CN104147303A - Immunity regulating hippocampus hard capsule and preparation method thereof - Google Patents
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Abstract
本发明涉及一种免疫调节海马硬胶囊及其制备方法，该硬胶囊由以下重量份的组分组成：海马1-5份，枸杞10-15份，五味子5-10份，山药13-20份，黄芪5-10份。本发明的海马硬胶囊的增免疫效果好，可奏标本兼治效果，能达愈后不易复发的目标，且制备方法采用传统工艺，操作简单且环保。The invention relates to an immunoregulatory hippocampus hard capsule and a preparation method thereof. The hard capsule is composed of the following components in parts by weight: 1-5 parts of hippocampus, 10-15 parts of wolfberry, 5-10 parts of schisandra, and 13-20 parts of Chinese yam , Astragalus 5-10 parts. The hippocampus hard capsule of the present invention has a good effect of enhancing immunity, can treat both symptoms and root causes, and can achieve the goal of not recurring easily after recovery. The preparation method adopts a traditional process, and the operation is simple and environment-friendly.
Description
技术领域technical field
本发明涉及一种硬胶囊，更具体的说，涉及一种免疫调节海马硬胶囊及其制备方法。The invention relates to a hard capsule, in particular to an immune-regulating hippocampus hard capsule and a preparation method thereof.
背景技术Background technique
海马为海龙科动物，性温、味甘，是我国名贵的强壮补益中药材。中国历版药典收藏的海马药材有5个品种：线纹海马、刺海马、大海马、三斑海马和小海马的干燥体，具有温肾壮阳，散结消肿的功效。海马具有较高的营养价值，蛋白质含量高达70%，含有7种氨基酸，七种7种为人体必需氨基酸；还含有大量的DHA，是前列腺和精子的主要物质基础；海马含有丰富的磷脂与补益作用有关，海马中Mn、Zn含量高与补肾壮阳作用吻合，并富含Fe，与其滋补肝肾补血生精作用相关。现代药理学研究证明，海马具有很多方面的药理作用。The hippocampus is a sea dragon family animal, warm in nature and sweet in taste, and is a valuable Chinese herbal medicine for strengthening and nourishing in my country. There are 5 varieties of hippocampus medicinal materials collected in Chinese Pharmacopoeia: the dried body of linear hippocampus, prickly hippocampus, big hippocampus, three-spotted hippocampus and small hippocampus, which has the effects of warming kidney and strengthening yang, dispelling stagnation and reducing swelling. Hippocampus has high nutritional value, protein content is as high as 70%, contains 7 kinds of amino acids, seven of which are essential amino acids for human body; it also contains a large amount of DHA, which is the main material basis of prostate and sperm; hippocampus is rich in phospholipids and supplements It is related to the effect. The high content of Mn and Zn in the hippocampus is consistent with the effect of nourishing the kidney and strengthening yang, and it is rich in Fe, which is related to the effect of nourishing the liver and kidney, nourishing blood and producing sperm. Modern pharmacological research has proved that the hippocampus has many pharmacological effects.
现有一些具有大补元气，固脱生津、健脾，补肺，固肾的增免疫的药物，均有这样或那样的不足，不能达到标本兼治的效果。Existing some medicines that greatly invigorate vital energy, solidify body fluid, invigorate the spleen, invigorate the lung, and strengthen the kidney all have deficiencies in one way or another, and cannot achieve the effect of treating both the principal and secondary aspects of the disease.
发明内容Contents of the invention
本发明的目的在于提供一种免疫调节海马硬胶囊。The object of the present invention is to provide an immunoregulatory hippocampus hard capsule.
为实现本发明的目的，本发明的技术方案如下：For realizing the purpose of the present invention, technical scheme of the present invention is as follows:
一种免疫调节海马硬胶囊，该硬胶囊由以下重量份的组分组成：An immunoregulatory hippocampus hard capsule, the hard capsule is composed of the following components by weight:
海马 1-5份，1-5 servings of hippocampus,
枸杞 10-15份，Goji berries 10-15 parts,
五味子 5-10份，Schisandra 5-10 parts,
山药 13-20份，Yam 13-20 parts,
黄芪 5-10份。Astragalus 5-10 parts.
海马具有强身健体、补肾壮阳、舒筋活络等药用功能，枸杞多糖可显著增强小鼠在CONA诱导下脾脏淋巴细胞的转化反应，在适应计量时可明显提高SRBC免疫后脾脏溶血空斑PFC数量。枸杞多糖所制备的含IL-2上清液使成年小鼠胸腺细胞在体外增殖活性提高，使老年小鼠IL-2的活性显著提高达到成年水平。这些结果表明枸杞多糖对IL-2的活性有增强作用并使老年小鼠IL-2的活性得到恢复。进一步的研究证实了枸杞多糖能增强小鼠腹腔巨噬细胞C3B～FC受体的抑制作用。细胞化学研究表明枸杞多糖能使巨噬细胞（MO）数量增加，体积增大，吞噬活动显著增强，并能提高T淋巴转化率，增加白细胞总数及嗜中性粒细胞，增强特异性免疫，促进细胞免疫和体液免疫。这些结果表明枸杞多糖能增强正常小鼠和CY处理后小鼠的T细胞介导的免疫反应与NK细胞的活性。五味子多糖能显著提高正常小鼠腹腔吞噬细胞百分率和吞噬指数，并能显著促进溶血素形成。大量五味子多糖可显著增强正常小鼠淋巴细胞转化率，小剂量可明显促进淋巴细胞转化率。黄芪多糖能通过刺激APS提高细胞表面粘附分子的表达而促进淋巴细胞及内皮细胞的粘附，从而促进淋巴细胞再循环，增加淋巴细胞与抗原的接触机会，这可能是APS免疫增强作用的机制之一。IL-2～zNK细胞的生长因子，具有活NK细胞作用。NK细胞存在于大颗粒淋巴细胞群中。APS可明显提高受伤小鼠脾脏、胸腺肠系膜淋巴结细胞质核、线粒体膜及线粒体膜的流动性，同时降低创伤后小鼠血清及淋巴细胞内过氧化脂质水平，这可能是保护淋巴细胞结构的途径。并能提高体内SOD的活性。因此，推测APS具有提高机体免疫功能，对抗创伤后淋巴细胞受抑制作用。并对感染后巨噬细胞功能异常，有明显地恢复作用。The hippocampus has medicinal functions such as strengthening the body, tonifying the kidney and strengthening yang, relaxing tendons and activating collaterals, etc. Lycium barbarum polysaccharide can significantly enhance the transformation reaction of spleen lymphocytes in mice induced by CONA, and can significantly improve the PFC of spleen hemolytic plaques after SRBC immunization when the dosage is adapted quantity. The IL-2-containing supernatant prepared from Lycium barbarum polysaccharides increased the proliferation activity of adult mouse thymocytes in vitro, and significantly increased the activity of IL-2 in aged mice to adult levels. These results indicated that Lycium barbarum polysaccharides enhanced the activity of IL-2 and restored the activity of IL-2 in aged mice. Further studies have confirmed that Lycium barbarum polysaccharides can enhance the inhibitory effect of C3B-FC receptors in peritoneal macrophages of mice. Cytochemical studies have shown that Lycium barbarum polysaccharides can increase the number and volume of macrophages (MO), significantly enhance phagocytic activity, increase the transformation rate of T lymphocytes, increase the total number of white blood cells and neutrophils, enhance specific immunity, and promote Cellular and humoral immunity. These results indicated that Lycium barbarum polysaccharides could enhance T cell-mediated immune response and NK cell activity in normal mice and CY-treated mice. Schisandra polysaccharides can significantly increase the percentage of phagocytes and phagocytic index in the peritoneal cavity of normal mice, and can significantly promote the formation of hemolysin. A large amount of Schisandra polysaccharide can significantly enhance the lymphocyte transformation rate of normal mice, and a small dose can significantly promote the lymphocyte transformation rate. Astragalus polysaccharides can promote the adhesion of lymphocytes and endothelial cells by stimulating APS to increase the expression of cell surface adhesion molecules, thereby promoting the recirculation of lymphocytes and increasing the contact opportunities between lymphocytes and antigens, which may be the mechanism of APS immune enhancement one. IL-2~zNK cell growth factor has the function of living NK cells. NK cells are present in a population of large granular lymphocytes. APS can significantly improve the plasma nucleus, mitochondrial membrane and mitochondrial membrane fluidity of the injured mouse spleen, thymic mesenteric lymph node, and reduce the level of lipid peroxide in serum and lymphocytes of mice after trauma, which may be the way to protect the structure of lymphocytes . And can improve the activity of SOD in vivo. Therefore, it is speculated that APS can improve the immune function of the body and resist the suppression of post-traumatic lymphocytes. It also has obvious recovery effect on the abnormal function of macrophages after infection.
本发明的另一目的是提供一种免疫调节海马硬胶囊的制备方法，该方法包括以下步骤：将海马、枸杞、五味子、山药、黄芪加水煎煮二次，第一次2-4小时，第二次1-2小时，过滤，滤液浓缩，浓缩液加入乙醇使醇含量达75%,冷藏（-1～3℃）20小时，过滤，滤液回收乙醇并浓缩至稠膏，干燥，粉碎，过筛，充填硬胶囊。Another object of the present invention is to provide a preparation method of immunoregulatory hippocampus hard capsules, the method comprising the following steps: adding water to decoct hippocampus, wolfberry, schisandra, yam, and astragalus twice, the first time for 2-4 hours, the second time Second time for 1-2 hours, filter, concentrate the filtrate, add ethanol to the concentrate to make the alcohol content reach 75%, refrigerate (-1~3°C) for 20 hours, filter, recover the ethanol from the filtrate and concentrate to a thick paste, dry, pulverize, pass Sieve and fill hard capsules.
在本发明的一优选实施例中，所述水为矿泉水。In a preferred embodiment of the present invention, the water is mineral water.
本发明的效果是：本发明具有益气补肾、活血通络之功效，经30例临床观察，总有效率为90.00%，愈显率为50.00%。The effect of the present invention is: the present invention has the effect of invigorating qi and tonifying kidney, promoting blood circulation and dredging collaterals. Through clinical observation of 30 cases, the total effective rate is 90.00%, and the curative effect rate is 50.00%.
本发明的海马硬胶囊的制备方法采用传统工艺，操作简单且环保。The preparation method of the hippocampus hard capsule of the present invention adopts traditional techniques, and is simple to operate and environmentally friendly.
具体实施方式Detailed ways
实施例1Example 1
（1）海马硬胶囊的配方：(1) Formula of hippocampus hard capsule:
海马 2g，Seahorse 2g,
枸杞 8g，Wolfberry 8g,
五味子 7g，Schisandra 7g,
山药 14g，Yam 14g,
黄芪 9g。Astragalus 9g.
(2)海马硬胶囊的制备方法：将配方量的海马、枸杞、五味子、山药、黄芪加水煎煮二次，第一次1小时，第二次3小时，过滤，滤液浓缩，浓缩液加入乙醇使醇含量达75%,冷藏（-1～3℃）20小时，过滤，滤液回收乙醇并浓缩至稠膏，干燥，粉碎，过120目筛，装入零号硬胶囊，每粒重0.5g。服用一个月效果显著。(2) The preparation method of hippocampus hard capsule: decoct the hippocampus, wolfberry, Schisandra chinensis, yam, and astragalus twice with water, the first time for 1 hour, and the second time for 3 hours, filter, concentrate the filtrate, add ethanol to the concentrated solution Make the alcohol content reach 75%, refrigerate (-1～3℃) for 20 hours, filter, recover ethanol from the filtrate and concentrate to a thick paste, dry, crush, pass through a 120-mesh sieve, and put into zero-size hard capsules, each weighing 0.5g . After taking it for a month, the effect is remarkable.
实施例2Example 2
（1）海马硬胶囊的配方：(1) Formula of hippocampus hard capsule:
海马 3g，Seahorse 3g,
枸杞 9g，Wolfberry 9g,
五味子 6g，Schisandra 6g,
山药 14g，Yam 14g,
黄芪 8g。Astragalus 8g.
(2)海马硬胶囊的制备方法：将配方量的海马、枸杞、五味子、山药、黄芪加水煎煮二次，第一次2小时，第二次3小时，过滤，滤液浓缩，浓缩液加入乙醇使醇含量达75%,冷藏（-1～3℃）20小时，过滤，滤液回收乙醇并浓缩至稠膏，干燥，粉碎，过120目筛，装入零号硬胶囊，每粒重0.5g。服用一个月效果显著。(2) The preparation method of hippocampus hard capsule: decoct the hippocampus, wolfberry, Schisandra chinensis, yam, and astragalus twice with water, the first time for 2 hours, and the second time for 3 hours, filter, concentrate the filtrate, add ethanol to the concentrated solution Make the alcohol content reach 75%, refrigerate (-1～3℃) for 20 hours, filter, recover ethanol from the filtrate and concentrate to a thick paste, dry, crush, pass through a 120-mesh sieve, and put into zero-size hard capsules, each weighing 0.5g . After taking it for a month, the effect is remarkable.
实施例3Example 3
（1）海马硬胶囊的配方：(1) Formula of hippocampus hard capsule:
海马 1g，Seahorse 1g,
枸杞 7g，Wolfberry 7g,
五味子 9g，Schisandra 9g,
山药 13g，Yam 13g,
黄芪 9g。Astragalus 9g.
(2)海马硬胶囊的制备方法：将配方量的海马、枸杞、五味子、山药、黄芪加水煎煮二次，第一次2小时，第二次4小时，过滤，滤液浓缩，浓缩液加入乙醇使醇含量达75%,冷藏（-1～3℃）20小时，过滤，滤液回收乙醇并浓缩至稠膏，干燥，粉碎，过120目筛，装入零号硬胶囊，每粒重0.5g。服用一个月效果显著。(2) The preparation method of hippocampus hard capsule: decoct the hippocampus, wolfberry, Schisandra chinensis, yam, and astragalus twice with water, the first time for 2 hours, and the second time for 4 hours, filter, concentrate the filtrate, add ethanol to the concentrated solution Make the alcohol content reach 75%, refrigerate (-1～3℃) for 20 hours, filter, recover ethanol from the filtrate and concentrate to a thick paste, dry, crush, pass through a 120-mesh sieve, and put into zero-size hard capsules, each weighing 0.5g . After taking it for a month, the effect is remarkable.
海马硬胶囊的服用方法:一日三次，每次三粒，一个月为一个疗程。必要时，可连续使用。The taking method of hippocampus hard capsule: three times a day, three capsules each time, one month is a course of treatment. It can be used continuously if necessary.
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| CN102258706A (en) * | 2010-05-27 | 2011-11-30 | 杜世超 | Traditional Chinese medicinal health-care wine |
-
2013
- 2013-05-15 CN CN201310178483.XA patent/CN104147303A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1194143A (en) * | 1996-05-31 | 1998-09-30 | 蔡国柱 | Sea horse oral liquor and its preparing method |
| CN1246345A (en) * | 1998-08-28 | 2000-03-08 | 王欢 | Medical liquor for nourishing kidney |
| CN1698878A (en) * | 2005-06-09 | 2005-11-23 | 青岛国风药业股份有限公司 | A pharmaceutical composition for invigorating the kidney, its preparation method and new application |
| CN1927048A (en) * | 2005-09-09 | 2007-03-14 | 杨浩民 | Antifatigue health product improving human body immunity function effectively and preparing method thereof |
| CN102258706A (en) * | 2010-05-27 | 2011-11-30 | 杜世超 | Traditional Chinese medicinal health-care wine |
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Application publication date: 20141119 |