CL2012001461A1 - Compuestos derivados de difenil-pirazolopiridinas, moduladores del receptor nuclear nurr-1; compuestos intermediarios; composición farmacéutica; y su uso para el tratamiento y prevención de enfermedades neurodegenerativas, traumatismos cerebrales, enfermedades inflamatorias, osteoporosis, cáncer, entre otras. - Google Patents
Compuestos derivados de difenil-pirazolopiridinas, moduladores del receptor nuclear nurr-1; compuestos intermediarios; composición farmacéutica; y su uso para el tratamiento y prevención de enfermedades neurodegenerativas, traumatismos cerebrales, enfermedades inflamatorias, osteoporosis, cáncer, entre otras.Info
- Publication number
- CL2012001461A1 CL2012001461A1 CL2012001461A CL2012001461A CL2012001461A1 CL 2012001461 A1 CL2012001461 A1 CL 2012001461A1 CL 2012001461 A CL2012001461 A CL 2012001461A CL 2012001461 A CL2012001461 A CL 2012001461A CL 2012001461 A1 CL2012001461 A1 CL 2012001461A1
- Authority
- CL
- Chile
- Prior art keywords
- compounds
- osteoporosis
- cancer
- pharmaceutical composition
- treatment
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 208000001132 Osteoporosis Diseases 0.000 title abstract 2
- 208000030886 Traumatic Brain injury Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 208000027866 inflammatory disease Diseases 0.000 title abstract 2
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- PIWSKNFAGSZLBM-UHFFFAOYSA-N 3,5-diphenyl-1h-pyrazolo[4,3-b]pyridine Chemical class C1=CC=CC=C1C1=NNC2=CC=C(C=3C=CC=CC=3)N=C12 PIWSKNFAGSZLBM-UHFFFAOYSA-N 0.000 title 1
- 108020005497 Nuclear hormone receptor Proteins 0.000 title 1
- 230000004770 neurodegeneration Effects 0.000 title 1
- 102000006255 nuclear receptors Human genes 0.000 title 1
- 108020004017 nuclear receptors Proteins 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
LA PRESENTE INVENCIÓN SE REFIERE A COMPUESTOS DE FÓRMULA (I), EN DONDE X, Y, R Y R1 SON COMO SE DEFINEN EN LA MEMORIA DESCRIPTIVA Y PLIEGO DE REIVINDICACIONES; SE DESCRIBE ADEMÁS LA COMPOSICIÓN FARMACÉUTICA QUE LOS COMPRENDE; EL USO DE LOS COMPUESTOS EN EL TRATAMIENTO DE ENFERMEDADES NEURODEGENERATIVAS, TRAUMATISMOS CEREBRALES, ENFERMEDADES INFLAMATORIAS, OSTEOPOROSIS, CÁNCER, ENTRE OTRAS; EL COMPUESTO INTERMEDIARIO DE SÍNTESIS DE FÓRMULA (VI -1) Y EL USO DEL MISMO EN LA SÍNTESIS DE LOS COMPUESTOS DE FÓRMULA I.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0958651A FR2953520B1 (fr) | 2009-12-04 | 2009-12-04 | Derives de diphenyl-pyrazolopyridines, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2012001461A1 true CL2012001461A1 (es) | 2012-10-12 |
Family
ID=42111360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2012001461A CL2012001461A1 (es) | 2009-12-04 | 2012-06-04 | Compuestos derivados de difenil-pirazolopiridinas, moduladores del receptor nuclear nurr-1; compuestos intermediarios; composición farmacéutica; y su uso para el tratamiento y prevención de enfermedades neurodegenerativas, traumatismos cerebrales, enfermedades inflamatorias, osteoporosis, cáncer, entre otras. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8680096B2 (es) |
| EP (1) | EP2507238B1 (es) |
| JP (1) | JP5738310B2 (es) |
| KR (1) | KR101696959B1 (es) |
| CN (1) | CN102762559B (es) |
| AR (1) | AR079250A1 (es) |
| AU (1) | AU2010326429B2 (es) |
| BR (1) | BR112012013511A2 (es) |
| CA (1) | CA2782704C (es) |
| CL (1) | CL2012001461A1 (es) |
| CO (1) | CO6551713A2 (es) |
| EA (1) | EA020652B1 (es) |
| FR (1) | FR2953520B1 (es) |
| IL (1) | IL220060A (es) |
| JO (1) | JO3098B1 (es) |
| MA (1) | MA33893B1 (es) |
| MX (1) | MX2012006421A (es) |
| MY (1) | MY157676A (es) |
| NZ (1) | NZ600368A (es) |
| PH (1) | PH12012501075A1 (es) |
| SG (1) | SG181138A1 (es) |
| TW (1) | TWI481606B (es) |
| UY (1) | UY33079A (es) |
| WO (1) | WO2011067544A1 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2950344B1 (fr) * | 2009-09-18 | 2011-11-25 | Sanofi Aventis | Derives de 5-phenyl-pyrazolopyridine, leur preparation et leur aplication en therapeutique. |
| FR2950345B1 (fr) * | 2009-09-18 | 2011-09-23 | Sanofi Aventis | Derives acetyleniques de 5-phenyl-pyrazolopyridine, leur preparation et leur application en therapeutique |
| WO2018098491A1 (en) | 2016-11-28 | 2018-05-31 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US20210188839A1 (en) * | 2016-11-28 | 2021-06-24 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| ES2992063T3 (es) | 2016-11-28 | 2024-12-09 | Praxis Prec Medicines Inc | Compuestos y procedimientos de uso de los mismos |
| IL267139B2 (en) * | 2016-12-08 | 2023-03-01 | Bayer Cropscience Ag | A method for the production of 5-(1-phenyl-h1-pyrazol-4-yl)-nicotinamide derivatives and similar compounds without isolation or purification of the phenylhydrazine intermediate |
| US11492345B2 (en) | 2017-02-13 | 2022-11-08 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2018187480A1 (en) | 2017-04-04 | 2018-10-11 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2019035951A1 (en) | 2017-08-15 | 2019-02-21 | Praxis Precision Medicines, Inc. | COMPOUNDS AND THEIR METHODS OF USE |
| CN112423760A (zh) | 2018-05-30 | 2021-02-26 | 普拉克西斯精密药物股份有限公司 | 离子通道调节剂 |
| EA202092908A1 (ru) | 2018-09-28 | 2021-05-14 | Праксис Пресижн Медсинз, Инк. | Модуляторы ионных каналов |
| US11773099B2 (en) | 2019-05-28 | 2023-10-03 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11505554B2 (en) | 2019-05-31 | 2022-11-22 | Praxis Precision Medicines, Inc. | Substituted pyridines as ion channel modulators |
| US11279700B2 (en) | 2019-05-31 | 2022-03-22 | Praxis Precision Medicines, Inc. | Ion channel modulators |
| US11767325B2 (en) | 2019-11-26 | 2023-09-26 | Praxis Precision Medicines, Inc. | Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators |
| CN111138325B (zh) * | 2019-12-20 | 2021-11-30 | 台州学院 | 一种(Z)-β-磺酰基烯胺类化合物的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001139575A (ja) * | 1999-11-15 | 2001-05-22 | Fujisawa Pharmaceut Co Ltd | 新規ピラゾロピリジン誘導体 |
| FR2906250B1 (fr) * | 2006-09-22 | 2008-10-31 | Sanofi Aventis Sa | Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique |
| JP5442449B2 (ja) * | 2006-12-22 | 2014-03-12 | アステックス、セラピューティックス、リミテッド | 新規化合物 |
| FR2928921B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines, leur preparation et leur application en therapeutique |
| FR2928923B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques |
| FR2928924B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique |
| US8198449B2 (en) * | 2008-09-11 | 2012-06-12 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| FR2950344B1 (fr) * | 2009-09-18 | 2011-11-25 | Sanofi Aventis | Derives de 5-phenyl-pyrazolopyridine, leur preparation et leur aplication en therapeutique. |
-
2009
- 2009-12-04 FR FR0958651A patent/FR2953520B1/fr not_active Expired - Fee Related
-
2010
- 2010-12-02 JO JOP/2010/0430A patent/JO3098B1/ar active
- 2010-12-03 KR KR1020127017287A patent/KR101696959B1/ko not_active Expired - Fee Related
- 2010-12-03 MY MYPI2012002449A patent/MY157676A/en unknown
- 2010-12-03 AR ARP100104462A patent/AR079250A1/es unknown
- 2010-12-03 NZ NZ600368A patent/NZ600368A/en not_active IP Right Cessation
- 2010-12-03 EA EA201290520A patent/EA020652B1/ru not_active IP Right Cessation
- 2010-12-03 BR BR112012013511A patent/BR112012013511A2/pt not_active IP Right Cessation
- 2010-12-03 SG SG2012039749A patent/SG181138A1/en unknown
- 2010-12-03 MX MX2012006421A patent/MX2012006421A/es active IP Right Grant
- 2010-12-03 MA MA35024A patent/MA33893B1/fr unknown
- 2010-12-03 PH PH1/2012/501075A patent/PH12012501075A1/en unknown
- 2010-12-03 CN CN201080062600.0A patent/CN102762559B/zh not_active Expired - Fee Related
- 2010-12-03 TW TW099142230A patent/TWI481606B/zh not_active IP Right Cessation
- 2010-12-03 EP EP10801625.4A patent/EP2507238B1/fr not_active Not-in-force
- 2010-12-03 WO PCT/FR2010/052605 patent/WO2011067544A1/fr not_active Ceased
- 2010-12-03 UY UY33079A patent/UY33079A/es not_active Application Discontinuation
- 2010-12-03 JP JP2012541567A patent/JP5738310B2/ja not_active Expired - Fee Related
- 2010-12-03 AU AU2010326429A patent/AU2010326429B2/en not_active Ceased
- 2010-12-03 CA CA2782704A patent/CA2782704C/fr not_active Expired - Fee Related
- 2010-12-03 US US13/513,497 patent/US8680096B2/en not_active Expired - Fee Related
-
2012
- 2012-05-30 IL IL220060A patent/IL220060A/en not_active IP Right Cessation
- 2012-06-04 CL CL2012001461A patent/CL2012001461A1/es unknown
- 2012-06-04 CO CO12093017A patent/CO6551713A2/es active IP Right Grant
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