CL2013000933A1 - Compuestos derivados de furo[3,2-d]pirimidina y sus sales; composicion farmaceutica que los comprende; y su uso para tratar una afeccion que esta mediada por la actividad de una proteina quinasa, tal como cancer, trastornos cardiovasculares, del snc e inmunes, y enfermedades relacionadas con la inmunodeficiencia adquirida. - Google Patents
Compuestos derivados de furo[3,2-d]pirimidina y sus sales; composicion farmaceutica que los comprende; y su uso para tratar una afeccion que esta mediada por la actividad de una proteina quinasa, tal como cancer, trastornos cardiovasculares, del snc e inmunes, y enfermedades relacionadas con la inmunodeficiencia adquirida.Info
- Publication number
- CL2013000933A1 CL2013000933A1 CL2013000933A CL2013000933A CL2013000933A1 CL 2013000933 A1 CL2013000933 A1 CL 2013000933A1 CL 2013000933 A CL2013000933 A CL 2013000933A CL 2013000933 A CL2013000933 A CL 2013000933A CL 2013000933 A1 CL2013000933 A1 CL 2013000933A1
- Authority
- CL
- Chile
- Prior art keywords
- furo
- cns
- pyrimidine
- cardiovascular
- mediated
- Prior art date
Links
- 208000029483 Acquired immunodeficiency Diseases 0.000 title 1
- 208000024172 Cardiovascular disease Diseases 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 102000001253 Protein Kinase Human genes 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 208000015114 central nervous system disease Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000002526 effect on cardiovascular system Effects 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- JUQAECQBUNODQP-UHFFFAOYSA-N furo[3,2-d]pyrimidine Chemical compound C1=NC=C2OC=CC2=N1 JUQAECQBUNODQP-UHFFFAOYSA-N 0.000 title 1
- 208000026278 immune system disease Diseases 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 108060006633 protein kinase Proteins 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
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- Diabetes (AREA)
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- Rheumatology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
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- Urology & Nephrology (AREA)
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- Tropical Medicine & Parasitology (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39115710P | 2010-10-08 | 2010-10-08 | |
| US201161503368P | 2011-06-30 | 2011-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2013000933A1 true CL2013000933A1 (es) | 2014-04-25 |
Family
ID=45928140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2013000933A CL2013000933A1 (es) | 2010-10-08 | 2013-04-05 | Compuestos derivados de furo[3,2-d]pirimidina y sus sales; composicion farmaceutica que los comprende; y su uso para tratar una afeccion que esta mediada por la actividad de una proteina quinasa, tal como cancer, trastornos cardiovasculares, del snc e inmunes, y enfermedades relacionadas con la inmunodeficiencia adquirida. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8551981B2 (es) |
| EP (1) | EP2624698A4 (es) |
| JP (1) | JP2013539762A (es) |
| KR (1) | KR20140005882A (es) |
| CN (1) | CN103442568A (es) |
| AR (1) | AR083358A1 (es) |
| AU (1) | AU2011311867A1 (es) |
| BR (1) | BR112013008240A2 (es) |
| CA (1) | CA2813437A1 (es) |
| CL (1) | CL2013000933A1 (es) |
| CO (1) | CO6731080A2 (es) |
| CR (1) | CR20130206A (es) |
| EC (1) | ECSP13012554A (es) |
| GT (1) | GT201300091A (es) |
| IL (1) | IL225622A0 (es) |
| MX (1) | MX2013003913A (es) |
| PE (1) | PE20140245A1 (es) |
| PH (1) | PH12013500661A1 (es) |
| RU (1) | RU2013120966A (es) |
| SG (1) | SG189837A1 (es) |
| TW (1) | TW201219398A (es) |
| UY (1) | UY33659A (es) |
| WO (1) | WO2012048222A1 (es) |
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| CN105566329B (zh) * | 2014-11-07 | 2019-02-12 | 温州医科大学 | 一种吡唑[5，6-d]并嘧啶类EGFR抑制剂及其抗肿瘤活性 |
| US10221172B2 (en) | 2015-01-13 | 2019-03-05 | Vanderbilt University | Benzothiazole and benzisothiazole-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
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-
2011
- 2011-10-07 TW TW100136629A patent/TW201219398A/zh unknown
- 2011-10-07 US US13/268,387 patent/US8551981B2/en active Active
- 2011-10-07 RU RU2013120966/04A patent/RU2013120966A/ru not_active Application Discontinuation
- 2011-10-07 UY UY0001033659A patent/UY33659A/es unknown
- 2011-10-07 CA CA2813437A patent/CA2813437A1/en not_active Abandoned
- 2011-10-07 PE PE2013000803A patent/PE20140245A1/es not_active Application Discontinuation
- 2011-10-07 JP JP2013532974A patent/JP2013539762A/ja active Pending
- 2011-10-07 BR BR112013008240A patent/BR112013008240A2/pt not_active IP Right Cessation
- 2011-10-07 KR KR1020137011942A patent/KR20140005882A/ko not_active Withdrawn
- 2011-10-07 AU AU2011311867A patent/AU2011311867A1/en not_active Abandoned
- 2011-10-07 MX MX2013003913A patent/MX2013003913A/es not_active Application Discontinuation
- 2011-10-07 CN CN2011800573262A patent/CN103442568A/zh active Pending
- 2011-10-07 SG SG2013025333A patent/SG189837A1/en unknown
- 2011-10-07 EP EP11831679.3A patent/EP2624698A4/en not_active Withdrawn
- 2011-10-07 WO PCT/US2011/055366 patent/WO2012048222A1/en not_active Ceased
- 2011-10-07 PH PH1/2013/500661A patent/PH12013500661A1/en unknown
- 2011-10-11 AR ARP110103722A patent/AR083358A1/es not_active Application Discontinuation
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2013
- 2013-04-05 GT GT201300091A patent/GT201300091A/es unknown
- 2013-04-05 CL CL2013000933A patent/CL2013000933A1/es unknown
- 2013-04-07 IL IL225622A patent/IL225622A0/en unknown
- 2013-04-16 EC ECSP13012554 patent/ECSP13012554A/es unknown
- 2013-05-08 CO CO13115325A patent/CO6731080A2/es not_active Application Discontinuation
- 2013-05-08 CR CR20130206A patent/CR20130206A/es unknown
Also Published As
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|---|---|
| WO2012048222A1 (en) | 2012-04-12 |
| US8551981B2 (en) | 2013-10-08 |
| TW201219398A (en) | 2012-05-16 |
| CO6731080A2 (es) | 2013-08-15 |
| KR20140005882A (ko) | 2014-01-15 |
| IL225622A0 (en) | 2013-06-27 |
| US20120122846A1 (en) | 2012-05-17 |
| EP2624698A1 (en) | 2013-08-14 |
| CR20130206A (es) | 2013-08-07 |
| PE20140245A1 (es) | 2014-03-30 |
| CN103442568A (zh) | 2013-12-11 |
| EP2624698A4 (en) | 2014-10-08 |
| AU2011311867A1 (en) | 2013-04-18 |
| RU2013120966A (ru) | 2014-11-20 |
| JP2013539762A (ja) | 2013-10-28 |
| CA2813437A1 (en) | 2012-04-12 |
| SG189837A1 (en) | 2013-06-28 |
| PH12013500661A1 (en) | 2017-08-23 |
| ECSP13012554A (es) | 2013-06-28 |
| UY33659A (es) | 2012-04-30 |
| BR112013008240A2 (pt) | 2017-12-12 |
| GT201300091A (es) | 2014-07-11 |
| AR083358A1 (es) | 2013-02-21 |
| MX2013003913A (es) | 2013-09-26 |
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