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CL2013002194A1 - Compuestos derivados de 1-(1-(quinazolin-2-il) o quinolin-2-il)metil-piperidina, 1-(naftalen-2-il)metil)-(piperidina o perhidro-azepina) y otros derivados de los mismos; su composicion farmaceutica; y uso como moduladores de la actividad de los receptores de s1p, en el tratamiento de esclerosis multiple, enfermedades autoinmunes, trastornos inflamatorios cronicos, asma, artritis, entre otras. - Google Patents

Compuestos derivados de 1-(1-(quinazolin-2-il) o quinolin-2-il)metil-piperidina, 1-(naftalen-2-il)metil)-(piperidina o perhidro-azepina) y otros derivados de los mismos; su composicion farmaceutica; y uso como moduladores de la actividad de los receptores de s1p, en el tratamiento de esclerosis multiple, enfermedades autoinmunes, trastornos inflamatorios cronicos, asma, artritis, entre otras.

Info

Publication number
CL2013002194A1
CL2013002194A1 CL2013002194A CL2013002194A CL2013002194A1 CL 2013002194 A1 CL2013002194 A1 CL 2013002194A1 CL 2013002194 A CL2013002194 A CL 2013002194A CL 2013002194 A CL2013002194 A CL 2013002194A CL 2013002194 A1 CL2013002194 A1 CL 2013002194A1
Authority
CL
Chile
Prior art keywords
piperidine
methyl
perhydro
quinazolin
quinolin
Prior art date
Application number
CL2013002194A
Other languages
English (en)
Inventor
Jermaine Thomas
Sha Mi
Edward Yin-Shiang Lin
Guo Zhu Zheng
Bin Ma
richard d Caldwell
Kevin Guckian
Gnanasanbandam Kumaravel
Original Assignee
Biogen Ma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Ma Inc filed Critical Biogen Ma Inc
Publication of CL2013002194A1 publication Critical patent/CL2013002194A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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Abstract

COMPUESTOS DERIVADOS DE 1-(1-(QUINAZOLIN-2—IL) O QUINOLIN-2-IL)-METIL-PIPERIDINA, 1-(NAFTALEN-2-IL)-METIL)- (PIPERIDINA O PERHIDRO-AZEPINA) Y OTROS DERIVADOS DE LOS MISMOS DE FÓRMULA (1) SU COMPOSICIÓN FARMACÉUTICA; Y USO COMO MODULADORES DE LA ACTIVIDAD DE LOS RECEPTORES DE SIP, EN EL TRATAMIENTO DE ESCLEROSIS MÚLTIPLE, ENFERMEDADES AUTOINMUNES, TRÁSTORNOS INFLAMATORIOS CRÓNICOS, ASMA, ARTRITIS ENTRE OTRAS.
CL2013002194A 2011-02-07 2013-07-31 Compuestos derivados de 1-(1-(quinazolin-2-il) o quinolin-2-il)metil-piperidina, 1-(naftalen-2-il)metil)-(piperidina o perhidro-azepina) y otros derivados de los mismos; su composicion farmaceutica; y uso como moduladores de la actividad de los receptores de s1p, en el tratamiento de esclerosis multiple, enfermedades autoinmunes, trastornos inflamatorios cronicos, asma, artritis, entre otras. CL2013002194A1 (es)

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