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Publication of CL2017003003A1publicationCriticalpatent/CL2017003003A1/en
Medicines Containing Material From Animals Or Micro-Organisms
(AREA)
Abstract
<p>La presente invención divulga un procedimiento para la quimerización de órganos y tejidos mediante tratamiento celular, mediante el cual, se evita el rechazo de órganos trasplantados y se disminuye o suspende el uso de drogas Inmunosupresoras en pacientes sometidos a procedimientos de trasplante. El procedimiento de la invención involucra un tratamiento de células de médula ósea mediante el cual se logra la quimerización del órgano donado. El procedimiento divulga el lavado del órgano que remueve células sanguíneas del donante y, posteriormente, el cultivo del órgano en presencia de células madre de médula ósea del receptor, mediante un medio de cultivo provisto de nutrientes vitales y factores de crecimiento, para posteriormente trasplantarlo en el paciente receptor.</p><p> The present invention discloses a procedure for the chimerization of organs and tissues by cellular treatment, whereby the rejection of transplanted organs is avoided and the use of immunosuppressive drugs in patients undergoing transplant procedures is decreased or suspended. The process of the invention involves a treatment of bone marrow cells by which chimerization of the donated organ is achieved. The procedure discloses the washing of the organ that removes donor blood cells and, subsequently, the culture of the organ in the presence of bone marrow stem cells of the recipient, by means of a culture medium provided with vital nutrients and growth factors, to subsequently transplant it into the receiving patient. </p>
CL2017003003A2016-12-012017-11-27
Procedure for organ chimerization by cellular treatment
CL2017003003A1
(en)
Modified pluripotent cells or a cell derived therefrom, method of transplanting a cell, method of treating a disease in a patient in need of transplanted cells, method of generating a modified pluripotent cell, method of generating a hypoimmunogenic pluripotent cell, and method of transplantation of a hypoimmunogenic pluripotent cell (hyp) or cell derived therefrom
Tissue transplantation involving, and tissues modified by decellularization and recellularization of donor tissues for minimized or obviated rejection reactions.