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CL2013002985A1 - Compuestos derivados de aminometilfenilo biciclico, como moduladores del receptor de esfingosina-1-fosfato; composicion farmaceutica que los comprende; y su uso para tratar enfermedades oculares, enfermedades inflamatorias, enfermedades autoinmunes e inmunosupresion, aterosclerosis, enfermedad de alzheimer. - Google Patents

Compuestos derivados de aminometilfenilo biciclico, como moduladores del receptor de esfingosina-1-fosfato; composicion farmaceutica que los comprende; y su uso para tratar enfermedades oculares, enfermedades inflamatorias, enfermedades autoinmunes e inmunosupresion, aterosclerosis, enfermedad de alzheimer.

Info

Publication number
CL2013002985A1
CL2013002985A1 CL2013002985A CL2013002985A CL2013002985A1 CL 2013002985 A1 CL2013002985 A1 CL 2013002985A1 CL 2013002985 A CL2013002985 A CL 2013002985A CL 2013002985 A CL2013002985 A CL 2013002985A CL 2013002985 A1 CL2013002985 A1 CL 2013002985A1
Authority
CL
Chile
Prior art keywords
diseases
aminomethylphenyl
sphingosine
immunosuppression
atherosclerosis
Prior art date
Application number
CL2013002985A
Other languages
English (en)
Inventor
Wha Bin Im
Janet A Takeuchi
Ling Li
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of CL2013002985A1 publication Critical patent/CL2013002985A1/es

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    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • A61K31/66Phosphorus compounds
    • A61K31/665Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/08Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms with acylated ring nitrogen atom
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CL2013002985A 2011-04-14 2013-10-14 Compuestos derivados de aminometilfenilo biciclico, como moduladores del receptor de esfingosina-1-fosfato; composicion farmaceutica que los comprende; y su uso para tratar enfermedades oculares, enfermedades inflamatorias, enfermedades autoinmunes e inmunosupresion, aterosclerosis, enfermedad de alzheimer. CL2013002985A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161475352P 2011-04-14 2011-04-14

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CL2013002985A1 true CL2013002985A1 (es) 2014-06-13

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CL2013002985A CL2013002985A1 (es) 2011-04-14 2013-10-14 Compuestos derivados de aminometilfenilo biciclico, como moduladores del receptor de esfingosina-1-fosfato; composicion farmaceutica que los comprende; y su uso para tratar enfermedades oculares, enfermedades inflamatorias, enfermedades autoinmunes e inmunosupresion, aterosclerosis, enfermedad de alzheimer.

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Country Link
US (4) US8716267B2 (es)
EP (2) EP2697212B1 (es)
JP (1) JP2014511878A (es)
KR (1) KR20140048874A (es)
CN (1) CN103619828A (es)
AU (2) AU2012242827A1 (es)
BR (1) BR112013026507A2 (es)
CA (2) CA2833313A1 (es)
CL (1) CL2013002985A1 (es)
IL (1) IL228850A0 (es)
MX (1) MX2013011979A (es)
RU (1) RU2013150173A (es)
SG (1) SG194184A1 (es)
WO (2) WO2012142288A1 (es)
ZA (1) ZA201307796B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013026507A2 (pt) * 2011-04-14 2016-12-27 Allergan Inc derivados de metil amina fenil bicíclicos como moduladores dos receptores de esfinfgosina-1 fosfato
CN112851562A (zh) * 2021-01-22 2021-05-28 烟台显华化工科技有限公司 一种芳香环液晶化合物及其液晶组合物和应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1469863A2 (en) * 2002-01-18 2004-10-27 Merck & Co., Inc. Selective s1p1/edg1 receptor agonists
EP1575964B1 (en) * 2002-01-18 2009-11-11 Merck & Co., Inc. N-(benzyl)aminoalkyl carboxylate, phosphinates, phosphonates and tetrazoles as edg receptor agonists
EP1622866B1 (en) * 2003-04-30 2012-07-25 Novartis AG Aminopropanol derivatives as sphingosine-1-phosphate receptor modulators
EP2644195A1 (en) * 2003-05-19 2013-10-02 Irm Llc Immunosuppressant Compounds and Compositions
PL1638551T3 (pl) * 2003-05-19 2012-05-31 Irm Llc Związki i kompozycje immunosupresyjne
CA2824106A1 (en) * 2003-08-29 2005-03-10 Ono Pharmaceutical Co., Ltd. Compound capable of binding s1p receptor and pharmaceutical use thereof
CA2591399C (en) * 2004-12-13 2014-05-20 Ono Pharmaceutical Co., Ltd. Aminocarboxylic acid derivative and medicinal use thereof
KR20080024533A (ko) * 2005-06-24 2008-03-18 액테리온 파마슈티칼 리미티드 신규한 티오펜 유도체
EP2017257B1 (en) * 2006-04-28 2014-08-06 Mitsubishi Tanabe Pharma Corporation 2-aminobutanol compound and use thereof for medical purposes
JP2009269819A (ja) * 2006-08-25 2009-11-19 Asahi Kasei Pharma Kk アミン化合物
WO2008097819A2 (en) * 2007-02-05 2008-08-14 Smithkline Beecham Corporation Chemical compounds
MX2010001446A (es) * 2007-08-08 2010-03-01 Merck Serono Sa Derivados de 6-amino-pirimidina-4-carboxamida y compuestos relacionados que se enlazan a los receptores para esfingosina 1-fosfato (s1p) para el tratamiento de esclerosis multiple.
JP2010536791A (ja) * 2007-08-15 2010-12-02 ユニバーシティ オブ バージニア パテント ファンデーション 二環式スフィンゴシン1−リン酸アナログ
AU2009323259A1 (en) * 2008-12-05 2011-06-23 Astellas Pharma Inc. 2H-chromene compound and derivative thereof
CN102712607B (zh) * 2009-11-24 2016-06-22 阿勒根公司 作为具有治疗效用的受体调节剂的化合物
AU2011332155A1 (en) * 2010-11-23 2013-07-04 Allergan, Inc. Novel phosphonic acids as S1P receptor modulators
CA2833305A1 (en) * 2011-04-14 2012-10-18 Allergan, Inc. Phenyl bicyclic methyl azetidine derivatives as sphingosine-1 phosphate receptors modulators
BR112013026507A2 (pt) * 2011-04-14 2016-12-27 Allergan Inc derivados de metil amina fenil bicíclicos como moduladores dos receptores de esfinfgosina-1 fosfato
CA2833545A1 (en) * 2011-04-18 2012-10-26 Allergan, Inc. Substituted bicyclic methyl amine derivatives as sphingosine-1 phosphate receptors modulators

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CA2833255A1 (en) 2012-10-18
AU2012242652A1 (en) 2013-10-31
CA2833313A1 (en) 2012-10-18
US20140206652A1 (en) 2014-07-24
US8716267B2 (en) 2014-05-06
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EP2696877A1 (en) 2014-02-19
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BR112013026507A2 (pt) 2016-12-27
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EP2697212A1 (en) 2014-02-19
MX2013011979A (es) 2014-02-06
US20130338108A1 (en) 2013-12-19
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