CN104161807A - Preparation method for medicine used for treating acute and chronic nasosinusitis and rhinitis - Google Patents
Preparation method for medicine used for treating acute and chronic nasosinusitis and rhinitis Download PDFInfo
- Publication number
- CN104161807A CN104161807A CN201310184526.5A CN201310184526A CN104161807A CN 104161807 A CN104161807 A CN 104161807A CN 201310184526 A CN201310184526 A CN 201310184526A CN 104161807 A CN104161807 A CN 104161807A
- Authority
- CN
- China
- Prior art keywords
- carrying
- granule
- rhinitis
- sugar
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010039083 rhinitis Diseases 0.000 title claims abstract description 16
- 230000001154 acute effect Effects 0.000 title claims abstract description 14
- 239000003814 drug Substances 0.000 title claims abstract description 14
- 230000001684 chronic effect Effects 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000008187 granular material Substances 0.000 claims abstract description 42
- 239000000463 material Substances 0.000 claims abstract description 15
- 238000004519 manufacturing process Methods 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000011230 binding agent Substances 0.000 claims abstract description 11
- 239000008213 purified water Substances 0.000 claims abstract description 7
- 238000007599 discharging Methods 0.000 claims abstract description 6
- 239000012530 fluid Substances 0.000 claims abstract description 6
- 238000002156 mixing Methods 0.000 claims abstract description 6
- 238000004806 packaging method and process Methods 0.000 claims abstract description 6
- 238000003756 stirring Methods 0.000 claims abstract description 6
- 201000009890 sinusitis Diseases 0.000 claims description 13
- 238000013019 agitation Methods 0.000 claims description 5
- 230000009514 concussion Effects 0.000 claims description 5
- 239000004744 fabric Substances 0.000 claims description 5
- 238000009413 insulation Methods 0.000 claims description 5
- 239000012567 medical material Substances 0.000 claims description 5
- 238000012856 packing Methods 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 238000005453 pelletization Methods 0.000 claims description 5
- 230000002572 peristaltic effect Effects 0.000 claims description 5
- 238000005070 sampling Methods 0.000 claims description 5
- 239000007788 liquid Substances 0.000 abstract description 6
- 238000005516 engineering process Methods 0.000 abstract description 3
- 230000007547 defect Effects 0.000 abstract description 2
- 239000007902 hard capsule Substances 0.000 abstract description 2
- 239000006187 pill Substances 0.000 abstract description 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- 238000005469 granulation Methods 0.000 abstract 1
- 230000003179 granulation Effects 0.000 abstract 1
- 230000010355 oscillation Effects 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000005303 weighing Methods 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 13
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000013558 reference substance Substances 0.000 description 3
- 238000004809 thin layer chromatography Methods 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- SMDOOINVMJSDPS-UHFFFAOYSA-N Astragaloside Natural products C1=C(O)C(OC)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)OC2C(C(OC3C(C(O)C(O)C(CO)O3)O)C(O)C(CO)O2)O)=C1 SMDOOINVMJSDPS-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000628997 Flos Species 0.000 description 2
- 239000009636 Huang Qi Substances 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- QMNWISYXSJWHRY-XWJCTJPOSA-N astragaloside Chemical compound O1[C@H](C(C)(O)C)CC[C@]1(C)[C@@H]1[C@@]2(C)CC[C@]34C[C@]4(CC[C@H](O[C@H]4[C@@H]([C@@H](O)[C@H](O)CO4)O)C4(C)C)C4[C@@H](O[C@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)CC3[C@]2(C)C[C@@H]1O QMNWISYXSJWHRY-XWJCTJPOSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 206010001076 Acute sinusitis Diseases 0.000 description 1
- 206010009137 Chronic sinusitis Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 241000158526 Nasalis Species 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- SIHHLZPXQLFPMC-UHFFFAOYSA-N chloroform;methanol;hydrate Chemical compound O.OC.ClC(Cl)Cl SIHHLZPXQLFPMC-UHFFFAOYSA-N 0.000 description 1
- 208000027157 chronic rhinosinusitis Diseases 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 210000003695 paranasal sinus Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a preparation method for a medicine used for treating acute and chronic nasosinusitis and rhinitis. The preparation method is characterized by comprising the following steps: respectively weighing a formulated amount of thick paste of medicinal materials and a formulated amount of powdered sugar in proportion for subsequent usage; taking the thick paste of medicinal materials, the powdered sugar and purified water in proportion, adding the above-mentioned substances into a liquid preparation tank, carrying out stirring and heating to allow sugar to be completely dissolved, carrying out heating to 70 DEG C, maintaining the temperature and standing the obtained material for subsequent usage; adding rest sugar into a fluid bed granulator, uniformly spraying a binder onto the material in the tank, taking a sample, observing granularity and carrying out discharging when moisture content is less than 5.0%; adding dry granules into an oscillation sieve for granule sorting, carrying out straightening granulation on coarse granules with a straightening granulator and then carrying out granule sorting again; carrying out total mixing; and carrying out packaging so as to obtain a medicinal granule. The preparation method for the medicinal granule used for treating acute and chronic nasosinusitis and rhinitis overcomes defects of conventional hard capsules or pills and has the advantages of fast action, easy administration, convenience in preservation, simple production technology and environment friendliness of production process.
Description
Technical field
The invention belongs to Chinese patent medicine preparing technical field, be specifically related to a kind of process for preparing medicine for the treatment of acute and chronic nasal sinusitis, rhinitis.
Background technology
Sinusitis, rhinitis are attributed to nasal sinusitis category by the traditional Chinese medical science.How because of affection of exogenous wind-cold or wind heat, for a long time and heat-transformation, heat stagnation lung meridian, impairment of purifying function of the lung, pathogenic heat is followed through upper criminal, due to the nose key of burning.In this disease treatment, answer dispelling wind to relieve the exterior syndrome, awakening consciousness, heat-clearing and toxic substances removing, promoting diuresis to eliminate damp pathogen is basic principle.Existing tcm clinical practice medication is conventionally joined and is formed by Fructus Platycaryae strobilaceac preface (removing seed), Spica Prunellae, the Radix Astragali, Radix Saposhnikoviae, Radix Glycyrrhizae, Flos Chrysanthemi Indici, Flos Magnoliae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong nine taste Chinese crude drugs 5, have pungently loose dispel the wind, effect that heat clearing away is sensible, the diseases such as treating acute and chronic sinusitis, rhinitis.The sings and symptoms of sinusitis, rhinitis is improved obviously, especially the diseases such as headache and dizziness, the congested swelling of nasal mucosa, the congested hypertrophy of concha nasalis, nasal secretion, nasal sinuses tenderness are had to good effect.
Summary of the invention
The object of the invention is to overcome the defect of existing hard capsule or pill, provide a kind of effective fast, be easy to take, preserve conveniently, production technology is simple, the preparation method of a kind of medicinal granule for the treatment of acute and chronic nasal sinusitis, rhinitis of production process environmental protection.
To achieve the above object of the invention, the technical solution used in the present invention is:
Treat a process for preparing medicine for acute and chronic nasal sinusitis, rhinitis, it is characterized in that comprising the steps:
1) batching: medical material thick paste 95-130 part and Icing Sugar 200-210 part of taking respectively recipe quantity are for subsequent use;
2) preparation binding agent: get it filled material thick paste 95-130 part, Icing Sugar 20-40 part and purified water 30-60 part, join in Agitation Tank, stir and heat, sugar is dissolved completely, be heated to 70 DEG C of insulations for subsequent use;
3) granulate: remaining Icing Sugar is joined in fluid bed granulator, starting device, adjust air quantity electric machine frequency at 30-50HZ, the peristaltic pump revolution of Control Nozzle flow is at 150-280r/min, binding agent is sprayed onto on pot interior material equably, temperature of charge is no more than 65 DEG C, and granularity, discharging when moisture is less than 5.0% are observed in sampling;
4) granulate: dry granule is added in concussion sieve and selects grain, screen cloth 12 orders and 60 orders, coarse granule is by selecting grain again after pelletizing machine granulate;
5) always mixed: granule to be joined in multidirectional mixer and mixed 15 minutes, make evenly;
6) packaging: the granule mixing is carried out to subpackage with particles packing machine, then carry out outer package.
Detailed description of the invention
To further instruction of the present invention, in embodiment, be parts by weight, but the present invention is not limited thereto below in conjunction with embodiment.
application Example one
embodiment 1
A process for preparing medicine for the treatment of acute and chronic nasal sinusitis, rhinitis, comprises the steps:
1) batching: 110 parts of the medical material thick pastes and 205 parts of the Icing Sugar that take respectively recipe quantity are for subsequent use; 2) preparation binding agent: 50 parts of 110 parts of the material thick pastes of getting it filled, 35 parts of Icing Sugar and purified water, join in Agitation Tank, stir and heat, sugar is dissolved completely, be heated to 70 DEG C of insulations for subsequent use; 3) granulate: remaining Icing Sugar is joined in fluid bed granulator, starting device, adjust air quantity electric machine frequency at 40HZ, the peristaltic pump revolution of Control Nozzle flow is at 200r/min, binding agent is sprayed onto on pot interior material equably, temperature of charge is no more than 65 DEG C, and granularity, discharging when moisture is less than 5.0% are observed in sampling; 4) granulate: dry granule is added in concussion sieve and selects grain, screen cloth 12 orders and 60 orders, coarse granule is by selecting grain again after pelletizing machine granulate; 5) always mixed: granule to be joined in multidirectional mixer and mixed 15 minutes, make evenly; 6) packaging: the granule mixing is carried out to subpackage with particles packing machine, then carry out outer package.
embodiment 2
A process for preparing medicine for the treatment of acute and chronic nasal sinusitis, rhinitis, comprises the steps:
1) batching: 95 parts of the medical material thick pastes and 200 parts of the Icing Sugar that take respectively recipe quantity are for subsequent use; 2) preparation binding agent: 30 parts of 95 parts of the material thick pastes of getting it filled, 20 parts of Icing Sugar and purified water, join in Agitation Tank, stir and heat, sugar is dissolved completely, be heated to 70 DEG C of insulations for subsequent use; 3) granulate: remaining Icing Sugar is joined in fluid bed granulator, starting device, adjust air quantity electric machine frequency at 30HZ, the peristaltic pump revolution of Control Nozzle flow is at 150r/min, binding agent is sprayed onto on pot interior material equably, temperature of charge is no more than 65 DEG C, and granularity, discharging when moisture is less than 5.0% are observed in sampling; 4) granulate: dry granule is added in concussion sieve and selects grain, screen cloth 12 orders and 60 orders, coarse granule is by selecting grain again after pelletizing machine granulate; 5) always mixed: granule to be joined in multidirectional mixer and mixed 15 minutes, make evenly; 6) packaging: the granule mixing is carried out to subpackage with particles packing machine, then carry out outer package.
embodiment 3
A process for preparing medicine for the treatment of acute and chronic nasal sinusitis, rhinitis, comprises the steps:
1) batching: 130 parts of the medical material thick pastes and 210 parts of the Icing Sugar that take respectively recipe quantity are for subsequent use; 2) preparation binding agent: 60 parts of 130 parts of the material thick pastes of getting it filled, 40 parts of Icing Sugar and purified water, join in Agitation Tank, stir and heat, sugar is dissolved completely, be heated to 70 DEG C of insulations for subsequent use; 3) granulate: remaining Icing Sugar is joined in fluid bed granulator, starting device, adjust air quantity electric machine frequency at 50HZ, the peristaltic pump revolution of Control Nozzle flow is at 280r/min, binding agent is sprayed onto on pot interior material equably, temperature of charge is no more than 65 DEG C, and granularity, discharging when moisture is less than 5.0% are observed in sampling; 4) granulate: dry granule is added in concussion sieve and selects grain, screen cloth 12 orders and 60 orders, coarse granule is by selecting grain again after pelletizing machine granulate; 5) always mixed: granule to be joined in multidirectional mixer and mixed 15 minutes, make evenly; 6) packaging: the granule mixing is carried out to subpackage with particles packing machine, then carry out outer package.
application Example two
embodiment 4assay
Get this product appropriate, porphyrize, precision takes 10g, add methanol 30ml, reflux 1 hour, filter, with methanol gradation washing filtering residue and container, merging filtrate and cleaning mixture, water bath method, the residue 20ml that adds water, slight fever is dissolved, be transferred in separatory funnel, with chloroform extraction 3 times, each 20ml, discard chloroform solution, water saturated n-butanol extraction 4 times for water liquid, each 15ml, merge n-butyl alcohol liquid, with 1%NaOH solution washing 3 times, each 15ml, discard alkali liquor, the saturated water washing of n-butyl alcohol 2 times for n-butyl alcohol liquid, each 15ml, discard water liquid, n-butyl alcohol liquid evaporate to dryness, residue adds methanol to be made to dissolve, be transferred in 2ml measuring bottle, add methanol and be diluted to scale, shake up, as need testing solution.Separately get astragaloside reference substance, add methanol and make the solution of every 1ml containing 0.5mg, product solution in contrast.Test according to thin layer chromatography (annex VI B of Chinese Pharmacopoeia version in 2000), draw reference substance solution 0.5 μ l and 1.5 μ l, need testing solution 4 μ l, cross point is on same silica gel g thin-layer plate respectively, taking 10 DEG C of following subnatants that spend the night of placing of chloroform-methanol-water (13:7:2) as developing solvent, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, 105 DEG C are dried 5～7 minutes, clear to speckle colour developing, take out, on lamellae, cover onesize glass plate, use immobilization with adhesive tape around, scan according to thin layer chromatography (annex VI B thin layer chromatography scanning of Chinese Pharmacopoeia version in 2000), wavelength: λ s=530nm, λ R=700nm, measure test sample and reference substance trap integrated value, calculate, obtain.
Every bag of this product in astragaloside (C44H68O4), is no less than 0.05mg containing the Radix Astragali.
Although the present invention describes with reference to specific embodiment as above; but those skilled in the art will be appreciated that; above embodiment illustrates the present invention instead of restriction the present invention, as long as the variation to above-described embodiment, modification all should fall in the application's the scope of claims request protection within the scope of connotation of the present invention.
Claims (3)
1. treat a process for preparing medicine for acute and chronic nasal sinusitis, rhinitis, it is characterized in that comprising the steps:
1) batching: medical material thick paste 95-130 part and Icing Sugar 200-210 part of taking respectively recipe quantity are for subsequent use;
2) preparation binding agent: get it filled in proportion material thick paste, Icing Sugar and purified water, join in Agitation Tank, stir and heat, sugar is dissolved completely, be heated to 70 DEG C of insulations for subsequent use;
3) granulate: remaining Icing Sugar is joined in fluid bed granulator, and starting device, adjusts air quantity electric machine frequency at 30-50HZ, the peristaltic pump revolution of Control Nozzle flow is at 150-280r/min, binding agent is sprayed onto on pot interior material equably, and granularity, discharging when moisture is less than 5.0% are observed in sampling;
4) granulate: dry granule is added in concussion sieve and selects grain, and screen cloth is 12 orders and 60 orders, coarse granule is by selecting grain again after pelletizing machine granulate;
5) always mixed: granule to be joined in multidirectional mixer and mixed 15 minutes, make evenly;
6) packaging: the granule mixing is carried out to subpackage with particles packing machine, then carry out outer package.
2. a kind of process for preparing medicine for the treatment of acute and chronic nasal sinusitis, rhinitis according to claim 1, is characterized in that in step (2): get it filled material thick paste 95-130 part, Icing Sugar 20-40 part and purified water 30-60 part.
3. a kind of process for preparing medicine for the treatment of acute and chronic nasal sinusitis, rhinitis according to claim 1, is characterized in that in step (3): in pot, temperature of charge is no more than 65 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310184526.5A CN104161807A (en) | 2013-05-20 | 2013-05-20 | Preparation method for medicine used for treating acute and chronic nasosinusitis and rhinitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310184526.5A CN104161807A (en) | 2013-05-20 | 2013-05-20 | Preparation method for medicine used for treating acute and chronic nasosinusitis and rhinitis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104161807A true CN104161807A (en) | 2014-11-26 |
Family
ID=51905933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310184526.5A Pending CN104161807A (en) | 2013-05-20 | 2013-05-20 | Preparation method for medicine used for treating acute and chronic nasosinusitis and rhinitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104161807A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1500487A (en) * | 2002-11-18 | 2004-06-02 | 杭州容立医药科技有限公司 | Oral compound levocetirizine pseudoephedrine formulation and its preparation |
| CN1883460A (en) * | 2006-06-06 | 2006-12-27 | 杭州中美华东制药有限公司 | An enteric coated mini-pill of pantoprazole sodium |
| CN102105136A (en) * | 2008-03-11 | 2011-06-22 | 蒂宝制药公司 | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
| CN102415986A (en) * | 2010-09-27 | 2012-04-18 | 复旦大学 | Insoluble drug solid dispersion containing phospholipid and bile salt and preparation method thereof |
| CN102949370A (en) * | 2012-11-27 | 2013-03-06 | 贵州信邦制药股份有限公司 | Roflumilast tablets as well as preparation method and detection method thereof |
-
2013
- 2013-05-20 CN CN201310184526.5A patent/CN104161807A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1500487A (en) * | 2002-11-18 | 2004-06-02 | 杭州容立医药科技有限公司 | Oral compound levocetirizine pseudoephedrine formulation and its preparation |
| CN1883460A (en) * | 2006-06-06 | 2006-12-27 | 杭州中美华东制药有限公司 | An enteric coated mini-pill of pantoprazole sodium |
| CN102105136A (en) * | 2008-03-11 | 2011-06-22 | 蒂宝制药公司 | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
| CN102415986A (en) * | 2010-09-27 | 2012-04-18 | 复旦大学 | Insoluble drug solid dispersion containing phospholipid and bile salt and preparation method thereof |
| CN102949370A (en) * | 2012-11-27 | 2013-03-06 | 贵州信邦制药股份有限公司 | Roflumilast tablets as well as preparation method and detection method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104042824B (en) | Preparation and detecting methods of traditional Chinese medicine composition for treating wind-cold-wetness evil | |
| CN102114075B (en) | Serial Chinese medicinal preparation for treating child common cold and preparation process and detection method thereof | |
| CN103134897B (en) | Rhiaoma iridis tectori capsule detecting method | |
| CN101954020A (en) | Chewable tablet for stimulating appetite and helping digestion | |
| CN102973861A (en) | Preparation method and quality control method of sugar-free compound fructus momordicae antitussive particles | |
| CN104161807A (en) | Preparation method for medicine used for treating acute and chronic nasosinusitis and rhinitis | |
| CN101708220A (en) | Method for preparing Chinese medicinal stomach medicament preparation and quality test method thereof | |
| CN104127471A (en) | Preparation method and quality control method for honeysuckle flower formula granule | |
| CN1595147B (en) | A method for detecting the content of madecassoside and/or asiaticoside in Sanjin preparation | |
| CN103585204A (en) | Thesium granule with high stability and preparation method thereof | |
| CN103550283A (en) | Eucommia ulmoides formula granules, preparation method and quality control method thereof | |
| CN108614065A (en) | A kind of method of quality control of mountain chrysanthemum Jiangya Granula | |
| CN101711834A (en) | Method for preparing medicine composition preparation of refined tuber fleeceflower preparation | |
| CN102727651B (en) | Preparation method and quality detection method of bezoar supernatant capsule | |
| CN105548454A (en) | Quality detecting method of traditional Chinese medicine preparation for helping digestion of children | |
| CN101385808A (en) | Quality control method of Zhupo Anshen Dan | |
| CN104857087A (en) | Pharmaceutic preparation with blood glucose reducing effect, and preparation method and application of pharmaceutic preparation | |
| CN103063792A (en) | Quality testing method of Xiaoer Huatan Zhike Granules | |
| CN116270770A (en) | Preparation method of drynaria rhizome formula particles | |
| CN102426207B (en) | Detection method for flavone component in clematis filamentosa dunn, and application thereof | |
| CN113181123A (en) | Anmian granules and preparation method thereof | |
| CN114425067A (en) | A kind of tonifying kidney and longevity preparation and quality control method thereof | |
| CN101041000B (en) | Medicine compound for treating snoring and the preparing method thereof | |
| CN104147140A (en) | Preparation method and quality control method of cortex fraxini formula granules | |
| CN101919960B (en) | Inflammation and heat clearing tablets and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20141126 |