CL2012000658A1 - Composicion farmaceutica que comprende microesferas entericamente recubiertas que contienen enzimas digestivas tal como lipasa y microesferas no recubiertas entericamente que contienen enzimas digestivas tal como proteasa; forma de dosis; y su uso tratar el dolor de pancreatitis e insuficiencia pancreatica. - Google Patents
Composicion farmaceutica que comprende microesferas entericamente recubiertas que contienen enzimas digestivas tal como lipasa y microesferas no recubiertas entericamente que contienen enzimas digestivas tal como proteasa; forma de dosis; y su uso tratar el dolor de pancreatitis e insuficiencia pancreatica.Info
- Publication number
- CL2012000658A1 CL2012000658A1 CL2012000658A CL2012000658A CL2012000658A1 CL 2012000658 A1 CL2012000658 A1 CL 2012000658A1 CL 2012000658 A CL2012000658 A CL 2012000658A CL 2012000658 A CL2012000658 A CL 2012000658A CL 2012000658 A1 CL2012000658 A1 CL 2012000658A1
- Authority
- CL
- Chile
- Prior art keywords
- digestive enzymes
- microspheres containing
- enterically
- containing digestive
- pancreatitis
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2813—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Composiciones farmacéuticas de encimas digestivas que comprende microesferas entericamente recubiertas que contienen enzimas digestivas tal como lipasa y microesferas no recubiertas que contienen enzimas digestivas tal como proteasa; forma de dosis; y método para tratar el dolor de pancreatitis y de la insuficiencia pancreática.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24346709P | 2009-09-17 | 2009-09-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2012000658A1 true CL2012000658A1 (es) | 2012-09-28 |
Family
ID=43730817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2012000658A CL2012000658A1 (es) | 2009-09-17 | 2012-03-15 | Composicion farmaceutica que comprende microesferas entericamente recubiertas que contienen enzimas digestivas tal como lipasa y microesferas no recubiertas entericamente que contienen enzimas digestivas tal como proteasa; forma de dosis; y su uso tratar el dolor de pancreatitis e insuficiencia pancreatica. |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8784884B2 (es) |
| EP (1) | EP2477645B1 (es) |
| JP (1) | JP5877399B2 (es) |
| KR (1) | KR101771752B1 (es) |
| CN (2) | CN102630164B (es) |
| AR (1) | AR078291A1 (es) |
| AU (1) | AU2010295494B2 (es) |
| BR (1) | BR112012005837A8 (es) |
| CA (1) | CA2774269C (es) |
| CL (1) | CL2012000658A1 (es) |
| CO (1) | CO6531419A2 (es) |
| ES (1) | ES2690661T3 (es) |
| HK (1) | HK1218886A1 (es) |
| IL (2) | IL218656A (es) |
| MX (1) | MX2012003214A (es) |
| MY (1) | MY161843A (es) |
| NZ (1) | NZ599143A (es) |
| RU (1) | RU2570376C2 (es) |
| SA (1) | SA110310695B1 (es) |
| TW (2) | TW201639545A (es) |
| UY (1) | UY32896A (es) |
| WO (1) | WO2011035079A1 (es) |
| ZA (1) | ZA201202761B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1319655B1 (it) | 2000-11-15 | 2003-10-23 | Eurand Int | Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione. |
| DK2079445T3 (en) | 2007-02-20 | 2016-02-15 | Allergan Pharmaceuticals Internat Ltd | Stable digestive compositions |
| US10087493B2 (en) | 2008-03-07 | 2018-10-02 | Aptalis Pharma Canada Ulc | Method for detecting infectious parvovirus in pharmaceutical preparations |
| EA029101B1 (ru) | 2010-10-01 | 2018-02-28 | Апталис Фарма Лимитид | Составы с низкой дозой панкрелипазы и кишечнорастворимым покрытием |
| RU2602183C2 (ru) | 2011-08-08 | 2016-11-10 | Апталис Фарма Лтд. | Способ проведения теста на растворение твердых композиций, содержащих пищеварительные ферменты |
| RU2679832C2 (ru) | 2013-08-09 | 2019-02-13 | Аллерган Фармасьютикалз Интернэйшнл Лимитед | Композиция пищеварительных ферментов, подходящая для энтерального введения |
| EP3157568A1 (en) | 2014-06-19 | 2017-04-26 | Aptalis Pharma Limited | Methods for removing viral contaminants from pancreatic extracts |
| FR3079146B1 (fr) * | 2018-03-23 | 2020-04-17 | Karim Ioualalen | Formulation gastroprotectrice de complexes d’enzymes permettant de restaurer la fonction digestive. |
| WO2021202363A1 (en) * | 2020-03-30 | 2021-10-07 | Wall Jai | Combined animal-derived and synthetically produced pancreatic enzyme replacement therapy |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1509866A (en) | 1975-06-10 | 1978-05-04 | Johnson & Johnson | Enteric coated digestive enzyme compositions |
| US4447412A (en) | 1983-02-01 | 1984-05-08 | Bilton Gerald L | Enzyme-containing digestive aid compostions |
| US5578304A (en) | 1992-06-22 | 1996-11-26 | Digestive Care Inc. | Compositions of digestive enzymes and salts of bile acids and process for preparation thereof |
| US5302400A (en) | 1992-06-22 | 1994-04-12 | Digestive Care Inc. | Preparation of gastric acid-resistant microspheres containing digestive enzymes and buffered-bile acids |
| US5460812A (en) | 1992-06-22 | 1995-10-24 | Digestive Care Inc. | Compositions of digestive enzymes and salts of bile acids and process for preparation thereof |
| US5260074A (en) | 1992-06-22 | 1993-11-09 | Digestive Care Inc. | Compositions of digestive enzymes and salts of bile acids and process for preparation thereof |
| DE4227385A1 (de) | 1992-08-19 | 1994-02-24 | Kali Chemie Pharma Gmbh | Pankreatinmikropellets |
| JP2000505801A (ja) | 1996-02-09 | 2000-05-16 | クアドラント・ホールディングズ・ケンブリッジ・リミテッド | トレハロースを含む固形製剤 |
| US5750104A (en) | 1996-05-29 | 1998-05-12 | Digestive Care Inc. | High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith |
| US20010046493A1 (en) | 2000-02-24 | 2001-11-29 | Alex Margolin | Lipase-containing composition and methods of use thereof |
| CN1156308C (zh) * | 2002-04-19 | 2004-07-07 | 北京世诺医药科技有限公司 | 多酶组合胶囊 |
| US20040121010A1 (en) * | 2002-10-25 | 2004-06-24 | Collegium Pharmaceutical, Inc. | Pulsatile release compositions of milnacipran |
| WO2004071374A2 (en) | 2003-02-11 | 2004-08-26 | Torrent Pharmaceuticals Limited | Once a day orally administered pharmaceutical compositions |
| JP2007509982A (ja) * | 2003-10-29 | 2007-04-19 | アルタス ファーマシューティカルズ インコーポレイテッド | 血漿コレシストキニン（ｃｃｋ）濃度を制御するための非膵臓プロテアーゼおよび痛みを処置するための非膵臓プロテアーゼ |
| US7387793B2 (en) | 2003-11-14 | 2008-06-17 | Eurand, Inc. | Modified release dosage forms of skeletal muscle relaxants |
| US7470435B2 (en) | 2003-11-17 | 2008-12-30 | Andrx Pharmaceuticals, Llc | Extended release venlafaxine formulation |
| DE602005009677D1 (de) | 2004-03-22 | 2008-10-23 | Solvay Pharm Gmbh | Orale pharmazeutische zusammensetzungen von produkten mit lipase, insbesondere von pankreatin, mit tensiden |
| DK1755656T3 (da) * | 2004-05-24 | 2010-10-04 | Novozymes As | Enzymer til farmaceutisk anvendelse |
| RU2385736C2 (ru) * | 2004-10-14 | 2010-04-10 | Элтус Фармасьютикалз Инк. | Композиции, содержащие липазу, протеазу и амилазу, предназначенные для лечения недостаточности поджелудочной железы |
| US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
| EP1896577A2 (en) * | 2005-06-24 | 2008-03-12 | Novozymes A/S | Lipases for pharmaceutical use |
| US20070025977A1 (en) | 2005-07-21 | 2007-02-01 | Mulberg Andrew E | Method of treating steatorrhea in infants |
| US20070148151A1 (en) | 2005-07-29 | 2007-06-28 | Martin Frink | Processes for the manufacture and use of pancreatin |
| US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
| US11266607B2 (en) * | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| WO2007053619A2 (en) | 2005-11-01 | 2007-05-10 | Bio-Cat, Inc. | A composition with a fungal (yeast) lipase and method for treating lipid malabsorption in cystic fibrous as well as people suffering from pancreatic lipase insufficiency |
| BRPI0712087A2 (pt) * | 2006-05-26 | 2012-07-17 | Nestec Ag | métodos de uso e composições nutricionais de extrato de rouchi |
| US20080199448A1 (en) * | 2007-02-16 | 2008-08-21 | Ross Mairi R | Enzyme composition for improving food digestion |
| DK2079445T3 (en) | 2007-02-20 | 2016-02-15 | Allergan Pharmaceuticals Internat Ltd | Stable digestive compositions |
| US20090117180A1 (en) | 2007-02-20 | 2009-05-07 | Giovanni Ortenzi | Stable digestive enzyme compositions |
| WO2010037695A1 (en) | 2008-09-30 | 2010-04-08 | Dsm Ip Assets B.V. | Enzyme composition and application thereof in the treatment of pancreatic insufficiency |
-
2009
- 2009-09-28 US US12/568,064 patent/US8784884B2/en active Active
-
2010
- 2010-09-16 TW TW105126319A patent/TW201639545A/zh unknown
- 2010-09-16 TW TW099131496A patent/TWI572372B/zh not_active IP Right Cessation
- 2010-09-17 CN CN201080041366.3A patent/CN102630164B/zh not_active Expired - Fee Related
- 2010-09-17 NZ NZ599143A patent/NZ599143A/en not_active IP Right Cessation
- 2010-09-17 CN CN201510490337.XA patent/CN105214073A/zh active Pending
- 2010-09-17 EP EP10817867.4A patent/EP2477645B1/en not_active Revoked
- 2010-09-17 ES ES10817867.4T patent/ES2690661T3/es active Active
- 2010-09-17 MX MX2012003214A patent/MX2012003214A/es active IP Right Grant
- 2010-09-17 MY MYPI2012001215A patent/MY161843A/en unknown
- 2010-09-17 AU AU2010295494A patent/AU2010295494B2/en not_active Ceased
- 2010-09-17 BR BR112012005837A patent/BR112012005837A8/pt not_active Application Discontinuation
- 2010-09-17 CA CA2774269A patent/CA2774269C/en not_active Expired - Fee Related
- 2010-09-17 AR ARP100103408A patent/AR078291A1/es not_active Application Discontinuation
- 2010-09-17 UY UY0001032896A patent/UY32896A/es not_active Application Discontinuation
- 2010-09-17 JP JP2012529909A patent/JP5877399B2/ja not_active Expired - Fee Related
- 2010-09-17 KR KR1020127009516A patent/KR101771752B1/ko not_active Expired - Fee Related
- 2010-09-17 RU RU2012113253/15A patent/RU2570376C2/ru active
- 2010-09-17 WO PCT/US2010/049203 patent/WO2011035079A1/en not_active Ceased
- 2010-09-18 SA SA110310695A patent/SA110310695B1/ar unknown
-
2012
- 2012-03-15 CL CL2012000658A patent/CL2012000658A1/es unknown
- 2012-03-15 IL IL218656A patent/IL218656A/en active IP Right Grant
- 2012-03-26 CO CO12050658A patent/CO6531419A2/es unknown
- 2012-04-16 ZA ZA2012/02761A patent/ZA201202761B/en unknown
-
2014
- 2014-06-05 US US14/296,832 patent/US20160051472A9/en not_active Abandoned
-
2016
- 2016-05-26 IL IL245875A patent/IL245875A0/en unknown
- 2016-06-17 HK HK16107000.5A patent/HK1218886A1/zh unknown
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