[go: up one dir, main page]

CL2018002591A1 - Peptides and combination of peptides for use in immunotherapy against amicrocytic lung cancer and other types of cancer - Google Patents

Peptides and combination of peptides for use in immunotherapy against amicrocytic lung cancer and other types of cancer

Info

Publication number
CL2018002591A1
CL2018002591A1 CL2018002591A CL2018002591A CL2018002591A1 CL 2018002591 A1 CL2018002591 A1 CL 2018002591A1 CL 2018002591 A CL2018002591 A CL 2018002591A CL 2018002591 A CL2018002591 A CL 2018002591A CL 2018002591 A1 CL2018002591 A1 CL 2018002591A1
Authority
CL
Chile
Prior art keywords
peptides
cancer
combination
lymphocytes
invention refers
Prior art date
Application number
CL2018002591A
Other languages
Spanish (es)
Inventor
Toni Weinschenk
Andrea Mahr
Oliver Schoor
Original Assignee
Immatics Biotechnologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of CL2018002591A1 publication Critical patent/CL2018002591A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K40/4268—MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/46—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/39—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by a specific adjuvant, e.g. cytokines or CpG
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A PÉPTIDOS, PROTEÍNAS, ÁCIDOS NUCLEICOS Y CÉLULAS DESTINADOS A LA UTILIZACIÓN EN MÉTODOS INMUNOTERAPÉUTICOS. EN PARTICULAR, LA PRESEN-TE INVENCIÓN SE REFIERE A LA INMUNOTERAPIA CONTRA EL CÁNCER. LA PRESENTE INVENCIÓN SE REFIERE ASIMISMO A EPÍTOPOS PEPTÍDICOS PARA LINFOCITOS T ASOCIADOS A TUMORES, SO-LOS O EN COMBINACIÓN CON OTROS PÉPTIDOS ASOCIADOS A TUMORES QUE, POR EJEMPLO, PUEDEN SERVIR COMO PRINCIPIOS ACTIVOS FARMACÉUTICOS EN COMPOSICIONES VACUNALES DESTINADAS A ESTIMULAR RESPUESTAS INMUNITARIAS ANTITUMORALES, O A ESTIMULAR EX VIVO LINFOCITOS T QUE DESPUÉS SERÁN TRANSFERIDOS A LOS PACIENTES. LOS PÉPTIDOS UNIDOS A MOLÉCULAS DEL COMPLEJO MAYOR DE HISTOCOMPATIBILIDAD (MHC), O LOS PÉPTIDOS COMO TALES, TAMBIÉN PUEDEN SER DIANAS DE ANTICUERPOS, DE RECEPTORES DE LINFOCITOS T SOLU-BLES, Y DE OTRAS MOLÉCULAS DE UNIÓN.THIS INVENTION REFERS TO PEPTIDES, PROTEINS, NUCLEIC ACIDS AND CELLS INTENDED FOR USE IN IMMUNOTHERAPEUTIC METHODS. IN PARTICULAR, THE PRESENT INVENTION REFERS TO IMMUNOTHERAPY AGAINST CANCER. THE PRESENT INVENTION REFERS ALSO TO PEPTIDE EPITHOPES FOR LYMPHOCYTES ASSOCIATED WITH TUMORS, SO-THOSE OR IN COMBINATION WITH OTHER TUMOR-ASSOCIATED PEPTIDES THAT, FOR EXAMPLE, MAY SERVE AS AN INITIATIVE COMPARTMENT DIFFERENTIAL COMPARTMENTS. STIMULATE EX VIVO LYMPHOCYTES T WHEN THEY WILL BE TRANSFERRED TO PATIENTS. PEPTIDES UNITED TO MOLECULES OF THE MAJOR HISTOCOMPATIBILITY COMPLEX (MHC), OR PEPTIDES AS SUCH, MAY ALSO BE A TARGET OF ANTIBODIES, OF RECEPTORS OF T SOLU-BLES LYMPHOCYTES, AND OF OTHER MOLECULES.

CL2018002591A 2016-03-16 2018-09-11 Peptides and combination of peptides for use in immunotherapy against amicrocytic lung cancer and other types of cancer CL2018002591A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662308944P 2016-03-16 2016-03-16
GBGB1604458.8A GB201604458D0 (en) 2016-03-16 2016-03-16 Peptides and combination of peptides for use in immunotherapy against cancers

Publications (1)

Publication Number Publication Date
CL2018002591A1 true CL2018002591A1 (en) 2018-11-05

Family

ID=55952389

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2018002591A CL2018002591A1 (en) 2016-03-16 2018-09-11 Peptides and combination of peptides for use in immunotherapy against amicrocytic lung cancer and other types of cancer
CL2023001346A CL2023001346A1 (en) 2016-03-16 2023-05-10 Use of peptides in immunotherapy against small cell lung cancer and others.

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2023001346A CL2023001346A1 (en) 2016-03-16 2023-05-10 Use of peptides in immunotherapy against small cell lung cancer and others.

Country Status (34)

Country Link
US (4) US20170296641A1 (en)
EP (2) EP4180450A1 (en)
JP (2) JP2019515650A (en)
KR (3) KR20250127181A (en)
CN (1) CN108779149A (en)
AU (3) AU2017235364B2 (en)
BR (1) BR112018017022A2 (en)
CA (1) CA3016410A1 (en)
CL (2) CL2018002591A1 (en)
CO (1) CO2018010009A2 (en)
CR (1) CR20180491A (en)
DK (1) DK3430027T5 (en)
EA (1) EA201891701A1 (en)
ES (1) ES2965011T3 (en)
FI (1) FI3430027T3 (en)
GB (1) GB201604458D0 (en)
HR (1) HRP20231570T1 (en)
HU (1) HUE064592T2 (en)
IL (1) IL261785A (en)
LT (1) LT3430027T (en)
MA (2) MA43327A1 (en)
MD (1) MD3430027T2 (en)
MX (1) MX2018011215A (en)
MY (1) MY198565A (en)
NZ (1) NZ746979A (en)
PE (1) PE20181824A1 (en)
PH (1) PH12018501865B1 (en)
PL (1) PL3430027T3 (en)
PT (1) PT3430027T (en)
RS (1) RS64907B1 (en)
SG (2) SG11201806905UA (en)
SI (1) SI3430027T1 (en)
UA (1) UA128576C2 (en)
WO (1) WO2017157972A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201604458D0 (en) 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Peptides and combination of peptides for use in immunotherapy against cancers
DK3430030T5 (en) * 2016-03-16 2024-09-23 Immatics Biotechnologies Gmbh TRANSFECTED T CELLS AND T CELL RECEPTORS FOR USE IN IMMUNOTHERAPY AGAINST CANCER
GB201609193D0 (en) 2016-05-25 2016-07-06 Immatics Biotechnologies Gmbh Novel peptides, combination of peptides as targets for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers
JP7075125B2 (en) 2016-05-25 2022-05-25 イマティクス バイオテクノロジーズ ゲーエムベーハー A novel peptide, peptide combination as a target and for use in immunotherapy for gallbladder cancer and cholangiocarcinoma and other cancers
DE102016123893A1 (en) 2016-12-08 2018-06-14 Immatics Biotechnologies Gmbh T cell receptors with improved binding
EP3539562A1 (en) 2018-03-12 2019-09-18 Eberhard Karls Universität Tübingen Medizinische Fakultät Immunotherapeutic peptides
DE102018108612A1 (en) * 2018-03-21 2019-09-26 Immatics US, Inc. METHOD FOR INCREASING PERSISTENCE OF ADOPTIVELY INFUNDED T CELLS
JP7677892B2 (en) * 2018-12-28 2025-05-15 エフ． ホフマン－ラ ロシュ アーゲー Peptide-MHC-I-Antibody Fusion Proteins for Therapeutic Use in Patients with Amplified Immune Responses - Patent application
TWI872076B (en) 2019-05-27 2025-02-11 美商英麥提克斯股份有限公司 Viral vectors and use thereof in adoptive cellular therapy
CA3142386A1 (en) 2019-06-06 2020-12-10 Immatics Biotechnologies Gmbh Sorting with counter selection using sequence similar peptides
KR20220038397A (en) * 2019-07-24 2022-03-28 리제너론 파아마슈티컬스, 인크. Chimeric antigen receptors with MAGE-A4 specificity and uses thereof
DE102019121007A1 (en) 2019-08-02 2021-02-04 Immatics Biotechnologies Gmbh Antigen binding proteins that specifically bind to MAGE-A
EP3827840A1 (en) 2019-11-29 2021-06-02 Academisch Ziekenhuis Leiden h.o.d.n. LUMC Teipp peptide variant and uses thereof
DE102021100038A1 (en) 2020-12-31 2022-06-30 Immatics US, Inc. MODIFIED CD8 POLYPEPTIDES, COMPOSITIONS AND METHODS OF USE THEREOF
MX2023007817A (en) 2020-12-31 2023-09-13 Immatics Us Inc Cd8 polypeptides, compositions, and methods of using thereof.
CN113667002B (en) * 2021-03-24 2023-03-28 深圳市新靶向生物科技有限公司 Antigenic peptide related to lung cancer driver gene mutation and application thereof
CN113087801B (en) * 2021-04-07 2022-07-05 深圳市核子基因科技有限公司 Kit for jointly detecting lung cancer by using nucleic acid and antibody
KR20240004937A (en) 2021-05-05 2024-01-11 이매틱스 바이오테크놀로지스 게엠베하 BMA031 antigen-binding polypeptide
CN114230636B (en) * 2021-11-12 2023-04-25 四川大学 A class of polypeptides and their applications, and medicines containing them
JP2025515604A (en) 2022-04-28 2025-05-20 イマティクス ユーエス，アイエヌシー． Dominant negative TGF beta receptor polypeptides, CD8 polypeptides, cells, compositions, and methods of use thereof
CA3250304A1 (en) 2022-04-28 2023-11-02 Immatics US, Inc. Membrane-bound il-15, cd8 polypeptides, cells, compositions, and methods of using thereof
WO2023212655A1 (en) 2022-04-28 2023-11-02 Immatics US, Inc. Il-12 polypeptides, il-15 polypeptides, il-18 polypeptides, cd8 polypeptides, compositions, and methods of using thereof
EP4519418A1 (en) 2022-05-05 2025-03-12 Immatics US, Inc. Methods for improving t cell efficacy
CN115785208B (en) * 2022-06-10 2024-07-12 河北博海生物工程开发有限公司 Lung cancer specific molecular target 01 and application thereof
CN115785207B (en) * 2022-06-10 2024-08-30 河北博海生物工程开发有限公司 Lung cancer specific molecular target 02 and application thereof
CN115894575B (en) * 2022-08-10 2024-11-19 河南大学 Polyoxometallate material constructed by non-classical three-layer cage-shaped clusters, and preparation method and application thereof
WO2024077601A1 (en) * 2022-10-14 2024-04-18 Guangdong Tcrcure Biopharma Technology Co., Ltd. Peptide vaccines against glioma and uses thereof
WO2025096649A1 (en) 2023-11-01 2025-05-08 Immatics US, Inc. Membrane-bound il-15, cd8 polypeptides, cells, compositions, and methods of using thereof
WO2025233432A1 (en) * 2024-05-07 2025-11-13 Immatics Biotechnologies Gmbh Use and dosage of an antigen-binding protein comprising a tcr specific for an hla-a*02 restricted peptide

Family Cites Families (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179338A (en) 1977-09-19 1979-12-18 Gordon Maurice R Microbiological medium suitable for sterilization by ionizing radiation
JPS6023084B2 (en) 1979-07-11 1985-06-05 味の素株式会社 blood substitute
WO1981001145A1 (en) 1979-10-18 1981-04-30 Univ Illinois Hydrolytic enzyme-activatible pro-drugs
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
EP0206448B1 (en) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
AU597574B2 (en) 1986-03-07 1990-06-07 Massachusetts Institute Of Technology Method for enhancing glycoprotein stability
US4861719A (en) 1986-04-25 1989-08-29 Fred Hutchinson Cancer Research Center DNA constructs for retrovirus packaging cell lines
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
GB8705477D0 (en) 1987-03-09 1987-04-15 Carlton Med Prod Drug delivery systems
DE3883899T3 (en) 1987-03-18 1999-04-22 Sb2, Inc., Danville, Calif. CHANGED ANTIBODIES.
US4975278A (en) 1988-02-26 1990-12-04 Bristol-Myers Company Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
US5202238A (en) 1987-10-27 1993-04-13 Oncogen Production of chimeric antibodies by homologous recombination
US5204244A (en) 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
US5278056A (en) 1988-02-05 1994-01-11 The Trustees Of Columbia University In The City Of New York Retroviral packaging cell lines and process of using same
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US5670488A (en) 1992-12-03 1997-09-23 Genzyme Corporation Adenovirus vector for gene therapy
PL174494B1 (en) 1992-11-13 1998-08-31 Idec Pharma Corp Therapeutic application of chimeric and radiotracer labelled antibodies, directed against the differentation antigen limited to human lymphocytes b, for treating lymphoma from lymphocytes b
WO1994019478A1 (en) 1993-02-22 1994-09-01 The Rockefeller University Production of high titer helper-free retroviruses by transient transfection
FR2712812B1 (en) 1993-11-23 1996-02-09 Centre Nat Rech Scient Composition for the production of therapeutic products in vivo.
IL116816A (en) 1995-01-20 2003-05-29 Rhone Poulenc Rorer Sa Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
CA2205007C (en) 1995-09-11 2010-12-14 Masamichi Koike Antibody against human interleukin-5 receptor .alpha. chain
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
ES2203782T3 (en) 1996-01-17 2004-04-16 Imperial College Innovations Limited IMMUNOTHERAPY THAT USES CYTOTOXIC T LYMPHOCYTES (CTL).
WO2000052163A1 (en) 1999-03-02 2000-09-08 Ludwig Institute For Cancer Research Cloning of cdna of mage's 5, 8, 9 and 11 and their uses in diagnosis of cancer
ATE411522T1 (en) 1999-12-06 2008-10-15 Univ Illinois HIGH-AFFFINE T-CELL RECEPTOR PROTEINS AND METHODS
CA2393730A1 (en) * 1999-12-13 2001-06-14 Epimmune Inc. Hla class i a2 tumor associated antigen peptides and vaccine compositions
JP4900884B2 (en) * 2000-07-31 2012-03-21 株式会社グリーンペプタイド Tumor antigen
AU2002257647A1 (en) 2001-03-09 2002-09-24 Callistogen Ag Induction of anti-tumor cytotoxic t-lymphocytes in humans using peptide epitopes found by computer based algorithms for vaccination
US6833441B2 (en) 2001-08-01 2004-12-21 Abmaxis, Inc. Compositions and methods for generating chimeric heteromultimers
CA2481304A1 (en) 2002-03-27 2003-10-09 Patrick Hwu Method for treating cancer in humans
DE10225139A1 (en) 2002-05-29 2004-02-26 Immatics Biotechnologies Gmbh Methods for the identification of immunoreactive peptides
WO2004044004A2 (en) 2002-11-09 2004-05-27 Avidex Limited T cell receptor display
GB0308731D0 (en) 2003-04-15 2003-05-21 Anticancer Therapeutic Inv Sa Method of radiotherapy
US7807392B1 (en) 2003-09-15 2010-10-05 Celera Corporation Lung disease targets and uses thereof
US7811828B2 (en) 2004-01-28 2010-10-12 Immatics Biotechnologies Gmbh Method for identifying and quantifying of tumuor-associated
MX2007010349A (en) 2005-02-24 2008-04-09 Cemines Inc Compositions and methods for classifying biological samples.
US9963510B2 (en) 2005-04-15 2018-05-08 Macrogenics, Inc. Covalent diabodies and uses thereof
EP1806359B1 (en) 2005-09-05 2010-03-17 Immatics Biotechnologies GmbH Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules
CN101287831B (en) 2005-09-13 2013-05-15 国立大学法人三重大学 T cell receptor and nucleic acid encoding the receptor
WO2008053573A1 (en) 2006-10-30 2008-05-08 National University Corporation Hokkaido University Remedy for malignant neoplasm
EA018456B1 (en) 2007-07-27 2013-08-30 Имматикс Байотекнолоджиз Гмбх NEW IMMUNOGENIC EPITOPES FOR IMMUNOTHERAPY
TR201807983T4 (en) 2007-08-29 2018-06-21 Sanofi Sa Humanized anti-CXCR5 antibodies, derivatives and uses.
KR101922788B1 (en) 2007-09-26 2018-11-27 추가이 세이야쿠 가부시키가이샤 Modified antibody constant region
US8603810B2 (en) 2008-05-09 2013-12-10 Agency For Science, Technology And Research T-cell having a T-cell receptor that recognizes epitope HBC18-27 of hepatitis B viral core antigen
SI2119726T2 (en) 2008-05-14 2018-03-30 Immatics Biotechnologies Gmbh Novel and powerful MHC-class II peptides derived from survivin and neurocan
TW201008574A (en) * 2008-08-19 2010-03-01 Oncotherapy Science Inc INHBB epitope peptides and vaccines containing the same
WO2010037395A2 (en) 2008-10-01 2010-04-08 Dako Denmark A/S Mhc multimers in cancer vaccines and immune monitoring
US9840695B2 (en) 2009-04-28 2017-12-12 Agriculture Victoria Services Pty Ltd Plant technology
EP2258719A1 (en) 2009-05-19 2010-12-08 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Multiple target T cell receptor
GB0917094D0 (en) 2009-09-29 2009-11-11 Ucl Biomedica Plc T-cell receptor
CA2777053A1 (en) 2009-10-06 2011-04-14 The Board Of Trustees Of The University Of Illinois Human single-chain t cell receptors
WO2011066265A1 (en) * 2009-11-25 2011-06-03 Ludwig Institute For Cancer Research Ltd. Cancer testis antigens as biomarkers in non-small cell lung cancer
GB201004551D0 (en) * 2010-03-19 2010-05-05 Immatics Biotechnologies Gmbh NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer
GB201006360D0 (en) 2010-04-16 2010-06-02 Immatics Biotechnologies Gmbh Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development
US9114100B2 (en) 2010-05-17 2015-08-25 Duke University Methods of treatment using ex vivo expansion of cord blood T cells
CN101870725B (en) * 2010-06-29 2012-06-27 郑州大学 MAGE (Melanoma Antigen Gene)-4 anti-tumor CTL (Cytotoxic T Lymphocyte) epitope peptide and application thereof
CA3071740C (en) 2010-09-20 2020-09-08 Biontech Ag Antigen-specific t cell receptors and t cell epitopes
TWI622597B (en) 2011-03-28 2018-05-01 賽諾菲公司 Dual variable region antibody binding protein with cross-binding domain orientation
US20130078250A1 (en) 2011-08-23 2013-03-28 Oliver Ast Bispecific t cell activating antigen binding molecules
CA2847332A1 (en) * 2011-08-31 2013-03-07 Mie University Vaccine preparation for cancer treatment
WO2013057596A1 (en) 2011-10-21 2013-04-25 Atena Srl Anatomic cushion accumulator for thermal treatment with heat or cold
EP2660250B1 (en) 2012-05-02 2018-11-14 Deutsches Rheuma-Forschungszentrum Berlin Tcr transgenic mouse model for immune disease
KR102499753B1 (en) 2012-07-27 2023-02-16 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 Engineering t-cell receptors
ES2925307T3 (en) 2012-09-14 2022-10-14 Us Health T cell receptors that recognize MHC class II restricted MAGE-A3
JOP20200236A1 (en) 2012-09-21 2017-06-16 Regeneron Pharma Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof
GB2508414A (en) 2012-11-30 2014-06-04 Max Delbrueck Centrum Tumour specific T cell receptors (TCRs)
SI2968520T1 (en) 2013-03-14 2022-01-31 Macrogenics, Inc. Bispecific molecules that are immunoreactive with immune effector cells expressing the activation receptor
EP2970484B2 (en) 2013-03-15 2022-09-21 Amgen Inc. Heterodimeric bispecific antibodies
JP6346266B2 (en) 2013-03-21 2018-06-20 サンガモ セラピューティクス， インコーポレイテッド Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
JP6549564B2 (en) 2013-06-26 2019-07-24 グアンドン シャンスエ ライフ サイエンス， リミテッド． Highly stable T cell receptor and its preparation and use
TWI777196B (en) 2013-08-05 2022-09-11 德商伊瑪提克斯生物科技有限公司 Novel peptides, cells, and their use against several tumors, methods for production thereof and pharmaceutical composition comprising the same
GB201319446D0 (en) 2013-11-04 2013-12-18 Immatics Biotechnologies Gmbh Personalized immunotherapy against several neuronal and brain tumors
US11203783B2 (en) 2013-11-21 2021-12-21 Repertoire Genesis Incorporation T cell receptor and B cell receptor repertoire analysis system, and use of same in treatment and diagnosis
HRP20240939T1 (en) 2013-12-17 2024-10-25 Genentech, Inc. Anti-cd3 antibodies and methods of use
US10202640B2 (en) 2014-05-07 2019-02-12 The Board Of Trustees Of The Leland Stanford Junior University Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing
GB201408255D0 (en) 2014-05-09 2014-06-25 Immatics Biotechnologies Gmbh Novel immunotherapy against several tumours of the blood, such as acute myeloid leukemia (AML)
WO2015172843A1 (en) * 2014-05-16 2015-11-19 Biontech Diagnostics Gmbh Methods and kits for the diagnosis of cancer
EP2985294A1 (en) 2014-08-14 2016-02-17 Deutsches Krebsforschungszentrum Recombinant antibody molecule and its use for target cell restricted T cell activation
US10973894B2 (en) * 2014-10-02 2021-04-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Methods of isolating T cells having antigenic specificity for a cancer-specific mutation
US20190030071A1 (en) 2014-11-03 2019-01-31 IMMURES S.r.I. T cell receptors
GB201423361D0 (en) 2014-12-30 2015-02-11 Immatics Biotechnologies Gmbh Method for the absolute Quantification of naturally processed HLA-Restricted cancer peptides
KR102680151B1 (en) 2015-01-23 2024-07-03 사노피 Anti-CD3 antibodies, anti-CD123 antibodies, and bispecific antibodies that specifically bind to CD3 and/or CD123
EP3067366A1 (en) 2015-03-13 2016-09-14 Max-Delbrück-Centrum Für Molekulare Medizin Combined T cell receptor gene therapy of cancer against MHC I and MHC II-restricted epitopes of the tumor antigen NY-ESO-1
GB201505305D0 (en) 2015-03-27 2015-05-13 Immatics Biotechnologies Gmbh Novel Peptides and combination of peptides for use in immunotherapy against various tumors
GB201506642D0 (en) 2015-04-20 2015-06-03 Ucl Business Plc T cell receptor
EA202090931A3 (en) 2015-05-18 2020-10-30 Тср2 Терапьютикс Инк. COMPOSITIONS AND METHODS FOR TCR REPROGRAMMING WITH HYBRID PROTEINS
EP3095792A1 (en) 2015-05-19 2016-11-23 Klinikum rechts der Isar der Technischen Universität München T cell receptor with specificity for myeloperoxidase peptide and uses thereof
CN105219719A (en) * 2015-10-20 2016-01-06 上海隆耀生物科技有限公司 A kind of test kit for activating ovarian cancer specific immune response
CN105219714A (en) * 2015-10-20 2016-01-06 上海隆耀生物科技有限公司 A kind of test kit for activating lung cancer specific immune response
MX2018004721A (en) 2015-10-23 2018-07-06 Eureka Therapeutics Inc CHEMICAL CONSTRUCTIONS ANTIBODY / T-CELL RECEIVER AND USES OF THE SAME.
GB201522592D0 (en) 2015-12-22 2016-02-03 Immunocore Ltd T cell receptors
DK3430030T5 (en) 2016-03-16 2024-09-23 Immatics Biotechnologies Gmbh TRANSFECTED T CELLS AND T CELL RECEPTORS FOR USE IN IMMUNOTHERAPY AGAINST CANCER
GB201604458D0 (en) 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Peptides and combination of peptides for use in immunotherapy against cancers
GB201604492D0 (en) 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Transfected t-cells and t-cell receptors for use in immunotherapy against cancers
WO2017180587A2 (en) 2016-04-11 2017-10-19 Obsidian Therapeutics, Inc. Regulated biocircuit systems
JP7109789B2 (en) 2016-08-02 2022-08-01 ティーシーアール２ セラピューティクス インク． Compositions and methods for TCR reprogramming using fusion proteins
WO2018026018A1 (en) 2016-08-05 2018-02-08 国立大学法人東北大学 Treatment and diagnosis of cancer or infectious disease using recognition mechanism of t cell receptor
GB201617716D0 (en) 2016-10-19 2016-11-30 Ucl Business Plc Cell
GB201617714D0 (en) 2016-10-19 2016-11-30 Ucl Business Plc T Cell receptor
DE102016121899A1 (en) 2016-11-15 2018-05-17 Immatics Biotechnologies Gmbh Process for the preparation of electrocompetent yeast cells and methods of using these cells
DE102016123893A1 (en) 2016-12-08 2018-06-14 Immatics Biotechnologies Gmbh T cell receptors with improved binding
CA3066932A1 (en) 2017-07-04 2019-01-10 Curevac Ag Novel nucleic acid molecules
PT3652215T (en) 2017-07-14 2021-05-18 Immatics Biotechnologies Gmbh Improved dual specificity polypeptide molecule
US20210147550A1 (en) 2017-08-18 2021-05-20 Joshua Michael Francis Antigen-binding proteins targeting shared antigens
CN111315769A (en) 2017-09-06 2020-06-19 加州理工学院 Dual-function receptor for signaling and antigen presentation (SABR)
CN118256563A (en) 2017-11-10 2024-06-28 北京卡替医疗技术有限公司 Method for amplifying immune cells
DE102017127984B4 (en) 2017-11-27 2019-12-05 Immatics US, Inc. Method for the propagation and activation of γδ T cells
CN120818057A (en) 2017-12-28 2025-10-21 磨石生物公司 Antigen binding proteins targeting common antigens
DE102018100967B4 (en) 2018-01-17 2019-08-14 Immatics US, Inc. METHOD FOR DETERMINING THE EFFECTIVENESS OF VIRAL VECTORS
WO2019151392A1 (en) 2018-01-31 2019-08-08 国立大学法人東北大学 Method for regulating antigen-specific mhc expression
AU2019218093A1 (en) 2018-02-09 2020-09-10 Immatics US, Inc. Methods for manufacturing T cells
DE102018108612A1 (en) 2018-03-21 2019-09-26 Immatics US, Inc. METHOD FOR INCREASING PERSISTENCE OF ADOPTIVELY INFUNDED T CELLS
RS63873B1 (en) 2018-04-11 2023-02-28 Enterome S A Antigenic peptides for prevention and treatment of cancer
KR20210010896A (en) 2018-05-14 2021-01-28 이뮤노코어 리미티드 Bifunctional binding polypeptide
EP3796923A4 (en) 2018-05-18 2022-03-09 Children's National Medical Center TARGETED THERAPY ENHANCED BY T LYMPHOCYTES
CN112368386A (en) 2018-05-23 2021-02-12 磨石肿瘤生物技术公司 Consensus antigens
EP3802614A1 (en) 2018-06-04 2021-04-14 Apo-T B.V. Methods and means for attracting immune effector cells to tumor cells
GB201819540D0 (en) 2018-11-30 2019-01-16 Adaptimmune Ltd T cell modification
HRP20240176T1 (en) 2019-01-17 2024-04-12 Immunocore Limited FORMULATIONS
GB201901306D0 (en) 2019-01-30 2019-03-20 Immunocore Ltd Multi-domain binding molecules
BR112021022303A2 (en) 2019-05-08 2022-01-18 2Seventy Bio Inc manipulated t cells
CA3140142A1 (en) 2019-05-21 2020-11-26 Novartis Ag Trispecific binding molecules against bcma and uses thereof
CN114585646B (en) 2019-06-18 2024-09-03 里珍纳龙药品有限公司 MAGE-A4 T cell receptor and methods of use thereof
GB201911286D0 (en) 2019-08-07 2019-09-18 Ucl Business Plc Method
WO2021073624A1 (en) 2019-10-17 2021-04-22 北京门罗生物科技有限公司 Chimeric antigen receptor for immunotherapy, preparation method therefor and use thereof
AU2021283960A1 (en) 2020-06-04 2023-02-02 Safeseal-Systems Self-sealing container
KR20240004937A (en) 2021-05-05 2024-01-11 이매틱스 바이오테크놀로지스 게엠베하 BMA031 antigen-binding polypeptide

Also Published As

Publication number Publication date
CO2018010009A2 (en) 2018-09-28
CA3016410A1 (en) 2017-09-21
KR20230004914A (en) 2023-01-06
AU2022287621B2 (en) 2024-08-15
AU2022202307A1 (en) 2022-04-28
JP2019515650A (en) 2019-06-13
SG11201806905UA (en) 2018-09-27
AU2022202307B2 (en) 2022-09-15
PH12018501865A1 (en) 2019-07-15
AU2017235364A1 (en) 2018-10-25
MD3430027T2 (en) 2024-03-31
CL2023001346A1 (en) 2023-10-06
MA43719B1 (en) 2023-11-30
US12168044B2 (en) 2024-12-17
GB201604458D0 (en) 2016-04-27
EP4180450A1 (en) 2023-05-17
JP2023055722A (en) 2023-04-18
IL261785A (en) 2018-10-31
DK3430027T5 (en) 2024-09-23
EP3430027B1 (en) 2023-09-13
US20200085930A1 (en) 2020-03-19
US20240100137A1 (en) 2024-03-28
WO2017157972A1 (en) 2017-09-21
PE20181824A1 (en) 2018-11-29
MA43327A1 (en) 2018-12-31
DK3430027T3 (en) 2023-12-04
EP3430027A1 (en) 2019-01-23
FI3430027T3 (en) 2023-11-29
ES2965011T3 (en) 2024-04-10
HUE064592T2 (en) 2024-03-28
CN108779149A (en) 2018-11-09
MA43719A (en) 2018-11-28
US20240123044A1 (en) 2024-04-18
MY198565A (en) 2023-09-05
LT3430027T (en) 2023-11-27
MX2018011215A (en) 2018-11-22
AU2022287621A1 (en) 2023-02-02
SI3430027T1 (en) 2024-01-31
EA201891701A1 (en) 2019-02-28
PL3430027T3 (en) 2024-03-04
HRP20231570T1 (en) 2024-03-15
KR20250127181A (en) 2025-08-26
PH12018501865B1 (en) 2024-01-24
KR20180121530A (en) 2018-11-07
RS64907B1 (en) 2023-12-29
CR20180491A (en) 2019-01-09
NZ746979A (en) 2025-03-28
UA128576C2 (en) 2024-08-21
US20170296641A1 (en) 2017-10-19
BR112018017022A2 (en) 2019-02-05
AU2017235364B2 (en) 2022-01-06
PT3430027T (en) 2023-12-15
SG10202006119TA (en) 2020-08-28

Similar Documents

Publication Publication Date Title
CL2018002591A1 (en) Peptides and combination of peptides for use in immunotherapy against amicrocytic lung cancer and other types of cancer
CL2018001531A1 (en) Peptides and combination of peptides for use in immunotherapy against breast cancer and other types of cancer
CL2018000324A1 (en) New peptides and new combinations of peptides for use in immunotherapy against prostate cancer and other types of cancer
CL2018002508A1 (en) Treatments against uterine cancer
CL2018001532A1 (en) New peptides and new combinations of peptides for use in immunotherapy against chronic lymphocytic leukemia (llc) and other cancers
CL2017003362A1 (en) New peptides and new combinations of peptides for use in immunotherapy against ovarian cancer and other types of cancer
CL2017003235A1 (en) New peptides and new combinations of peptides for use in immunotherapy and methods for creating supports for use against pancreatic cancer and other types of cancer
CL2019002093A1 (en) New peptides and new peptide combinations for use in immunotherapy against ovarian and other cancers.
CL2019003313A1 (en) New peptides (seq id no: 128) and new peptide combinations for use in immunotherapy against epithelial ovarian cancer and other cancers. (divisional request 201800124)
CL2018003293A1 (en) New peptides and new combination of peptides as targets and for use in immunotherapy against gallbladder cancer and cholangiocarcinoma, as well as other types of cancer.
CL2017001391A1 (en) New peptides and new combination of peptides for use in immunotherapy against hepatocellular carcinoma (chc) and other cancers
CL2019002880A1 (en) Peptides and combinations thereof for use in immunotherapy against various types of cancer.
CL2018002113A1 (en) New peptides, combinations of peptides and supports for use in the immunotherapeutic treatment of various types of cancer (divisional application 201800545)
MX2022005060A (en) Novel peptides and combination of peptides for use in immunotherapy against lung cancer, including nsclc and other cancers.
CR20200515A (en) Peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers
CL2018002610A1 (en) Transfected T lymphocytes and T lymphocyte receptors for use in cancer immunotherapy
CR20200561A (en) Novel peptides and combination of peptides for use in immunotherapy against nhl and other cancers
CR20210234A (en) Novel peptides and combination of peptides for use in immunotherapy against pancreatic cancer and other cancers
CL2018002969A1 (en) Immunotherapy against melanoma and other types of cancer
CL2020000020A1 (en) New peptides and new peptide combinations for use in immunotherapy against lung cancer, including nsclc, sclc, and other cancers.
CL2019002878A1 (en) Peptides and peptide combinations for use in immunotherapy against leukemia and other cancers.
CL2018002427A1 (en) Peptides and combination of peptides for the use of immunotherapy against pancreatic cancer and other types of cancer. (divisional application 201702346)
CL2018001533A1 (en) New peptides and combination of peptides for use in immunotherapy against various types of cancer
CL2023001324A1 (en) Peptides, combinations, cells for immunotherapy against bladder cancer and other cancers
MX2022002263A (en) NEW PEPTIDES AND NEW COMBINATIONS OF PEPTIDES AND SUPPORTS FOR USE IN IMMUNOTHERAPY AGAINST COLORECTAL CARCINOMA AND OTHER TYPES OF CANCER.