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CL2012002355A1 - Compuestos derivados de 1,3,4,8-tetrahidro-2h-pirido[1,2-a]pirazina; composicion farmaceutica que los comprende; kit farmaceutico; y su uso como inhibidores de la integrasa del vih para el tratamiento de una enfermedad infecciosa del vih. - Google Patents

Compuestos derivados de 1,3,4,8-tetrahidro-2h-pirido[1,2-a]pirazina; composicion farmaceutica que los comprende; kit farmaceutico; y su uso como inhibidores de la integrasa del vih para el tratamiento de una enfermedad infecciosa del vih.

Info

Publication number
CL2012002355A1
CL2012002355A1 CL2012002355A CL2012002355A CL2012002355A1 CL 2012002355 A1 CL2012002355 A1 CL 2012002355A1 CL 2012002355 A CL2012002355 A CL 2012002355A CL 2012002355 A CL2012002355 A CL 2012002355A CL 2012002355 A1 CL2012002355 A1 CL 2012002355A1
Authority
CL
Chile
Prior art keywords
pyrido
pyrazine
tetrahydro
treatment
compounds derived
Prior art date
Application number
CL2012002355A
Other languages
English (en)
Inventor
Yuki Bessho
Susumu Miyazaki
Kaoru Adachi
Seiji Kawashita
Hirotaka Isoshima
Shunichi Fukuda
Kengo Oshita
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44506987&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2012002355(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of CL2012002355A1 publication Critical patent/CL2012002355A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos derivados de 1,3,4,8-tetrahidro-2h-pirido[1,2-a]pirazina; composición farmacéutica que los comprende; kit farmacéutico; y su uso para el tratamiento del virus VIH.
CL2012002355A 2010-02-26 2012-08-24 Compuestos derivados de 1,3,4,8-tetrahidro-2h-pirido[1,2-a]pirazina; composicion farmaceutica que los comprende; kit farmaceutico; y su uso como inhibidores de la integrasa del vih para el tratamiento de una enfermedad infecciosa del vih. CL2012002355A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010043567 2010-02-26
US33972910P 2010-03-09 2010-03-09

Publications (1)

Publication Number Publication Date
CL2012002355A1 true CL2012002355A1 (es) 2013-01-25

Family

ID=44506987

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012002355A CL2012002355A1 (es) 2010-02-26 2012-08-24 Compuestos derivados de 1,3,4,8-tetrahidro-2h-pirido[1,2-a]pirazina; composicion farmaceutica que los comprende; kit farmaceutico; y su uso como inhibidores de la integrasa del vih para el tratamiento de una enfermedad infecciosa del vih.

Country Status (19)

Country Link
US (2) US10065950B2 (es)
EP (1) EP2540720B1 (es)
JP (1) JP5765965B2 (es)
KR (1) KR20120130185A (es)
CN (1) CN102858771A (es)
AR (1) AR080314A1 (es)
AU (1) AU2011221037A1 (es)
BR (1) BR112012021595A2 (es)
CA (1) CA2789457A1 (es)
CL (1) CL2012002355A1 (es)
CO (1) CO6571861A2 (es)
MX (1) MX2012009869A (es)
NZ (1) NZ601847A (es)
PE (1) PE20130010A1 (es)
PH (1) PH12012501689A1 (es)
RU (1) RU2012140961A (es)
SG (1) SG183484A1 (es)
TW (1) TW201139437A (es)
WO (1) WO2011105590A1 (es)

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CN103736081A (zh) * 2013-12-18 2014-04-23 首都医科大学附属北京佑安医院 Ontak在制备清除潜伏hiv病毒药物中的应用
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JOP20190130A1 (ar) 2016-12-02 2019-06-02 Merck Sharp & Dohme مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv)
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SMT202400330T1 (it) 2018-05-31 2024-09-16 Shionogi & Co Derivati policiclici della carbammoilpiridone per il trattamento dell'hiv
HUE059677T2 (hu) 2019-03-22 2022-12-28 Gilead Sciences Inc Áthidalt triciklusos karbamoilpiridon-vegyületek és ezek gyógyszerészeti alkalmazása
US20200398978A1 (en) 2019-06-20 2020-12-24 Bell Helicopter Textron Inc. Low-drag rotor blade extension
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Also Published As

Publication number Publication date
EP2540720B1 (en) 2015-04-15
JP5765965B2 (ja) 2015-08-19
EP2540720A4 (en) 2013-07-31
PH12012501689A1 (en) 2012-11-05
US10065950B2 (en) 2018-09-04
CA2789457A1 (en) 2011-09-01
WO2011105590A1 (ja) 2011-09-01
EP2540720A1 (en) 2013-01-02
BR112012021595A2 (pt) 2017-02-21
PE20130010A1 (es) 2013-02-05
NZ601847A (en) 2014-03-28
RU2012140961A (ru) 2014-04-10
JP2011195585A (ja) 2011-10-06
CO6571861A2 (es) 2012-11-30
KR20120130185A (ko) 2012-11-29
US20180319798A1 (en) 2018-11-08
CN102858771A (zh) 2013-01-02
MX2012009869A (es) 2012-09-12
AU2011221037A1 (en) 2012-09-06
AR080314A1 (es) 2012-03-28
US20120108564A1 (en) 2012-05-03
TW201139437A (en) 2011-11-16
SG183484A1 (en) 2012-09-27

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