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CL2011002457A1 - Peptido antigenico fosforilado de una proteina tau presente en la superficie de un liposoma; composicion farmaceutica que comprende el peptido antigeno tau en la superficie de un liposoma; uso para preparar un medicamento para tratar trastorno o enfermedad neurodegenerativa . - Google Patents

Peptido antigenico fosforilado de una proteina tau presente en la superficie de un liposoma; composicion farmaceutica que comprende el peptido antigeno tau en la superficie de un liposoma; uso para preparar un medicamento para tratar trastorno o enfermedad neurodegenerativa .

Info

Publication number
CL2011002457A1
CL2011002457A1 CL2011002457A CL2011002457A CL2011002457A1 CL 2011002457 A1 CL2011002457 A1 CL 2011002457A1 CL 2011002457 A CL2011002457 A CL 2011002457A CL 2011002457 A CL2011002457 A CL 2011002457A CL 2011002457 A1 CL2011002457 A1 CL 2011002457A1
Authority
CL
Chile
Prior art keywords
liposome
tau
disease
pharmaceutical composition
phosphorylated
Prior art date
Application number
CL2011002457A
Other languages
English (en)
Inventor
Leuven Fred Van
Andrea Pfeifer
Andreas Muhs
Maria Pihlgren
Original Assignee
Ac Immune Sa
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42269736&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2011002457(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ac Immune Sa, Univ Leuven Kath filed Critical Ac Immune Sa
Publication of CL2011002457A1 publication Critical patent/CL2011002457A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • G—PHYSICS
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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Abstract

LA PRESENTE INVENCIÓN SE REFIERE A UN PÉPTIDO ANTIGÉNICO, COMPOSICIONES FARMACÉUTICAS PARA EL USO TERAPÉUTICO Y DIAGNÓSTICO DE ENFERMEDADES Y TRASTORNOS QUE SON CAUSADOS POR O ASOCIADOS CON OVILLOS NEUROFIBRILARES. EN PARTICULAR, LA INVENCIÓN SE REFIERE A LA COMPOSICIÓN FARMACÉUTICA QUE COMPRENDE UN PÉPTIDO ANTIGÉNICO, PARTICULARMENTE UN FOSFO-PÉPTIDO ANTIGÉNICO QUE IMITA UN FOSFO-EPITOPE DE LA PROTEINA TAU PATOLÓGICA MAYOR, PA RA EL USO EN LA PREPARACIÓN DE UN MEDICAMENTO ÚTIL PARA TRATAR TAUOPATIAS QUE INCLUYE LA ENFERMEDAD DE ALZHEIMER.
CL2011002457A 2009-04-03 2011-10-03 Peptido antigenico fosforilado de una proteina tau presente en la superficie de un liposoma; composicion farmaceutica que comprende el peptido antigeno tau en la superficie de un liposoma; uso para preparar un medicamento para tratar trastorno o enfermedad neurodegenerativa . CL2011002457A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09157303 2009-04-03

Publications (1)

Publication Number Publication Date
CL2011002457A1 true CL2011002457A1 (es) 2012-03-16

Family

ID=42269736

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2011002457A CL2011002457A1 (es) 2009-04-03 2011-10-03 Peptido antigenico fosforilado de una proteina tau presente en la superficie de un liposoma; composicion farmaceutica que comprende el peptido antigeno tau en la superficie de un liposoma; uso para preparar un medicamento para tratar trastorno o enfermedad neurodegenerativa .
CL2013002888A CL2013002888A1 (es) 2009-04-03 2013-10-08 Anticuerpo que se une peptido antigenico que se obtiene a partir de una proteina tau; composicion farmaceutica que comprende; uso para tratar trastorno o enfermedad neurodegenerativa;kit de ensayo, linea celular (div 2457-2011).

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2013002888A CL2013002888A1 (es) 2009-04-03 2013-10-08 Anticuerpo que se une peptido antigenico que se obtiene a partir de una proteina tau; composicion farmaceutica que comprende; uso para tratar trastorno o enfermedad neurodegenerativa;kit de ensayo, linea celular (div 2457-2011).

Country Status (28)

Country Link
US (3) US8647631B2 (es)
EP (2) EP3097925B1 (es)
JP (2) JP5810076B2 (es)
KR (2) KR101770436B1 (es)
CN (2) CN105524160B (es)
AU (1) AU2010233856B2 (es)
BR (1) BRPI1015088B1 (es)
CA (1) CA2757345C (es)
CL (2) CL2011002457A1 (es)
CO (1) CO6390113A2 (es)
CR (1) CR20110509A (es)
DK (2) DK3097925T3 (es)
EC (1) ECSP11011367A (es)
ES (2) ES2595371T3 (es)
HU (2) HUE044981T2 (es)
IL (1) IL215451A (es)
MA (1) MA34120B1 (es)
MX (1) MX2011010353A (es)
MY (1) MY171300A (es)
NZ (1) NZ595856A (es)
PL (2) PL3097925T3 (es)
PT (2) PT3097925T (es)
RU (1) RU2582916C2 (es)
SG (1) SG175037A1 (es)
SI (2) SI3097925T1 (es)
UA (1) UA107571C2 (es)
WO (1) WO2010115843A2 (es)
ZA (1) ZA201107776B (es)

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