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CL2019000061A1 - Anticuerpo para anti-claudin 18a2 y su utilización. - Google Patents

Anticuerpo para anti-claudin 18a2 y su utilización.

Info

Publication number
CL2019000061A1
CL2019000061A1 CL2019000061A CL2019000061A CL2019000061A1 CL 2019000061 A1 CL2019000061 A1 CL 2019000061A1 CL 2019000061 A CL2019000061 A CL 2019000061A CL 2019000061 A CL2019000061 A CL 2019000061A CL 2019000061 A1 CL2019000061 A1 CL 2019000061A1
Authority
CL
Chile
Prior art keywords
claudin
antibody
points
methods
invention consists
Prior art date
Application number
CL2019000061A
Other languages
English (en)
Inventor
Wang Peng
Jiang Hua
Yang Linlin
SHI Zhimim
Wang Huamao
Li Zonghai
Original Assignee
Carsgen Therapeutics Co Ltd
Shanghai Cancer Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2017/082024 external-priority patent/WO2017186121A1/zh
Application filed by Carsgen Therapeutics Co Ltd, Shanghai Cancer Inst filed Critical Carsgen Therapeutics Co Ltd
Publication of CL2019000061A1 publication Critical patent/CL2019000061A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K9/0012—Galenical forms characterised by the site of application
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants

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  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

LA PRESENTE INVENCIÓN CONSISTE EN UN ANTICUERPO PARA ANTI-CLAUDIN 18A2 Y UNA CÉLULA EFECTORA INMUNE QUE APUNTA A CLAUDIN 18A2. TAMBIÉN SE PROPORCIONAN MÉTODOS PARA INDUCIR LA MUERTE CELULAR Y TRATAR TUMORES.
CL2019000061A 2016-07-08 2019-01-08 Anticuerpo para anti-claudin 18a2 y su utilización. CL2019000061A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610536449 2016-07-08
PCT/CN2017/082024 WO2017186121A1 (zh) 2016-04-26 2017-04-26 一种改善免疫应答细胞功能的方法

Publications (1)

Publication Number Publication Date
CL2019000061A1 true CL2019000061A1 (es) 2019-05-03

Family

ID=60912336

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019000061A CL2019000061A1 (es) 2016-07-08 2019-01-08 Anticuerpo para anti-claudin 18a2 y su utilización.

Country Status (13)

Country Link
US (2) US11111295B2 (es)
EP (1) EP3483182B1 (es)
JP (1) JP7587921B2 (es)
KR (1) KR102723896B1 (es)
CN (1) CN109790222B (es)
AU (1) AU2017294276B2 (es)
BR (1) BR112019000327A8 (es)
CA (1) CA3030257A1 (es)
CL (1) CL2019000061A1 (es)
ES (1) ES2979068T3 (es)
IL (1) IL264144B2 (es)
SG (1) SG11201900171QA (es)
WO (1) WO2018006882A1 (es)

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* Cited by examiner, † Cited by third party
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US11111295B2 (en) * 2016-07-08 2021-09-07 Cafa Therapeutics Limited Antibody for anti-claudin 18A2 and use thereof
JP2021512875A (ja) 2018-02-02 2021-05-20 カースゲン セラピューティクス カンパニー リミテッドＣａｒｓｇｅｎ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｃｏ．， Ｌｔｄ． 細胞免疫療法の組み合わせ
IL276830B2 (en) 2018-03-08 2025-08-01 Phanes Therapeutics Inc Anti-claudin 18.2 antibodies and uses thereof
CN111989344A (zh) * 2018-03-09 2020-11-24 科济生物医药（上海）有限公司 用于治疗肿瘤的方法和组合物
AU2019235033A1 (en) * 2018-03-14 2020-07-30 Beijing Xuanyi Pharmasciences Co., Ltd. Anti-claudin 18.2 antibodies
WO2019210863A1 (zh) 2018-05-03 2019-11-07 科济生物医药（上海）有限公司 免疫效应细胞及其应用
CN112154204B (zh) 2018-05-15 2025-01-07 科济生物医药（上海）有限公司 基因工程化的细胞及应用
EP3794037A4 (en) 2018-05-18 2022-03-02 Lanova Medicines Limited Company ANTI-CLAUDIN 18.2 ANTIBODIES AND USES THEREOF
US20210292427A1 (en) 2018-07-24 2021-09-23 Cafa Therapeutics Limited Method for treating tumor using immune effector cell
CN112770723B (zh) * 2018-07-25 2024-08-02 阿克罗斯生物科学公司 Cldn 18.2特异性单克隆抗体及其使用方法
CN110857322A (zh) * 2018-08-22 2020-03-03 瑞阳(苏州)生物科技有限公司 抗人claudin 18.2单克隆抗体及其应用
TW202023613A (zh) * 2018-08-27 2020-07-01 大陸商南京聖和藥業股份有限公司 一種抗Claudin18_2抗體及其應用
CN109206524B (zh) * 2018-09-25 2022-04-05 山东兴瑞生物科技有限公司 抗Claudin18A2嵌合抗原受体、其修饰的T细胞及T细胞制备方法和用途
WO2020063988A1 (zh) * 2018-09-30 2020-04-02 科济生物医药（上海）有限公司 Cldn18的抗体和化疗药物的联合治疗
KR20210100655A (ko) * 2018-12-07 2021-08-17 제트엘아이피 홀딩 리미티드 항-클라우딘 항체 및 이의 용도
US20230158071A1 (en) 2018-12-07 2023-05-25 Crage Medical Co., Limited Tumor combined immunotherapy
CN113166246B (zh) * 2018-12-28 2024-10-18 四川科伦博泰生物医药股份有限公司 一种抗体及其用途
EP3902839A4 (en) 2018-12-28 2022-12-14 Nanjing GenScript Biotech Co., Ltd. 18.2 CLAUDINE BINDING FRACTIONS AND THEIR USES
US20220152101A1 (en) 2019-01-07 2022-05-19 Carsgen Therapeutics Co., Ltd. Cellular immunotherapy combination
CN116333141B (zh) * 2019-01-15 2025-10-03 浙江道尔生物科技有限公司 抗cld18a2纳米抗体及其应用
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