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CL2012003729A1 - Composicion farmaceutica oral que comprende monohidrato de monolactato de 4-amino-5-fluoro-3-[6-(4-metil-piperazin-1-il)-1h-bencimidazol-2-il]-1h-quinolin-2-ona, uno o mas rellenos, un desintegrante y un lubricante; proceso de preparacion de la composicion. - Google Patents

Composicion farmaceutica oral que comprende monohidrato de monolactato de 4-amino-5-fluoro-3-[6-(4-metil-piperazin-1-il)-1h-bencimidazol-2-il]-1h-quinolin-2-ona, uno o mas rellenos, un desintegrante y un lubricante; proceso de preparacion de la composicion.

Info

Publication number
CL2012003729A1
CL2012003729A1 CL2012003729A CL2012003729A CL2012003729A1 CL 2012003729 A1 CL2012003729 A1 CL 2012003729A1 CL 2012003729 A CL2012003729 A CL 2012003729A CL 2012003729 A CL2012003729 A CL 2012003729A CL 2012003729 A1 CL2012003729 A1 CL 2012003729A1
Authority
CL
Chile
Prior art keywords
benzimidazol
quinolin
piperazin
disintegrant
fluoro
Prior art date
Application number
CL2012003729A
Other languages
English (en)
Inventor
Jeewan Thakur
Zhihui Qiu
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2012003729A1 publication Critical patent/CL2012003729A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composición farmacéutica oral que comprende monohidrato de monolactato de 4-amino-5-fluoro-3-[6-(4-metil-piperazin-1-il)-1h-bencimidazol-2-il]-1h-quinolin-2-ona, uno o más rellenos, un desintegrante y un lubricante; proceso de preparación de la composición.
CL2012003729A 2010-06-30 2012-12-28 Composicion farmaceutica oral que comprende monohidrato de monolactato de 4-amino-5-fluoro-3-[6-(4-metil-piperazin-1-il)-1h-bencimidazol-2-il]-1h-quinolin-2-ona, uno o mas rellenos, un desintegrante y un lubricante; proceso de preparacion de la composicion. CL2012003729A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10168028 2010-06-30

Publications (1)

Publication Number Publication Date
CL2012003729A1 true CL2012003729A1 (es) 2013-04-12

Family

ID=42751565

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012003729A CL2012003729A1 (es) 2010-06-30 2012-12-28 Composicion farmaceutica oral que comprende monohidrato de monolactato de 4-amino-5-fluoro-3-[6-(4-metil-piperazin-1-il)-1h-bencimidazol-2-il]-1h-quinolin-2-ona, uno o mas rellenos, un desintegrante y un lubricante; proceso de preparacion de la composicion.

Country Status (38)

Country Link
US (1) US9545402B2 (es)
EP (2) EP3446686A1 (es)
JP (1) JP6043281B2 (es)
KR (2) KR101840182B1 (es)
CN (2) CN106943355B (es)
AR (1) AR081776A1 (es)
AU (1) AU2011273519B2 (es)
BR (1) BR112012033479A8 (es)
CA (1) CA2801826C (es)
CL (1) CL2012003729A1 (es)
CO (1) CO6650354A2 (es)
CR (1) CR20120623A (es)
CU (1) CU20120177A7 (es)
DK (1) DK2588086T3 (es)
DO (1) DOP2012000324A (es)
EA (1) EA026244B1 (es)
EC (1) ECSP13012411A (es)
ES (1) ES2701161T3 (es)
GE (1) GEP20146049B (es)
GT (1) GT201200348A (es)
HU (1) HUE042355T2 (es)
IL (1) IL223799A (es)
MA (1) MA34387B1 (es)
MX (1) MX345404B (es)
MY (2) MY163369A (es)
NI (1) NI201200189A (es)
NZ (1) NZ604055A (es)
PE (1) PE20130481A1 (es)
PH (1) PH12012502519A1 (es)
PL (1) PL2588086T3 (es)
PT (1) PT2588086T (es)
SG (1) SG186182A1 (es)
TN (1) TN2012000574A1 (es)
TR (1) TR201818761T4 (es)
TW (1) TWI583384B (es)
UA (1) UA109659C2 (es)
UY (1) UY33472A (es)
WO (1) WO2012001074A2 (es)

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WO2013063003A1 (en) 2011-10-28 2013-05-02 Novartis Ag Method of treating gastrointestinal stromal tumors
CN104093402A (zh) 2012-01-31 2014-10-08 诺华股份有限公司 Rtk抑制剂与抗雌激素的组合及其治疗癌症的应用
BR112015000349A2 (pt) 2012-07-11 2017-06-27 Novartis Ag método de tratamento de tumores estromais gastrointestinais
US9395468B2 (en) 2012-08-27 2016-07-19 Ocular Dynamics, Llc Contact lens with a hydrophilic layer
WO2014058785A1 (en) 2012-10-10 2014-04-17 Novartis Ag Combination therapy
US9492535B2 (en) 2013-03-14 2016-11-15 Aimmune Therapeutics, Inc. Peanut formulations and uses thereof
CN109125283A (zh) * 2013-03-14 2019-01-04 艾慕恩治疗公司 用于口服脱敏的花生制剂的制备
WO2015073758A1 (en) 2013-11-15 2015-05-21 Ocular Dynamics, Llc Contact lens with a hydrophilic layer
WO2015187736A1 (en) * 2014-06-02 2015-12-10 Allergen Research Corporation Placebo formulations and uses thereof
CA2970010A1 (en) 2014-12-09 2016-06-16 Karen Havenstrite Medical device coating with a biocompatible layer
TWI790189B (zh) 2015-01-02 2023-01-21 美商梅拉洛伊卡公司 細菌組成物
WO2016189435A1 (en) * 2015-05-22 2016-12-01 Novartis Ag Pharmaceutical compositions
CA3080601A1 (en) 2017-11-02 2019-05-09 Aimmune Therapeutics, Inc. Methods of oral immunotherapy
WO2020037151A1 (en) 2018-08-16 2020-02-20 Aimmune Therapeutics, Inc. Peanut oral immunotherapy with maintenance dose
CA3123605A1 (en) 2018-12-20 2020-06-25 Aimmune Therapeutics, Inc. Peanut oral immunotherapy dosing schedule for missed doses
WO2020231843A1 (en) 2019-05-10 2020-11-19 Aimmune Therapeutics, Inc. Methods for improving the quality of life of a patient with a peanut allergy
US10835531B1 (en) 2019-06-18 2020-11-17 Oncology Venture ApS Methods for predicting drug responsiveness in cancer patients
US20230302139A1 (en) * 2020-07-31 2023-09-28 University Of Florida Research Foundation, Incorporated Targeted rna degradation allows precision repurposing of protein-targeted small molecule medicines to rna
CN119745892A (zh) * 2023-09-27 2025-04-04 南京迈诺威医药科技有限公司 含有别孕烷醇酮衍生物的药物组合物及其用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5009897A (en) * 1988-06-24 1991-04-23 Abbott Laboratories Pharmaceutical granules and tablets made therefrom
HU230787B1 (en) 2000-09-11 2018-05-02 Novartis Vaccines & Diagnostics Inc Quinolinone derivatives as tyrosine kinase inhibitors
EP1539754A4 (en) 2002-08-23 2009-02-25 Novartis Vaccines & Diagnostic BENZIMIDAZOCHINOLINONE AND ITS USE
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
GB0504203D0 (en) * 2005-03-01 2005-04-06 Novartis Ag Organic compounds
AU2006249847B2 (en) * 2005-05-23 2012-12-20 Novartis Ag Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one lactic acid salts
EP1909777A2 (en) * 2005-07-22 2008-04-16 Myriad Genetics, Inc. High drug load formulations and dosage forms
CN101316593B (zh) * 2005-11-29 2012-05-02 诺瓦提斯公司 喹啉酮类的制剂
MY148529A (en) * 2005-11-29 2013-04-30 Novartis Ag Formulations of quinolinones
BRPI0808714A2 (pt) 2007-03-09 2014-08-12 Novartis Ag Uso de compostos, tais como 4-amino-5-fluoro-3-[6-(4-metil piperazinil-1)- 1h-benzimidazolil-2] quinolinona-(1h)-2 e tautômeros, sais, e misturas dos mesmos no preparo de medicamentos para o tratamento do melanoma
CA2696807C (en) 2007-11-08 2017-11-28 Ambit Biosciences Corp. Methods of administering n-(5-tert-butyl-isoxazol-3-yl)-n'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea to treat proliferative disease
PE20091628A1 (es) * 2008-03-19 2009-11-19 Novartis Ag Formas cristalinas y dos formas solvatadas de sales de acido lactico de 4-amino-5-fluoro-3-[5-(4-metilpiperazin-1-il)-1h-benzimidazol-2-il]quinolin-2(1h)-ona
EP2108365A1 (en) 2008-04-09 2009-10-14 LEK Pharmaceuticals d.d. Single dosage pharmaceutical formulation comprising eprosartan mesylate
MA34106B1 (fr) 2010-04-16 2013-03-05 Novartis Ag Combinaison de composés organiques

Also Published As

Publication number Publication date
CA2801826A1 (en) 2012-01-05
UY33472A (es) 2012-01-31
EP3446686A1 (en) 2019-02-27
ES2701161T3 (es) 2019-02-21
NZ604055A (en) 2015-02-27
UA109659C2 (xx) 2015-09-25
WO2012001074A2 (en) 2012-01-05
MY177741A (en) 2020-09-23
AU2011273519B2 (en) 2014-05-15
CN106943355B (zh) 2020-09-01
MA34387B1 (fr) 2013-07-03
ECSP13012411A (es) 2013-03-28
HUE042355T2 (hu) 2019-06-28
GEP20146049B (en) 2014-02-25
MX345404B (es) 2017-01-30
TWI583384B (zh) 2017-05-21
PH12012502519A1 (en) 2021-06-23
TR201818761T4 (tr) 2019-01-21
GT201200348A (es) 2014-03-14
CU20120177A7 (es) 2013-04-19
BR112012033479A2 (pt) 2016-11-29
PL2588086T3 (pl) 2019-04-30
EA026244B1 (ru) 2017-03-31
KR20170139170A (ko) 2017-12-18
EA201291410A1 (ru) 2013-05-30
JP6043281B2 (ja) 2016-12-14
DOP2012000324A (es) 2013-02-28
EP2588086A2 (en) 2013-05-08
AR081776A1 (es) 2012-10-17
JP2013530196A (ja) 2013-07-25
IL223799A (en) 2017-04-30
KR20130091319A (ko) 2013-08-16
KR101840182B1 (ko) 2018-03-19
CO6650354A2 (es) 2013-04-15
MY163369A (en) 2017-09-15
EP2588086B1 (en) 2018-09-12
DK2588086T3 (en) 2019-01-07
AU2011273519A1 (en) 2013-01-31
MX2012015091A (es) 2013-02-12
PT2588086T (pt) 2018-12-18
PE20130481A1 (es) 2013-05-01
US20130090344A1 (en) 2013-04-11
NI201200189A (es) 2013-12-17
CR20120623A (es) 2013-02-11
US9545402B2 (en) 2017-01-17
CN106943355A (zh) 2017-07-14
CA2801826C (en) 2018-04-10
BR112012033479A8 (pt) 2017-10-31
TN2012000574A1 (en) 2014-04-01
WO2012001074A3 (en) 2012-03-22
SG186182A1 (en) 2013-01-30
CN103068373A (zh) 2013-04-24
TW201206903A (en) 2012-02-16

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