CN104127804A - 一种治疗糖尿病足溃疡的中药 - Google Patents
一种治疗糖尿病足溃疡的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗糖尿病足溃疡的中药，由以下重量配比的药材制备而成：空心木12份、苦蘵果实8份、蓟罂粟子10份、假木通15份、菊叶三七5份、黑心姜12份、湖北海棠根14份、红毛七9份、黄水枝6份、海蓬子14份、厚皮香花10份、胡颓子根12份、花酸苔10份、还魂草15份。临床实验证明，本发明能够安全有效治疗糖尿病足溃疡。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗糖尿病足溃疡的中药。
背景技术
糖尿病足溃疡主要指初期的糖尿病病人，没有出现周围神经病变和周围血管病变的人群，却已出现足部感染如甲沟炎、脚气感染等所造成的足部感染、化脓、溃烂等症状。本病是糖尿病的严重并发症之一，患者从皮肤到骨与关节的各层组织均可受累，严重者可以发生局部或全足的坏疽，需要截肢。因此，糖尿病足溃疡是糖尿病患者致残、致死的主要原因。随着近年来糖尿病发病率的急剧增高，糖尿病足溃疡的发病率也显著增加，治疗糖尿病足溃疡是临床的棘手问题，目前，国内外尚缺乏治疗糖尿病足溃疡的疗效明显的药物。
本发明中药所涉及药材的研究现状如下：
空心木【来源】药材基源：为忍冬科植物鬼吹箫及狭萼鬼吹箫的茎叶或根。拉丁植物动物矿物名：Leycesria formosa Wall.var.stenosepala Rehd.采收和储藏：茎叶夏、秋季采收，根全年均可采挖，均鲜用或切段晒干。【性味】味苦；性凉。【功能主治】利湿清热；活血止血。主湿热黄疸；风湿痹痛；哮喘；月经不调；外伤出血；膀胱炎；骨折损伤。【用法用量】内服：煎汤，9-15g；或泡酒。外用：适量，捣敷，或煎水外洗。
苦蘵果实【来源】药材基源：为茄科植物苦蘵的果实。拉丁植物动物矿物名：Physalis pubescens L.采收和储藏：秋季果实成熟时采收，鲜用或晒干。【性味】味酸：性平。【功能主治】解毒；利湿。主牙痛；天疱疮；疔疮。【用法用量】内服：煎汤，6-9g。外用：适量，捣汁涂。
蓟罂粟子【来源】药材基源：为罂粟科植物蓟罂粟ArgemonemexicanaL.的种子。拉丁植物动物矿物名：Argemone mexicana L.采收和储藏：夏末果实成熟时采下果实，晒干，压破，除去果壳，取种子。【功能主治】缓泻；催吐；解毒；止痛。主便秘；疝痛；牙痛；梅毒。【用法用量】内服：煎汤2-4g。
假木通【来源】药材基源：为双子叶植物药萝藦科植物假木通的黑蔓藤的叶或根。拉丁植物动物矿物名：Stephanotis chunii Tsiang采收和储藏：夏季采叶，晒干；秋季挖根，洗净，切片，晒干。【性味】味甘；辛；性温。【归经】肝；肾经。【功能主治】补血；活血；下乳。主月经不调；痛经；产后血虚，乳汁不足。【用法用量】内服：煎汤，6-15g。
菊叶三七【来源】为菊科土三七属植物土三七Gynura segetum(Lour.)Merr.，以根或全草入药。秋冬挖根，除去残茎、须根及泥土晒干。夏秋采全草，洗净，鲜用或晒干。【性味】甘、微苦，温。【功能主治】散瘀止血，解毒消肿。用于吐血，衄血，尿血，便血，功能性子宫出血，产后瘀血腹痛，大骨节病；外用治跌打损伤，痈疖疮疡，蛇咬伤，外伤出血。【用法用量】1～3钱；外用适量，鲜品捣烂敷患处。
黑心姜【来源】药材基源：为姜科植物黑心姜的根茎。拉丁植物动物矿物名：Curcuma caesia Roxb.采收和储藏：夏、秋季采收，除去茎叶及须根，洗净，鲜用或切片晒干。【性味】味苦；辛；性温。【功能主治】祛风除湿；消肿止痛。主风湿痹痛；胸腹胀痛；产后腰痛；头风痛；跌打损伤。【用法用量】内服：煎汤，9-15g；或浸酒。外用：适量，鲜品捣烂，调酒炒热外搽。
湖北海棠根【来源】药材基源：为蔷微科植物湖北海棠的根。拉丁植物动物矿物名：Malus hupehensis(Pamp.)Rehd.采收和储藏：夏、秋采挖，洗净，切片，鲜用或晒干。【功能主治】活血通络。主跌打损伤。【用法用量】内服：煎汤，鲜品60-90g。外用：适量，研末，调敷。
红毛七【来源】药材基源：为小檗科植物红毛七的根和根茎。拉丁植物动物矿物名：Caulophyllumrobustum Maxim.采收和储藏：夏、秋季采挖，除去茎叶、泥土，洗净，晒干。【性味】辛；苦；性温【归经】肝；胃。【功能主治】活血散瘀；祛风除湿；行气止痛。主月经不调；痛经；产后血瘀腹痛；脘腹寒痛；跌打损伤，风湿痹痛。【用法用量】内服：煎汤，3-15g；或浸酒；或研末。
黄水枝【来源】药材基源：为虎耳草科植物黄水枝的全草。拉丁植物动物矿物名：Tiarella polyphyllaD.Don【性味】苦；寒；无毒。【归经】肺经。【功能主治】清热解毒，活血祛瘀，消肿止痛。主疮疖，无名肿痛，咳嗽，气喘，肝炎，跌打损伤。【用法用量】内服：煎汤，9-15g；或浸酒。外用捣烂。
海蓬子【来源】药材基源：为藜科植物盐角草的全草。拉丁植物动物矿物名：SalicorniaeuropaeaL.[S.europaeaL.var.herbaceaL.；S.herbaceaL.]采收和储藏：夏季收割全草，洗净晒干。【功能主治】平肝；利尿；降压。主高血压；头痛。【用法用量】内服：煎汤，9-15g。
厚皮香花【来源】药材基源：为山茶科植物厚皮香的花。拉丁植物动物矿物名：Ternstroemiagymnanthera(Wight etArn.)Sprague[Cleyera gymnanthera Wight et Arn.]采收和储藏：7-8月采集，鲜用或晒干。【功能主治】杀虫止痒。主疥癣瘙痒。【用法用量】外用：适量，捣烂外敷或擦患处。
胡颓子根【来源】为胡颓子科植物胡颓子Elaeagnus pungens Thunb.的根。拉丁植物动物矿物名：Elaeagnus pungens Thunb.采收和储藏：夏、秋季采挖，洗净，切片晒干。【性味】味苦；酸；性平。【归经】肺；脾经。【功能主治】活血止血；祛风利湿；止咳平喘；解毒敛疮。主味血；咯血；便血；月经过多；风湿关节痛；黄疸；水肿；泻痢；小儿疳积：咳喘；咽喉肿痛；疮疥；跌扑损伤。
花酸苔【来源】为秋海棠科植物花叶秋海棠的全草。拉丁植物动物矿物名：Begonia cathayana Hemsl.采收和储藏：全年可采，鲜用或晒干。【性味】味酸；涩，性凉。【功能主治】清肺目咳；解毒散瘀消肿。主肺热咳嗽；乳蛾；百日咳，痈疮肿毒；烧烫伤；跌打瘀肿。【用法用量】外用：煎汤，6-9g。外用：适量；鲜品捣敷；或捣汁涂；或干品研末撒敷。
还魂草【来源】为景天科植物轮叶景天的全草。夏、秋季采，洗净鲜用。【性味】苦涩，平。【功能主治】解毒，消肿，止血。治创伤，无名肿毒，蛇咬及蝎螫。【用法用量】外用：捣敷或绞汁涂。
发明内容
本发明旨在提供一种治疗糖尿病足溃疡的中药，通过选择合适的药材及其配比，达到安全有效治疗糖尿病足溃疡的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗糖尿病足溃疡的中药，其特征在于，由以下重量配比的药材制备而成：空心木12份、苦蘵果实8份、蓟罂粟子10份、假木通15份、菊叶三七5份、黑心姜12份、湖北海棠根14份、红毛七9份、黄水枝6份、海蓬子14份、厚皮香花10份、胡颓子根12份、花酸苔10份、还魂草15份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2010年3月-2012年6月间共收集87例糖尿病足溃疡住院患者，其中男52例，女35例，均属于Wagner分级法中1～3级患者，年龄55-70岁，糖尿病平均病程1-8年，糖尿病足病程平均28天。将患者随机分为：治疗组45例，对照组42例。两组年龄、病情等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗措施：75例患者均给饮食控制、胰岛素等降糖，有效抗生素及清创、局部处理等综合治疗
2.2对照组：在综合治疗的基础上，患者给予西洛他唑片、甲基维生素B12口服，2次/日，疗程28天。
2.3治疗组：在综合治疗的基础上，口服本发明按照具体实施例1制得的胶囊，早晚各一次，疗程28天。
3、疗效判定与治疗结果
3.1疗效标准
痊愈：溃疡面积愈合或基本愈合。显效：溃疡面积明显缩小，小于治疗前的50％，局部分泌物减少，坏死组织大部分脱落或部分肉芽新生。有效：溃疡面积缩小，但仍大于治疗前的50％。无效：溃疡面积无明显缩小，分泌物无明显减少，局部无明显变化或恶化者。
3.2治疗统计结果见表1。
表1两组疗效比较
注：经x2检验，对照组与治疗组有显著性差异(P＜0.05)，表明治疗组优于对照组
可见，本发明制得的药物能够安全有效治疗糖尿病足溃疡。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：空心木12克、苦蘵果实8克、蓟罂粟子10克、假木通15克、菊叶三七5克、黑心姜12克、湖北海棠根14克、红毛七9克、黄水枝6克、海蓬子14克、厚皮香花10克、胡颓子根12克、花酸苔10克、还魂草15克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗糖尿病足溃疡。口服，每日分早晚两次服用。
具体实施例2
称取：空心木12克、苦蘵果实8克、蓟罂粟子10克、假木通15克、菊叶三七5克、黑心姜12克、湖北海棠根14克、红毛七9克、黄水枝6克、海蓬子14克、厚皮香花10克、胡颓子根12克、花酸苔10克、还魂草15克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，粉碎，即得符合正常成人1天用量的散剂。
用于治疗糖尿病足溃疡。口服，每日分早晚两次服用。
具体实施例3
称取：空心木12克、苦蘵果实8克、蓟罂粟子10克、假木通15克、菊叶三七5克、黑心姜12克、湖北海棠根14克、红毛七9克、黄水枝6克、海蓬子14克、厚皮香花10克、胡颓子根12克、花酸苔10克、还魂草15克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人1天用量的颗粒剂。
用于治疗糖尿病足溃疡。口服，每日分早晚两次服用。
Claims (1)
1.一种治疗糖尿病足溃疡的中药，其特征在于，由以下重量配比的药材制备而成：空心木12份、苦蘵果实8份、蓟罂粟子10份、假木通15份、菊叶三七5份、黑心姜12份、湖北海棠根14份、红毛七9份、黄水枝6份、海蓬子14份、厚皮香花10份、胡颓子根12份、花酸苔10份、还魂草15份。
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