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CL2017001118A1 - Receptores quimericos de antígeno anti–cldn y métodos de uso - Google Patents

Receptores quimericos de antígeno anti–cldn y métodos de uso

Info

Publication number
CL2017001118A1
CL2017001118A1 CL2017001118A CL2017001118A CL2017001118A1 CL 2017001118 A1 CL2017001118 A1 CL 2017001118A1 CL 2017001118 A CL2017001118 A CL 2017001118A CL 2017001118 A CL2017001118 A CL 2017001118A CL 2017001118 A1 CL2017001118 A1 CL 2017001118A1
Authority
CL
Chile
Prior art keywords
methods
chimeric receptors
cldn
antigen chimeric
cldn antigen
Prior art date
Application number
CL2017001118A
Other languages
English (en)
Inventor
David Liu
Paul Anthony Escarpe
Scott J Dylla
Robert A Stull
Original Assignee
Abbvie Stemcentrx Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2014/064165 external-priority patent/WO2015069794A2/en
Application filed by Abbvie Stemcentrx Llc filed Critical Abbvie Stemcentrx Llc
Publication of CL2017001118A1 publication Critical patent/CL2017001118A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

<p>EN LA PRESENTE SE PROPORCIONAN NUEVOS RECEPTORES QUIMÉRICOS DE ANTÍGENO ANTI–CLDN Y MÉTODOS DE USO DE LOS MISMOS PARA TRATAR TRASTORNOS PROLIFERATIVOS.</p>
CL2017001118A 2014-11-05 2017-05-05 Receptores quimericos de antígeno anti–cldn y métodos de uso CL2017001118A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2014/064165 WO2015069794A2 (en) 2013-11-06 2014-11-05 Novel anti-claudin antibodies and methods of use
US201562157928P 2015-05-06 2015-05-06
US201562247108P 2015-10-27 2015-10-27

Publications (1)

Publication Number Publication Date
CL2017001118A1 true CL2017001118A1 (es) 2018-01-05

Family

ID=55909771

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017001118A CL2017001118A1 (es) 2014-11-05 2017-05-05 Receptores quimericos de antígeno anti–cldn y métodos de uso

Country Status (23)

Country Link
US (1) US20170334991A1 (es)
EP (1) EP3215523A4 (es)
JP (1) JP2017535283A (es)
KR (1) KR20170085531A (es)
CN (1) CN107207580A (es)
AU (1) AU2015343079A1 (es)
BR (1) BR112017009517A2 (es)
CA (1) CA2966618A1 (es)
CL (1) CL2017001118A1 (es)
CO (1) CO2017005538A2 (es)
CR (1) CR20170235A (es)
DO (1) DOP2017000110A (es)
EA (1) EA201790967A1 (es)
EC (1) ECSP17031725A (es)
IL (1) IL252090A0 (es)
MA (1) MA40921A (es)
MX (1) MX2017005797A (es)
PE (1) PE20171060A1 (es)
PH (1) PH12017500825A1 (es)
SG (1) SG11201703669YA (es)
TW (1) TW201625677A (es)
WO (1) WO2016073649A1 (es)
ZA (1) ZA201703471B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ595212A (en) 2009-03-30 2014-02-28 Eisai R&D Man Co Ltd Liposome composition
SG11201603397QA (en) * 2013-11-06 2016-05-30 Stemcentrx Inc Novel anti-claudin antibodies and methods of use
ES2952680T3 (es) 2016-04-28 2023-11-03 Eisai R&D Man Co Ltd Eribulina para inhibir el crecimiento tumoral
BR112019007145A2 (pt) * 2016-10-14 2019-07-02 Eisai R&D Man Co Ltd combinação de um antagonista de pd-1 e eribulina para o tratamento de câncer urotelial
EP3690038A4 (en) 2017-09-29 2021-05-19 Daiichi Sankyo Company, Limited ANTIBODY PYRROLOBENZODIACEPINE DERIVATIVE CONJUGATE
WO2020051562A2 (en) 2018-09-07 2020-03-12 Beam Therapeutics Inc. Compositions and methods for improving base editing
CA3112011A1 (en) 2018-09-07 2020-03-12 Beam Therapeutics Inc. Compositions and methods for delivering a nucleobase editing system
EP3892333A4 (en) * 2018-12-07 2022-11-30 CRAGE medical Co., Limited Tumor combined immunotherapy
JP2022524906A (ja) * 2019-01-07 2022-05-11 クレージュ メディカル カンパニー，リミテッド 細胞免疫療法の組み合わせ
SG11202108339TA (en) * 2019-02-08 2021-08-30 Biontech Cell & Gene Therapies Gmbh Chimeric antigen receptor-modified cells for the treatment of cldn6-expressing cancers
WO2020205759A1 (en) * 2019-03-29 2020-10-08 Pact Pharma, Inc. Personalized neoantigen-specific adoptive cell therapies
US12415853B2 (en) 2019-05-16 2025-09-16 Qilu Pharmaceutical Co., Ltd. Antibody against claudin 18A2 and use thereof
US12036204B2 (en) 2019-07-26 2024-07-16 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
WO2021129927A1 (en) * 2019-12-23 2021-07-01 Biontech Cell & Gene Therapies Gmbh Treatment with immune effector cells engineered to express an antigen receptor
CN113637082A (zh) * 2020-04-27 2021-11-12 启愈生物技术(上海)有限公司 一种靶向人claudin和人PDL1蛋白的双特异抗体及其应用
US20210347847A1 (en) * 2020-05-11 2021-11-11 The Broad Institute, Inc. Therapeutic targeting of malignant cells using tumor markers
TW202241935A (zh) 2020-12-18 2022-11-01 美商世紀治療股份有限公司 具有可調適受體專一性之嵌合抗原受體系統
KR20230154317A (ko) * 2021-03-05 2023-11-07 상하이 젠베이스 바이오테크놀로지 씨오., 엘티디. 항-cldn6 항체 및 이의 용도
CN114478802B (zh) * 2022-01-28 2023-05-26 郑州大学 一种嵌合抗原受体及其应用
CN115991770A (zh) * 2022-05-11 2023-04-21 迈威(上海)生物科技股份有限公司 抗人gas6抗体或其抗原结合片段及其应用
WO2024088325A1 (zh) * 2022-10-25 2024-05-02 科济生物医药（上海）有限公司 抗体及其应用
CN117169518B (zh) * 2023-11-03 2024-01-19 赛德特(北京)生物工程有限公司 T淋巴细胞制剂中的cd3抗体残留物的检测方法和试剂盒
WO2025209525A1 (zh) * 2024-04-03 2025-10-09 江苏恒瑞医药股份有限公司 抗cldn6抗体、其抗体-药物偶联物及其医药用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101074261A (zh) * 2006-04-30 2007-11-21 北京同为时代生物技术有限公司 Trail受体1和/或trail受体2特异性抗体及其应用
CN101951953A (zh) * 2007-02-27 2011-01-19 株式会社未来创药研究所 含抗grp78抗体作为有效成分的药物组合物
EP2241578B1 (en) * 2008-01-11 2016-04-20 The University of Tokyo Anti-cldn6 antibody
NZ734307A (en) * 2009-11-11 2020-05-29 Ganymed Pharmaceuticals Ag Antibodies specific for claudin 6 (cldn6)
EP2404936A1 (en) * 2010-07-06 2012-01-11 Ganymed Pharmaceuticals AG Cancer therapy using CLDN6 target-directed antibodies in vivo
ES2769574T3 (es) * 2013-03-15 2020-06-26 Michael C Milone Reconocimiento de células citotóxicas con receptores quiméricos para inmunoterapia adoptiva
SG11201603397QA (en) * 2013-11-06 2016-05-30 Stemcentrx Inc Novel anti-claudin antibodies and methods of use
ME03407B (me) * 2014-04-01 2020-01-20 Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh Klaudin-6 specifični imunoreceptori i t-ćelijsкi epitopi
WO2016180467A1 (en) * 2015-05-11 2016-11-17 Biontech Cell & Gene Therapies Gmbh Enhancing the effect of car-engineered t cells by means of nucleic acid vaccination
SG11201804673WA (en) * 2015-12-04 2018-06-28 Abbvie Stemcentrx Llc Novel anti-claudin antibodies and methods of use

Also Published As

Publication number Publication date
BR112017009517A2 (pt) 2017-12-19
PH12017500825A1 (en) 2017-10-18
WO2016073649A1 (en) 2016-05-12
US20170334991A1 (en) 2017-11-23
ZA201703471B (en) 2019-06-26
EP3215523A1 (en) 2017-09-13
AU2015343079A1 (en) 2017-05-25
DOP2017000110A (es) 2017-05-31
SG11201703669YA (en) 2017-06-29
CR20170235A (es) 2017-07-21
CA2966618A1 (en) 2016-05-12
TW201625677A (zh) 2016-07-16
EA201790967A1 (ru) 2017-10-31
EP3215523A4 (en) 2018-06-20
MA40921A (fr) 2017-09-12
MX2017005797A (es) 2017-10-23
CN107207580A (zh) 2017-09-26
IL252090A0 (en) 2017-07-31
CO2017005538A2 (es) 2017-10-10
KR20170085531A (ko) 2017-07-24
PE20171060A1 (es) 2017-07-21
JP2017535283A (ja) 2017-11-30
ECSP17031725A (es) 2017-06-30

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