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CL2017001842A1 - Método para fabricar un conjugado inmunogenico que comprende polisacarido de streptococcus pneumoniae serotipo 3 enlazado en forma covalente a una proteína portadora (divisional de solicitud n°3782-2007). - Google Patents

Método para fabricar un conjugado inmunogenico que comprende polisacarido de streptococcus pneumoniae serotipo 3 enlazado en forma covalente a una proteína portadora (divisional de solicitud n°3782-2007).

Info

Publication number
CL2017001842A1
CL2017001842A1 CL2017001842A CL2017001842A CL2017001842A1 CL 2017001842 A1 CL2017001842 A1 CL 2017001842A1 CL 2017001842 A CL2017001842 A CL 2017001842A CL 2017001842 A CL2017001842 A CL 2017001842A CL 2017001842 A1 CL2017001842 A1 CL 2017001842A1
Authority
CL
Chile
Prior art keywords
streptococcus pneumoniae
carrier protein
polysaccharide
covalently linked
manufacturing
Prior art date
Application number
CL2017001842A
Other languages
English (en)
Inventor
William P Hausdorff
George Rainer Siber
Peter R Paradiso
A Krishna Prasad
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39876611&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2017001842(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of CL2017001842A1 publication Critical patent/CL2017001842A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dry Formation Of Fiberboard And The Like (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

<p>Se describe una composición inmunogénica que tiene 13 conjugados distintos polisacérido-proteina y opcionalmente un adyuvante basado en aluminio. Cada conjugado contiene un pohsacárido capsular preparado a partir de un serotipo diferente de Streptococcus pneumoniae (1, 3, 4, 5, 6A, 66, 7F, 9V, 14, 18C, 19F y 23F) conjugado a una proteina portadora. La composición inmunogenica preparada como una vacuna aumenta la cobertura contra Ia enfermedad neumococal en infantes y nifios de poca edad globalmente y proporciona cobertura para serotipos 6A y 19A que no dependen de las limitaciones de protección cruzada de serogrupo. Se describe también un método para fabricar un conjugado inmunogenico que comprende polisacárido serotipo 3 de Streptococcus pneumoiae enlazado en forma covalente a una proteina portadora; el método incluye Ia oxidación de ácido periódico del polisacárido en presencia de cationes bivalentes.</p>
CL2017001842A 2006-12-22 2017-07-14 Método para fabricar un conjugado inmunogenico que comprende polisacarido de streptococcus pneumoniae serotipo 3 enlazado en forma covalente a una proteína portadora (divisional de solicitud n°3782-2007). CL2017001842A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/644,924 US7709001B2 (en) 2005-04-08 2006-12-22 Multivalent pneumococcal polysaccharide-protein conjugate composition

Publications (1)

Publication Number Publication Date
CL2017001842A1 true CL2017001842A1 (es) 2018-05-04

Family

ID=39876611

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2007003782A CL2007003782A1 (es) 2006-12-22 2007-12-21 Metodo para fabricar un conjugado inmunogenico que comprende polisacarido de streptococcus pneumoniae serotipo 3 enlazado en forma covalente a una proteina portadora.
CL2017001842A CL2017001842A1 (es) 2006-12-22 2017-07-14 Método para fabricar un conjugado inmunogenico que comprende polisacarido de streptococcus pneumoniae serotipo 3 enlazado en forma covalente a una proteína portadora (divisional de solicitud n°3782-2007).

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2007003782A CL2007003782A1 (es) 2006-12-22 2007-12-21 Metodo para fabricar un conjugado inmunogenico que comprende polisacarido de streptococcus pneumoniae serotipo 3 enlazado en forma covalente a una proteina portadora.

Country Status (20)

Country Link
US (2) US7709001B2 (es)
EP (2) EP2417983B1 (es)
JP (1) JP5523836B2 (es)
KR (3) KR101700837B1 (es)
CN (2) CN103599529B (es)
AT (1) ATE545431T1 (es)
AU (1) AU2007353769B2 (es)
BR (1) BRPI0720624A2 (es)
CA (1) CA2673477C (es)
CL (2) CL2007003782A1 (es)
DK (2) DK2417983T3 (es)
ES (2) ES2424940T3 (es)
IL (2) IL199350A (es)
MX (1) MX2009006705A (es)
PL (2) PL2094298T3 (es)
PT (2) PT2417983E (es)
RU (1) RU2493870C2 (es)
SI (2) SI2094298T1 (es)
WO (1) WO2008143709A2 (es)
ZA (1) ZA200904760B (es)

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