[go: up one dir, main page]

CL2016000507A1 - Hidrogel que comprende los grupos 1, 2-diol o 1, 3-diol acetilados con una especie radiopaca; composición que comprende un hidrogel; método para realizar un polímero radiopaco; método para formar una microesfera de hidrogel radiopaca; y uso de hidrogel o composición. - Google Patents

Hidrogel que comprende los grupos 1, 2-diol o 1, 3-diol acetilados con una especie radiopaca; composición que comprende un hidrogel; método para realizar un polímero radiopaco; método para formar una microesfera de hidrogel radiopaca; y uso de hidrogel o composición.

Info

Publication number
CL2016000507A1
CL2016000507A1 CL2016000507A CL2016000507A CL2016000507A1 CL 2016000507 A1 CL2016000507 A1 CL 2016000507A1 CL 2016000507 A CL2016000507 A CL 2016000507A CL 2016000507 A CL2016000507 A CL 2016000507A CL 2016000507 A1 CL2016000507 A1 CL 2016000507A1
Authority
CL
Chile
Prior art keywords
hydrogel
radiopaque
composition
diol
making
Prior art date
Application number
CL2016000507A
Other languages
English (en)
Inventor
Stéphane Hohn
Andrew Lennard Lewis
Sean Leo Willis
Matthew R Dreher
Yiqing Tang
Koorosh Ashrafi
Original Assignee
Biocompatible Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocompatible Uk Ltd filed Critical Biocompatible Uk Ltd
Publication of CL2016000507A1 publication Critical patent/CL2016000507A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L29/00Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers
    • C08L29/02Homopolymers or copolymers of unsaturated alcohols
    • C08L29/04Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00Processes of treating or compounding macromolecular substances
    • C08J3/02Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075Macromolecular gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/555Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0409Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414Particles, beads, capsules or spheres
    • A61K49/0419Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0457Semi-solid forms, ointments, gels, hydrogels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476Particles, beads, capsules, spheres
    • A61K49/048Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1213Semi-solid forms, gels, hydrogels, ointments, fats and waxes that are solid at room temperature
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • A61L24/0015Medicaments; Biocides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • A61L24/0031Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment
    • C08F8/18Introducing halogen atoms or halogen-containing groups
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/12Chemical modification
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08KUse of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00Use of organic ingredients
    • C08K5/02Halogenated hydrocarbons
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08KUse of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K7/00Use of ingredients characterised by shape
    • C08K7/16Solid spheres
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/06Flowable or injectable implant compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/36Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00Applications
    • C08L2203/02Applications for biomedical use

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgery (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)

Abstract

En esta solicitud se propone hidrogel que comprende los grupos 1,2-diol a 1,3-diol acetilados con una especie radiopaca; composición que comprende un hidrogel; método para realizar un polímero radiopaco; método para formar una microesfera de hidrogel radiopaca; y uso de un hidrogel.
CL2016000507A 2013-09-06 2016-03-04 Hidrogel que comprende los grupos 1, 2-diol o 1, 3-diol acetilados con una especie radiopaca; composición que comprende un hidrogel; método para realizar un polímero radiopaco; método para formar una microesfera de hidrogel radiopaca; y uso de hidrogel o composición. CL2016000507A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1315923.1A GB2521997A (en) 2013-09-06 2013-09-06 Radiopaque polymers

Publications (1)

Publication Number Publication Date
CL2016000507A1 true CL2016000507A1 (es) 2016-10-21

Family

ID=49486860

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016000507A CL2016000507A1 (es) 2013-09-06 2016-03-04 Hidrogel que comprende los grupos 1, 2-diol o 1, 3-diol acetilados con una especie radiopaca; composición que comprende un hidrogel; método para realizar un polímero radiopaco; método para formar una microesfera de hidrogel radiopaca; y uso de hidrogel o composición.

Country Status (19)

Country Link
US (4) US10350295B2 (es)
EP (2) EP3041515B1 (es)
JP (3) JP6606078B2 (es)
KR (2) KR102277607B1 (es)
CN (3) CN111494699B (es)
AU (3) AU2014316839B2 (es)
BR (1) BR112016004806A8 (es)
CA (1) CA2922964C (es)
CL (1) CL2016000507A1 (es)
GB (1) GB2521997A (es)
HK (1) HK1223276A1 (es)
IL (1) IL244269B (es)
MX (1) MX2016002973A (es)
MY (1) MY181356A (es)
PH (1) PH12016500279A1 (es)
RU (1) RU2016109543A (es)
SG (2) SG11201601315PA (es)
WO (1) WO2015033093A1 (es)
ZA (1) ZA201602110B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2777083C (en) 2009-10-06 2014-11-25 Regents Of The University Of Minnesota Bioresorbable embolization microspheres
GB2519738A (en) * 2013-09-06 2015-05-06 Biocompatibles Uk Ltd Radiopaque polymers
GB2521997A (en) * 2013-09-06 2015-07-15 Biocompatibles Uk Ltd Radiopaque polymers
AU2016206983B2 (en) 2015-01-12 2019-08-22 Biosphere Medical, Inc. Radiopaque monomers, polymers, microspheres, and methods related thereto
GB201515602D0 (en) 2015-09-03 2015-10-21 Biocompatibles Uk Ltd Polymers and microspheres
US10182979B2 (en) 2016-03-22 2019-01-22 Regents Of The University Of Minnesota Biodegradable microspheres
EP3541368B1 (en) 2016-11-16 2023-07-12 The United States of America, as represented by the Secretary, Department of Health and Human Services Imageable particles, methods of making and methods of use thereof
JP2020063191A (ja) * 2017-02-20 2020-04-23 国立大学法人東京工業大学 薬物送達用担体及び薬物送達システム
GB2566091B (en) * 2017-09-04 2023-03-29 Univ Limerick Formulation for 3D printing and a 3D printed article
CN111741747A (zh) * 2018-02-23 2020-10-02 范·里恩·贝希尔有限公司 包含药物的多孔栓塞微球
GB201810788D0 (en) 2018-06-29 2018-08-15 Biocompatibles Uk Ltd Biodegradable polymer
JP7322073B2 (ja) 2018-06-29 2023-08-07 バイオコンパティブルズ ユーケー リミテッド 放射線不透過性ポリマー
GB201810784D0 (en) * 2018-06-29 2018-08-15 Biocompatibles Uk Ltd Radiopaque polymers
CN108785691A (zh) * 2018-07-06 2018-11-13 中南大学湘雅二医院 一种对微小病灶进行定位检测的人造结节及定位方法
CA3110898A1 (en) 2018-09-20 2020-03-26 Reva Medical, Llc Porous bioresorbable radiopaque embolic microspheres for drug delivery
CN109289081B (zh) * 2018-09-30 2021-01-19 华中科技大学鄂州工业技术研究院 一种抗粘连的聚乙烯醇栓塞微球及其制备方法和应用
TW202031299A (zh) * 2018-11-13 2020-09-01 大陸商上海盛迪醫藥有限公司 一種聚合物及其組合物
JP7391978B2 (ja) * 2019-03-22 2023-12-05 バイオコンパティブルズ ユーケー リミテッド 塞栓マイクロスフェア及び方法
GB201910286D0 (en) * 2019-07-18 2019-09-04 Biocompatibles Uk Ltd Radiopaque polymers
CN110372484B (zh) * 2019-07-23 2020-05-22 赵修文 一种不透射线的聚乙烯醇微球
EP4025616A4 (en) * 2019-09-12 2023-11-08 Endoshape, Inc. X-RAY DENSITY POLYMERS FOR MEDICAL DEVICES
KR20220156862A (ko) * 2020-03-17 2022-11-28 마이크로벤션, 인코포레이티드 액체 색전제
US20230277719A1 (en) * 2020-09-04 2023-09-07 Blackswan Vascular, Inc. Liquid Embolic Compositions with Controlled Release of Radiopaque and Therapeutic Compounds and Methods of Using the Same
CN114057600B (zh) * 2021-12-02 2024-02-02 上海汇禾医疗科技股份有限公司 一种可x射线显影分子、载药栓塞微球及其制备方法
CN118434411A (zh) 2021-12-23 2024-08-02 波士顿科学医疗设备有限公司 化学栓塞组合物及其治疗方法
CN114146190B (zh) * 2021-12-30 2024-01-26 科睿驰(深圳)医疗科技发展有限公司 一种高悬浮性显影微球及其制备方法
CN114262279B (zh) * 2021-12-30 2022-12-16 上海汇禾医疗科技有限公司 一种x射线可显影分子、栓塞微球及其制备方法
CN115487342B (zh) * 2022-08-17 2023-11-24 海南百迈科医疗科技股份有限公司 一种自显影可吸收栓塞微球及其制备方法
CN116256442A (zh) * 2022-09-26 2023-06-13 科睿驰(深圳)医疗科技发展有限公司 一种聚乙烯醇栓塞微球中含碘化合物的检测方法
US20250049964A1 (en) * 2023-08-08 2025-02-13 Boston Scientific Scimed, Inc. Injectable shear-thinning and self-assembling hydrogels
CN117323459B (zh) * 2023-09-25 2024-10-18 至微(深圳)医学科技有限公司 一种可显影栓塞微球及其制备方法与应用

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2860986A (en) 1956-08-31 1958-11-18 Eastman Kodak Co Partially acetalized polyvinyl alcohol containing active halogen
US3631225A (en) * 1970-04-28 1971-12-28 Union Carbide Corp Preparation of polyvinyl acetals
US3840482A (en) 1971-09-13 1974-10-08 Ici Australia Ltd Process for curing poly(vinyl alcohol)matrix beads
US4406878A (en) 1978-08-02 1983-09-27 Eastman Kodak Company Iodinated contrast agent for radiography
US4306031A (en) 1979-08-14 1981-12-15 Mitsubishi Chemical Industries Limited Weakly acidic cation exchange resin and process for producing same
JPS5649734A (en) * 1979-09-29 1981-05-06 Nitto Electric Ind Co Ltd Crosslinking of polyvinyl alcohol type polymer
US5011797A (en) 1988-01-29 1991-04-30 The Curators Of The University Of Missouri Composition and method for radiation synovectomy of arthritic joints
CA2014114A1 (en) * 1989-04-06 1990-10-06 Solomon Rosenblatt Polymeric broad-spectrum antimicrobial materials
JP2981566B2 (ja) * 1989-08-03 1999-11-22 三菱化学株式会社 熱転写記録用受像体
US5082909A (en) * 1990-10-12 1992-01-21 Hercules Incorporated Pure tungsten oxyphenolate complexes as DCPD polymerization catalysts
JP3227190B2 (ja) * 1990-12-26 2001-11-12 キヤノン株式会社 電子写真感光体、それを用いた電子写真装置および装置ユニット
DK0586524T3 (es) 1991-06-03 1997-05-20 Nycomed Imaging As
JPH0656676A (ja) 1992-08-05 1994-03-01 Hori Shinichi 血管塞栓用懸濁液
US5330739A (en) * 1992-12-04 1994-07-19 Sterling Winthrop Inc. Iodinated benzoyl acetals and ketals for x-ray imaging
TW272976B (es) * 1993-08-06 1996-03-21 Ciba Geigy Ag
ES2231783T3 (es) 1994-01-21 2005-05-16 Sirtex Medical Limited Material de particulas de itrio.
TW360671B (en) * 1995-02-03 1999-06-11 Novartis Ag Process for producing mold body and the cross-linkable polymer used therein
AU4438696A (en) * 1995-02-03 1996-08-21 Novartis Ag Crosslinked polymers
US6433056B1 (en) * 1997-10-17 2002-08-13 Hercules Incorporated Fluidized polymer suspension of hydrophobically modified poly(acetal- or ketal-polyether) polyurethane and polyacrylate
AU1064800A (en) 1998-11-12 2000-06-05 Nycomed Amersham Plc Products and methods
US6255033B1 (en) * 1999-07-30 2001-07-03 Creo, Ltd. Positive acting photoresist compositions and imageable element
EP1250361A2 (en) * 1999-11-15 2002-10-23 BioCure, Inc. Degradable poly(vinyl alcohol) hydrogels
EP1263803B1 (en) * 2000-03-13 2007-09-19 BioCure, Inc. Embolic compositions
DE60119906T2 (de) * 2000-03-13 2007-01-11 Biocure, Inc. Zusammensetzungen zur erhöhung des gewebevolumens und beschichtungszusammensetzungen
US6652883B2 (en) * 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
EP1180698A1 (en) * 2000-08-08 2002-02-20 THOMSON multimedia Lens sheet for a display device
US6911219B2 (en) * 2001-09-27 2005-06-28 Surgica Corporation Partially acetalized polyvinyl alcohol embolization particles, compositions containing those particles and methods of making and using them
EP1490120B1 (en) 2002-03-29 2009-11-11 Boston Scientific Limited Embolization
DE10223338B4 (de) * 2002-05-25 2005-06-16 Forschungszentrum Karlsruhe Gmbh Technik Und Umwelt Polymere mit Halogenfunktionen und Verfahren zu deren Herstellung und deren Verwendung
US8012454B2 (en) * 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
CN103908704B (zh) * 2003-02-12 2017-09-01 生物相容英国有限公司 用于实体瘤的化学栓塞治疗的组合物
US7959900B2 (en) 2004-03-05 2011-06-14 Xl Sci-Tech, Inc. Particulate materials and compositions for radio therapy
US7201918B2 (en) 2004-11-16 2007-04-10 Microvention, Inc. Compositions, systems and methods for treatment of defects in blood vessels
ES2568782T3 (es) 2005-05-09 2016-05-04 Biosphere Medical, S.A. Composiciones y métodos de uso de microesferas y agentes de contraste no iónicos
JP3984277B2 (ja) * 2005-11-21 2007-10-03 日東電工株式会社 ナフチル基を有する重合体を含有する光学フィルム
EP1810698A1 (en) * 2006-01-24 2007-07-25 Biocompatibles UK Limited Process for producing radiopaque embolic microspheres
WO2007098041A1 (en) * 2006-02-17 2007-08-30 Medtronic, Inc. Polyketal polymers, and methods of making and using same
WO2008051291A2 (en) 2006-04-11 2008-05-02 Ordway Research Institute Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof
ES2403645T5 (es) 2006-06-22 2020-11-16 Biocompatibles Uk Ltd Producto farmacéutico rehidratable
WO2008039827A2 (en) 2006-09-26 2008-04-03 Aeris Therapeutics, Inc. Polymer systems for lung volume reduction therapy
US8198365B2 (en) 2007-05-11 2012-06-12 Aeris Therapeutics, Llc Lung volume reduction therapy using crosslinked non-natural polymers
EP1992371A1 (de) 2007-05-15 2008-11-19 Occlutech GmbH Bioresorbierbare röntgenopake Polymermaterialien und daraus hergestellte Occlussionsinstrumente
CN103784408A (zh) * 2007-07-24 2014-05-14 安迅生物制药公司 用于制备微粒的技术
AU2008282295A1 (en) * 2007-07-30 2009-02-05 Auspex Pharamaceuticals, Inc. Substituted indoles
EP2090592A1 (en) 2007-07-31 2009-08-19 OctoPlus Sciences B.V. Biodegradable hydrogels based on click chemistry
CN101810587B (zh) * 2007-08-10 2012-05-23 苏州迦俐生生物医药科技有限公司 微球型栓塞剂的制备工艺
CN101125225A (zh) * 2007-08-10 2008-02-20 苏州迦俐生生物医药科技有限公司 微球型栓塞剂及其制备工艺
US20090092675A1 (en) * 2007-10-05 2009-04-09 Boston Scientific Scimed, Inc. Compositions containing multiple polymers and particles made using the compositions
GB0725070D0 (en) * 2007-12-21 2008-01-30 Iopharma Technologies Ab Product
US20090169471A1 (en) 2007-12-28 2009-07-02 Boston Scientific Scimed, Inc. Particles for injection and processes for forming the same
US20090269390A1 (en) 2008-04-25 2009-10-29 Medtronic, Inc. Medical devices, polymers, compositions, and methods for delivering a haloacetate
US8790701B2 (en) 2008-04-28 2014-07-29 Surmodics, Inc. Poly-α(1→4)glucopyranose-based matrices with hydrazide crosslinking
JP5960051B2 (ja) 2009-08-04 2016-08-02 プシロクス・エービーPsilox AB イオン置換リン酸カルシウム粒子
EP2365009A1 (en) * 2010-03-10 2011-09-14 Universite Claude Bernard Lyon 1 (UCBL) Radiopaque, non-biodegradable, water-insoluble iodinated benzyl ethers of poly(vinyl alcohol), preparation method thereof, injectable embolizing compositions containing thereof and use thereof
ES2368307B1 (es) 2010-04-28 2012-10-17 Universidade De Santiago De Compostela Hidrogeles elaborados a base de polímeros aniónicos de origen natural.
HUP1000362A2 (en) 2010-07-12 2012-11-28 Egis Gyogyszergyar Nyrt Antiseptic and disinfecting compositions having reduced iodine content
EP2646000B1 (en) 2010-11-29 2015-04-29 Centre Hospitalier Universitaire Vaudois Chemoembolization composition comprising anti-angiogenic agents
EP2650026B1 (en) 2010-12-09 2019-03-27 Toray Industries, Inc. Biodegradable particles, vascular occlusion material, and method for producing biodegradable particles
GB201101429D0 (en) 2011-01-27 2011-03-16 Biocompatibles Uk Ltd Drug delivery system
EP2786972A4 (en) * 2011-12-02 2015-08-05 Sumitomo Metal Mining Co HEAT SHIELDING SHEET COMBINED HEAT-SHIELDED AND TRANSPARENT SUBSTRATE, VEHICLE WITH HEAT-LIGHTING SHIELDS OF THE TRANSPARENT LAMINATED SUBSTRATE AS WINDOW MATERIAL AND BUILDINGS WITH HEAT-LIGHT SHADES OF THE TRANSPARENT LAMINATED SUBSTRATE AS WINDOW MATERIAL
CN105517580A (zh) 2013-03-15 2016-04-20 马修·R·德勒埃 可成像栓塞微球
WO2014151885A1 (en) 2013-03-15 2014-09-25 Iris International, Inc. Conjugation of multiple vancomycin molecules on a polyvinyl alcohol backbone for the capture of microorganisms
GB2519738A (en) 2013-09-06 2015-05-06 Biocompatibles Uk Ltd Radiopaque polymers
GB2521997A (en) 2013-09-06 2015-07-15 Biocompatibles Uk Ltd Radiopaque polymers

Also Published As

Publication number Publication date
MY181356A (en) 2020-12-21
JP6606078B2 (ja) 2019-11-20
GB2521997A (en) 2015-07-15
KR102193612B1 (ko) 2020-12-22
IL244269A0 (en) 2016-04-21
JP2022023869A (ja) 2022-02-08
JP6962981B2 (ja) 2021-11-05
CN110950981A (zh) 2020-04-03
BR112016004806A8 (pt) 2020-02-11
US20160228556A1 (en) 2016-08-11
KR20160052565A (ko) 2016-05-12
US10568967B2 (en) 2020-02-25
CA2922964C (en) 2023-09-05
JP2016531921A (ja) 2016-10-13
WO2015033093A1 (en) 2015-03-12
AU2021215248A1 (en) 2021-09-09
CN110950981B (zh) 2023-02-17
JP2020073636A (ja) 2020-05-14
CN105517581A (zh) 2016-04-20
AU2020201495B2 (en) 2021-05-13
US10350295B2 (en) 2019-07-16
CN105517581B (zh) 2020-04-24
SG10201901683VA (en) 2019-03-28
US20200254099A1 (en) 2020-08-13
AU2014316839B2 (en) 2020-03-12
EP3041515A1 (en) 2016-07-13
JP7163471B2 (ja) 2022-10-31
AU2021215248B2 (en) 2023-03-16
HK1223276A1 (zh) 2017-07-28
CA2922964A1 (en) 2015-03-12
MX2016002973A (es) 2016-07-14
AU2020201495A1 (en) 2020-03-19
WO2015033093A9 (en) 2016-04-07
US11040104B2 (en) 2021-06-22
AU2014316839A9 (en) 2016-06-16
CN111494699A (zh) 2020-08-07
IL244269B (en) 2018-06-28
AU2014316839A1 (en) 2016-04-21
PH12016500279A1 (en) 2016-05-02
EP3492110A1 (en) 2019-06-05
RU2016109543A (ru) 2017-10-11
GB201315923D0 (en) 2013-10-23
US11957755B2 (en) 2024-04-16
CN111494699B (zh) 2022-05-31
US20210275674A1 (en) 2021-09-09
US20190142946A1 (en) 2019-05-16
KR102277607B1 (ko) 2021-07-15
SG11201601315PA (en) 2016-03-30
EP3041515B1 (en) 2022-01-12
KR20200143747A (ko) 2020-12-24
EP3492110B1 (en) 2023-03-08
ZA201602110B (en) 2017-08-30

Similar Documents

Publication Publication Date Title
CL2016000507A1 (es) Hidrogel que comprende los grupos 1, 2-diol o 1, 3-diol acetilados con una especie radiopaca; composición que comprende un hidrogel; método para realizar un polímero radiopaco; método para formar una microesfera de hidrogel radiopaca; y uso de hidrogel o composición.
MX2019009789A (es) Metodos de seleccion para microorganismos que imparten propiedades beneficiosas a las plantas.
CL2018000829A1 (es) Anticuerpos anti-cd19 humano con alta afinidad
MX2020000734A (es) Enantiómeros s de beta-hidroxibutirato y butanodiol, y métodos para usarlos.
CL2017003356A1 (es) Moduladores cot y métodos de uso de los mismos
MX2018009553A (es) Metodos de seleccion.
CL2013001999A1 (es) Metodo de preparacion de un gel de colageno reticulado por radiacion que comprende la irradiacion del colageno liquido con radiacion para asi obtener un colageno reticulado; gel de colageno; y uso.
BR112015024640A2 (pt) processo para a preparação de um polímero antibacteriano, polímero antibacteriano, uso do polímero e produto antibacteriano
CL2013003450A1 (es) Composicion que contiene oxintomodulina, un polimero de polietilenglicol y 9-fluorenilmetoxicarbonilo o 2-sulfo-9-fluorenilmetoxicarbonilo; metodos de uso.
MX2017007585A (es) Anticuerpos anti-c10orf54 y usos de los mismos.
MX2015015409A (es) Proceso para la preparacion de eritrocitos cargados con una o mas sustancias de interes farmaceutico y eritrocitos asi obtenidos.
CO7250444A2 (es) Uso de seaprose para eliminar biopelículas bacterianas
CL2016000009A1 (es) Tratamiento de rosacea papulopustular con ivermectina.
BR112017023112A2 (pt) composição de curativo de ferida, método de fabricação da mesma, curativo de ferida, e, uso de uma composição de curativo de ferida
SV2017005466A (es) Pirazolpiridinaminas como inhibidores de mknk1 y mknk2
CL2015002470A1 (es) Composición para formar una estructura porosa absorbente
PE20160601A1 (es) Metodo
CO2019003424A2 (es) Extracto de planta impregnado de alulosa y método de preparación para el mismo
DOP2015000298A (es) Compuestos nuevos para el tratamiento del cáncer
CL2013003093A1 (es) Composiciones que comprende cation de polihidroxioxoaluminio detectable por rmn; metodo de fabricacion de los mismos; y su uso.
ECSP16058769A (es) Composicion para la administracion oral de agente bioactivos
BR112017011685A2 (pt) composições compreendendo 15-hepe e métodos de tratamento ou prevenção da fibrose usando as mesmas
MX2018007191A (es) Composicion para beneficiar la piel a base de un solvente hidroxi funcionalizado.
CL2012003265A1 (es) Polisacarido de semillas de tamarindo para usarse en el tratamiento de enfermedades infecciosas; composicion farmacéutica y/o dermocosmética antiinflamatoria que contiene dicho polisacárido; uso de un polisacárido de semilla de tamarindo.
BR112017007753A2 (pt) uso de uma composição cosmética que compreende ácido 10-hidroxiesteárico.