CL2012001464A1 - Compuestos derivados de (2-amino-5,5-difluor-5,6-dihidro-4h-[1,3]oxazin-4-il)-fenilamida, inhibidores bace1 y/o bace2; composicion farmaceutica; procedimiento de preparacion; y uso en el tratamiento terapeutico y/o profilactico de enfermedades tales como alzheimer y diabetes. - Google Patents

Compuestos derivados de (2-amino-5,5-difluor-5,6-dihidro-4h-[1,3]oxazin-4-il)-fenilamida, inhibidores bace1 y/o bace2; composicion farmaceutica; procedimiento de preparacion; y uso en el tratamiento terapeutico y/o profilactico de enfermedades tales como alzheimer y diabetes.

Info

Publication number: CL2012001464A1
Authority: CL; Chile
Prior art keywords: difluor; bace1; phenylamide; oxazin; alzheimer
Prior art date: 2009-12-11

Application number

CL2012001464A

Other languages

English (en)

Inventor

David Guba Wolfgang Hilpert Hans Mauser Harald Mayweg Alexander V Narquizian Robert Pinard Em Banner

Original Assignee

F Hoffmann La Roche Ag Siena Biotech S P A

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-12-11

Filing date

2012-06-05

Publication date

2014-03-07

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43585547&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2012001464(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2012-06-05 Application filed by F Hoffmann La Roche Ag Siena Biotech S P A filed Critical F Hoffmann La Roche Ag Siena Biotech S P A

2014-03-07 Publication of CL2012001464A1 publication Critical patent/CL2012001464A1/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
- C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

CL2012001464A 2009-12-11 2012-06-05 Compuestos derivados de (2-amino-5,5-difluor-5,6-dihidro-4h-[1,3]oxazin-4-il)-fenilamida, inhibidores bace1 y/o bace2; composicion farmaceutica; procedimiento de preparacion; y uso en el tratamiento terapeutico y/o profilactico de enfermedades tales como alzheimer y diabetes. CL2012001464A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP09178983		2009-12-11

Publications (1)

Publication Number	Publication Date
CL2012001464A1 true CL2012001464A1 (es)	2014-03-07

Family

ID=43585547

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL2012001464A CL2012001464A1 (es)	2009-12-11	2012-06-05	Compuestos derivados de (2-amino-5,5-difluor-5,6-dihidro-4h-[1,3]oxazin-4-il)-fenilamida, inhibidores bace1 y/o bace2; composicion farmaceutica; procedimiento de preparacion; y uso en el tratamiento terapeutico y/o profilactico de enfermedades tales como alzheimer y diabetes.

Country Status (26)

Country	Link
US (1)	US8389513B2 (es)
EP (1)	EP2509965A1 (es)
JP (1)	JP5584778B2 (es)
KR (1)	KR101506773B1 (es)
CN (1)	CN102712609A (es)
AR (1)	AR079327A1 (es)
AU (1)	AU2010330031B2 (es)
BR (1)	BR112012013175A2 (es)
CA (1)	CA2776727C (es)
CL (1)	CL2012001464A1 (es)
CO (1)	CO6541656A2 (es)
CR (1)	CR20120262A (es)
EC (1)	ECSP12011961A (es)
IL (1)	IL219107A (es)
IN (1)	IN2012DN03043A (es)
MA (1)	MA34779B1 (es)
MX (1)	MX2012006493A (es)
MY (1)	MY169962A (es)
NZ (1)	NZ599008A (es)
PE (1)	PE20121500A1 (es)
PH (1)	PH12012500619A1 (es)
RU (1)	RU2515221C2 (es)
SG (1)	SG181610A1 (es)
TW (1)	TWI487704B (es)
UA (1)	UA103272C2 (es)
WO (1)	WO2011069934A1 (es)

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Publication number	Publication date
US8389513B2 (en)	2013-03-05
CA2776727A1 (en)	2011-06-16
AU2010330031A1 (en)	2012-06-07
ECSP12011961A (es)	2012-07-31
SG181610A1 (en)	2012-07-30
RU2515221C2 (ru)	2014-05-10
JP2013513563A (ja)	2013-04-22
BR112012013175A2 (pt)	2019-09-24
PE20121500A1 (es)	2012-11-05
CR20120262A (es)	2012-07-27
NZ599008A (en)	2013-08-30
IL219107A0 (en)	2012-06-28
AR079327A1 (es)	2012-01-18
MA34779B1 (fr)	2014-01-02
KR101506773B1 (ko)	2015-03-27
JP5584778B2 (ja)	2014-09-03
IN2012DN03043A (es)	2015-07-31
CO6541656A2 (es)	2012-10-16
KR20120104598A (ko)	2012-09-21
PH12012500619A1 (en)	2012-10-22
EP2509965A1 (en)	2012-10-17
MX2012006493A (es)	2012-07-03
CN102712609A (zh)	2012-10-03
CA2776727C (en)	2016-05-31
UA103272C2 (uk)	2013-09-25
AU2010330031B2 (en)	2013-06-20
TW201124408A (en)	2011-07-16
IL219107A (en)	2015-10-29
TWI487704B (zh)	2015-06-11
US20110144097A1 (en)	2011-06-16
WO2011069934A1 (en)	2011-06-16
MY169962A (en)	2019-06-19
RU2012126989A (ru)	2014-01-20

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CL2012001464A1 (es)	2014-03-07	Compuestos derivados de (2-amino-5,5-difluor-5,6-dihidro-4h-[1,3]oxazin-4-il)-fenilamida, inhibidores bace1 y/o bace2; composicion farmaceutica; procedimiento de preparacion; y uso en el tratamiento terapeutico y/o profilactico de enfermedades tales como alzheimer y diabetes.
PH12013502090A1 (en)	2018-03-21	1,3 oxazines as bace1 and/or bace2 inhibitors
IN2012DN00766A (es)	2015-06-26
MX2013014007A (es)	2014-03-12	[1,3] oxazinas.
PH12013502316A1 (en)	2015-09-04	Halogen-alkyl-1,3 oxazines as bace1 and/or bace2 inhibitors
PH12013502156A1 (en)	2014-01-06	1,3-oxazines as bace1 and/or bace2 inhibitors
CL2007002708A1 (es)	2008-04-04	Compuestos derivados de pirrolo[2,3-b]piridina; procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, caquexia, trastornos inflamatorios, entre otros.
WO2012104263A3 (en)	2012-09-27	1,4 oxazines as bace1 and/or bace2 inhibitors
MX2013007558A (es)	2013-08-21	1,4-oxazinas como inhibidores de los genes enzima de segmentacion de la proteina precursora del sitio 1 y/o 2 (bace1 y/o bace2).
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PH12013502262A1 (en)	2016-01-22	Spiro-[1,3]-oxazines and spiro-[1,4]-oxazepines as bace1 and/or bace2 inhibitors
CL2007003765A1 (es)	2008-08-22	Compuestos derivados de 2-oxo-4-hidroxi-benzotiazol; procesode preparacion; composicion farmaceutica; combinacion farmaceutica; y uso en el tratamiento de enfermedades tales como epoc, bronquitis, asma y bronquiectasias.
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CL2008000690A1 (es)	2008-09-12	Compuestos derivados del acido indol-3-propionico; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hiperlipidemia, hipertension; entre otras.
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PH12014501334A1 (en)	2014-09-15	Fluoromethyl-5,6-dihydro-4h-[1,3]oxazines
CL2007002207A1 (es)	2008-02-01	Compuestos derivados de sulfonilaminas; composicion farmaceutica; y uso de los compuestos en el tratamiento del glaucoma.
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MX2013014194A (es)	2014-03-21	1,3-tiazepinas fusionadas a ciclopropilo como inhibidores de beta-secretasa 1 (bace) y/o beta-secretasa 2 (bace 2).
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