037213 diet Effects 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
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- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 2
- 102000018997 Growth Hormone Human genes 0.000 description 2
- 108010051696 Growth Hormone Proteins 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 235000013351 cheese Nutrition 0.000 description 2
- 238000010411 cooking Methods 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000012173 estrus Effects 0.000 description 2
- 230000035558 fertility Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 description 2
- 229940035638 gonadotropin-releasing hormone Drugs 0.000 description 2
- 239000000122 growth hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
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- 230000001850 reproductive effect Effects 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 241000252983 Caecum Species 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 235000019730 animal feed additive Nutrition 0.000 description 1
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- 210000001842 enterocyte Anatomy 0.000 description 1
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- 239000003337 fertilizer Substances 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- 230000008217 follicular development Effects 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
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- 210000005027 intestinal barrier Anatomy 0.000 description 1
- 230000004673 intestinal mucosal barrier function Effects 0.000 description 1
- 210000004731 jugular vein Anatomy 0.000 description 1
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- 244000144972 livestock Species 0.000 description 1
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- 230000016087 ovulation Effects 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
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- 230000002093 peripheral effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940119528 pork insulin Drugs 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
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- 229910052708 sodium Inorganic materials 0.000 description 1
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- Fodder In General (AREA)
Abstract
The invention discloses an application of sodium butyrate to preparation of a feed or feed additive of promoting flaudio-videoonoid secretion. The sodium butyrate is provided optimally in a coating controlled release preparation form. According to the application, through feeding the sodium butyrate to a sow in a puberty, the fact that the concentrations of insulin and auxin in blood of the sow are improved is found, and further the fact that the sodium butyrate can promote the synthesis and the secretion of the insulin and the auxin of animals and can be used for preparing the feed or feed additive with a corresponding function can be determined.
Description
Technical field
The present invention relates to field of feed additive technology, relate in particular to the application of sodium butyrate in feed or the feed addictive of the secretion of preparation promotion auxone.
Background technology
Sodium butyrate (n-butyric acie sodium salt, sodium bu-tvrate, C
4h
7o
2na), relative molecular mass is 110.09.The sodium butyrate of industrial production is white in color or off-white color, like villous, can hygroscopic powder. have the special cheese sample smell that becomes sour, have moisture absorption, soluble in water, pH value of water solution is alkalescence.Sodium butyrate is more stable under normal storage and room temperature, sealing state, but can not be with incompatible material, dust, overheated, strong oxidizer is mixed deposits.The active ingredient of sodium butyrate is short chain volatile aliphatic acid butyric acid, and free butyric acid has special smell, therefore, is made into metastable sodium salt and is applied in herding and Feed Manufacturing.
Sodium butyrate can be dissociated into butyric acid root (C in animal body
4h
7o
-) and sodium ion (Na
+).Free butyric acid has special smell. be different from other short chain volatile aliphatic acid such as acetic acid or propionic acid, butyric acid root has water fat amphiphilic, bias toward lipophilic, in the time that being 4～6, pH is generally difficult for being decomposed, after feeding, 60% above butyric acid root was kept away the small intestine of aqueous environments, directly enter caecum and colon, mainly absorbed by intestinal mucosa epithelium dispersivity with non-particulate forms, also exist and bicarbonate ion (HCO
3 -) exchange the mode absorbing, absorb the highest at colonic segment.
After butyric acid is absorbed by colonic mucosa epithelial cell, can be transported to the further metabolism of liver or be consumed as energy substance by colonic mucosa epithelial cell, its final metabolite is ketoboidies and carbon dioxide, for protection of intestinal mucosal barrier cells provides the energy of 75% left and right.Nearly all butyric acid can be absorbed by enterocyte.Tracer method is found. butyric acid can enter total blood circulation.In addition, in peripheral tissues, butyric acid can be oxidized for Fatty synthesis rapidly, also can enter the synthetic butterfat of mammary gland.
Sodium butyrate is the main energy source of intestinal mucosa epithelial cell proliferation, can promote that small intestinal mucosa grows, and strengthens mucous membrane permeability, thereby improves small intestine digestion and absorption function; Can also repair impaired colon epithelial cell, regulate Colon Water salt balance, reduce the generation of animal diarrhoea, there is in actual applications good result of use.
Sodium butyrate has special cheese acid smell, and easily the moisture absorption, free-running property are poor, give processing, transport and use and all brought certain inconvenience, are unfavorable for extensively promoting the use of.More alarmingly be, because the temperature in difference and production and the environment for use of storage, mixing, granulating process and the Diet Formula of feed, the difference of humidity all can cause the loss of sodium butyrate, when reducing result of use, also can cause other unstability raw materials that loss reaction occurs.
As CN103238730A discloses a kind of preparation method of animal feed additive microencapsulated coating sodium butyrate, comprise: by hydroxypropyl methylcellulose, shitosan and silica mix and are incorporated in 230 DEG C of high-boilings expansions in fluid bed, then Aqueous sodium butyrate solutions is sprayed on above-mentioned three kinds of mixture of substances, low-temperature setting after high temperature drying, make sodium butyrate particle curing molding, then by coated fertilizer Brazil wax, palm oil grease and polyethylene glycol are dissolved in organic solvent, in fluid bed, carry out end spray dressing, obtain the uniform sodium butyrate particle of coating, make sodium butyrate mass percent between 30-70%.This patent can effectively be covered sodium butyrate stink, allows sodium butyrate slowly discharge at enteron aisle, for whole enteron aisle provides energy.
Summary of the invention
The present invention, by by sodium butyrate feeding puberty sow, finds insulin and auxin concentration raising in sow blood, has promoted the raising of sow fertility and puberty to shift to an earlier date.
Based on above discovery, the invention provides the application of sodium butyrate in feed or the feed addictive of the secretion of preparation promotion auxone.
Described sodium butyrate can add in feed or feed addictive with pulvis, particle or coated slow release formulation form, is preferably with coated slow release formulation, i.e. sodium butyrate coated slow release formulation.
The preparation of described coated slow release formulation can be with reference to the disclosed method of CN103238730A.
Described animal can be livestock or poultry, be specifically as follows pig, chicken, and the specific embodiment of the invention provides the application example of the sow in two weeks before and after oestrus.
Preferably, the addition of described sodium butyrate in feed is 150-300ppm.
Described feed is basal diet, can sow basal diet, piglet basal diet or poultry basal diet.
The present invention is by the sow sodium butyrate before and after feeding puberty, in discovery sow blood, the concentration of insulin and auxin improves, and then think that sodium butyrate can promote the synthetic and secretion of animal insulin and auxin, can be for the preparation of thering is the adding in feed or feed addictive of corresponding function, thus improve sow fertility and promote oestrus in advance.
Detailed description of the invention
1 materials and methods
1.1 test material
Dihydropyridine and coated slow-release sodium butyrate (commodity are called excellent general fourth, sodium butyrate content 30%), provided by Hangzhou Kangdequan Feed Co., Ltd, and concrete preparation method is with reference to the disclosed method of CN103238730A;
Experimental animal: 96 of DLY three way cross sows (body weight 75kg).
1.2 feedings and managements: test pig adopts group feeding, fully feeds, and every day 3 times, freely drinks water.Preliminary trial period 7d, the basic diet of feeding, is just trying phase 28d.
1.3 test periods: 2010.3-2010.4
1.4 test sites: boar test site, academy of agricultural sciences of Zhejiang Province
1.5 experimental design:
By 96 test sows, be divided at random four groups, be respectively control group, test I group, test II group and test III group, 6 repetitions of each processing (hurdle), 4 of each repetitions.Each processing is the different daily rations of feeding respectively, and control group is feeding basal diet only, test I group feeding basal diet+dihydropyridine 1000ppm, the excellent general fourth of test II group feeding basal diet+500ppm, the excellent general fourth of test III group feeding basal diet+1000ppm.Basal diet, with reference to replacement gilt trophic level, selects the premix of Kang Di feed company of the U.S. to be mixed with powder.
1.6 test method
Insulin radioimmunoassay determination box for serum insulin content (Tianjin nine ancient cooking vessel medical biotechnology Co., Ltds provide) is measured, and assay method is pressed kit description operation; Growth hormone in serum (GH) content employment GH radiommunoassay box (nine ancient cooking vessel medical biotechnology Co., Ltds provide by Tianjin) is measured, and assay method is pressed kit description operation.
1.7. data processing
Different disposal group bulk sample carries out jugular vein dynamically takes a blood sample, and blood sample low temperature is preserved, and after laboratory processes, measures Peripheral Blood insulin and GH concentration, with Biological Statistic Analysis Software SPSS13.0 variance analysis and check its conspicuousness.
2 results
The impact that 2.1 different disposal groups change insulin concentration
Dihydropyridine group and control group insulin concentration are along with the processing time changes little.The excellent general fourth group insulin concentration of various dose is along with the processing time rises gradually, with control group significant difference (P < 0.05), after the 21st day, the excellent general fourth of high dose (1000ppm) is organized insulin concentration apparently higher than the excellent general fourth of low dosage (500ppm) group, significant difference (P < 0.05).The results are shown in Table 1.
The impact (unit, mIU/L) of the excellent general fourth of table 1 various dose on puberty father's former wife pork insulin concentration
Note: same shoulder mark is without letter or contain identical lowercase alphabet differential different not remarkable (P > 0.05), and lowercase difference person represents significant difference (P < 0.05).
Result of the test shows, adds sodium butyrate and can promote the secretion of sow serum insulin in puberty backup sow diets.Insulin is the critical hormone of contact animal metabolism and production status, it acts on hypophysis, strengthen the release frequency of gonadotropin-releasing hormone (GRH) (GnRH), increase the release of luteotropin (LH) and follicular stimulating hormone (FSH), thereby promotion follicular development, has improved ovulation rate.Infer thus, sodium butyrate is by promoting insulin secretion to improve sow reproductive performance.
2.2 GH change in concentration rules
Excellent general fourth (1000ppm) group GH concentration, along with the processing time raises gradually, reaches higher level in the time processing the 28th day; Excellent general fourth (500ppm) group GH concentration is along with the processing time changes rising gradually; Dihydropyridine group and control group GH concentration are along with the processing time changes little; Two excellent general fourth groups of dosage are compared with control group, GH concentration difference is (P < 0.05) significantly, and after the 21st day, improve the excellent general fourth group of GH concentration effect 1000ppm and be obviously better than the excellent general fourth group of 500 ppm, significant difference (P < 0.05).The results are shown in Table 2.
The excellent general fourth of table 2 various dose on the initial stage before the impact (unit, μ g/L) of sow GH concentration
Note: same shoulder mark is without letter or contain identical lowercase alphabet differential different not remarkable (P > 0.05), and lowercase difference person represents significant difference (P < 0.05)
From this result of the test, in puberty backup sow diets, add sodium butyrate and can promote the secretion of sow growth hormone of serum, sodium butyrate can affect sow Reproductive Performance by GH, promotes sow puberty in advance.
Claims (7)
1. the application of sodium butyrate in feed or the feed addictive of the secretion of preparation promotion auxone.
2. application as claimed in claim 1, is characterized in that, described animal is the sow in two weeks before and after puberty.
3. application as claimed in claim 1, is characterized in that, described sodium butyrate adds in feed or feed addictive with pulvis, particle or coated slow release formulation form.
4. application as claimed in claim 1, is characterized in that, described sodium butyrate adds in feed or feed addictive with coated slow release formulation form.
5. the application as described in claim 3 or 4, is characterized in that, in described coated slow release formulation, the percentage by weight of sodium butyrate is 30-70%.
6. application as claimed in claim 1, is characterized in that, the addition of described sodium butyrate in feed is 150-300ppm.
7. the application as described in claim 1 or 6, is characterized in that, described feed is basal diet.
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|---|---|---|---|
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|---|---|---|---|
| CN201410370480.0A CN104171407A (en) | 2014-07-30 | 2014-07-30 | Application of sodium butyrate to preparation of feed or feed additive of promoting flaudio-videoonoid secretion |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104585509A (en) * | 2015-02-03 | 2015-05-06 | 广东绿生源饲料科技有限公司 | Forage-use granular sodium butyrate and preparation method thereof |
| CN106721055A (en) * | 2016-11-30 | 2017-05-31 | 杭州康德权饲料有限公司 | Feeding coating compound acidulant and preparation method thereof |
| CN111228234A (en) * | 2020-01-07 | 2020-06-05 | 宋凤香 | Coated lidocaine and preparation method and application thereof |
| CN117481261A (en) * | 2023-11-20 | 2024-02-02 | 华中农业大学 | Feed additives used to increase ovulation rate and litter size of sows and their preparation methods and applications |
| CN120713079A (en) * | 2025-08-29 | 2025-09-30 | 长沙学院 | Aquatic population breeding and seedling raising method based on water temperature-hormone coordinated regulation and its application |
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| CN102919581A (en) * | 2012-10-30 | 2013-02-13 | 浙江科盛饲料股份有限公司 | Feed additive, functional feed, and preparation method and application of functional feed |
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| CN111228234A (en) * | 2020-01-07 | 2020-06-05 | 宋凤香 | Coated lidocaine and preparation method and application thereof |
| CN117481261A (en) * | 2023-11-20 | 2024-02-02 | 华中农业大学 | Feed additives used to increase ovulation rate and litter size of sows and their preparation methods and applications |
| WO2025107563A1 (en) * | 2023-11-20 | 2025-05-30 | 华中农业大学 | Feed additive for improving ovulation rate and litter size of sows, preparation method therefor, and use thereof |
| CN120713079A (en) * | 2025-08-29 | 2025-09-30 | 长沙学院 | Aquatic population breeding and seedling raising method based on water temperature-hormone coordinated regulation and its application |
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