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CL2017002199A1 - Vectores retrovirales a lentivirales - Google Patents

Vectores retrovirales a lentivirales

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Publication number
CL2017002199A1
CL2017002199A1 CL2017002199A CL2017002199A CL2017002199A1 CL 2017002199 A1 CL2017002199 A1 CL 2017002199A1 CL 2017002199 A CL2017002199 A CL 2017002199A CL 2017002199 A CL2017002199 A CL 2017002199A CL 2017002199 A1 CL2017002199 A1 CL 2017002199A1
Authority
CL
Chile
Prior art keywords
transmembrane
cell activating
mitogenic
protein
domain
Prior art date
Application number
CL2017002199A
Other languages
English (en)
Inventor
Martin Pulé
Leila Mekkaoui
Original Assignee
Ucl Business Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52876362&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2017002199(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ucl Business Plc filed Critical Ucl Business Plc
Publication of CL2017002199A1 publication Critical patent/CL2017002199A1/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K35/76—Viruses; Subviral particles; Bacteriophages
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
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    • C12N2740/10011—Retroviridae
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    • C12N2740/16011—Human Immunodeficiency Virus, HIV
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    • C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
    • C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
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    • C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
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    • C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
    • C12N2810/859—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from immunoglobulins

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Abstract

<p>La presente invención proporciona un vector retroviral o lentiviral que tiene una envoltura viral que comprende: (i) una proteína transmembranal mitogénica activadora de células T que comprende un dominio mitogénico y un dominio transmembranal; y/o (ii) una proteína transmembranal basada en citocinas activadora de células T que comprende un dominio de citocina y un dominio transmembranal, en donde la proteína transmembranal mitogénica o basada en citocinas activadora de células T no forma parte de una glucoproteína de envoltura viral. Cuando células tales como células T o células asesinas naturales, se transducen por un vector viral, éstas se activan en forma simultánea por la proteína transmembranal mitogénica activadora de células T y/o la proteína transmembranal basada en citocinas activadora de células T.</p>
CL2017002199A 2015-03-02 2017-08-30 Vectores retrovirales a lentivirales CL2017002199A1 (es)

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GB201503500A GB201503500D0 (en) 2015-03-02 2015-03-02 Cell

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CL2017002199A1 true CL2017002199A1 (es) 2018-03-16

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CL2017002199A CL2017002199A1 (es) 2015-03-02 2017-08-30 Vectores retrovirales a lentivirales

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US (3) US10954530B2 (es)
EP (2) EP3904523A1 (es)
JP (3) JP6695347B2 (es)
KR (1) KR20180002602A (es)
CN (1) CN107406860A (es)
AU (1) AU2016227474A1 (es)
BR (1) BR112017018251A2 (es)
CA (1) CA2977472A1 (es)
CL (1) CL2017002199A1 (es)
ES (1) ES2877398T5 (es)
GB (1) GB201503500D0 (es)
IL (1) IL253820B (es)
MX (1) MX2017010553A (es)
RU (1) RU2017133854A (es)
SG (1) SG11201706721PA (es)
WO (1) WO2016139463A1 (es)

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KR101697473B1 (ko) 2014-11-26 2017-01-18 주식회사 녹십자랩셀 T 세포를 이용한 자연살해세포의 배양방법
LT3288573T (lt) 2015-04-30 2020-03-25 Psioxus Therapeutics Limited Onkolitinis adenovirusas, koduojantis b7 baltymą
US10046317B2 (en) * 2015-08-11 2018-08-14 Chevron U.S.A. Inc. Middle distillate hydrocracking catalyst containing zeolite beta with low OD acidity and large domain size
JP7195141B2 (ja) 2015-10-22 2022-12-23 ジュノ セラピューティクス ゲーエムベーハー 形質導入のための方法、キット、作用物質および装置
CN108697745A (zh) 2015-12-17 2018-10-23 皮斯奥克斯治疗公司 编码抗tcr复合体抗体或片段的b组腺病毒
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US11325948B2 (en) 2016-03-19 2022-05-10 Exuma Biotech Corp. Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL
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